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Anticancer Activities by Combined Treatment of Red Ginseng Acidic Polysaccharide (RGAP) and Anticancer Agents (홍삼산성다당체 (RGAP)와 항암제의 병용투여에 의한 항암시너지 효과)

  • Kwak, Yi-Seong;Kim, Young-Sook;Shin, Han-Jae;Song, Yong-Bum;Park, Jong-Dae
    • Journal of Ginseng Research
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    • v.27 no.2
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    • pp.47-51
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    • 2003
  • Synergistic anticancer activities of red ginseng acidic polysaccharide (RGAS) showing immunomodulatory activity were evaluated by combined treatment with anticancer agents such as Cyclophosphamide (CY) or 5-Fluorouracil (5-FU) in experimental tumor models. The combined treatment of RGAP (100 mg/kg) and CY (3 mg/kg) exhibited 71% of survival rate in lift span of sarcoma 180-bearing mice, while single treatment of RGAP (100 mg/kg) and CY (3 or 10 mg/kg) exhibited 43, 14 and 43% of survival rates, respectively. In addition, when RGAP (100 mg/kg) was administered in combination with 5-FU (2.5 mg/kg) to sarcoma 180 tumor-bearing mice, higher survival rate was found when compared with RGAP or 5-FU treatment alone. Moreover, tumor weights in LL/2 lung carcinoma-bearing mice treated combined with RGAP (100 mg/kg) and 5-FU (5 or 10 mg/kg) was obviously decreased when compared with 5-FU alone. These results suggest that clinical trials of RGAP as an adjuvant in cancer chemotheraphy can be higly feasible.

A Study on the Utilization and Control Method of Hybrid Switching Tap Based Automatic Voltage Regulator on Smart Grid (스마트그리드의 탭 전환 자동 전압 조정기의 다중 스위칭 제어 방법 및 활용 방안에 관한 연구)

  • Park, Gwang-Yun;Kim, Jung-Ryul;Kim, Byung-Gi
    • Journal of the Korea Society of Computer and Information
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    • v.17 no.12
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    • pp.31-39
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    • 2012
  • In this paper, we propose a microprocessor-based automatic voltage regulator(AVR) to reduce consumers' electric energy consumption and to help controlling peak demanding power. Hybrid Switching Automatic Voltage Regulator (HS-AVR) consist of a toroidal core, several tap control switches, display and command control parts. The coil forms an autotransformer which has a serial main winding and four parallel auxiliary windings. It controls the output voltage by changing the combination of the coils and the switches. Relays are adopted as the link switches of the coils to minimize the loss. To make connecting and disconnecting time accurate, relays of the circuit have parallel TRIACs. A software phase locked loop(PLL) has been used to synchronize the timings of the switches to the voltage waveform. The software PLL informs the input voltage zero-crossing and positive/negative peak timing. The traditional voltage transformers and AVRs have a disadvantage of having a large mandatory capacity to accommodate maximum inrush current to avoid the switch contact damage. But we propose a suitable AVR for every purpose in smart grid with reduced size and increased efficiency.

Effects of Hambag Mushroom (Grifola frondosa)-Powder on Hyperglycemia and Hyperlipemia in STZ and High Fat Diet-induced Diabetic Rats (STZ 및 고지방식이에 의해 유도된 흰쥐의 고혈당 및 고지혈에 대한 함박잎새버섯분말의 효능)

