• Journal of Oral Medicine and Pain
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• 제36권4호
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• pp.245-252
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• 2011

전통적으로 항구취 제제로 널리 쓰여 온 세틸피리디늄 및 염화아연이 함유된 양치액은 장기간의 사용에도 부작용이 없이 구취를 효과적으로 감소시키는 것으로 알려져 있다. 본 연구에서는 세틸피리디늄 및 염화아연을 주성분으로 한 구강 양치액의 아침 구취에 대한 효과를 관찰하고자 했다. 총 8명의 건강한 남자를 대상으로 crossover study를 진행했으며 1주일의 washout 기간을 두었다. 대상자들에게는 30초간 실험 용액 10 mL를 양치하게 했으며 1주일 후에 같은 방법으로 증류수를 양치하게 했다. 구취의 측정은 오전 8:30 분에 이루어졌으며 양치 전, 양치 후 1시간, 2시간, 3시간에 평가를 하였다. 구취의 평가는 관능구취검사와 이동성 황화합물 측정기(Halimeter)를 이용하였다. 세틸피리디늄과 염화아연을 함유한 구강 양치액은 양치 후 3시간까지 아침 구취를 감소시켰다. 관능구취검사 수치와 휘발성 황화합물의 농도는 실험군에서 시간에 따라 유의한 감소를 보였고 그 감소 양상은 두 군 간에 유의한 차이를 보였다. 결론적으로, 세틸피리디늄과 염화아연을 함유한 구강 양치액은 건강한 대상자의 아침 구취를 3시간까지 유의하게 감소시킬 수 있어 구취제거를 위한 양치액으로 그 효용성이 매우 크다.

• 한국치위생학회지
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• 제17권6호
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• pp.983-992
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• 2017

Objectives: This study is to compare measuring gingival and peridontal indices and changes in dental plaque per period using a three mix types of dentifrice and to investigate dental diseases preventive effects depending on gingivitis reducing effect of dentifrice through a clinical experiment. Methods: This study targeted adult females and males with mild to moderate gingivitis from age 20 to 60. The Calculus index, Papillary Marginal Attached Gingival (PMA) index, Gingival index, Patient Hygiene Performance (PHP) index, and Plaque index were measured at pre-experiment and at 1, 2, 4 weeks post experiment. Results: The PMA, Gingival index, PHP index, plaque index of experimentla group decreased after 4 weeks (p<0.05). Conclusions: A three mix types of dentifrice for relieving tooth sensitivity was verified to be effective in removing dental plaque and reducing gingivitis.

• 한국치위생학회지
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• 제23권4호
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• pp.227-234
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• 2023

Objectives: Cetylpyridinium chloride CPC-based mouthwashes are well known to have no harmful ingredients in the mouth and can be used for a long time. The purpose of this study was to evaluate the effect of using CPC-based mouthwashes to suppress the biofilm formation and antibiotics for handling orthodontic appliances. Methods: To measure the antibacterial effect, Streptococcus mutans (S. mutans) cultured orthodontic appliances were precipitated in Gargreen and Polident for 5 minutes, incubated at 37℃ for 24 hours(h). In order to measure the biofilm removal effect, the degree of biofilm formation on the orthodontic appliances was stained with a methylene blue and the difference before and after was compared using image J software program (NIH Image J; NIH, Bethesda, MD). Results: The viability of S. mutans according to the concentration showed that Gargreen and Polident inhibited colony formation compared to the control, respectively (p<0.01). The degree of biofilm formation was significantly higher in the control, however both Gargreen and Polident significantly reduced it compared to the before and after condition on removable orthodontic appliances (p<0.01). Conclusions: This study suggests that the use of Gargreen, a cetylpyridinium chloride based oral cleaning cleanser, could be replaced by Polident for antibacterial effect and biofilm formation on removable orthodontic appliances.

