• Journal of agricultural medicine and community health
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• v.33 no.2
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• pp.204-220
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• 2008

Objectives: This study was performed to determine the levels of depression symptoms among the community elderlies and to reveal its related factors, specifically aimed at revealing psycho-social factors such as social support net-work, sense of self-esteem, state anxiety, interpersonal behavior trait and locus of control. Methods: The interviews were performed during the period from April 1st to June 30th, 2007 to the 790 elderlies in urban and rural areas. Results: The mean scores of depression (CES-D) among all subjects were 16.65±10.97(urban: 18.81±10.31, rural: 14.49±11.20) and they were higher in urban than rural. The level of depression symptoms was influenced by the variables of educational level, with or without spouse, bear for living expenses, sense of satisfaction in daily life. As for health related behaviors, they were influenced by the variables of with or without regular exercise. As for health status, they were influenced by the subjective health status, with or without disability of body, visual acuity, hearing ability, ability of food mastication, urinary incontinence, with or without help in activity of daily living (ADL) and instrumental activity of daily living (IADL). As for social support net-work and social activities, they were influenced by number of offspring, frequency of offspring contents, frequency of going out and activity of hobbies. As for psycho-social factors, they were influenced by sense of self-esteem, state anxiety and social support, especially, the level of depression symptoms was higher influenced by the variables of psycho-social factors than other variables. Conclusions: Lower of the level of depression symptoms among the community elderlies would require development and application of programs to keep under management psycho-social factors as well as looking for ways to promoting the present health status.

• Journal of Hospice and Palliative Care
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• v.1 no.1
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• pp.23-29
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• 1998

Purpose : Validity of WHO guideline of cancer pain management has been proven and many trials were done for resolution of inadequate management of cancer pain. We assessed the severity of pain in terminal cancer patients and patient's characteristics influencing inadequate pain management. Methods : This study was done on 100 patients who was confirmed as terminal in Seoul National University Hospital from lune 1997 to November. For getting the informations about dermographic and medical characteristics such as performance and metastasis, and drug-adjusted pain severity the patients, we reviewed the medical records and interview the patients. we assessed the adequacy of prescribed analgesics with WHO guidelines of pain management, and patient's characteristics influencing on adequacy of pain management. Results : 85.0 percent of cancer patient had pain when diagnosed as terminal cancer and 68% of patient had pain above moderate severity. 38.0 percent of those were given inadequate pain management and the greater pain severity, the less adequate(P<0.001). Sex, age, primary site of cancer, metastasis, symptoms such as depression and anxiety, and performance were not significant. Conclusion : Despite guidelines for pain management, many patients with terminal cancer received inadequate pan management. Their is a need for education about evaluation of pain and guidelines of pain management.

• The Journal of the Korea Contents Association
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• v.20 no.11
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• pp.676-685
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• 2020

This study attempted to examine the subjectivity of early postpartum mothers' perceptions of comprehensive nursing care services targeting at early postpartum mothers hospitalized at general wards, and applied Q methodology to find types of subjectivity and characteristics of the types. P-sample 21 subjects were asked to read Q sample 25 statements about comprehensive nursing care services and indicate their level of agreement to those statements on a 9-point scale. The data were collected during the period from March 16 to March 31, 2020, and the collected data were analyzed using PC-QUANL program. The results of the study showed differences in the respondents' perceptions, which led to the classification into three types. "Type 1" is "those calling for continuous emotional management for early postpartum mothers." "Type 2" is "those seeing the role of a family in the recovery period as important." The respondents of this type considered a bond of sympathy should be formed in the family in relation to the new tasks of the mother's recovery and the child's birth. "Type 3" is "those calling for differentiated operation guidelines according to the motivation for hospitalization." The respondents of this type recognized that the operation guidelines limiting the residing of guardians need to be improved for early postpartum mothers.

• Korean Journal of Psychosomatic Medicine
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• v.28 no.1
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• pp.53-62
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• 2020

Objectives : This study investigated lifetime experiences of trauma, treatment retention, and psychiatric symptoms among outpatients with panic disorder after initiation of pharmacotherapy. Our research hypothesis was that panic patients with childhood trauma would display more severe symptoms and less treatment retention compared to those without such history. Methods : A total of 135 first-visit outpatients with DSM-IV panic disorder were approached during the period from March 2012 to August 2016. Fifty-three patients (39%) either refused or returned incomplete questionnaires, leading to a final sample size of 82. Participants completed the Trauma History Screen, the Beck Depression Inventory, the Beck Anxiety Inventory, and the Abbreviated PTSD checklist. Results : The number of lifetime trauma was significantly correlated with treatment retention (rho=-0.269, p=0.015). Among subtypes of trauma, only childhood physical abuse was significantly correlated with treatment retention (rho=-0.298, p=0.007). Conclusions : Our results indicated that psychological trauma, particularly of an interpersonal nature from childhood, can affect pharmacotherapy treatment retention in panic disorder. This may be mediated by poor patient-doctor relationships originating from trust issues among childhood trauma survivors or lack of perceived improvement due to the more severe symptoms and unfavorable course experienced by those with childhood trauma. Further studies are needed to explore the reasons for poor treatment adherence in this population.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.9 no.4
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• pp.428-438
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• 2016

