• Journal of Nutrition and Health
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• v.29 no.6
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• pp.642-650
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• 1996

Apo E polymorphism (e2, e3, e4) was among the first reported genetic polymorphism that explained part of the normal variation in plasma cholesterol concentrations. Both alleles E2 and E4 are significantly more frequent in patients with mixed forms of hyperlipidemia and contribute on the observed differences in CHD risk among different populations. Effects of apo E polymorphism on the distribution of plasma lipid profiles were studied in 105 normolipidemic healthy women. The relative frequencies of common alleles for gene locus of apo E in this study were that E3 allele was 0.848, E4 allels was 0.087, and E2 allele was 0.067. SBP and DBP were slightly more elevated in E2 allele than those in E3 and E4. The pulsation was also significantly (p<0.016) increased by E2 allele with excess body fat % in E2 allele. There were no differences in total-, total HDL-, VLDL+LDL-, VLDL- and LDL cholesterol among the apo E alleles. However, apo E2 allele subject had lower level of total HDL and HDL2 cholesterol (P<0.047) and significantly higher lev디 of HDL3 cholesterol (P<0.05) than those in apo E3 and E4 allele subject. The conclusion is that first, it seems that apo E4-mediated alteration through LDL B/E receptors or E receptors in cholesterol metabolism results in lower plasma TG or remanate particles and in higher levels of VLDL+LDL or LDL. Second, apo E2 allele shows reciprocal effects of E4 on the plasma lipid metabolism, respecitvely. Third, apo E2 allele was more atherogenic than apo E4 because the higher levels of HDL3/HDL2 ratio and atherogenic index[(TC-HDL)/HDL]were criticized.

• The Journal of Engineering Geology
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• v.24 no.2
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• pp.227-235
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• 2014

The deformation modulus is one of the essential factors in determining ground behavior and safety during tunnel excavation. In this study, we conducted a back-analysis using crown settlements measured during tunnel excavation, using a horizontal inclinometer on a fault zone of pegmatite, and calculated the deformation modulus of the fault zone. This deformation modulus calculation was then compared with deformation moduli found through established relationships that use the correlation between RMR and the deformation modulus, as well as the results of pressure-meter tests. The deformation moduli calculated by back-analysis differs significantly from the deformation moduli determined through established relationships, as well as the results from pressure-meter tests conducted across the study area. Furthermore, the maximum crown settlements derived from numerical analysis conducted by applying deformation moduli determined by these established relationships and the pressure-meter tests produced noticeable differences. This result indicates that in the case of a weak rock mass, such as a fault zone, it is inappropriate to estimate the deformation modulus using preexisting relationships, and caution must be taken when considering the geological and geotechnical characteristics of weak rock.

• Journal of Hospice and Palliative Care
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• v.18 no.1
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• pp.51-59
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• 2015

Purpose: Predicting life expectancy of terminally ill cancer patients is very important. In many studies, ferritin is detected at higher levels in the sera of cancer patients, and higher ferritin level correlates with aggressiveness of disease and poor outcomes of patients. This study evaluated a prognostic role of serum ferritin levels in terminally ill cancer patients. Methods: This study enrolled 65 terminally ill cancer patients from March through June 2012. We assessed routine laboratory findings including serum ferritin levels as well as demographic and clinical characteristics of the patients. To examine the association between serum ferritin levels and patient's characteristics, we used Spearman's correlation analysis, Wilcoxon's rank sum test or Kruskal-Wallis test, as appropriately. For multivariate analysis, Cox's proportional hazard regression model was used to evaluate significance of serum ferritin levels as a prognostic factor. Results: A negative correlation between serum ferritin levels and survival time was found. After adjusting for sex, age, performance status, creatinine levels and white blood cell counts, serum ferritin levels were significantly associated with survival time. Conclusion: Even at the very end of life of terminal cancer patients, serum ferritin levels were an independent prognostic factor for survival.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.38 no.4
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• pp.537-545
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• 2018

