• Progress in Medical Physics
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• v.25 no.4
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• pp.271-280
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• 2014

Recently, digital breast tomosynthesis (DBT) has been investigated to overcome the limitation of conventional mammography for overlapping anatomical structures and high patient dose with cone-beam computed tomography (CBCT). However incomplete sampling due to limited angle leads to interference on the neighboring slices. Many studies have investigated to reduce artifacts such as interference. Moreover, appropriate filters for tomosynthesis have been researched to solve artifacts resulted from incomplete sampling. The primary purpose of this study is finding appropriate filter scheme with FBP reconstruction for DBT system to reduce artifacts. In this study, we investigated characteristics of various filter schemes with simulation and prototype digital breast tomosynthesis under same acquisition parameters and conditions. We evaluated artifacts and noise with profiles and COV (coefficinet of variation) to study characteristic of filter. As a result, the noise with parameter 0.25 of Spectral filter reduced by 10% in comparison to that with only Ramp-lak filter. Because unbalance of information reduced with decreasing B of Slice thickness filter, artifacts caused by incomplete sampling reduced. In conclusion, we confirmed basic characteristics of filter operations and improvement of image quality by appropriate filter scheme. The results of this study can be utilized as base in research and development of DBT system by providing information that is about noise and artifacts depend on various filter schemes.

• Journal of the Korean Society of Radiology
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• v.81 no.3
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• pp.632-643
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• 2020

Purpose To investigate the correlation between magnetic resonance (MR) image-based radiomics features and the genomic features of breast cancer by focusing on biomolecular intrinsic subtypes and gene expression profiles based on risk scores. Materials and Methods We used the publicly available datasets from the Cancer Genome Atlas and the Cancer Imaging Archive to extract the radiomics features of 122 breast cancers on MR images. Furthermore, PAM50 intrinsic subtypes were classified and their risk scores were determined from gene expression profiles. The relationship between radiomics features and biomolecular characteristics was analyzed. A penalized generalized regression analysis was performed to build prediction models. Results The PAM50 subtype demonstrated a statistically significant association with the maximum 2D diameter (p = 0.0189), degree of correlation (p = 0.0386), and inverse difference moment normalized (p = 0.0337). Among risk score systems, GGI and GENE70 shared 8 correlated radiomic features (p = 0.0008-0.0492) that were statistically significant. Although the maximum 2D diameter was most significantly correlated to both score systems (p = 0.0139, and p = 0.0008), the overall degree of correlation of the prediction models was weak with the highest correlation coefficient of GENE70 being 0.2171. Conclusion Maximum 2D diameter, degree of correlation, and inverse difference moment normalized demonstrated significant relationships with the PAM50 intrinsic subtypes along with gene expression profile-based risk scores such as GENE70, despite weak correlations.

• Journal of Korea Multimedia Society
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• v.3 no.5
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• pp.470-478
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• 2000

Color images from various application areas have their own characteristics. Practical segmentation systems need specialized methods to death with the characteristics. In this paper. we propose a distributed genetic algorithm based segmentation method for color breast carcinoma cell images. To extract positive nuclei and negative nuclei from the cell images, a distributed genetic algorithm with improved genetic operations and an evaluation function is used. As initial values, representative colors from images are introduced to work well with the cell images. A test to verify the validity of the proposed method shows well-segmented images. This result suggests that the method is pertinent to be but into practical use for the images haying limited objects with limited colors.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2004.05a
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• pp.13-18
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• 2004

최근 몇 년간 방사선 의학진단과 관련된 연구가 한층 높아진 가운데 유방암은 여성의 암 중에서 1위를 차지하고 조기에 진단하고 치료하기 위한 국가적인 노력이 필요한 시점이다. 이렇듯 여성들의 유방암 발생빈도수가 급증하면서 대두 되고 있는 것이 조기 진단방법인 Mammography와 초음파 진단이며 그로인하여 발생하는 오진률 역시 많은 연구가 진행 되고 있다. 먼저 Mammography 및 초음파 진단의 문제점 보면 첫째 촬영과정에서의 오차, 둘째 영상의 선명도 ,셋째 전문의의 판독에 대한오차, 넷째 의사의 경험으로 진단함으로 표준화가 존재하지 않는다는 공통적인 문제점을 가지고 있다. 본 연구에서는 CAD 시스템의 프레임웍 및 요소 기술을 제시하여 의사의 진단을 보조적 수행이 보다 수월하도록 하고자 한다. 본 연구에서는 CAD시스템의 기능은 Detection기능(Image enhancement, Morphology, segment detection)과 Diagnosis기능( Neural Natwork등을 이용하여 증상을 판단)이다. 또한 과거 자료를 이용한 변이 및 변화를 예측함으로써 향후 있을 위험요소에 대비가 가능한 모듈과 전문의사가 대화형으로 빠르게 진단지식을 구축할 수 있는 지능형, 대화형 온라인 진단기능을 추가함으로써 외국의 CAD시스템과는 많은 차이가 있다고 볼 수 있다.

