• Tuberculosis and Respiratory Diseases
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• v.56 no.3
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• pp.268-279
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• 2004

Background : The tuberculin skin test has been used to diagnose latent tuberculosis infection, but is not widely used to diagnose or exclude pulmonary tuberculosis. The objective of this study was to evaluate the diagnostic utility of the tuberculin test in diagnosing and excluding pulmonary tuberculosis, and differentiating pulmonary tuberculosis from nontuberculous mycobacteria (NTM) pulmonary disease, when a sputum acid-fast bacilli (AFB) smear was positive. Material and Methods : From October 2002 to August 2003, among all the inpatients of the Division of Pulmonary and Critical Care Medicine at Samsung Medical Center, 258 patients with clinical suspicion of pulmonary tuberculosis were enrolled and underwent a tuberculin test. Results : 156 males and 102 females were included, with a mean age of 57.5 years. The final diagnoses included lung cancer in 89 cases (34.5%), pulmonary tuberculosis in 59 cases (22.9%), bacterial pneumonia in 33 cases (12.8%) and NTM pulmonary disease in 24 cases (9.3%). The positive tuberculin test rate was higher in the tuberculosis than non-tuberculosis group; 81.4 (48/59) vs. 42.4% (81/199). (p<0.001). In 208 patients with a negative sputum AFB smear, the result of the tuberculin test was positive in 69.4% (25/36) of the tuberculosis group and in 44.8% (77/172) of the non-tuberculosis group (p=0.007), so a positive result of the tuberculin test could predict pulmonary tuberculosis with 69.4% sensitivity, 55.2% specificity, a 24.5% positive predictive value and a 89.6% negative predictive value. In 50 patients with a positive sputum AFB smear, the positive rates of the tuberculin test were 83.9% (26/31) in tuberculosis group and 21.1% (4/19) in NTM pulmonary disease group (p<0.001), so a positive result of the tuberculin skin test could predict pulmonary tuberculosis with 83.9% sensitivity, 78.9% specificity, a 86.7% positive predictive value and a 75.0% negative predictive value. Conclusion : The tuberculin test could be useful in excluding pulmonary tuberculosis when the sputum AFB smear is negative, and to differentiate pulmonary tuberculosis from NTM pulmonary disease when the sputum AFB smear is positive.

• Annals of Clinical Microbiology
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• v.21 no.4
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• pp.75-79
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• 2018

Background: Urine culture is one of the most frequently requested tests in microbiology. Automated urine analyzers yield much infection-related information. The Sysmex UF-5000 analyzer (Sysmex, Japan) is a new flow cytometry urine analyzer capable of quantifying urinary particles, including bacteria, WBCs, and yeast-like cells (YLCs) and can provide a Gram stainability flag. In this work, we evaluated how many unnecessary urine cultures could be screened out using the UF-5000. Methods: We compared the culture results of 126 urine samples among 453 requested urine cultures (from sources other than the Urology and Nephrology departments) with urinalysis results. Urine cultures were considered positive if bacterial or YLC growth was ${\geq}10^4CFUs/mL$. Results: We used urinalysis cut-off values of $50/{\mu}L$ and $100/{\mu}L$ for bacteria and YLC, respectively. Forty eight of the 126 (38.1%, or 10.6% of 453 requested) cultures were below these cut-off values and did not contain any culture-positive samples. Conclusion: Bacteria and YLC counts generated using the UF-5000 analyzer could be used to screen out negative cultures and reduce urine culture volume by ~10% without sacrificing detection of positive cultures.

• Clinical and Experimental Pediatrics
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• v.50 no.9
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• pp.896-900
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• 2007

Purpose : The aim of this study was to investigate the speech problems in benign rolandic epilepsy (BRE) according to the seizure focus in EEG and semiology. Methods : Twenty three patients [right origin (13 patients) or left side (10 patients)] who met the BRE criteria by International League Against Epilepsy (ILAE) were prospectively enrolled. We excluded the patients who had abnormal MRI or showed both side spikes in EEG. Computerized Speech Lab was used to assess the speech characteristics of the patients. Results : The error pattern of laryngeal articulation in BRE was exclusively substitution of stop consonants, these errors showed more frequent in the left group (16.0% vs 25.5%). Voice onset time (VOT) of stop consonants and Total duration (TD) of word in both groups were prolonged than normal control group, especially in left group (P<0.05). The first formant of vowel /o/ and second formant of /e/ were significantly decreased in left group (P<0.05). The right group scored wider on pitch range ($192.9{\pm}54.0Hz$) and energy range in spontaneous speech ($14.2{\pm}6.4db$) than the left group ($233.3{\pm}12.5Hz$, $19.4{\pm}9.3db$, respectively, P>0.05). Duration of counting (5 to 9) in left group slower than right group ($8.6{\pm}1.7$ vs $7.9{\pm}1.8sec$). Conclusion : Our data suggested that interictal spikes and seizures in either centrotemporal sides, especially left side group, may induce speech problems. We recommend the logopedic and phoniatric evaluations of speech in BRE patients.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.14 no.2
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• pp.104-109
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• 2003