Determination of the time parameters such as the travel time in the design flood is very important. The travel time is mainly used for flood and river management, and the travel time of non flood season is used for maintenance flow and management of the river. Estimation of travel time for natural rivers is mainly based on the geomorphological factors of the basin. In addition to the topographical factors, the travel time is calculated by considering the factors of the runoff curve, velocity and rainfall intensity. However, there is no study on the estimation of travel time considering both the rainfall condition and the soil moisture accounting by the frequency period. Therefore, the travel time calculation is divided into the case of setting the Hwanggang Dam and the Imjin bridge water level station of Imjin river as the natural river considering rainfall condition by the frequency period and the soil moisture accounting, and the case of traveling the Imjin bridge water level station according to the condition of outflow of the Hwanggang Dam. For the sections set as natural rivers, the results were verified by comparing with the newly developed travel time calculation method. Based on the results, the travel times of the Hwanggang Dam outflow conditions were calculated. The time to travel in this study can be secured flood control of the Imjin river basin and time to prepare for danger when outflowing the the Hwanggang Dam.

• Journal of Nutrition and Health
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• v.41 no.7
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• pp.612-620
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• 2008

This study assessed the effects of soy isoflavones supplementation with exercise on urinary mineral (calcium, magnesium, copper, zinc) excretion as an index of bone resorption rates in 67 postmenopausal women. A total subjects were assigned to Isoflavone (90 mg/day) or placebo groups. These groups were further divided into groups that undergone a regular exercise or a rather sedentary state performing daily activity only. We conducted study eight week period. Result showed urinary zinc excretion was more significantly decreased in the isoflavone-sedentary group ($-180.76\;{\pm}\;171.30\;ug/day$) than in the placebo-sedentary group ($-31.23\;{\pm}\;146.60\;ug/day$), placebo-exercise group ($40.93\;{\pm}\;193.44\;ug/day$) and isoflavione-exercise group ($-1.21\;{\pm}\;160.61\;ug/day$) (p < 0.05), but no significant changes in the differences between the values of the pre and post study values in urinary calcium, magnesium and copper excretion. These results suggest that Isoflavone supplementation decrease urinary zinc excretion rate in postmenopausal subjects.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.14 no.1
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• pp.22-25
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• 2018

Lennox-Gastaut syndrome (LGS) is one of the most severe epileptic encephalopathies of childhood onset. It is characterized by multiple types of generalized seizures, slowness of intellectual growth, and specific electroencephalogram pattern. It is one of the most difficult epilepsy syndromes to treat and is frequently resistant to treatment. In this case report, we report a case of dental treatment under general anesthesia in a child with LGS. A 4-year-6-month old boy with LGS visited Seoul National University Dental Hospital for dental treatment. Dental treatment was planned under general anesthesia because of his medical condition. Treatment was successfully done without any postoperative complications. If a LGS patient requires dental treatment, a treatment plan should be established to take into account the degree of seizure, the medication being used, and the cooperation of the patient. If the degree of seizure is severe and the patient's cooperation is poor, dental treatment under general anesthesia would be advantageous.

• Korean Journal of Agricultural and Forest Meteorology
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• v.19 no.1
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• pp.10-18
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• 2017

Korean Red Pine (Pinus densiflora) has been protected and used as the most ecologically and socio-culturally important tree species in Korea. However, as dieback of Korean red pines has occurred in the protected area of the forest genetic resources. The aims of this study is to identify causes for dieback of pine tree by investigating topographical characteristics of pine tree dieback and its correlation to meteorological factors. We extracted the dead trees from the time series aerial images and analyzed geomorphological characteristics of dead tree concentration area. As a result, 1,956 dead pine trees were extracted in the study region of 2,600 ha. Dieback of pine trees was found mostly in the areas with high altitude, high solar radiation, low topographic wetness index, south and south-west slopes, ridgelines, and high wind exposure compared to other living pine forest area. These areas are classified as high temperature and high drought stress regions due to micro-climatic characteristics affected by topographic factors. As high temperature and drought stress are generally increasing with climate change, we can evaluated that a risk of pine tree dieback is also increasing. Based on these geomorphological characteristics, we developed a pine tree dieback risk map using Maximum Entropy Model (MaxEnt), and it can be useful for establishing Korean red pine protection and management strategies.

