Journal of fish pathology (한국어병학회지)

The Korean Society of Fish Pathology (한국어병학회)
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Histamine-induced dilation of gastric glandular tubules of flounder, Paralichthys olivaceus

히스타민 유도 넙치(Paralichthys olivaceus) 위선부의 확장성 내강에 대한 조직학적 관찰

  • Ryu, Gab-Min (Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University) ;
  • Song, Na-Young (Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University) ;
  • Lee, Mu-Kun (Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University) ;
  • Huh, Min-Do (Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University)
  • 류갑민 (부경대학교 수산생명의학과) ;
  • 송나영 (부경대학교 수산생명의학과) ;
  • 이무근 (부경대학교 수산생명의학과) ;
  • 허민도 (부경대학교 수산생명의학과)
  • Published : 2007.04.30
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Abstract

In order to differentiate the gastric tubular dilatation of olive flounder, Paralichthys olivaceus, from an atrophic change, a series of histological studies was carried out for normal gastric gland, naturally occurring and histamine-induced dilated glandular tubules. Normal glandular tubules were histologically quite similar to those already reported from other fish species. Naturally occurring, dilated gastric glandular tubules had the epithelial characteristics suffering from atrophy under light microscope, which was also the case in the histamine-induced gastric gland. But on semi-thin sections the area corresponding to the empty space of dilated lumina were actually shadowed with relatively bright area. Under transmission electron microscope this brightly shadowed area turned out to be an area tightly packed with abundant, slender cytoplasmic processes in both cases. These results strongly suggested that the dilative gastric glandular tubules under light microscope might be a morphological change indicating increased glandular activity rather than a pathologic atrophic change.

본 실험은 양식 넙치에서 임상적으로 빈번히 발생하는 위선세관의 확장성 변화가 위축성 변화인지를 알기 위하여 넙치의 정상 위선구조를 분명히 하는 한편 확장성 위선세관에 대하여 광학 및 전자현미경적 소견을 추구하고, 위액분비를 촉진하는 물질로 알려진 히스타민을 주사한 후 그 형태학적인 변화 내용을 서로 비교검토하였다. 외관상 건강한 넙치의 위선세관을 포함한 위선부의 조직학적 구조에 있어서는 이미 밝혀진 다른 어종과 큰 차이가 없었다. 광학현미경상에서 양식 넙치는 위선세관의 내강이 확장되고 소관 상피의 세포질의 양이 줄어든 위축성 변화를 보였고, 히스타민 주사 넙치에서도 유사한 소견을 보였다. 그러나 semi-thin 표본상에서 확장된 위선세관의 내강은 밝은 영역으로 나타났고, 이 밝은 영역은 주자전자현미경상에서 가늘고 긴 다수의 세포질 돌기로 이루어진 것임을 알 수 있었다. 따라서 광학현미경 하에서 관찰되는 위선세관의 확장성 변화는 위축성 병변이기 보다는 위액분비활동 증가 내지 과다에 따른 형태학적 변화의 하나인 것으로 추정되었다.

Keywords

References

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