• The Korean Journal of Nuclear Medicine
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• v.33 no.6
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• pp.527-536
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• 1999

Purpose: Radiotracers that bind to the central benzodiazepine receptor are useful for the investigation of various neurological and psychiatric diseases. [C-11]Flumazenil, a benzodiazepine antagonist, is the most widely used radioligand for central benzodiazepine receptor imaging by PET. We synthesized 3-(2-[F-18]fluoro)flumazenil, a new fluorine-18 ($t_{1/2}$= 110 min) labeled analogue of benzodiazepine receptor imaging agent, and evaluated in vivo for biodistribution in mice. Materials and Methods: Flumazenil (Ro 15-1788) was synthesized by a modification of the reported method. Precursor of 3-(2-[F-18]fluoro)flumazenil, the tosylated flumazenil derivative was prepared by the tosylation of the ethyl ester by ditosylethane. [F-18] labeling of tosyl substitued flumazenil precursor was performed by adding F-18 ion at $85^{\circ}C$ in the hot ceil for 20 min. The reaction mixture was trapped by C18 cartridge, washed with 10% ethanol, and eluted by 40% ethanol. Bidistribution in mice was determined after intravenous injection. Results: The total chemical yield of tosylated flumazenil derivative was ${\sim}40%$. The efficiency of labeling 3-(2-[F-18]fluoro)flumazenil was 66% with a total synthesis time of 50 min. Brain uptakes of 3-(2-[F-18]fluoro)flumazenil at 10, 30, 60 min after injection, were $2.5{\pm}0.37,\;2.2{\pm}0.26,\;2.1{\pm}0.11$ and blood activities were $3.7{\pm}0.43,\;3.3{\pm}0.07,\;3.3{\pm}0.09%ID/g$, respectively. Conclusion: We synthesized a tosylated flumazenil derivative which was successfully labeled with no-carrier-added F-18 by nucleophilic substitution.

• International Journal of Highway Engineering
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• v.8 no.4 s.30
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• pp.1-11
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• 2006

Currently, road mobility improved from the National Road Improvement. Nevertheless delineation system is facility that enhanced driver's safety, that was set up often inconsistent or nonexistent over the road exit ramp So it judged functional investigation will be necessary. This study suggested setting type of the delineation system. That was based on a field study and reviews the legal standard of it and considering driver's cognition behavior. For the study, make a 3D-simulation and so could objectively a comparative test. Comparison variable between delineation setting type is selected conspicuity and visibility. Cased that illustrated characteristics of driver's visual cognition behavior. The experiment was used Eye Marker Recorder for measure the gaze frequency more quantitatively and objectively. And used the ANOVA analysis for significance testing between delineation setting type. A significant percent of the conspicuity analyzed types(Safe mark, Obstacle Sign, Warning Light, and Tubular Maker) in road exit ramp for recognize. And gaze frequency that measure of effectiveness of visibility are measured. On the analysis result, the visibility was significance difference between delineation setting type and visibility of types was best.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2013.10a
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• pp.332-334
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• 2013

일반적인 도등은 통항이 곤란한 좁은 수로, 만 입구, 항구 등에서 선박을 안전한 항로로 유도하기 위하여 항로의 연장선상의 육지에 설치하여 2개의 등화를 수직선상에 보고 진입하게 하는 광파표지이다. 그러나 저도 도등은 위와 같은 기능이 아닌 군사지역인 저도어장 어선들의 안전한 조업을 할 수 있도록 해주는 지표가 된다. 본 발표에서 저도 도등의 구체적 역할과 그 효과에 대하여 논하고자 한다.

• Journal of Korean Society of Transportation
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• v.35 no.4
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• pp.278-291
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• 2017

Effective installation and operations of traffic safety signs in the advance warning area is of considerable interest for safer traffic management at freeway work zones. This study evaluated the feasibility of traffic safety sign installation based on a driving simulation experiment to take drivers' responsive characteristics into consideration. Both the compliance rate for speed limit and a lane-changing safety index were used for evaluating a set of driving simulation scenarios. It was identified that providing speed limit signs to reduce speed in advance and afterward guiding lane-changing could lead to safer maneuvering of vehicles entering work zones. The outcomes of this study are expected to be useful for revising freeway work zone management policies toward crash prevention.

• Journal of the Korean Association of Geographic Information Studies
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• v.26 no.1
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• pp.1-10
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• 2023

With the advent of the 4th industrial revolution era, interest in autonomous driving technology is increasing. Accordingly it is necessary to seek safe driving by recognizing surrounding situations using sensors attached to autonomous vehicles along with the applicability of existing traffic facilities to autonomous driving lanes and the utilization of HD maps. In this study, in order to deduce the role of sensor only physical facilities which recognized through a laser scanner on an autonomous vehicle developed to improve road and traffic infrastructure, through comparative analysis with existing road facilities such as road signs, safety signs, and gaze guidance facilities. Sign facilities can promote driving safety by allowing autonomous vehicles to perform specific actions directly. In order to promote safe driving by recognizing sign facilities by using sensors for autonomous vehicles, it is necessary to prepare standards for installation, management, and use, and it is considered that management and supervision should be carried out continuously according to the standards.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.37 no.5
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• pp.915-926
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• 2017