  • Lee, Soon-Lee;Park, Yeong-Chul;Kim, Jong-Bong
    • Journal of Life Science
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    • v.17 no.10
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    • pp.1387-1393
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    • 2007
  • Hambag mushroom is edible mushroom, and one of new strains in Grifola frondosa. It was developed from Korean wild Grifola frondosa by National Institute Science & Technology. In this study, we investigated the effects of the powder extracted from fruit-body of hambag mushroom on hyperglycemia, hyperlipemia and pancreatic cells in rats with streptozotocin (STZ) and high fat diet-induced diabetes. The diabetic rats were fed with hambag mushroom-powder (1 and 2% of diet weight) for 6 weeks. And then the levels of blood glucose and lipid and the pancreatic tissue were analyzed and compared. The diabetic rats fed with hambag mushroom-powder lost less body weight than those fed with the powder-free normal diet. flood glucose levels in the diabetic rats fed with hambag mushroom-powder at all concentrations was lower by 50% than in the diabetic rats fed with normal diet. The levels of total cholesterol, triglyceride and LDL-cholesterol in the diabetic rats fed with hambag mushroom-powder were increased compared to those in the diabetic rats fed with normal diet. There were the blood levels of cholesterol, triglyceride and LDL-cholesterol by hambag mushroom-powder concentrations in a dose-dependent response. The decreased damage of pancreatic tissue in the group treated with hambag mushroom-powder could be suggested possibly as one of mechanisms for the effects of hambag mushroom-powder on hyperglycemia and hyperlipemia.

Phase Formation Behavior and Charge-discharge Properties of Carbon-coated Li2MnSiO4 Cathode Materials for Lithium Rechargeable Batteries (리튬이차전지용 탄소 코팅된 Li2MnSiO4 양극활물질의 상형성 거동 및 충방전 특성)

  • Sun, Ho-Jung;Chae, Suman;Shim, Joongpyo
    • Journal of the Korean Electrochemical Society
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    • v.18 no.4
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    • pp.143-149
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    • 2015
  • Carbon-coated $Li_2MnSiO_4$ powders as the active materials for the cathode were synthesized by planetary ball milling and solid-state reaction, and their phase formation behavior and charge-discharge properties were investigated. Calcination temperature and atmosphere were controlled in order to obtain the ${\beta}-Li_2MnSiO_4$ phase, which was active electrochemically, and the carbon-coated $Li_2MnSiO_4$ active material powders with near single phase ${\beta}-Li_2MnSiO_4$ could be fabricated. The particles of the synthesized powders were secondary particles composed of primary ones of about 100 nm size. The carbon incorporation was essential to enable the Li ions to be inserted and extracted from $Li_2MnSiO_4$ active materials, and the initial capacity of 192 mAh/g could be obtained in the $Li_2MnSiO_4$ active materials with 4.8 wt% of carbon.

Various Meanings of Wolji Pond Construction in Shilla Dynasty (월지 조성 목적의 중의성(重意性) 고찰)

  • Hong, Kwang-Pyo
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.34 no.3
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    • pp.67-77
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    • 2016
  • This study was initiated from question raised on existing study achievement that purpose for Wolji construction simply was to build gardens. In this research, after raising a question on existing theory about the Wolji construction, another purpose of Wolji construction is investigated. Study result is as follows. First, two questions raised on Wolji construction are "Was Wolji constructed as a garden from the beginning?" and "Was Wolji region available land as now at time of creation?" However, it was verified that the purpose of Wolji construction was to use not as a garden but as a detention pond, and the land of such region was unserviceable at time of Wolji construction. Second, in terms of locations and Topography, it was confirmed that Wolji has a favorable condition for undercurrent function as it is positioned at the end point of flow path formed by gushout water spurting from the water flooded from Bukcheon, or low and wetland. Third, from hydraulic point of view, Bukcheon always has a possibility of flooding occurrence before completing river bank build up, and such flooding damage was curved at Guhwangdongwonji, and at Wolji once again in order to prevent the damage spread into the center of Wanggyeong. Fourth, from urban planning point of view, it was confirmed that urban functions were not established in Wolji region before Wolji construction, and urban planning was completed through the opening of roads and others, after Wolji construction. Fifth, it was confirmed that inflow and outflow device of Wolji, and vertical stone platform at western side of Wolji were the facilities to provide sufficient functions as detention ponds.

