• Information Systems Review
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• v.12 no.3
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• pp.75-88
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• 2010

Business models in open market systems targeting smart phone users are determined by several important factors. First, by providing developers efficient technical platforms, it contains a setting for developers to learn, apply and improve the skills relating to the product category easily while they stay beyond a corporate boundary. Second, by the first condition, a huge population of talented developers becomes to join a specific open market where will invite more customers to use their applications. Hence it will attract more and more developer participants who will finally give a rise to a persistent market growth. Third, the evaluation system between platform providers and application producers, and one between application producers and application users may underlie the trust relationships between them. The research conducted a multiple embedded case study to test the success factors of open market based business models. It focused on smart phone game communities that have installed user evaluation, and feedback systems. The user innovation empowerment model within the social game networks has highlighted the theories on the roles and characteristics of lead users, and lead user network behaviors for future NPD participations.

• The KIPS Transactions:PartC
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• v.12C no.5 s.101
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• pp.623-632
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• 2005

In ad-hoc network, there is no fixed infrastructure such as base stations or mobile switching centers. The security of ad-hoc network is more vulnerable than traditional networks because of the basic characteristics of ad-hoc network, and current muting protocols for ad-hoc networks allow many different types of attacks by malicious nodes. Malicious nodes can disrupt the correct functioning of a routing protocol by modifying routing information, by fabricating false routing information and by impersonating other nodes. We propose a routing suity mechanism based on one-time digital signature. In our proposal, we use one-time digital signatures based on one-way hash functions in order to limit or prevent attacks of malicious nodes. For the purpose of generating and keeping a large number of public key sets, we derive multiple sets of the keys from hash chains by repeated hashing of the public key elements in the first set. After that, each node publishes its own public keys, broadcasts routing message including one-time digital signature during route discovery and route setup. This mechanism provides authentication and message integrity and prevents attacks from malicious nodes. Simulation results indicate that our mechanism increases the routing overhead in a highly mobile environment, but provides great security in the route discovery process and increases the network efficiency.

• Journal of Astronomy and Space Sciences
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• v.24 no.4
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• pp.327-338
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• 2007

We estimate the momentum fluxes of short-period gravity waves which are observed in the OI 557.7 nm nightglow emission with all-sky camera at Mt. Bohyun ($36.2^{\circ}\;N,\;128.9^{\circ}\;E$) in Korea. The intrinsic phase speed ($C_{int}$), the intrinsic period (${\tau}_{int}$), and vertical wavelength (${\lambda}_z$) are also deduced from the horizontal wavelength (${\lambda}_h$), observed period (${\tau}_{ob}$), propagation direction (${\phi}_{ob}$), observe phase speed (${\upsilon}_{ob}$) of the gravity wave on the all-sky images. The neutral winds to deduce intrinsic wave parameters are measured with Fabry-Perot interferometer on Shigaraki ($34.8^{\circ}\;N,\;13.1^{\circ}\;E$) in Japan. We selected 5-nights of observations during the period between July 2002 and December 2006 considering of the weather and instrument conditions in two observation sites. The mean values of intrinsic parameter of gravity waves are $({\tau}_{int})\;=\;12.9\;{\pm}\;6.1\;m/s,\;({\lambda}_z)\;=\;12.9\;{\pm}\;6.5,\;and\;(C_{int})\;=\;40.6\;{\pm}\;11.6\;min$. The mean value of calculated momentum fluxes for four nights besides of ${\lambda}_z\;<\;6\;km$ is $12.0\;{\pm}\;15.2\;m^2/s^2$. It is needed the long-term coherent observation to obtain typical values of momentum fluxes of the mesospheric gravity waves using all-sky camera and the neutral wind measurements.

