• Journal of Yeungnam Medical Science
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• v.12 no.1
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• pp.1-9
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• 1995

A monoclonal antibody to PCNA, which can be used on routinely processed tissue, was applied to 25 cases of gastric adenomas and 64 cases of gastric adenocarcinomas in order to diffentiate adenoma and adenocarcinoma and also to evaluate the prognostic value in adenocarcinoma. The results were summerized as follows: The peNA labelling index was $29.14{\pm}12.77%$ in control, $44.09{\pm}17.11%$ in adenoma and $80.15{\pm}10.69$ in adenocarcinoma, resulting in significant increase in adenocarcinoma compared to adenoma. In adenocarcinoma, no significant correlation was observed between PCNA labelling index and histologic grade, and there was increased tendency of PCNA labelling index in proportion to depth of invasion without statistical significance. The PCNA index was significantly increased in advanced adenocarcinoma compared to early gastric carcinoma, and also in positive nodal metastasis group than in negative group. From above results, the PCNA stain will be able to provide a helpful method for the differential diagnosis between gastric adenoma and adenocarcinoma, and could be a useful prognostic factor in adenocarcinoma if other factors are considered together.

• Journal of Yeungnam Medical Science
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• v.8 no.2
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• pp.76-83
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• 1991

A total of 53 gastric adenomas from endoscopically biopsied gastric mucosa were examined histopathologically. The average age at the time of endoscopic biopsy was 59 years, and gastric adenomas were found to be more frequent in the aged, particularly above the age of 50. The majority of adenomas occurred at the antrum. Concerning the shape of the adenomas, Yamada type II was more frequent(55%). All adenomas were accompanied by varying degree of intestinal metaplasia, and this findings suggest that gastric adenoma develops from intestinal metaplasia. In adenomas with severe atypia(grade III), endocrine cells(argyrophil and argentaffin cells)were markedly decreased or absent. Gastric adenocarcinomas coexistent with adenoma were seen in 5(9.4%) out of 53 cases, and were more frequent in male than female patients(sex ratio, 4 : 1) and the average age was 61.4 years. It is suggested that there is a necessity of thorough follow-up study for definitive correlation between gastric adenoma and adenocarcinoma.

• Journal of fish pathology
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• v.20 no.1
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• pp.83-91
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• 2007

In order to differentiate the gastric tubular dilatation of olive flounder, Paralichthys olivaceus, from an atrophic change, a series of histological studies was carried out for normal gastric gland, naturally occurring and histamine-induced dilated glandular tubules. Normal glandular tubules were histologically quite similar to those already reported from other fish species. Naturally occurring, dilated gastric glandular tubules had the epithelial characteristics suffering from atrophy under light microscope, which was also the case in the histamine-induced gastric gland. But on semi-thin sections the area corresponding to the empty space of dilated lumina were actually shadowed with relatively bright area. Under transmission electron microscope this brightly shadowed area turned out to be an area tightly packed with abundant, slender cytoplasmic processes in both cases. These results strongly suggested that the dilative gastric glandular tubules under light microscope might be a morphological change indicating increased glandular activity rather than a pathologic atrophic change.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1992.05a
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• pp.58-58
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• 1992

연구자들은 제 2상 임상시험의 모델을 검토하기 위하여, 비무작위적 제 2상 임상시험을 진행 위선암환자에서 시행하였다. 병리조직학적으로 확인되고, 객관적으로 계측가능 병변이 있는 위선암 환자를 대상으로 하였으며, 위선암의 조직 진단은 위선암의 모든 유형을 포함하였다. 환자는 (Datelliptinium)율 1일 250 mg/$m^2$씩 3일 연속 30분에 걸쳐 정주하고, 매 3주마다 반복하였다. 반응의 완전평가는 초치료전 실시하여, 14-25명의 환자가 포함될 예정으로 시작하여 총 15명의 환자가 포함되었다. 매 환자마다 매 치료 주기전에 평가를 실시하였다. 최소 1주기 (3일 치료)를 끝낸 환자에서도 반응평가가 가능한 것으로 간주하였으며 치료기간은 반응의 정도와 치료에 대한 내약력으로 결정하였고, 만일 치료에 대해 현저한 독성이 발생되지 않는다면, 치료 반응이 계속되는 동안 약물투여를 계속하였다. 국소진행암의 경우 약물의 반응이 현저하고, 환자의 전신상태가 현저히 개선되어 외과적 절제가 가능하면, 관해로 간주하고 외과적 절제를 실시 후 약물은 4회 투여하고 치료 종료 후 추적 관찰할 계획으로 시행하였다.