Early Larval Growth of Flesh Prawn (Fenneropenaeus chinensis) (대하(Fenneropenaeus chinensis)의 초기 유생성장)

  • Park In-Seok;Hur Jun Wook
    • Korean Journal of Environmental Biology
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    • v.23 no.1
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    • pp.27-31
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    • 2005
  • Early larval growth for total length (TL) and body weight (BW) in flesh prawn (Fenneropenaeus chinensis) was studied from hatching to 25 days after hatching. Mean total length at nauplius and zoea stages was 0.21-0.39 mm and 0.62-1.03 mm, respectively. Mean total length of mysis stage grew from 1.28 mm (9 days after hatching) to 5.98 mm (21 days after hatching). The increase of body weight during experimental period showed step by step growth pattern due to metamorphosis of this species. The relationship between BW and TL from hatching to 25 days after hatching was BW = 2E-5TL/sup 4.1707/ (r²= 0.9746).

Thickness Determination of Ultrathin Gate Oxide Grown by Wet Oxidation

  • 장효식;황현상;이확주;조현모;김현경;문대원
    • Proceedings of the Korean Vacuum Society Conference
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    • 2000.02a
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    • pp.107-107
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    • 2000
  • 최근 반도체 소자의 고집적화 및 대용량화의 경향에 다라 MOSFET 소자 제작에 이동되는 게이트 산화막의 두께가 수 nm 정도까지 점점 얇아지는 추세이고 Giga-DRAM급 차세대 UNSI소자를 제작하기 위해 5nm이하의 게이트 절연막이 요구된다. 이런 절연막의 두께감소는 게이트 정전용량을 증가시켜 트랜지스터의 속도를 빠르게 하며, 동시에 저전압동작을 가능하게 하기 때문에 게이트 산화막의 두께는 MOS공정세대가 진행되어감에 따라 계속 감소할 것이다. 따라서 절연막 두께는 소자의 동작 특성을 결정하는 중요한 요소이므로 이에 대한 정확한 평가 방법의 확보는 공정 control 측면에서 필수적이다. 그러나, 절연막의 두께가 작아지면서 게이트 산화막과 crystalline siliconrksm이 계면효과가 박막의 두께에 심각한 영향을 주기 때문에 정확한 두께 계측이 어렵고 계측방법에 따라서 두께 계측의 차이가 난다. 따라서 차세대 반도체 소자의 개발 및 양산 체계를 확립하기 위해서는 산화막의 두께가 10nm보다 작은 1nm-5nm 수준의 박막 시료에 대한 두께 계측 방법이 확립이 되어야 한다. 따라서, 본 연구에서는 습식 산화 공정으로 제작된 3nm-7nm 의 게이트 절연막을 현재까지 알려진 다양한 두께 평가방법을 비교 연구하였다. 절연막을 MEIS (Medim Energy Ion Scattering), 0.015nm의 고감도를 가지는 SE (Spectroscopic Ellipsometry), XPS, 고분해능 전자현미경 (TEM)을 이용하여 측정 비교하였다. 또한 polysilicon gate를 가지는 MOS capacitor를 제작하여 소자의 Capacitance-Voltage 및 Current-Voltage를 측정하여 절연막 두께를 계산하여 가장 좋은 두께 계측 방법을 찾고자 한다.다. 마이크로스트립 링 공진기는 링의 원주길이가 전자기파 파장길이의 정수배가 되면 공진이 일어나는 구조이다. Fused quartz를 기판으로 하여 증착압력을 변수로 하여 TiO2 박막을 증착하였다. 그리고 그 위에 은 (silver)을 사용하여 링 패턴을 형성하였다. 이와 같이 공진기를 제작하여 network analyzer (HP 8510C)로 마이크로파 대역에서의 공진특서을 측정하였다. 공진특성으로부터 전체 품질계수와 유효유전율, 그리고 TiO2 박막의 품질계수를 얻어내었다. 측정결과 rutile에서 anatase로 박막의 상이 변할수록 유전율은 감소하고 유전손실은 증가하는 결과를 나타내었다.의 성장률이 둔화됨을 볼 수 있다. 또한 Silane 가스량이 적어지는 영역에서는 가스량의 감소에 의해 성장속도가 둔화됨을 볼 수 있다. 또한 Silane 가스량이 적어지는 영역에서는 가스량의 감소에 의해 성장속도가 줄어들어 성장률이 Silane가스량에 의해 지배됨을 볼 수 있다. UV-VIS spectrophotometer에 의한 비정질 SiC 박막의 투과도와 파장과의 관계에 있어 유리를 기판으로 사용했으므로 유리의투과도를 감안했으며, 유리에 대한 상대적인 비율 관계로 투과도를 나타냈었다. 또한 비저질 SiC 박막의 흡수계수는 Ellipsometry에 의해 측정된 Δ과 Ψ값을 이용하여 시뮬레이션한 결과로 비정질 SiC 박막의 두께를 이용하여 구하였다. 또한 Tauc Plot을 통해 박막의 optical band gap을 2.6~3.7eV로 조절할 수 있었다. 20$0^{\circ}C$이상으로 증가시켜도 광투과율은 큰 변화를 나타내지 않았다.부터 전분-지질복합제의 형성 촉진이 시사되었다.이것으로 인하여 호화억제에 의한 노화 방지효과가 기대되었지만 실제로 빵의 노화는 현저히 진행되었다