• Progress in Medical Physics
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• v.24 no.3
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• pp.183-190
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• 2013

Recently, the photoacoustic imaging system has been widely and intensively developed, and has been shown the possibility of diagnosis for early stage cancer. In this study, we developed a photoacoustic tomography imaging system with a commercial ultra sound device and a linear array probe. A tube phantom and a chicken breast phantom was made for the possibility of a system as a breast cancer detection. A moving average filter and a band pass filter with 3~6 MHz bandwidth were developed for background noise elimination before delay-and-sum beamforming algorithm was used for image reconstruction. As a result, we showed that some signal processing procedure before beamforming was effective for the photoacoustic image reconstruction.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.12
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• pp.1124-1131
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• 2011

In this paper, image reconstruction algorithm for breast cancer detection using MT(Microwave Tomography) was investigated. The breast cancer detection system under development uses 16 transmit/receive antennas. The signal waveform was a sinusoidal wave at 900 MHz. To solve the 2D inverse scattering problem, we used the 2D FDTD (Finite Difference Time Domain) method for forward calculation and LMA(Levenberg-Marquardt Algorithm) for optimization. The result of the image reconstruction using the numerical phantom by MRI(Magnetic Resonance Imaging) obtained from real patient of breast cancer showed that we can detect the position of the tumor accurately.

• Journal of Korea Multimedia Society
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• v.13 no.5
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• pp.702-709
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• 2010

The performance of mass segmentation is greatly influenced by an initial position of a mass. Some researchers performed mass segmentation with the initial position of a mass given by radiologists. The purpose of our research is to find the initial position for mass segmentation and to notify the segmented mass to radiologists without any additional information on mammograms. The proposed system consists of breast segmentation by region growing and opening operations, decision of an initial seed with characteristics of masses, and mass segmentation by a level set segmentation. A seed for mass segmentation is set based on mass scoring measure calculated by block-based variances and masked information in a sub-sampled mammogram. We used a DDSM database to evaluate the system. The accuracy of mass detection is 78% sensitivity at 4 FP/image, and it reached 92% if multiple views for masses were considered.

• Journal of Biomedical Engineering Research
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• v.25 no.5
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• pp.335-342
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• 2004

This paper describes a trans-admittance scanner for breast cancer detection. A FPGA-based sinusoidal waveform generator produces a constant voltage. The voltage is applied between a hand-held electrode and a scan probe placed on the breast. The scan probe contains an 8x8 array of electrodes that are kept at the ground potential. Multi-channel precision digital ammeters using the phase-sensitive demodulation technique were developed to measure the exit current from each electrode in the array. Different regions of the breast are scanned by moving the probe on the breast. We could get trans-admittance images of resistor and saline phantoms with an anomaly inside. The images provided the information on the depth and location of the anomaly. In future studies, we need to improve the accuracy through a better calibration method. We plan to test the scanner's ability to detect a cancer lesion inside the human breast.

• Journal of the Korean Society of Radiology
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• v.6 no.2
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• pp.121-127
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• 2012

Of this study, it was found that there were 250 mammographic units in total installed and used in the areas for this study, and 36 units were used in general hospitals, 53 units in hospitals and 116 units in clinics. That is, the units in clinics accounted for 50% out of the whole units. As for the image acquisition method, it was found there were 131 units using F/S, 67 units using CR and 7 units using DR respectively. At present, F/S system was mainly used in the areas. As for the materials of target/filter, it was found that Mo/Mo was mostly used (66%), followed by Mo/Rh (25%). As for the size of focus, both 0.1 mm for small focus and 0.3 mm for large focus were mainly used for the units.

• Journal of the Korean Society of Radiology
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• v.17 no.7
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• pp.1067-1073
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• 2023

Breast cancer is one of the top three most common cancers in modern women, and the incidence rate is increasing rapidly. Breast cancer has a high family history and a mortality rate of about 15%, making it a high-risk group. Therefore, breast cancer needs constant management after an early examination. Among the various equipment that can diagnose cancer, ultrasound has the advantage of low risk and being able to diagnose in real time. In addition, breast ultrasound will be more useful because Asian women's breasts are denser and less sensitive. However, the results of ultrasound examinations vary greatly depending on the technology of the examiner. To compensate for this, we intend to incorporate motion tracking technology. Motion tracking is a technology that specifies and analyzes a location according to the movement of an object in a three-dimensional space. Therefore, real-time control is possible, and complex and fast movements can be recorded in real time. We would like to present the production of an ultrasound examination guide using these advantages.