• Journal of Korean Traditional Oncology
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• v.15 no.1
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• pp.19-27
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• 2010

The roots and leaves of Angelica keiskei (AK) have been used for the treatment of various diseases including coronary heartdisease, hypertension, and cancer in the Korean folk medicine. However, the mechanism by which methylenechloride fraction (MF) from AK exerts anti-tumorigenic activity in human prostate cancer cells has not been fully understood. In the present study, we report the MF exerted the highest cytotoxicity against prostate cancer DU145 cells compared with other fractions. Especially, MF caused the accumulation of sub-G1 DNA contents of cell cycle and increased annexin V-positive apoptotic bodies and DNA fragmentation. MF down-regulated several proliferative (Cyclin D1) and anti-apoptotic (Bcl-xl, Bcl-2, IAP-1/2, and survivin)gene products in these cells. Hence, MF induced apoptosis through the caspase-3 activation in DU145 cells. We further confirmed that caspase-3 plays an importance role in MF-induced apoptosis in DU145 cells by using caspase-3 inhibitor. Additionally, we observed that MF potentiated Dox-induced apoptosis in DU145 cells. Taken together, our data demonstrate the evidence that MF induces apoptosis depend on caspase-3 activation of and overcomes resistance to chemotherapy in human prostate cancer cells.

• Journal of Chest Surgery
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• v.31 no.3
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• pp.266-270
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• 1998

The management of malignant pleural effusion is a difficult problem. Tetracycline was probably the most commonly used sclerosing agent, but parenteral tetracycline is no longer available. This prospective study was designed to determine the efficacy of insufflated talc in producing plerodesisin patients with malignant pleural effusions. Fifteen patients managed between March 1995 and March 1997 underwent thoracoscopy and had 4 gm sterile asbestos-free talc insufflation throughout the pleural space. The mean interval between the procedure and last follow-up was 101 days(range: 25-233 days). The results of treatment were clinically and radiologically compared with pre-operative status. The results were as follows: 1. The patients were 6 men and 9 women with a mean age of 55.1 years(range: 31-74 years). The primary tumors were lung cancer in 10 patients, breast cancer in two, hepatoma in one, stomach cancer in one, and adenocarcinoma of unkown origin in one. 2. Cancer cell positive ratio was 36% in sputum cytology study and 100% in thoracoscopic biopsy. 3. Symptoms improved in 94% of patients treated by talc pleurodesis. 4. After 30 days of the procedure, there was radiologically no recurrence of plural fluid in 94% patients. 5. There were wound infection in one, respiratory failure in one. In conclusion, the insufflation of 4 gm sterile asbestos-free talc in the pleural space is an effective method to control malignant pleural effusions and patients selection is important factor for reexpansion the lung.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.37 no.3
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• pp.629-636
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• 2017

Urban railway are the most widely used means of transportation in the metropolitan area. It is difficult to draw out problems through the quantitative analysis technique because most of the research results show that most of the guide signs are installed with many or few guide signs. In this study, we propose a method to evaluate the information load and proper installation location at the main decision point in the transfer passageway for Suseo Station by applying Positive Guidance. As a result of analyzing the information load using this technique, it is suggested that the necessary information should be provided centered on the copper node because it provides confusion of the users by providing the same information in the transfer line. It is necessary to obtain guidance on how to remove the sign (advertising, high ceilings, etc). The study will be regarded as a key for the basis and placement of the guidelines for determining the appropriateness of the in the future urban railway station sign guide.

• The Journal of Engineering Geology
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• v.20 no.4
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• pp.425-436
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• 2010

We established a stochastic 3-D fracture network system for fractured rock masses located in Il-Gwang Mine, Busan, to explore the relationship between the acidity of mine drainage and fracture geometry. A field scanline survey and borehole image processing were performed to estimate the best probability distributions of fracture geometry parameters. The stochastic 3-D fracture network system constructed for the rock masses was validated and deemed to be successful. The 3-D fracture network model was suitable for developing conceptual ideas on fluid flow in fractures at a field experimental site. An injection well and three observation wells were drilled at the field experimental site to monitor the acidity of mine drainage induced by the injection of fresh water. The field experiment, which was run for 29 days, yielded a significant relationship (with a high coefficient of determination) between the fracture geometry parameters and the acidity of mine drainage. The results show that pH increased with increasing relative frequency of fracture strike, and decreased with increasing fracture density. The concentration of $SO^{2-}_4$ decreased with increasing relative frequency of fracture strike, and increased with increasing fracture density.