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Effect of Glutathione on Lead Induced Modulation of NO Synthesis in RAW 264.7 Cell (RAW 264.7 Cell에서 납에 의한 NO 생성의 조절에 미치는 Glutathione의 효과)

  • Oh, Gyung-Jae;Kwon, Keun-Sang;Yoon, Wook-Hee;Shin, Sae-Ron
    • Journal of Preventive Medicine and Public Health
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    • v.35 no.4
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    • pp.269-274
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    • 2002
  • Objectives : To evaluate the elect of glutathione(GSH) on lead induced modulation of nitric oxide(NO) synthesis, and to examine how lead modulates NO production in macrophages. Methods : This study was observed in a culture of RAW 264.7 cells, which originated from a tumor in a Balb/c mouse that was induced by the Abelson murine leukemia virus. The compounds investigated were lead chloride, N-acetyl-cystein(NAC), and Buthionine Sulfoximine( BSO). Results : ATP synthesis in RAW 264.7 cells was unchanged by each lead concentration exposure in a dose dependent manner. The NO synthesis was decreased when exposed to lead($PbCl_2$) concentration $0.5{\mu}M$. The presence of $300{\mu}M$ NAC, used as a pretreatment in the culture medium, caused the recovery of the lead induced decrease in NO synthesis, but in the presence of $300{\mu}M$ BSO as a pretreatment, there was no recoverey. Pretreatment with NAC and BSO had no affect on ATP synthesis at any of the lead concentrations used. Conclusions : These results indicated that GSH has a protective effect toward lead toxicity, and suggested that the inhibition of NO production in macrophage due to lead toxicity may be related to cofactors of iNOS (inducible nitric oxide synthase)

Development of Long-term Rainfall-Runoff Analysis System in SeongDeok Dam Watershed (성덕댐 유역의 장기유출 분석체계 구축)

