• 한국전산유체공학회:학술대회논문집
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• 2009.04a
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• pp.57-65
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• 2009

An efficient and high-fidelity design approach for wing-body shape optimization is presented. Depending on the size of design space and the number of design of variable, aerodynamic shape optimization process is carried out via different optimization strategies at each design stage. In the first stage, global optimization techniques are applied to planform design with a few geometric design variables. In the second stage, local optimization techniques are used for wing surface design with a lot of design variables to maintain a sufficient design space with a high DOF (Degree of Freedom) geometric change. For global optimization, Kriging method in conjunction with Genetic Algorithm (GA) is used. Asearching algorithm of EI (Expected Improvement) points is introduced to enhance the quality of global optimization for the wing-planform design. For local optimization, a discrete adjoint method is adopted. By the successive combination of global and local optimization techniques, drag minimization is performed for a multi-body aircraft configuration while maintaining the baseline lift and the wing weight at the same time. Through the design process, performances of the test models are remarkably improved in comparison with the single stage design approach. The performance of the proposed design framework including wing planform design variables can be efficiently evaluated by the drag decomposition method, which can examine the improvement of various drag components, such as induced drag, wave drag, viscous drag and profile drag.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.4B
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• pp.363-374
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• 2008

Intensity-Duration-Frequency (IDF) curve that is essential to calculate rainfall quantiles for designing hydraulic structures in Korea is generally formulated by regression analysis. In this study, IDF curve derived by the cumulative distribution function ("IDF by CDF") of the proper probability distribution function (PDF) of each site is suggested, and the corresponding parameters of IDF curve are computed using genetic algorithm (GA). For this purpose, IDF by CDF and the conventional IDF derived by regression analysis ("IDF by REG") were computed for 22 Korea Meteorological Administration (KMA) rainfall recording sites. Comparisons of RMSE (root mean squared error) and RRMSE (Relative RMSE) of rainfall intensities computed from IDF by CDF and IDF by REG show that IDF by CDF is more accurate than IDF by REG. In order to accommodate the effect of the recent intensive rainfall of Korea, the rainfall intensities computed by the two IDF curves are compared with that by at-site frequency analysis using the rainfall data recorded by 2006, and the result from IDF by CDF show the better performance than that from IDF by REG. As a result, it can be said that the suggested IDF by CDF curve would be the more efficient IDF curve than that computed by regression analysis and could be applied for Korean rainfall data.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.38 no.1
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• pp.97-103
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• 2001

Hidden Markov Model (HMM) is the most widely used method in speech recognition. In general, HMM parameters are trained to have maximum likelihood (ML) for training data. Although the ML method has good performance, it dose not take account into discrimination to other words. To complement this problem, a word verification method by re-recognition of the recognized word and its similar word using the discriminative function of the two words. To find the similar word, the probability of other words to the HMM is calculated and the word showing the highest probability is selected as the similar word of the mode. To achieve discrimination to each word the weight to each state is appended to the HMM parameter. The weight is calculated by genetic algorithm. The verificator complemented discrimination of each word and reduced the error occurred by similar word. As a result of verification the total error is reduced by about 22%

• The KIPS Transactions:PartB
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• v.16B no.2
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• pp.157-161
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• 2009

Minimum Letter Flips(MLF) and Weighted Minimum Letter Flips(WMLF) can perform the haplotype reconstruction more accurately from SNP fragments when they have many errors and gaps by introducing the related genotype information. And it is known that WMLF is more accurate in haplotype reconstruction than those based on the MLF. In the paper, we analyze two models under the conditions that the different rates of homozygous site in the genotype information and the different confidence levels according to the sequencing quality. We compare the performance of the two models using neural network and genetic algorithm. If the rate of homozygous site is high and sequencing quality is good, the results of experiments indicate that WMLF/GI has higher accuracy of haplotype reconstruction than that of the MCIH especially when the error rate and gap rate of SNP fragments are high.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.31 no.5
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• pp.243-250
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• 2018

In this paper, design technique using genetic algorithms(GA) for design optimization of composite leaf springs is presented here. After the initial design has been validated by the car plate spring as a finite element model, the genetic algorithm suggests the process of optimizing the number of layers of composite materials and their angles. Through optimization process, the weight reduction process of leaf springs and the number of repetitions are compared to the existing algorithm results. The safety margin is calculated by organizing a finite element model to verify the integrity of the structure by applying an additive sequence optimized through the genetic algorithm to the structure. When GA is applied, layer thickness and layer angle of complex leaf springs have been obtained, which contributes to the achievement of minimum weight with appropriate strength and stiffness. A reduction of 65.6% original weight is reached when a leaf steel spring is replaced with a leaf composite spring under identical requirement of design parameters and optimization.

