• 동의신경정신과학회지
• /
• 제19권3호
• /
• pp.55-68
• /
• 2008

Background: Microglia produces a barrage of factors (IL-l, TNF-$\alpha$, NO, superoxide) that are toxic to neurons and playa major role in the cellular immune response associated with the pathology of Alzheimer's disease(AD). OJaJiHwangEumJa(OJJHEJ) has been usually used for the treatment of senile disorders. For enhancing efficacy and convenience, the change of the drug delivery device of oriental herbal medicine is required. Objective: This experiment was designed to investigate the effect of the OJJHEJ hot water extract & ultra-fine powder on proinflammatory cytokine of microglia and memory deficit model. Method: The effects of the OJJHEJ hot water extract on production of IL-1$\beta$, IL-6, TNF-$\alpha$, in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. The effects of the OJJHEJ hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine and AChE in serum of the memory deficit mice induced by scopolamine were investigated. Results: 1. The OJJHEJ hot water extract suppressed the production of IL-1$\beta$, IL-6, TNF-$\alpha$ in BV2 microglial cell line and the production of IL-6 was suppressed significantly. 2. The OJJHEJ hot water extract & ultra-fine powder decreased AChE significantly in the serum of the memory deficit mice induced by scopolamine. 3. The OJJHEJ hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. Conclusions: This experiment shows that the OJJHEJ hot water extract & ultra-fine powder might be effective for the prevention and treatment of memory impairment diseases. Investigation into the clinical use of the OJJHEJ hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.

• 한국측량학회지
• /
• 제28권6호
• /
• pp.587-594
• /
• 2010

측지망은 측량작업과 조정계산의 기준으로써 그 구성이 측량성과의 품질에 많은 영향을 미침에도 불구하고 대부분의 측지망 설계는 경험적 또는 단순한 기하학적 강도만을 기준으로 설계되어진다. 본 논문은 해석적 기법에 의한 측지망의 최적화 설계를 위하여 측지망의 품질을 평가하기 위한 다양한 기준을 분석하고 제시하기 위한 것으로써 측지망 품질평가 기준으로 정밀도(오자타원, 2DRMS, CEP), 신뢰성(내적신뢰성) 및 견인성(최대전단변형률, 주변형률, 면적변형률)을 제시하고 이를 실제 측지망의 설계에 적용함으로써 그 효용성을 평가하였다. 기관측된 실제 측지망에 8가지 품질평가 인자를 적용하여 측지망 최적화 설계의 효용성을 평가한 결과, 최적화 설계 전 후 품질평가 인자는 평균값에 있어서 정밀도는 2%, 신뢰성은 3%, 견인성은 3,001%로 향상되었으며, 최대값에 있어서 정밀도는 5% 신뢰성은 7%, 견인성은 16,957% 향상된 것으로 분석되었다.

• 한국측량학회지
• /
• 제28권6호
• /
• pp.573-578
• /
• 2010

위성항법시스템에서 정확한 위성궤도결정 기술은 측위 정확도 향상의 필수적인 조건이다. 이 연구에서는 GLONASS의 방송궤도력과 4차 Runge-Kutta 수치적분법을 이용하여 위성좌표를 결정하였으며, 적분간격과 적분시간에 따른 위성궤도의 정확도를 비교하였다. 적분간격에 따른 위성궤도 정확도분석결과, 적분간격이 l초일 때와 300초일 때의 3차원 RMS 오자의 차이가 3cm에 불과한 반면 처리시간은 100배 이상 향상되었다. 적분시간에 따른 위성좌표의 3차원 RMS 오차는 적분시간이 30분, 150분, 300분일 때 각각 8.3m, 187.3m, 661.5m로 나타났으며, 이를 통해 적분시간을 짧게 할수록 정확도가 향상되는 것을 확인하였다. 따라서 이 연구에서는 GLONASS 측위를 위한 위성좌표 결정의 정확도 향상을 위해 적분시간을 최소화할 수 있는 Forward와 Backward 적분을 적용하는 방안을 제안하였으며, 이와 같은 방법을 사용할 경우 5m이하의 위성좌표 산출 정확도를 확보할 수 있다.