The purpose of this study is to analyze the EGG measures from Lx Speech Studio program (Laryngograph Ltd, UK) in patient with vocal nodule. Thirty female adults (15 patient with vocal nodule, 15 normal speaker) produced sustained vowel and read the passage. They were grouped into three groups based on Grade (GRBAS) : normal-G0, nodule-Gl, nodule-G2. Estimates of Fx (Hz), Qx(%), Jitter, Shimmer, and HNR were made from a 500msec midportion of vowel. In addition, DFx(Hz), DQx(%), CFx(%) and CAx(%) were obtained from reading the passage. These data were compared among groups. The results were as follow Jitter, Shimmer, HNR were significantly higher in nodule-G2 group than in normal-G0 & patient-Gl group. In nodule-G2 group, CFx and CAx from reading passage were significantly higher. For patients with nodule, asymmetry or irregularity were observed in graphs of QxFx ＆ CFx provided by Quantitative Analysis.

• Proceedings of the Korea Contents Association Conference
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• 2010.05a
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• pp.218-220
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• 2010

85명의 유방암 환자를 대상으로 이들의 유방영상을 검토하고 유방암 환자들의 특징을 살펴보고자 한 본 논문에서 유방암 환자들의 평균나이는 51.9세이었고, 유방암이 가장 많이 발생하는 부위는 상외측(43.5%)인 것으로 조사되었으며, 유방암이 가장 많이 발생하는 연령은 40대 인 것으로 조사되었다. 유방암 환자들의 유방조직밀도는 69.4%가 dense breast이었고, 30.6%가 fatty breast인 것으로 조사되었으며, 이 두 그룹의 평균연령은 dense breast를 가진 그룹이 유의하게 낮은 것으로 조사되었다. 유방영상의 위음성률은 27.1%, 민감도는 72.9%로 조사되었고, dense breast를 가진 환자들의 유방영상 위음성률은 32.2%, 민감도는 67.8%로 조사되었다.

• Proceedings of the KSLP Conference
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• 1994.06a
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• pp.110-116
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• 1994

보통사람의 성대는 일상회화중 1초에 100∼300번의 진동을 하며 노래를 하는 경우는 1,000번 이상도 진동하게 되므로 우리의 유안으로는 그 자세한 진동상태를 관찰할 수가 없어 특수한 기기를 사용해야만 한다. 현재로서 사용되는 특수기기로는 후두스트로보스코피(laryngostroboscopy), 초고속영화법(ultra high speed photography), 그로토그라피(glottography) 및 카이모그라피(kymography) 등이 있다. 이 중 초고속영화법은 1초에 3,000회 이상의 성대진동을 촬영할 수 있어 연구 및 교육에 대단히 유용한 기기이나 가격이 비싸고 그 data를 분석하는데 시간이 많이 걸려 일반임상검사로서는 부적당하며 그로토그라피는 성대자체를 직접 관찰하는 것이 아니고 그 관측결과를 그래프로 나타내주는 기기로서 에에는 초음파, 광전 및 전기를 이용한 방법등이 있다. (중략)

• Proceedings of the KSLP Conference
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• 2003.11a
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• pp.151-152
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• 2003

말소리가 만들어지는 과정 중에서 성대에서 성대음이 만들어지는 과정이 가장 핵심적인 과정이라고 할 수 있다. 이때의 성대의 진동을 관찰할 수 있는 방법은 1) 초고속 영화 촬영(Ultra-speed cinematography), 2) 스트로보스코피(Stroboscopy), 3) 성문파형검사(Glottography) 등이 사용되어 왔다. 1)은 고가의 장비이며 분석도 어려워서 아주 극소수의 연구기관에서만 부분적으로 사용되어 왔고, 2)와 3)은 임상에서 그리고 연구실에서 널리 사용되어 왔다. 스트로보스코피의 영상을 비디오로 녹화하는 장비는 이제는 이비인후과 영역에서 웬만한 종합병원급 의료기관 이라면 거의 필수적인 장비로 자리잡고 있다 그만큼 성대의 미세한 병변에 대한 진단적 가치가 높다고 할 수 있겠다. 스트로보스코피는 끊어져서 발생되는 제논 광선이 내시경을 통하여 성대에 전해지고, 성대의 실제의 진동 보다. 아주 느리게 움직이는 것 같은 일종의 허상이 화면에 나타나고 이를 비디오시스템으로 저장하여 관찰하는 것이다(Fig. 1, 2). (중략)