The aim of this study, in order to reduce the support burden of dementia primary caregiver, within the framework of long-term care insurance system to present its founding model for the development of new services. Previous research as analytical materials and based on the CARE study between 2012 to 2013. Primary caregiver burden of patient are both physical, psychological and economic aspects as well as difficulties in many aspects and had influence on many factors such as age, care burden, economic, health, and social support. It also came high-risk primary caregiver suffer from depression. This primary caregiver to take advantage of the elderly long-term care insurance system implemented at the time of the institutional support necessary for since 2008, presented additional services in this study. Of increasing the small sizes day care center (tentative name) to open an as established in the settlements at a scale of less than nine, within 5 minutes from the residence, limited dementia by expertise in the disease home care services scale model of the current system service It was to improve the quality of existing shares, small group sizes for day care centers and community life apart.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.10
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• pp.3808-3819
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• 2010

This study was performed to determine the levels of quality of life(QOL) according to the grade of long-term care service in the elderly people who were judged from long-term care insurance, and to reveal its association with related variables. The interviews were made to 958 elderlies in urban and rural areas from March 1 to May 31, 2009. The mean scores of QOL among all subjects were $55.4{\pm}15.62$(Grade I; $49.7{\pm}14.17$, Grade II; $56.8{\pm}14.62$, Grade III; $59.4{\pm}16.36$), and they were lower according to the higher grade of long-term care insurance. The multiple regression analysis was used to reveal the explanatory powers of factors influencing on the level QOL. Such factors as educational level, monthly income, subjective health status, depression and MMSE-K were shown to affect their QOL in Grade I, Grade II, and Grade III with explanatory powers of 45~62%.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.7 no.2
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• pp.190-202
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• 1996

This study assessed psychiatrically referred 5-to 13-year-old children who presented inattention or hyperactivity as chief complaints. Demographic characteristics, primary diagnosis, and comorbid psychiatric conditions of them were identified, and they were assessed using questionnaires and neuropsychological tests. Primary diagnoses included ADHD, anxiety disorder, mental retardation, depression, oppositional defiant disorder, developmental language disorder and others. functional enuresis, conduct disorder, and developmental language disorder were among the secondarily diagnosed disorders. In patients diagnosed as ADHD, overall comorbidity rate was 55.3%. The disorders that frequently co-occured with ADHD were specific developmental disorder, conduct disorder, oppositional defiant disorder, anxiety disorder and other. ADHD groups with or without comorbidity differed in performance IQ and CPT scores. ADHD group differed from externalizing disorders group in the information subscore of IQ, MFFT, and CPT scores, and differed in teachers rating scales, the uncommunication factor of CBCL, and CPT card error compared with internalizing disorders group. The authors concluded that inattentive or hyperactive children should be assessed using various instruments to differentiate other disorders and to identify possible presence of comorbid conditions.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.229-229
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• 1994