The subway is the transportation means most commonly used by the citizens of the metropolitan area along with the buses in the metropolitan area and major metropolitan municipalities. However, satisfaction with the signboards is low and the signboards need to be improved. In this study, we investigated the problem of guide signs of city hall and exchange area with L - shaped history structure for guide signs affecting route finding. As a result, it is necessary to confirm whether the moving distance is long and moving accurately to the desired destination due to the L - shaped historical structure in both the station and the alternate area. In both stations, the number of the guide signs, Problems such as installation position, height, other. In this study, the movement within the subway station is classified according to the space. The type of guide sign installation was defined, and the specific principles for guiding the movement route were proposed. This research is expected to be useful as an important basic data for the types and layout of subway stations.

• The Korean Journal of Nuclear Medicine
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• v.31 no.4
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• pp.440-451
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• 1997

This study was designed to prospect the $^{111}In$-labelled paclitaxel as tumor imaging agent. In order to provide a taxol molecule with a functional group which is able to chelate In-111, taxol-DTPA conjugate and 2'-hemisuccinyltaxol were synthesized by esterification of taxol at C-2'on C-13 carbon with DTPA anhydride and succinic anhydride, respectively. Synthesis yield of the taxol derivatives was 34% for taxol-DTPA and 80% for 2'-hemisuccinyltaxol. Cytotoxicity of the taxol derivatives were measured by MTT method toward cell lines HT29, B16, P388, and CT26. The cytotoxic activities of the taxol derivatives were maintained, although less active than taxol. Radiolabelling of the taxol derivatives were proceeded directly with $^{111}InCl_3$ or indirectly with $^{111}In$-citrate(ligand-exchange method). The ligand-exchange method was not suitable because some precipitates appeared during the reaction. On the contrary, by direct radiolabelling method, we were able to obtain taxol-DTPA-$^{111}In$ in 100% radiochemical yield. However, 2'-hemisuccinyltaxol was not labelled by both methods. Yield and radiochemical purity of the radiolabelled com-pound were determined by HPLC, paper chromatography and instant thin layer chromatography. Taxol-DTPA-$^{111}In$ was characterized to be hydrophilic by lipophilicity test, and nearly non-adhesive to HT29, B16, P388, and CT26 by cell binding affinity test. Binding affinity of the taxol-DTPA-$^{111}In$ complex to serum proteins was also examined by protein precipitation with 30% trichloroacetic acid. The results showed that 30% of the taxol-DTPA-$^{111}In$ complex binds with serum proteins.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2010.04a
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• pp.145-147
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• 2010

This study is the visually emotional identification lighting for easy to distinguish using 3colors LED on AtoN facility in shore and harbor, which have realized a controller for certainly express the mouth of a harbor by red light and green light of both sides a harbor and for synchronization at a time of right and left or serial sequential the harbor guidance light through synchronizer or timer by GPS. There is expectation effect that is prevent a confusion about distinguish of facility by ship's operator and to beautify a night scene of harbor, which is expressed to emotional identification lighting differ from great many lighting of harbor with variable color lighting the lighthouse body and vertical layer color lighting using LED. The function of AtoN is adapted that guidance light through synchronization or serial sequential lighting and display of harbor safety message by CW lighting, and this system is the power consumption greatly reduce by candle alternated high light LED.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.37 no.3
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• pp.629-636
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• 2017

Urban railway are the most widely used means of transportation in the metropolitan area. It is difficult to draw out problems through the quantitative analysis technique because most of the research results show that most of the guide signs are installed with many or few guide signs. In this study, we propose a method to evaluate the information load and proper installation location at the main decision point in the transfer passageway for Suseo Station by applying Positive Guidance. As a result of analyzing the information load using this technique, it is suggested that the necessary information should be provided centered on the copper node because it provides confusion of the users by providing the same information in the transfer line. It is necessary to obtain guidance on how to remove the sign (advertising, high ceilings, etc). The study will be regarded as a key for the basis and placement of the guidelines for determining the appropriateness of the in the future urban railway station sign guide.

• Archives of design research
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• v.13 no.1
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• pp.247-256
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• 2000

Recently, foreign tourists and car owners or motorists are increasing, so tourist sign boards are necessary to inform them. Unfortunately, tourist sign boards are difficult to understand because they are often written incorrectly. This paper has a thorough grasp of this problem and will present an ideal standard model which is precise and detailed. This paper includes research of tourist boards sign Seoul, Kyongju, Pusan, Kwangju, Yosu, Kwang reung in Korea. Also tourist sign boards in the U.K, France, Switzerland, Italy and Austria will be discussed. A survey was conducted of eight hundred people to determine tourist information is obtained. In conclusion, tourist sign board should convey accurate and useful information to people of all ages. Tourist information should be systematic and logical. An ideal standard model of tourist signs will render traveling easier for tourists all over the world. It will be more convenient for both kinds of tourist; domestic and foreign. Futhermore good tourist sign board will give an excellent and bright image.