• Journal of Gastric Cancer
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• v.8 no.4
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• pp.182-188
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• 2008

Purpose: Transcriptional factors of CREB (cAMP response element binding protein) are involved in regulating the gene expression in response to a variety of signaling pathways. The proteins produced by the CREB genes play key roles in many physiological processes, including memory and long-term potentiation. The retinoic acid receptor (RAR) axis mediates epithelial cell differentiation and proliferation in many tissues. This study examined the expressions of RAR and CREB and their relationship with the clinicopathologic factors and their significance. Materials and Methods: The levels of the RAR and CREB expressions were measured in 150 gastric adenocarcinomas by performing immunohistochemical staining. Results: 1. An RAR protein expression was found in 63.3% of the adenocarcinomas (95/150) and a CREB expression was found in 60.7% (91/150) of the adenocarcinomas. 2. An RAR protein expression was found in 72.2% (78/108) of the intestinal type adenocarcinomas and in 40.5% (17/42) of the diffuse type adenocarcinomas (P<0.05). Based on the depth of invasion, an RAR protein expression was found in 58.3% (14/24) of the T1 adenocarcinomas, in 61.9% (13/21) of the T2 adenocarcinomas, in 63.5% (61/96) of the T3 adenocarcinomas, in 77.8% (7/9) of the T4 adenocarcinomas and in 74.7% (62/83) of the adenocarcinomas with lymph node metastasis and in 49.2% (33/67) of the adenocarcinomas without lymph node metastasis (P<0.01). 3. A CREB expression was found in 69.4% (75/108) of the intestinal type and in 38.1% (16/42) of the diffuse type (P>0.05). Based on the depth of invasion, a CREB expression was found in 50% (12/24) of the T1 adenocarcinomas, in 52.4% (11/21) of the T2 adenocarcinomas, in 64.6% (62/96) of the T3 adenocarcinomas, in 66.6% (6/9) of the T4 adenocarcinomas, in 71.1% (59/83) of the adenocarcinomas with lymph node metastasis and in 47.8% (32/67) of the adenocarcinomas without lymph node metastasis (P<0.01). 4. The RAR protein and CREB expressions coincided in 71.4% of the gastric adenocarcinomas and a significant correlation between them was found (P<0.05). Conclusion: We found a significant relationship between the expression of RAR and CREB and the histology and lymph node metastasis of gastric cancer. Further studies are needed to confirm their biologic meaning in gastric carcinogenesis.

• The Korean Journal of Pharmacology
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• v.31 no.1 s.57
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• pp.75-84
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• 1995

Acid secretion and NO synthase activity were determined in isolated gastric glands following hypoxia/reoxygenation and acidosis to investigate the involvement of NO in acid secretion. Isolated gastric glands were exposed to hypoxia (30 min)/reoxygenation (1 h) and/or to acidosis (pH 6.0 and 4.0). Acid secretion was measured by the ratio of $[^{14}C]-aminopyrine$ accumulation between intra- and extraglands. NO synthase activity was determined by percent conversion to $[^{14}C]-citrulline\;from\;[^{14}C]L-arginine$, a precursor of NO. The results indicate that dibutyryl cAMP stimulated acid secretion dose-dependently but had no effect on NO synthase activity in basal gastric glands. Hypoxia/reoxygenation significantly suppressed acid secretion both in unstimulated and stimulated gastric glands, which was exaggerated by acidosis. Constitutive NO synthase, activity, not responded to dibutyryl cAMP, was also inhibited by hypoxia/reoxygenation and acidosis. In conclusion, pathologic state of gastric mucosa such as hypoxia/reoxygenation and acidosis suppresses both acid secretion and NO release but the role of NO in acid secretion stimulated by dibutyryl cAMP in basal gastric glands is not significant.

• Science of Emotion and Sensibility
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• v.26 no.2
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• pp.13-24
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• 2023

This study tested whether the evaluation of moral cleansing behavior following an immoral act depends on the resources available to the wrongdoer. To this end, resource availability was manipulated by the wrongdoer's characteristics (socioeconomic status vs. physical health condition) and type of moral cleansing (donation vs. volunteer work), and participants rated the pain of the moral cleansing behavior, hypocrisy, and forgivability. Study 1 presents a scenario where a wrongdoer, either high or low in socioeconomic status, conducts moral cleansing via donation or volunteer work. Participants judged donation by those high in socioeconomic status to be not so painful, hypocritical, and unforgivable. Study 2 described a scenario in which a wrongdoer, either physically strong or weak, performs an act of moral cleansing either by donation or volunteer work. Participants considered those sickly wrongdoers' volunteer work to be painful, less hypocritical, and (compared with other conditions) more forgivable. Mediation analyses showed that in both Studies 1 and 2, pain in moral cleansing influenced the hypocrisy judgment which, in turn, affected perceived forgivability. These results indicate that, even for the same expiatory behavior, moral judgment depends on the actor's available resources. That is, people believe that moral cleansing should involve pain; otherwise, the act is hypocritical and unforgivable.

• The Korean Publising Journal, Monthly
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• s.320
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• pp.11-11
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• 2002

• Nuclear industry
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• v.27 no.10 s.296
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• pp.30-33
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• 2007

• Nuclear industry
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• v.28 no.10
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• pp.64-66
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• 2008