선택성이 높고 뛰어난 약효를 지닌 항 바이러스제의 개발은 신약개발의 중요한 영역중에 하나이다. 현재 AIDS 치료제로 사용되고 AZT를 비롯하여 항virus 효과를 나타내는 약물의 대부분은 구조적으로 nucleoside계에 속하는 화합물로서 수 많은 약리학적 연구 및 합성 화학적 연구가 이루어져 왔다. 특히 합성 화학적 측면에서 이들 화합물의 합성은 크게 두가지로 나누어지는데 그것은 sugar 부위의 변형을 통한 방법과 염기 부위의 변형을 통한 방법에 의해 새로운 항 바이러스제를 개발하는 것이다. 최근의 연구 동향에 있어서 주목할 만한 변화의 하나는 sugar 부위의 구조적 변형을 시도하는데 있어서 종래의 5원환 형태에서 환이 개열된 형태의 acyclic nucleoside에 대한 연구가 이루어져 좋은 효과를 거두고 인다는 사실이다. Acyclovir, Ganciclovir등 의 개발이 그것이다. 본 연구에서는 종래의 acyclic nucleoside가 ribose sugar의 2'번 및 3'번 탄소를 제거한 acyclic ether 형태로 되어있는 것과는 다르게 ether 부위의 산소를 탄소 치환한 carbo-acyclic nucleoside를 합성하고자 하였다. Acyclic nucleoside를 합성하고자 하였다. Acyclic nucleoside의 side chain의 conformation이 항 바이러스 작용을 나타내는데 필수 불가결한 점을 감안할때, carbo-acyclic nucleoside계 화합물은 보다 다양하게 변형될 수 있는 장점을 가지고 있다. 이러한 관점에서 side chain의 2'번 및 3'번 탄소는 side chain의 conformation을 좌우하는 결정적 요인으로 작용할 것으로 판단된다. 따라서 본 연구에서는 이들 탄소를 중심으로한 분자수식을 시도하기로 하고 bioisosterism을 이용하여 3'위치의 수소를 fluoride로 치환한 화합물을 설계하여 합성을 시도하였다.silyl group-5'-무치환 화합물을 tosyl, azido화 한다음 desilylation하여 얻었다. 목적하는(1) 화합물의 diasteromer 인 2',3'-dihydroxy-5'-무치환 유도체(3)는 (4)화합물 합성시 얻은 hemiactal을 key intermediate로 하여 TsNHNH$_2$, NaB(CN)H$_3$ 및 NaOAc로 처리하므로서 얻을수 있었다. 이들 화합물들의 각종 DNA 및 RNA virus에 대한 항 바이러스작용을 검토한 결과 현저한 항 바이러스 작용을 나타내지 않았다.분화유도 활성을 나타내어 항종양제로의 개발에 많은 흥미가 기대된다.기대된다.oxylic acid (compound 10)를 합성하였다.10^{－7}$ M)에 의한 단백인산화에 대하여는 더 미약한 억제-효과를 나타내었다. 이상의 결과는 PDE-1과 항우울약들의 항혈소판작용은 PKC-기질인 41-43 kD와 20 kD의 인산화를 억제함에 기인되는 것으로 사료된다.다. 것으로 사료된다.다.바와 같이 MCl에서 작은 Dv 값을 갖는데, 이것은 CdCl$_{4}$$^{2-}$ 착이온을 형성하거나 ZnCl$_{4}$$^{2-}$ , ZnCl$_{3}$$^{-}$같은 이온과 MgCl$^{+}$, MgCl$_{2}$같은 이온종을 형성하기 때문인것 같다. 한편 어떠한 용리액에서던지 NH$_{4}$$^{+}$의 경우 Dv값이 제일 작았다. 바. 본 연구의 목적중의 하나인 인체유해 중금속이온인 Hg(II), Cd(II)등이 NaCl같은 염화물이 함유된 시료용액에 공해이온으로 존재할 경우 흡착에 의한 제거가 가능하다. 한편 이같은 중금속이온의 흡착실험은 특히 해수중의 금속이온의 회수연구에도

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.11
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• pp.446-457
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• 2019

The purpose of this study was to analyze the association between family members and adolescent boys smoking. The data were evaluated by frequency analysis, 𝑥² test and logistic regression analysis using 27,276 people who responded to the 14th(2018) Korean Youth Risk Behavior Survey. Among male students, the nonsmoking rate was 91.5% and the smoking rate was 8.5%(2.5% of occasional smoking and 6.0% of frequent smoking). The study results showed that the smoking status of male students was varied significantly according to the number of smokers among the family members(p<0.001). Meanwhile, smoking based on the characteristics of socio-demographic factors was affected by grades, school records, economic status, and parents' educational background(p<0.001). Smoking by health factors showed a significant difference in alcohol consumption, suicidal thoughts, depression experiences, stress recognition, frequency of breakfast consumption, level of fatigue after sleep, and subjective perception of health(p<0.001). Male smokers were more likely to smoke when two family members smoked than only one(p<0.001). These results confirmed that smoking in boys was affected by the smoking status of family members and suggested that the smoking cessation program of family smokers can be effective in designing smoking cessation prevention and smoking cessation projects.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.1
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• pp.146-154
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• 2015

This study was conducted, to investigate the level of self-control, mental health and the interrelationship of college students and to analyze the differences between these variables according to the level of smart phone usage. The subjects of our study were collected 246 students. The survey was conducted from April 25th to May 28th in 2012. The result indicated that cellphone overuse group has the lowerer self-control(t=3.53, p=.001) and the more mental health discomfort(t=-3.61, p=.000) than non-smart phone overuse group. In non-smart phone overuse group, the usage of smart phone was negatively correlated with self-control(r=-0.27, p=.005) and communication(r=-0.20, p=.043). And in the other group, the usage of smart phone was positively correlated with mental health discomfort(r=0.22, p=.009). These findings imply that it maybe needed to examine effect factors of the smart phone usage according to the level of smart phone usage.