• Science of Emotion and Sensibility
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• v.23 no.4
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• pp.33-40
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• 2020

As the number of automobile registrations increases and luxury expectations grow, consumers are increasingly interested in indoor environment of vehicles. Therefore, manufacturers have an increasing interest in improving the indoor comfort as well as automobile performance. Research on indoor automobile comfort can help manufacturers increase driver satisfaction and reduce driver stress and discomfort, thereby reducing the risk of traffic accidents. Using electroencephalogram (EEG) measurements, we investigated the change in comfort and comfortable temperature according to the ventilating seat temperature change for both men and women. Results showed that the sensation of comfort was statistically significantly higher at 25℃ than at 28℃. Secondly, there was no statistically significant difference in temperature-based comfort feeling between male and female subjects. In the future, if the correlation between the driver's comfort feeling and the change in ventilating seat temperature is analyzed, it is possible to reduce traffic accidents caused by human error and reduce the electric energy consumption of the automobile.

• The Southeast Asian review
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• v.28 no.1
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• pp.145-171
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• 2018

Laos' 2017 is a year of political "stagnation" and economic "change". In the political arena, despite the achievements such as the improvement of the corruption perception index (CPI), it is necessary to watch the progress of the reform. Diplomatically, the influence of China is expected to increase further. In particular, since November 2017, Xi Jinping's visit to Laos is expected to strengthen the framework of cooperation between the economic corridor and Lanchang-Mekong Cooperation Meeting. And Laos continued to have friendly relations with other neighboring countries, the ASEAN countries. However, the issue of the Laos-Cambodian border issue following the general election in Cambodia may recur. The economic sector maintained a high growth rate due to capital inflows from the construction of large infrastructures and the favorable tourism industry, but structural problems such as deficits in the fiscal and current account should be resolved. Korea and Laos discussed the comprehensive cooperation between the two countries through the Mekong Senior Officials' Meeting in March 2017 and the Ministerial Meeting of the Korean-Lao Foreign Minister in September 2017. Laos is Korea's eighth ODA aid (grant), and ODA will become an important diplomatic cooperation channel between the two countries in the future. In the economic relationship, the trade sector is on a declining trend, but investment and human exchanges are steadily increasing.

• 한국노년학
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• v.29 no.1
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• pp.135-147
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• 2009

Recently, The number of hypertension is increasing with westernized diet and lack of exercise. Many researchers are trying to treat and prevent hypertension by exercise therapy. However, not only did most of studies analyze the effect and usefulness of exercise related to lowering hypertension, but also there is no analysis of the difference of fitness with regard to hypertension according to ages. It is assumed to be important research work to be continued to identify, from the public health's point of view, the difference of fitness with regard to hypertension according to ages can be a essential data for treating and preventing hypertension. Thus, this study is to identify the difference of fitness according to hypertension of adult female over 20s and emphasize the importance of fitness level to the hypertension. Also, this study is to devise valuable study by examining the difference of cardiovascular function. Subjects were 8889 of adult female over 20s. Subjects visited promotion of health center at Y Gu public health center and took comprehensive medical test including hypertension test in Seoul in Korea. It was divided into normal, prehypertension, stage I hypertension and stage II hypertension group by JNC7. The evaluation of cardiorespiratory function was by resting heart rate and lung capacity, the evaluation of fitness was by cardiorespiratory endurance, muscular endurance, muscular strength, power, agility, balance, and flexibility, and the difference of fitness was analyzed by ANCOVA revising independent variable of BMI, drinking, and smoking which affects hypertension. At result, there was significant difference between normal and hypertension group according to most ages in two variable of all cardiorespiratory function, seven fitness variable. Through this study, it was defined that hypertension group had lower cardiorespiratory function and fitness than normal group.