  • Choi, Hyun Gu;Kim, Bong Jae;Kim, Seon Uk;Park, Byeong Woo
    • Proceedings of the Korea Water Resources Association Conference
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    • 2018.05a
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    • pp.429-429
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    • 2018
  • 성덕댐은 기존 농업용 저수지였던 수락저수지를 다목적댐으로 재개발한 우리나라 최초의 사례로 2006년 11월에 착공하였다. 댐재개발 사업은 장랠 물 부족이 예상되나, 현재 마땅한 댐 개발적지가 부족하여 수자원 확보를 위해 기존의 댐을 재개발하는 것으로, 기 개발된 수자원의 활용도 제고 및 환경적으로 건전하고 지속 가능한 수자원을 개발하는 사업을 말한다. 기존의 수락저수지의 재원은 높이 19.0m, 길이 150.0m, 총 저수량 $806,000m^3$이었으며, 성덕다목적댐으로 재개발 되면서 증가된 주요재원은 높이 58.5m, 길이 274.0m, 총 저수량 $27,900,000m^3$이다. 성덕다목적댐 건설이 완료됨에 따라 기존의 농업용수($8,400m^3$/일) 공급뿐만 아니라 하천유지용수 $5,800m^3$/일 및 경북 청송, 영천, 경산지역에 생활용수와 공업용수를 $42,300m^3$/일를 공급할 수 있게 되었으며, 홍수조절용량 $4,200,000m^3$을 확보하여 유역의 홍수예방에도 기여할 수 있다. 댐의 운영기준을 수립하기 위해서는 적어도 20년 이상의 댐 유입량 자료가 필요하지만 성덕댐의 경우 댐 유입량 자료의 확보가 쉽지 않은 상황이다. 이에 K-water에서 개발하고 다양한 다목적 댐 유역에 적용한 경험이 있는 격자기반 강우-유출 모형인 K-DRUM(K-water Distributed Rainfall rUnoff Model)을 이용하여 성덕댐 유역의 장기유출모형을 구축하였다. 격자기반 수문모형의 장점은 공간적인 비균질성을 고려하여 물리적인 유출과정을 모형화할 수 있고, 이로 인해 신뢰성 있는 수문해석이 가능하기 때문이다. 성덕댐 유역의 K-DRUM 모형을 구축하기 위해서 토지이용도, 토양도(종류, 유효토심), 하천차수도, 유역도, 표고분포도 등을 수집하였으며, 격자는 60m의 정사각형 격자로 약 11,500개를 구성하여 적용하였다. 기상자료로는 안동, 의성, 영천 기상대의 강우자료와 안동 기상대의 기상자료를 활용하였다. 모형의 보정을 위해서는 2016년을 시단위로 모의하였으며 성덕댐 유입량와 비교하여 매개변수를 보정하였고, $R^2$는 0.72, NSE는 0.70, RMSE는 1.82로 신뢰도 높은 보정결과를 획득할 수 있었다. 보정된 매개변수를 성덕댐 유역의 장기유출에 적용하였으며, 1997년부터 2017년까지 총 21년 장기유출 모의를 수행하였으며, 모의결과는 댐 운영기준의 기초자료로 활용하였다.

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Hormone Analysis during Artificial Estrus Induction in Korean Black Goats (흑염소의 인공수정 발정동기화 처리방법에 따른 호르몬 변화분석)

  • Kim, Kwan-Woo;Jeon, Dayeon;Lee, Jinwook;Kim, Seungchang;Lee, Sang-Hoon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.8
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    • pp.224-230
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    • 2019
  • The purpose of the study is to investigate the change in the blood progesterone (P4) and estrogen (E2) levels when applying different estrus induction protocols to Korean black goats, and this was done to gain understanding about their reproduction physiology. For the experiment, we performed three estrus induction protocols that are commonly used in bovine: controlled internal drug release (CIDR) + prostaglandin $F2{\alpha}$ ($PGF2{\alpha}$), $PGF2{\alpha}$ + gonadotropin-releasing hormone (GnRH) + $PGF2{\alpha}$, and CIDR + $PGF2{\alpha}$ + PMSG. The P4 and E2 concentrations showed different patterns until the last treatment of the three protocols. However, similar concentration patterns were shown after the last treatment in all the protocols. In conclusion, we monitored the blood P4 and E2 levels in Korean black goats following three different estrus induction protocols. Our findings may be used in other breeding programs of Korean black goats, such as artificial insemination and embryo transfer.