• Journal of The Korean Society of Agricultural Engineers
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• v.46 no.5
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• pp.41-52
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• 2004

In this study, parameters of long and short term runoff model were optimized using genetic algorithm as a basic research for integrated water management in a watershed. In case of Korea where drought and flood occurr frequently, the integrated water management is necessary to minimize possible damage of drought and flood. Modified TANK model was optimized as a long term runoff model and storage-function model was optimized as a short term runoff model. Besides distinguished parameters were applied to modified TANK model for supplementing defect that the model estimates less runoff in the storm period. As a result of application, simulated long and short term runoff results showed 7% and 5% improvement compared with before optimized on the average. In case of modified TANK model using distinguished parameters, the simulated runoff after optimized showed more interrelationship than before optimized. Therefore, modified TANK model can be applied for the long term water balance as an integrated water management in a watershed. In case of storage-function model, simulated runoff in the storm period showed high interrelationship with observed one. These optimized models can be applied for the runoff analysis of watershed.

• Journal of Life Science
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• v.31 no.12
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• pp.1110-1119
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• 2021

The purpose of this study was to investigate whether the inflammatory response in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages could be promoted by particulate matter 2.5 (PM_2.5) stimulation. To this end, the levels of inflammatory parameters, reactive oxygen species (ROS) and inflammation-regulating genes were investigated in RAW 264.7 cells treated with PM_2.5 in the presence or absence of LPS. Our results showed that the production levels of pro-inflammatory mediators (nitric oxide and prostaglandin E₂) and cytokines (interleukin-6 and -1β) were significantly increased by PM_2.5 stimulation in LPS-treated RAW 264.7 cells, which was correlated with increased expression genes involved in their production. In addition, when LPS-treated RAW 264.7 cells were exposed to PM_2.5, nuclear factor-kappaB (NF-κB) expression was further increased in the nucleus, and the expression of inhibitor of NF-κB as well as NF-κB in the cytoplasm was decreased. These results suggest that the co-treatment of PM_2.5 and LPS further increases the activation of the NF-κB signaling pathway compared to each treatment alone, thereby contributing to the promotion of transcriptional activity of inflammatory genes. Furthermore, although the generation of ROS was greatly increased by PM_2.5 in LPS-treated RAW 264.7 cells, the NF-κB inhibitor did not reduce the generation of ROS. In addition, when the generation of ROS was artificially suppressed, the production of inflammatory mediators and the activation of NF-κB were both abolished. Therefore, our results suggest that the increase in the NF-κB-mediated inflammatory response induced by PM_2.5 in LPS-treated RAW 264.7 macrophages was a ROS generation-dependent phenomenon.

• Journal of the Korean Chemical Society
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• v.53 no.6
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• pp.653-662
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• 2009

Developing effective tools for predicting absorption, distribution, metabolism, excretion properties and toxicity (ADME/T) of new chemical entities in the early stage of drug design is one of the most important tasks in drug discovery and development today. As one of these attempts, support vector machines (SVM) has recently been exploited for the prediction of ADME/T related properties. However, two problems in SVM modeling, i.e. feature selection and parameters setting, are still far from solved. The two problems have been shown to be crucial to the efficiency and accuracy of SVM classification. In particular, the feature selection and optimal SVM parameters setting influence each other, which indicates that they should be dealt with simultaneously. In this account, we present an integrated practical solution, in which genetic-based algorithm (GA) is used for feature selection and grid search (GS) method for parameters optimization. hERG ion-channel inhibitor classification models of ADME/T related properties has been built for assessing and testing the proposed GA-GS-SVM. We generated 6 different models that are 3 different single models and 3 different ensemble models using training set - 1891 compounds and validated with external test set - 175 compounds. We compared single model with ensemble model to solve data imbalance problems. It was able to improve accuracy of prediction to use ensemble model.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.6
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• pp.1287-1291
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• 2009

The genes of cyanide hydratase(CHT), a kind of nitrilases whichhydrolyze cyanide to formamide were extracted from N. crassa and A. nidulans, the two fungal strains. The recombinant forms of the CHT originated from N. crassa and A. nidulans were prepared with N-terminal hexahistidine purificationtags or no tags, and expressed in E. coli. The enzymes were purified using immobilized metal affinity chromatography. They were compared according to their pH activity profiles, and kinetic parameters. The N. crassa CHT has the wider pH range of activity above 50% and three-fold higher turnover rate (6.6 ${\times}$ $10^8$ $min^{-1}$) than the A. nidulans, meanwhile the CHT of A. nidulans has the higher $K_m$ value. Expression of CHT in both N. crassa and A. nidulans were induced by the presence of KCN, regardless of any presence of nitrogen sources. Max. 82% of KCN was degraded in 60 min for biological degradation tests.

• Journal of Korea Water Resources Association
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• v.42 no.5
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• pp.365-374
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• 2009

Probability plotting positions are used for the graphical display of annual maximum rainfall or flood series and the estimation of exceedance probability of those values. In addition, plotting positions allow a visual examination of the fitness of probability distribution provided by frequency analysis for a given data. Therefore, the graphical approach using plotting position has been applied to many fields of hydrology and water resources planning. In this study, the plotting position formula for the Gumbel distribution is derived by using the order statistics and the probability weight moment of the Gumbel distribution for various sample sizes. And then, the parameters of plotting position formula for the Gumbel distribution are estimated by using genetic algorithm. The appropriate plotting position formulas for the Gumbel distribution are examined by the comparison of root mean square errors and biases between theoretical reduced Gumbel variates and those calculated from derived and existing plotting position formulas. As the results, Gringorten's plotting position formula has the smaller root mean square errors and biases than any other formulas.