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Effect of a Mouthwash Containing Cetylpyridinium and Zinc Chloride on Oral Malodor

세틸피리디늄(Cetylpyridinium) 및 염화아연(Zinc chloride)을 함유한 구강 양치액의 구취제거 효과에 대한 연구

  • Kim, Ju-Sik (Dept. of Oral Medicine and Oral Diagnosis, School of Dentistry & Dental Research Institute, Seoul National University) ;
  • Park, Ji-Woon (Dept. of Oral Medicine and Oral Diagnosis, School of Dentistry & Dental Research Institute, Seoul National University) ;
  • Kim, Dae-Jung (Dept. of Oral Medicine and Oral Diagnosis, School of Dentistry & Dental Research Institute, Seoul National University) ;
  • Kim, Young-Ku (Dept. of Oral Medicine and Oral Diagnosis, School of Dentistry & Dental Research Institute, Seoul National University) ;
  • Lee, Jeong-Yun (Dept. of Oral Medicine and Oral Diagnosis, School of Dentistry & Dental Research Institute, Seoul National University)
  • 김주식 (서울대학교 치의학대학원 구강내과.진단학 교실, 치의학연구소) ;
  • 박지운 (서울대학교 치의학대학원 구강내과.진단학 교실, 치의학연구소) ;
  • 김대중 (서울대학교 치의학대학원 구강내과.진단학 교실, 치의학연구소) ;
  • 김영구 (서울대학교 치의학대학원 구강내과.진단학 교실, 치의학연구소) ;
  • 이정윤 (서울대학교 치의학대학원 구강내과.진단학 교실, 치의학연구소)
  • Received : 2011.11.01
  • Accepted : 2011.12.10
  • Published : 2011.12.30

Abstract

The aim of this study is to clinically evaluate the effect of a mouthwash containing cetylpyridinium and zinc chloride on reduction of morning oral malodor in healthy subjects measured by organoleptic measurement and a portable sulfide monitor. A total of 8 healthy non-smoking male volunteers were enrolled in this study of crossover design consisting of two experimental phases. The subjects were instructed to rinse the mouth with 10 mL of the experimental mouthwash containing cetylpyridinium and zinc chloride for 30 seconds at the first phase. At the second phase after a one-week washout period, each subject rinsed with distilled water as a control. All experiments were conducted at around 8:30 a.m. and oral malodor was measured using organoleptic measurement and a portable sulfide monitor just before rinsing with the experimental mouthwash or control (baseline), 1 hr, 2 hrs, and 3 hrs after rinsing. The mouthwash containing cetylpyridinium and zinc chloride reduced morning oral malodor up to 3 hrs after rinsing. Organoleptic score and concentrations of volatile sulfur compounds after use of the experimental mouthwash significantly decreased with time, and the decreases were significantly different between the mouthwash and control. In conclusion, the mouthwash containing cetylpyridinium and zinc chloride is significantly effective on reduction of morning oral malodor in healthy subjects by 3 hrs.

전통적으로 항구취 제제로 널리 쓰여 온 세틸피리디늄 및 염화아연이 함유된 양치액은 장기간의 사용에도 부작용이 없이 구취를 효과적으로 감소시키는 것으로 알려져 있다. 본 연구에서는 세틸피리디늄 및 염화아연을 주성분으로 한 구강 양치액의 아침 구취에 대한 효과를 관찰하고자 했다. 총 8명의 건강한 남자를 대상으로 crossover study를 진행했으며 1주일의 washout 기간을 두었다. 대상자들에게는 30초간 실험 용액 10 mL를 양치하게 했으며 1주일 후에 같은 방법으로 증류수를 양치하게 했다. 구취의 측정은 오전 8:30 분에 이루어졌으며 양치 전, 양치 후 1시간, 2시간, 3시간에 평가를 하였다. 구취의 평가는 관능구취검사와 이동성 황화합물 측정기(Halimeter)를 이용하였다. 세틸피리디늄과 염화아연을 함유한 구강 양치액은 양치 후 3시간까지 아침 구취를 감소시켰다. 관능구취검사 수치와 휘발성 황화합물의 농도는 실험군에서 시간에 따라 유의한 감소를 보였고 그 감소 양상은 두 군 간에 유의한 차이를 보였다. 결론적으로, 세틸피리디늄과 염화아연을 함유한 구강 양치액은 건강한 대상자의 아침 구취를 3시간까지 유의하게 감소시킬 수 있어 구취제거를 위한 양치액으로 그 효용성이 매우 크다.

Keywords

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