• 대한한방내과학회지
• /
• 제26권3호
• /
• pp.605-614
• /
• 2005

Objectives : Ojawhan was formulated to contain various natural products known to cure erectile dysfunction. This study was aimed to investigate the effects of Ojawhan on the nitric oxide synthase(NOS) activity, nitrite level, antioxidation and erectile responses in rat's corpus cavernosum penis. Methods : Ojawhan was washed, dried in the shade and crushed. The crushed Ojawhan ,was extracted 3 times, each time with 3 volumes of methyl alcohol at $60^{\circ}C$ for 24 h. The extract was filtered and evaporated under a reduced pressure using a rotary evaporator to yield 62g. Ojawhan extract oral-administered 100 mg per 1 kg of body weight for 30 days. First, samples were treated with Ojawhan, then ethanol-treated rats and L-N-Nitroarginine methyl ester(L-NAME) treated rats were put with the samples. Result : The level of urethral lipid peroxide in the ethanol-Ojawhan double administered rats was decreased as low as in the normal group, while the one in the ethanol-treated group was increased. The urethral NOS activity, the level of urethral nitrite, the level of testosterone and the erectile response to cavernous nerve stimulation in the ethanol-Ojawhan double administered rats were increased as high as in the normal group while the one in the ethanol-treated group was decreased. The electile response to cavernous nerve stimulation and the level of nitrite in L-NAME ($10^{-4}$)-treated rats was restored by the administration of Ojawhan as high as in the normal group. Conclusions : Ojawhan was effective in restoring the ethanol-induced or L-NAME-induced erectile dysfunction in rats.

• 암석학회지
• /
• 제28권4호
• /
• pp.299-306
• /
• 2019

우리나라 선사시대 유적지 중 하나인 연천 삼거리에서 출토된 흑요석제 석기에 대한 산지를 유추해 보았다. 삼거리 흑요석제 석기에 포함된 미세결정 중 산화광물과 휘석은 연정 내지 포이킬리틱 조직을 보이며, 휘석의 미세결정은 그 조성이 헤덴버자이트 내지 오자이트의 조성을 가진다. 기질에 대한 주성분 산화물의 함량에서 삼거리 흑요석제 석기는 좁은 범위의 일정한 값을 나타내며 SiO₂ 함량이 73.8~75.5 wt.%의 산성의 유문암 조성을 나타낸다. 기질의 희토류원소 함량 역시 일정하며 뚜렷한 Eu 음의 이상을 보인다. 삼거리 흑요석제 석기의 이러한 광물학적 및 지구화학적 특징을 우리나라 주변 흑요석 대표 산지인 백두산과 일본 규슈의 흑요석과 비교해 보았을 때, 흑요석제 석기의 원석이 백두산에서 유래되었을 가능성이 크다.

• 건축역사연구
• /
• 제18권2호
• /
• pp.27-45
• /
• 2009

This study was to analyze the philological character of Qingwujing(靑烏經). Qingwujing is the oldest and representative documents of FengShui, especially famous for FengShui XingQi(形氣) theories. In spite of is fame, a systematic research for Qingwujing was not yet fulfilled up to now in Korea. In is the main reason why have to research the philological character of Qingwujing. The results from this research were described as following. Qingwujing(靑烏經) as knows of Qingwujing's writer is very famous already in Han 한(漢) dynasty for his accurate FengShui methods. His FengShui thories getting more powerfyl from WeiChen(魏晉) to Tang(唐) dynasty. In Tang(唐) dynasty Qingwujing was abolished by government rulers, but it recovered and retouched by some scholars from Tang(唐) and Song(宋) dynasty. In the process, the block book of Qingwujing were changed for four or five kinds. Qingwujing's block books of Ming(明) dynasty are Yimenguangdu(夷門廣牘), Xiaoshisanjing(小十三經), Jujiabibei(居家必備), and Shuofu(說郛). It's block books of Qing(淸) dynasty are Gujintushujicheng(古今圖書集成), Sikuquanshu(四庫全書), Xuejintaoyuan(學津討原), and Ershierziquanji(二十二子全集). It's block book of Choson(朝鮮) dynasty is KyujangKak(奎章閣). Among them distinctive characters been founded, but the basic contents and theories are almost same. In Korea, Qingwuzi's FengShui theories were confirmed in Silla(新羅) dynasty, and it recoreded in Soongboksa inscription written by Choi-CheeWon. Qingwu(靑烏) or Qingwuzi were known for a great FengShui master of a FengShui standing theories in Koryeo(高麗) and Choson dynasty among royal families and the aristocratic classes. And Qingwujing was a representative FengShui theory book in wh0.1ole period of Choson dynasty. Now for understanding traditional FengShui theories, we have to understand the main FengShui theories on Choson dynasty at first. For understanding Choson FengShui, the study on philological character of Qingwujing is the basic works. If those works fulfilled successfully, we can understand FengShui theories and FengShu itself more correctly.

• 중환자간호학회지
• /
• 제8권2호
• /
• pp.23-32
• /
• 2015

Purpose: The purpose of this study was to analyze the effects of simulation-based training on nursing students' knowledge and ability to perform advanced cardiovascular life support. Methods: A nonequivalent control group non-synchronized design was used. The participants were, in total, 59 junior college nursing students (experimental group: 30, control group: 29). The data were analyzed with a ${\chi}^2$-test, independent t-tests, and analysis of covariance (ANCOVA) using IBM SPSS Statistics 23 program. Results: The experimental group ($80.8{\pm}8.4$), who received simulation-based advanced cardiovascular life support education, showed a higher level of knowledge of advanced cardiovascular life support than the control group ($75.0{\pm}9.9$), who received lecture-based education. In addition, the experimental group ($106.4{\pm}11.9$) showed a higher level of ability to perform advanced cardiovascular life support than the control group ($86.5{\pm}9.9$). Conclusion: Simulation-based advanced cardiovascular life support education was more effective for increasing the knowledge and performance ability of college students than lecture-based education. Therefore, simulation-based training should be used to improve the knowledge and ability of nursing students and should be applied with reinforced systematic education programs.

