• 건강소식
• /
• v.10 no.10 s.95
• /
• pp.17-25
• /
• 1986

아직 무슨 원인으로 당뇨병이 일어나는지 알려져 있지 않지만, 학자들은 복합적인 요인이 있다고 믿고 있는데, 한 가지 요인은 유전 소아당뇨병입니다. 그러나 이것은 한 가지 유전인자에 의한 것이 아니고 복합인자에 의한 유전입니다. 최근 연구에서 환경적인 요인이 당뇨병을 일으킬 수 있다는 것을 알아냈습니다.

• 건강소식
• /
• v.30 no.4 s.329
• /
• pp.16-17
• /
• 2006

비만은 다양한 원인에 의해 발생된다. 일반적으로 유전적 소인과 환경 요인이 한데 어우러져 발생한다고 일컬으며, 유전 요인은 어쩔 수 없으니 환경요인에 비중을 두어 설명하는 경향이 강하다. 필자는 그러한 설명을 비껴 유전적요인, 2차적으로 비만을 가져오는 원인 등에 대한 내용을 먼저 소개한다.

• The Korean Journal of Applied Statistics
• /
• v.28 no.5
• /
• pp.859-870
• /
• 2015

Economic-traits of livestock are affected by environmental and genetic factors. We are interested in genetic factors that influence the economic-traits of Korean cattle. It is necessary to adjust environmental factors in order to enhance the accuracy of the genetic effect analysis. In this paper, we propose a statistical model of Korean cattle that exclude environmental breeding farm and age factors. We formulated an adjusted economic-trait value, and applied multifactor dimensionality reduction (MDR) method to data of before-and-after adjustment to identify major FABP4 genes. We were able to increase the accuracy of the analysis after adjustment and identify superior FABP4 genes that influence grade and fatty acid.

• The Korea Swine Journal
• /
• v.10 no.6 s.106
• /
• pp.83-88
• /
• 1988

수퇘지의 번식능력은 성성숙, 유전자형, 연령, 영양, 온도, 건강상태, 종부빈도 등의 요인에 의해 성욕감퇴, 수정율 저하, 산자수 감소, 불임, 자돈의 성장저해 등의 심각한 경제적 손실이 발생한다.

• Journal of the Korean Data and Information Science Society
• /
• v.25 no.5
• /
• pp.1025-1038
• /
• 2014

Linear mixed model has often been utilized for genetic association analysis with family-based samples. The correlation matrix for family-based samples is constructed with kinship coefficient and assumes that parental phenotypes are independent and the amount of correlations between parent and offspring is same as that of correlations between siblings. However, for instance, there are positive correlations between parental heights, which indicates that the assumption for correlation matrix is often violated. The statistical validity and power are affected by the appropriateness of assumed variance covariance matrix, and in this thesis, we provide the linear mixed model with flexible variance covariance matrix. Our results show that the proposed method is usually more efficient than existing approaches, and its application to genome-wide association study of body mass index illustrates the practical value in real data analysis.

• Korean Journal of Biological Psychiatry
• /
• v.15 no.1
• /
• pp.14-22
• /
• 2008

Objectives : The authors purposed to present data for explaining gene-environmental interaction causing depressive disorder by examining the effects of genetic factors related to the serotonin system and environmental factors such as stressful life events in early adulthood. Methods : The subjects were 150 young adults(mean age 25.0${\pm}$0.54), a part of 534 freshmen who had completed the previous study of genotyping of TPH1 gene. We assessed characteristics of life events, depression and anxiety scale and checked if they had a depressive disorder with DSM-IV SCID interview. Along with TPH1 A218C genotype confirmed in previous study, TPH2 -1463G/A and 5HTR2A -1438A/G genes were genotyped using the SNaPshot$^{TM}$ method. Results : In comparison with the group without C allele of TPH1 gene, the number of life events had a significant effect on the probability of depressive disorder in the group with C allele. Other alleles or genotypes did not have a significant effect on the causality of life events and depressive disorder. Conclusion : The results of this study suggest that TPH1 C allele is a significant predictor of onset of depressive disorder following environmental stress. It means that the TPH1 gene may affect the gene-environmental interaction of depressive disorder.

• Proceedings of the Korean Society of Fisheries Technology Conference
• /
• 2003.05a
• /
• pp.233-234
• /
• 2003

근교약세의 요인으로는 열성유해유전자의 호모 접합체화에 의한 적응성의 저하가 생각되어진다. 그 중에서도 가장 유해성이 높은 유전자로는 열성치사유전자가 있다. 그러나, 이러한 열성 치사유전자을 보유한 개체는 죽어버리기 때문에 직접적인 검출은 불가능하다. 따라서, 동조염색체의 호모화가 되는 교배실험과 표식유전자에 의한 연사분석이 필요하다. 본 연구는 참전복의 열성치사유전자의 유무을 명확히 파악하기 위하여 형매교배와 비형매교배을 포함한 전체교배를 하였으며, 참전복을 대상으로 개발한 마이크로사데라이트(microsatellite)좌을 유전표식으로 이용하여 각 교배구의 유전자형의 분리를 조사했다. (중략)

• Management & Information Systems Review
• /
• v.35 no.3
• /
• pp.95-113
• /
• 2016

The study examines the question of what discriminant factors may affect differences between two groups classified by researchers' satisfaction with and continuous use intention of genetic resources(microorganisms). Survey data from researchers who are using microorganisms from a gene bank was used to empirically test. The survey, covering 150 researchers, was conducted from March 26 through April 17 2015. Linear discriminant analysis was used to test the research questions described in the study. Results from the tests show that utilization value and suitability of genetic resources for researchers' R&D activities play key roles in discriminating between the two groups classified by researchers' satisfaction with and continuous use intention of genetic resources, relatively lower and higher groups. The results indicate that useful trait information of and degree in promotion of researches by genetic resources appear to be weak in discriminating between the two groups, and that novelty of genetic resources does not play a crucial role in making a distinction between the two groups. We propose some policy implications based on the results of the study.

• Journal of Korean Philosophical Society
• /
• v.116
• /
• pp.181-206
• /
• 2010

It is widely recognized that human beings have moral responsibility for their actions because they have free will to choose and control their acts. Unlike natural phenomena, however, human acts cannot be interpreted with simple, visible ones. Human acts are quite different from natural phenomena because they come about through a number of complicated, invisible phases taking place in our mind. In addition, human actions are under the influence of internal and external factors. Those various internal and external factors are divided into four sectors as follows; (1) the factors that can fall under control of our free will, (2) the factors in the interim phase that could come under our control, (3) the factors that are partially determined that we cannot choose or control over, and (4) the factors that completely determined, and can't be chosen or controlled. we have to pay attention to the fact that we can choose or control the internal and external factors that influence human action. However, there are still factors that are impossible to choose or control with our will. So it is highly unreasonable to hold accountable for actors by means of the factors that can't be chosen or controlled. Hence, the society should be also accountable for the acts of actors influenced by heredity and environment. For this, Politics should affect the external, undesirable, and uncontrollable factors beyond actors power. Education has to exert its influence over the internal and genetic factors by instilling sound values in human mind, too. It is because happy and desirable future will be possible by giving equal opportunities to us including the youth.

• KOREAN POULTRY JOURNAL
• /
• v.19 no.12 s.218
• /
• pp.56-61
• /
• 1987

파란을 일으키는 요인에는 영양, 생리, 유전, 환경온도, 사양관리, 질병 및 닭의 일령, 케이지 형태, 바닥구조, 집란횟수, 기계기구 등이 있다.