• 한국식품위생안전성학회지
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• 제33권1호
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• pp.83-88
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• 2018

시중에 유통 중인 물휴지 62 품목을 선정하여 살균보존제 성분 및 유해물질 함유 여부 등의 안전성을 조사하였다. 일반적으로 화장품 및 식품에 가장 많이 사용하는 살균 보존제인 안식향산나트륨은 46 품목에서 200~3500 ppm 검출되었고 파라벤류는 1 품목에서 파라옥시안식향산메칠이 9 ppm 검출되었다. 사용할 수 없는 살균보존제인 메칠클로로이소치아졸리논과 메칠이소치아졸리논(3:1)혼합물이 1 품목에서 검출되어 부적합 판정되었으며, 메칠클로로이소치아졸리논 5 ppm, 메칠이소치아졸리논 140 ppm 검출되었다. 염화세틸피리디늄은 5 품목에서 7~13 ppm 검출되었으며, 모두 허용기준 이내로 나타났다. 잔류유해물질인 포름알데히드 검사결과는 $0.069{\sim}1.796{\mu}g/g$로 허용기준인 $20{\mu}g/g$ 이하였다. 메탄올은 5~51 ppm 검출되었으며, 이 중 4 품목에서 허용기준인 20 ppm보다 2배 이상의 농도가 나타났다. 안전한 제품이 유통될 수 있도록 메탄올의 잔류경로에 대한 지속적인 조사 및 모니터링이 필요하다고 판단된다. 물휴지의 pH를 측정한 결과 4.0~8.2로 나타나 유통화장품의 pH 3.0~9.0 기준에 적합하였으나, 물휴지에는 pH 기준이 설정되어 있지 않으므로 안전관리를 위해서는 pH 기준을 설정하는 고시개정이 필요할 것이다.

• Journal of Periodontal and Implant Science
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• 제29권1호
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• pp.141-151
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• 1999

To evaluate the effect of cetylpyridinium chloride in a powder form when used concomitantly with a commercial flouride containing tooth paste on inhibition of plaque formation, on gingivitis, and on irritation of oral mucosa, a double--blind, randomized parallel study was set up. Cetylpyridinium chloride was incorporated into a ligh brown colored powder with menthol added for scent. There were no diffemces between the active agent and the placebo which did not contain cetylpyridinium chloride in appearance, color, smell, taste, or dispenser. 98 healthy volunteers were assigned to one of two groups: brushing 3 times a day with flouride toothpaste and cetylpyridinium chloride powder, or brushing 3 times a day with flouride toothpaste and placebo. Before the test period, the subjects received through tooth cleaning and polishing. At basteline, GI, PI, BOP, and GCF of the Ramfjord teeth were measured in the experimental and placebo groups including 58 and 42 subjects repectively, After 4 weeks, GI, PI, BOP, GCF, compliance, irritation of the oral mucosa(redness, pus drainage, edema) and adverse reactions were measured. The PI, GI, and BOP of the experimental group recorded at baseline are 0.19${\pm}$0.19, 0.42${\pm}$0.31, and 0.08${\pm}$0.15. These scores showed significant decrease after 4 weeks of test period(0.11${\pm}$0.15, 0.22${\pm}$0.24, 0.02${\pm}$0.09 repectively at the end of the study) and inhibition of plaque accumulation and resolution of gingival inflammation could be observed. GCF shoed slight increase but this was not statistically different. Comparison of changes in measured scores of control and experimental groupshow GI, PI of the test indices have decreased. Test group showed significantly greater decrease in gingivitis and plaque accumulation after 4 weeks. GCF and BOP also showed greater decrease thant the control group but this difference was not statistically significant. At no time of the study period did any of the subjects show signs of irritation of the oral mucosa or adverse reactions. Following conclusions could be obtained from this study. The combined use of cetl powder and flouride toothpaste showed greater inhibition of plaque accumulation and greater decrease of gingivitis than use of flouride toothpaste with placebo agent.