• Journal of the Korean Society for Precision Engineering
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• v.27 no.5
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• pp.92-101
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• 2010

This study evaluated the structure and quality of osteoporotic vertebral bone. To induce osteoporosis, eight rats were ovariectomized (OVX). All rats were divided into two groups (Normal group: 4, OVX group: 4). Total lumbar vertebrae for each rat were scanned by in-vivo ${\mu}CT$ at 0, 4 and 8 weeks. Morphological characteristics (BV/TV, Tb.Th, Tb.N, Tb.Sp and SMI) were calculated by in-vivo ${\mu}CT$ image analyzer. Three dimensional finite element models were analyzed to investigate bone strength of OVX and Normal groups. Moreover, the elastic modulus was quantitatively analyzed to evaluate the quality changes of osteoporotic bone. In the OVX group, BV/TV, Tb.Th and Tb.N were significantly decreased at all the lumbar over time (p<0.05). We also investigated a contrary tendency in Tb.Sp and SMI, compared to the above results in each group. A degree of alteration of mechanical characteristics in OVX group was decreased over measuring time (p<0.05). Bone quality presented by distribution of elastic modulus was improved in the Normal group more than OVX group. The findings of the present study indicated that both bone structure and quality of whole lumbar could be tracked and detected by analyzing the morphological and biomechanical characteristics of bones, based on a nondestructive method.

• The Journal of Engineering Geology
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• v.5 no.1
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• pp.31-44
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• 1995

The puppose of this study is to propose the numerical modelling criteria for underground opening, rock mass continuum is regarded as homogeneous rock behaved linear elastic. The results of this study are summarized as follows: - Boundaries of the finite element mesh should be located at least 6 radii away from the center of the opening. - For circular openings, tension only developed when $K_0$ was less than one-fourAs the ratio of initial horiwntal to vertical stress increased, the inward springline movement increased and the inward crown movement decreased. - The displacement patterns developing for opening I shaped horse-shoe and opening II shaped powerstation are similar to those for circular openings. For both type opening I and opening II, stress concentrations develop at the intersection of the wall and floor. Greater stress concentrations are found for the type opening II.

• Journal of Veterinary Clinics
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• v.15 no.2
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• pp.370-377
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• 1998

본 연구는 황색포도상구균의 병원성 인자인 alpha-toxin, casular polysaccharides (CPS)와 fibronectin-binding protein (FnBP)을 이용해 실험동물인 토끼에서의 항체가 형성 능과 공격접종 후 방어능에 관한 연구를 위하여 수행되었으며 향후 젖소 유방염 아단위 항원 을 이용한 백신개발 가능성을 탐색하고자 수행되어졌다. 황색포도상구균의 alpha-toxin, capsu18r polysaccharides (CPS)91 fibronectin-binding protein (FnBP) 항원을 이통재 효소면 역측정법을 통한 혈중 IgG 항체가수준을 측정하였으며 alpha-toxin, capsular polysaccharides (CPS)와 fibronectin-binding protein (FnBP)으로 면역시킨 토끼에서 대조군의 토끼보다 혈 중 항체가 수준이 1차 면역 이후 유의성 있게 높았다 (p<0.05). 백신에 사용된 alpha-toxin, capsular polysaccharides (CPS)와 fibronectin-binding protein (FnBP) 항원중 capsular polysaccharides (CPS)가 다른 alpha toxin과 fibronectin-binding protein (FnBP)의 혈중항 체가 수준과 비교하여 볼 때 비교적 낮은 수준이었다. 세균을 혈중으로 공격접종한 후 대조군 과 백신접종군의 혈중내 세균제거율에 있어 대조군에 비해 백신접종군에서 유의성 있게 낮은 균수를 보였다 (p<0.05). 또한 장기내 균수측정실험결과 대조군의 장기보다 백신접종군에서 유의성 있게 세균수가 낮게 출현하였다 (p<0.05). 결론적으로 본 연구결과 황색포도상구균의 3가지 항훤 alpha-toxin, capsular polysaccharide와 재조합 fibronectin binding protein을 이 퐁한 실험동물에서 안단위 유방염 백신은 방어능이 있다고 생각된다.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.12
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• pp.1599-1604
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• 2012

In general, internal defects, such as shrinkage in casting, cause stress concentration and can be a starting point for cracks. Therefore, it is important to understand the effects of internal defects on the mechanical properties including the impact behavior. This study aim is to evaluate the effects of internal casting defects on the impact performance of Al-alloy castings. Both an experimental method and computational analysis were used to achieve the research objective. The internal defects in the casting were scanned using an industrial CT scanner, and their shape was simplified using ellipsoidal primitives for impact analysis. The good agreement between the experimental and computer simulation results verified the reliability of the proposed computational method for the FEA of casting components with internal defects.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.5
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• pp.567-573
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• 2014

Since the development of microelectromechanical systems (MEMS) technology for the medical field, various micro-fluid transfer systems have been studied. This paper proposes a micro-piezoelectric pump that imitates a stomach's peristalsis by using two separate piezoelectric elements, in contrast to existing micro-pumps. This piezoelectric pump is operated by using the valve-less traveling wave of peristalsis movement. If the piezoelectric plates at the two separated plates are actuated at the input voltage, a traveling wave occurs between the two plates. Then, the fluid migrates by the pressure difference generated by the traveling wave. Finite element analysis was performed to understand the mechanics of the combined system with piezoelectric elements, elastic structures, and fluids. The effects of design variables such as the chamber height and number of ceramics on the flow rate of the fluid were examined.