• 대한한의학방제학회지
• /
• 제17권1호
• /
• pp.113-120
• /
• 2009

Objectives : This study focuses on the effect of the extract which We manufactured by adding Aliium sativum to Ojayeonjonghwan on the amount of semen, the number and the activity of sperm. Methods : We observed any changes in the amount of semen, the number and the activity of sperm after orally administering the test drug for thirty days and taking semen samples from a selected group of men - healthy men in their 20s, as well as men in their 40s who were feeling a decrease in energy. Results : This experiment showed the result that the amount of semen increased by adding Aliium sativum to Ojayeonjonghwan in the case of men in their 20s, but did not show a statistically significant result. It showed the result that the amount of semen increased by a statistically significant level as well as the activity of sperm. Consequently, the result indicated that orally administering the extract added Aliium sativum to Ojayeonjonghwan increased the amount of semen, the number and the activity of sperm for men in their 20s. Men in their 40s who are feeling a decline in energy generally decreased the amount of semen, the number and the ratio of activity of sperm. However the amount of semen remarkably increased and the number and the activity of sperm increased but the result was not statistically significant after orally administering the test drug for thirty days. Conclution : Eventually, the result after orally administering the test drug to the group of men in their 20s and 40s for thirty days indicated that both groups increased the amount of semen, number of sperm and activity of sperm to a statistically significant degree.

• 대한예방한의학회지
• /
• 제9권1호
• /
• pp.49-63
• /
• 2005

Objectives : Ojayeonjonghwan(五子衍宗丸) is composed of Polygonum multiflorum THUNB, and some medical herbs that are known as formula of senescence delay effects. The purpose of this study is to investigate th effect of Ojayeonjonghwan on antioxidant enzyme activities, such as Thiobarbituric acid reactive substance(TBARS), Superoxide dismutase(SOD), Catalase(CAT), Glutathione preoxidase (GSH-px) in rat erythrocytes and blood plasma. Methods : Sprague-Dawley rats were divided into 3 groups, Normal group (supplied enough water and feeds only, Normal Group), D-galatose administered group(injected D-galatose 50mg/kg, 1time/day for 6 weeks, Control Group) and Ojayeonjonghwan administered group (D-galactose 50mg/kg and Ojayeonjonghwan extracts 245.0mg/200g 1time/day for 6 weeks, OJY Group). Rats were sacrificed and TBARS, SOD, CAT, GSH-px, Plasma total lipid, Plasma triglyceride and cholesterol were measured in rat erythrocytes and blood plasma. Results : TBARS in plasma concentration of OJY group was significantly lower than that of control group. Red blood cell(RBC) SOD activity of OJY group was significantly higher than that of control group(F=16.057, p=0.0001, ANOVA test), RBC GSH-px activity of OJY group was increased(F=4.271, p=0.034, ANOVA test). RBC catalase activities of all experimental group were not significantly different. Total lipid and triglyceride concentration in plasma of all experimental groups were not significantly different. Total cholesterol concentrations in plasma of OJY group were significantly lower than those of control group(F=4.387, p=0.032, ANOVA test). Conclusions : According to the above results, it is considered that Ojayeonjonghwan is effective in inhibiting lipid peroxidation and increasing antioxidative enzyme activities in D-galactose induced aging rat.

• 한국식물병리학회지
• /
• 제13권4호
• /
• pp.195-199
• /
• 1997

1995년 12월 전라북도 지역 내에 유통되고 있는 시클라멘의 꽃잎 중앙부에 진회색~흑색 원형 반점을 형성하거나, 꽃잎 주변에 흑색 수침상을 나타내는 탄저병의 발생이 관찰되었다. 병반으로 붜 분리된 균은 PDA 배지상에서 회백색을 띄었으며, 8.3~15.0${\times}$2.5~6.3 ${\mu}m$ 크기의 양끝이 둥근 무색 단포의 원통형~타원형의 분새오자를 형성하였고, 갈색 곤봉형의 부착기와 이병조직에서 갈색 둥근형의 분생자층을 형성하였다. 이에 따라 시클라멘 탄저병징에서 분리한 병원균은 국내에서 미보고된 Colletotrichum gloeosporioides로 동정되었으며, 균사생장 및 분생포자 형성을 위한 배양적정 온도는 25~30$^{\circ}C$였다.