• Proceedings of the Korean Information Science Society Conference
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• 2002.10d
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• pp.685-687
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• 2002

일반적으로 인간이 사용하는 몇 개의 주요단어를 이용하여, 문서의 분야나 주제어가 되는 일본어 키워드를 추출하는 점에 주목한다. 먼저, 학술논문에서 저자 자신이 부여한 키워드 중 분야 명이나 주제어가 문서 중에 출현하지 않는 경우를 분석하고, 단어의 개념정보를 기초로 복합어 생성규칙을 구축한다. 문서 의미와 상관없는 키워드의 추출을 억제하기 위해 중요도 결정법을 새롭게 제안한다. 추출된 키워드의 타당성 검사를 위해 자연.음성언어에 관한 일본어 논문 65파일의 타이틀과 초록부분을 이용하여 추출된 키워드의 타당성에 대한 실험을 한 결과 추출 정밀도는 중요도의 상위 1개를 출력한 경우 75%가 되어 제안방법의 유효성을 확인할 수 있었다.

• Clinical and Experimental Pediatrics
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• v.50 no.11
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• pp.1061-1066
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• 2007

Purpose : Early identification of developmental disabilities allows intervention at the earliest possible point to improve the developmental potential. The Ages and Stages Questionnaire (ASQ), a parent- completed questionnaire, can be used as a substitute for formal screening tests. The purpose of this study was to evaluate the validity of the Korean version of the ASQ (K-ASQ) as a screening tool for detecting developmental delay of young Korean children in the setting of a busy pediatric outpatient clinic. Methods : Parents completed the K-ASQ in the waiting room of the pediatric outpatient clinic of St. Mary's Hospital, Catholic University Medical College. Out of 150 completed the ASQ, 67 who were born term and had no previous diagnosis of developmental delay, congenital anomalies, or neurological abnormalities were enrolled. The cut-off values of less than 2 standard deviations (SD) below the mean for the ASQ were used to define a "fail", and children who failed in one or more domains tested were classified as "screen-positive". Diagnosis of developmental delay was made when the developmental indices fell below -1 SD of the Bayley Scales of Infant Development-II. Results : (1) The mean age of children was $16.4{\pm}7.4$ months. Ten children (14.9%) were small-for- gestational age infants. The mean birth weight and gestational age were $3.1{\pm}0.6kg$ and $38.8{\pm}1.4$ weeks. Nine children (13.4%) were twins and 33 (49.0%) were male. The mean maternal education in years was $13.6{\pm}2.4$, and 31.3% had full-time jobs. The time for completing the ASQ was $10.2{\pm}3.0$ minutes. (2) Seventeen children (25.4%) were classified as screen-positive, four of them were delayed in development. Among eight children diagnosed with developmental delay, four were screen-positive and the other four were screen-negative by the ASQ. (3) The test characteristics of the ASQ were as follows: sensitivity (50.0%); specificity (78.0%); positive predictive value (23.5%); negative predictive value (92.0%). Conclusion : The high negative predictive value of the K-ASQ supports its use as a screening tool for developmental delay in the setting of a pediatric outpatient clinic.

• Neonatal Medicine
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• v.18 no.2
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• pp.265-271
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• 2011

Purpose: Extended spectrum $\beta$-lactamase (ESBL) producing organism is an important cause of infections in the neonatal intensive care unit (NICU) since 1990s. The aim of this study is to investigate the differences of clinical characteristics and hematologic studies between neonates with ESBL-positive organism and those with ESBL-negative organism. Methods: The subjects included 48 neonates admitted to NICU at Inje University Sanggye Paik Hospital from January 2005 to September 2010, from whom a total of 58 Escherichia coli or Klebsiella pneumonia were detected. The data were categorized in 2 groups, neonates with ESBL-positive and ESBL-negative. We compared clinical characteristics and hematologic studies between two groups. Results: Of 48 neonates and 53 isolates, ESBL-positive were 18 neonates and 20 isolates. Both ESBL-positive and ESBL-negative isolates were largely found in urine, each with 10 and 23. Of 20 ESBL-positive isolates, 13 (65%) and 7 (35%) were ESBL producing Escherichia coli and Klebsiella pneumonia, respectively. ESBL-positive neonates were associated with low 1 and 5 minutes Apgar scores (P=0.002 and P=0.001, respectively), more uses of oxygen (56% vs. 27%; P=0.005), longer duration of oxygen uses (15.8${\pm}$38.43 days vs. 4.3${\pm}$12.5 days; P=0.008) and more frequent anemia (33% vs. 7%; P=0.040). Conclusion: ESBL-positive neonates may have more anemia and lower Apgar score at birth. We can consider the use of cabapenem earlier if infant with previous antibiotics is confirmed to be infected with ESBL-positive organisms.