• Journal of the Society of Naval Architects of Korea
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• v.34 no.4
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• pp.61-71
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• 1997

Numerical and experimental studies are carried out to analyse the resistance characteristics of a hydrofoil catamaran which is advancing on calm water with uniform speed. For the hydrofoil catamaran with modified Wigley hull which has asymmetric transverse section and transom stem, the studies are carried out for the range of Froude number 0.2 to 1.0 and the angle of attack of the hydrofoil $0.0^{\circ}$ to $3.0^{\circ}$. The model tests are carried out in the ship model basin of Inha University. Also the numerical computations using a finite difference method are performed for the simulations of fluid flow around the hull form and the results are compared with the results of the model tests. The present computation results show well quantitative agreement with the experimental results. The experimental results show that the shape and angle of attack of the foils exerts a considerable influence on the running posture and resistance performance of ship.

• Childhood Kidney Diseases
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• v.7 no.1
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• pp.86-90
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• 2003

An 8-month-old male infant presented with persistent, gross, orange-colored crystals in his urine. His physical and neurological development was normal. Laboratory study showed hyperuricemia, hyperuricosuria and urate crystaluria. He was determined to have partial hypoxanthine-guanine phosphoribosyl transferase(HPRT) deficiency. The molecular genetic analysis revealed a missense mutation in the patient's HPRT gene. By sequencing the patient's cDNA, we identified an A-to-G transition at nucleotide 239, resulting in the replacement of Aspartate with Glycine at amino acid 80 in the HPRT. To our knowledge, this mutation has not previously been reported. Our patient is now being placed on allopurinol therapy, and has had no problem since. Partial HPRT deficiency has been known to cause recurrent acute renal failure without the phenotypic features of Lesch-Nyhan syndrome. Therefore, we think that early diagnosis and treatment are very crucial in preventing acute renal failure.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.10
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• pp.1243-1248
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• 2011

Internal defects are a major concern in the casting process because they have a significant influence on the strength and fatigue life of casting products. In general, they cause stress concentration and can be a starting point of cracks. Therefore, it is important to understand the effects of internal defects on mechanical properties such as fatigue life. In this study, fatigue experiments on tensile specimens with internal defects were performed. The internal defects in the casting product were scanned by an industrial CT scanner, and its shape was simplified by ellipsoidal primitives for the structural and fatigue analysis. The analysis results were compared with experimental results for casting products with internal defects. It was demonstrated that it is possible to consider internal defects of casting products in stress and fatigue analysis. The proposed method provides a tool for the prediction of the fatigue life of casting products and the investigation of the effects of internal defects on mechanical performance.

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 2005.10a
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• pp.336-342
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• 2005

Stone column or granular compaction pile have been used in widely during the several decades as a technique to reinforce soft cohesive soils and increase bearing capacity, accelerate consolidation settlement of the foundation soil. The bearing capacity of the granular compaction pile is governed mainly by the lateral confining pressure mobilized in the native soft soil to restrain bulging collapse of the granular pile. Therefore, the technique becomes unfeasible in soft, compressible clayey soils that do not provide sufficient lateral confinement. This paper presents the main results of numerical study of granular compaction pile which is partly mixed with lean concrete. 3D finite element analyses are performed with composite reinforced foundations by both granular compaction pile and partly mixed granular compaction pile with lean-mixed concrete.

• Journal of the Korean Geotechnical Society
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• v.28 no.4
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• pp.35-42
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• 2012

This paper evaluates the effect of anisotropic conductivity on the seepage face and reliability index of an homogeneous dam with and without toe drain. The analysis are conducted under steady state saturated-unsaturated seepage condition using finite element method. Various anisotropic conductivity ratios were interpreted under such conditions as the vertical conductivity is reduced while the horizon conductivity is fixed. The shear strength of soil is defined by the modified Mohr-Coulomb failure criterion. The analysis results demonstrate that the length of seepage face and reliability index at the downstream and upstream of the dam increase with an increasing anisotropic ratio. These results of the seepage face and reliability index, however, depend on the total head difference between the upstream slope and downstream toe. The difference in seepage face and reliability index is attributed to the different equipotential head with different anisotropic ratios of the dam material.