• The Journal of Korean Society for Radiation Therapy
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• v.8 no.1
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• pp.109-114
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• 1996

PURPOSE : To investigate the effect of asymmetric jaws for delivering a uniform accurate dose of radiation to the junctions. METHODS & MATERIALS : A linear accelerator with a set of asymmetric jaws(varian 600C, 2100C, 2100CD with 4mev, 10mev, 10mev). Dose disribution was measured at the junctions with films in phantom. Total $10{\times}20cm^2$ with each $10{\times}10cm^2$ in deviation of ${\pm}1mm$ jaws. RESULTS : Film dosimetry showed the accuracy of asymmetric jaws depending on the machine. CONCLUSION : Understanding the mechanical characteristics of the use of half-beam at the junctions, without hot or cold regions.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.41 no.1
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• pp.9-16
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• 2005

This study was conducted in order to improvement of fishing gear and fishing operating system for anchovy boat seine by labor saving improved nets. Field experiments were carried out observe geometry of nets and fishing operating system by catcher boats. The obtained results are summarized as follows : The Vertical net opening of fore wing net, wing net, inside wing net, square, fore bag net, flapper, after bag net of the labor saving improved net according to the distance between catcher boats were varied in the range of 5.0${\sim}$7.8, 14.4${\sim}$21.1, 16.2${\sim}$21.2, 14.0${\sim}$17.3, 11.7${\sim}$13.9, 5.4${\sim}$6.9, 8.2${\sim}$9.8m respectively, varied in the range of 50${\sim}$78, 25${\sim}$36, 24${\sim}$31, 31${\sim}$38, 61${\sim}$73, 71${\sim}$91, 87${\sim}$104% of the actual ratio of net opening in each part. Labor saving improved net was performed instant net opening in fore wing net and maintained stable net opening and towing depth by means of attached net pendant. Also, it was minimized as net pocket phenomenon leading to guide anchovy for more catch by means of attached body net. The opening in accordance with distance between catcher boats and towing speed. The catch of labor saving improved net was increased than traditional net due to decrement of net resistance by improvement of bag net leading to increasement of towing speed and reduction of escape anchovy as well as improve nets of whole operation system.

• Applied Biological Chemistry
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• v.51 no.2
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• pp.129-135
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• 2008

Berberine is an isoquinoline alkaloid used in traditional Chinese medicine and has been isolated from a variety of plants, such as Coptis chinensis and Phellodendron amurense. It has a wide spectrum of clinical applications such as in anti-tumor, anti-microbial, and anti-inflammatory activities. However, it is still unknown that berberine related with reactive oxygen species (ROS)-mediated apoptosis pathway in human hepatoma HepG2 cells. In the present study, we are examined the molecular mechanism of ROS- and p38 MAP kinase-mediated apoptosis by berberine in HepG2 cells. Berberine increased cytotoxicity effects by time- and does-dependent manner. $LD_{50}$ was detected 50 ${\mu}M$ at 48h of exposure to berberine. Nuclei cleavage and apoptotic DNA fragmentation were observed in cells treated with 50 ${\mu}M$ of berberine for 48h. Moreover, berberine induced the activating of caspase-3, p53, p38 and Bax expression, whereas the expression of anti-apoptotic signaling pathways, Bcl-2, was decreased. Additionally, berberine-treated cells had an increased level of generation of ROS and nitric oxide (NO). These results indicated that berberine induces apoptosis of HepG2 cells may be mediated oxidative injury acts as an early and upstream change, triggers mitochondrial dysfunction, Bcl-2 and Bax modulation, p38 and p53 activation, caspase-3 activation, and consequent leading to apoptosis.