• Journal of Korea Technology Innovation Society
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• v.17 no.3
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• pp.563-583
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• 2014

We classified collaboration types of Government-supported Research Institutes (GRIs) in Korea to make a creation knowledge with the openness and the diversity. The openness is described to collaboration dependence and leading intensity, and the diversity is expressed to collaboration diversity and collaboration concentration. We suggest four taxonomy models explained in terms of the openness and the diversity with country level and institute level. This study uses 39,507 papers in SCOUPS DB that include author(s) affiliated to 26 GRIs. It concludes that many GRIs is classified to the type of multilateral collaboration follower in institute level and to the type of global network player in country level from the perspective of openness. In the aspect of diversity, many GRIs is concentrated to the collaboration type of picky eater or monophagous in institute level and to the multinatioal asymmetry type or non-multinational asymmetry type in country level. It is necessary for GRIs to lead collaboration and to transfer inhouse R&D institutes with high performance to be competitive institutes which make high quality knowledge.

• The korean journal of orthodontics
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• v.26 no.5 s.58
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• pp.637-645
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• 1996

In non-growing Class III malocclusion, the critical aspects which determine the need of orthognatic surgery are the severity of skeletal discrepancy, incisor inclination, overbile and soft tissue profile. Two-jaw surgery is more effective in correcting severe sagittal, vertical, transverse skeletal discrepancies and facial asymmetry. And more esthetic and stable profile can be achieved by two-jaw surgery Some midfacial deficiency Patients can be treated by Pyramidal Le Fort II osteotomy to maintain infraorbital rim and malar complex and to advance nasomaxillary complex. Others who require advancement of infraorbital rim and malar complex can be treated by quadrangular Le Fort II osteotomy. On the following cases, patients who had represented midfacial deficiency and mandibular prognathism were treated with combined orthodontic-surgical therapy by Le Fort II osteotomy and BSSRO.

• Proceedings of the KAIS Fall Conference
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• 2010.11b
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• pp.646-650
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• 2010

최근 들어 고용없는 성장 및 청년 실업율이 높아지면서 기술을 기반으로 한 창업의 산실인 창업보육센터(Business Incubator : BI)의 역할이 주목을 받고 있다. 이와 더불어 이에 대한 연구들로서 BI의 효율적인 운영과 성과측면에도 많은 연구들이 이루어져 왔다. 국내외 선행연구들은 크게 BI의 지원서비스유형 및 정도가 입주기업의 성과에 미치는 영향 과 입주 기업의 특성유형 및 정도가 성과에 미치는 영향으로 대분된다. 즉 BI의 성공요소들(Critical Success Factors), BI의 지원서비스, BI 내부조직 등과 BI 성과와의 상관관계분석 등에 초점이 맞추어 졌다. 또한 입주기업들이 BI 입주시 지니고 있는 잠재적인 역량 즉, 사업아이템 경쟁력이나 CEO역량, 기술 사업화 역량들이 기업들의 사업화성공률 향상과 BI의 성과에 영향을 미치는 것으로 분석되었다. 그러나 BI의 성과에 영향을 미치는 업무시스템 관여정도와 매니저의 역량에 대한 연구는 미흡한 측면이 있었다. 따라서 본 연구는 이러한 문제들을 연구하기 위하여 첫째, BI가 제공하는 보육서비스 특성과 이러한 특성들이 BI성과에 영향을 미치는 상관관계를 분석하고 둘째, BI의 업무역량이 보육지원서비스와 BI 성과에 미치는 조절효과를 분석하고자 하였다.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1981.05a
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• pp.14.1-14
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• 1981

Neurofibroma are slow growing benign tumors arising from the neurilemal sheath (Schwann cells) and fibroblasts of the peripheral nerve. This benign tumor may occur as a solitary lesion or as a part of the syndrome of neurofibromatosis. The neurofibroma of oral tissues is rare in otolaryngologic field and usually presents as a firm, elevated, nonpainful lesion that shows the usual histologic findings of a neurofibroma or neurilemmoma. Recently, we have experienced a neurofibroma arising from the tongue in a 54 year old female and removed successfully under local anesthesia. No evidence of recurrence has been observed up to date.

• Journal of Life Science
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• v.29 no.1
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• pp.9-17
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• 2019

As tumors develop, they encounter microenvironmental stress, such as hypoxia and glucose depletion, due to poor vascular function, thereby leading to necrosis, which is observed in solid tumors. Necrotic cells are known to release cellular cytoplasmic contents, such as high mobility group box 1 (HMGB1), into the extracellular space. The release of HMGB1, a proinflammatory and tumor-promoting cytokine, plays an important role in promoting inflammation and metabolism during tumor development. Recently, HMGB1 was shown to induce the epithelial-mesenchymal transition (EMT) and metastasis. However, the underlying mechanism of the HMGB1-induced EMT, invasion, and metastasis is unclear. In this study, we showed that noninvasive breast cancer cells MCF-7 formed tightly packed, rounded spheroids and that the cells in the inner regions of a multicellular tumor spheroid (MTS), an in vitro model of a solid tumor, led to necrosis due to an insufficient supply of O2 and glucose. In addition, after 7 d of MTS culture, the EMT was induced via the transcription factor Snail. We also showed that HMGB1 receptors, including RAGE, TLR2, and TLR4, were induced by MTS culture. RAGE, TLR2, and TLR4 shRNA inhibited MTS growth, supporting the idea that RAGE/TLR2/TLR4 play critical roles in MTS growth. They also prevented MTS culture-induced Snail expression, pointing to RAGE/TLR2/TLR4-dependent Snail expression. RAGE, TLR2, and TLR4 shRNA suppressed the MTS-induced EMT. In human cancer tissues, high levels of RAGE, TLR2, and TLR4 were detected. These findings demonstrated that the HMGB-RAGE/TLR2/TLR4-Snail axis played a crucial role in the growth of the MTS and MTS culture-induced EMT.

• 한국벤처창업학회:학술대회논문집
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• 2018.11a
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• pp.187-192
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• 2018

현재 급변하는 정보기술, 다양성을 추구하는 시장의 니즈, 미리 예측하지 못한 다양한 형태의 경쟁자 등의 출현으로 인해 경영환경이 급변하고 있는 것은 더 이상 새로운 현상이라고 보기는 어렵다. 이와 같이 급변하는 경영 환경은 기업 간 경쟁 심화를 불러일으키고 있으며, 경쟁 심화는 생존 및 발전을 위해 기업 특성에 맞지 않는 무분별한 전략을 활용하면서 오히려 역효과를 내고 있다는 문제를 야기하고 있다. 특히 변화하고 있는 환경 내 벤처기업 및 창업기업들의 경우 창업 후 생존율이 점차 낮아지면서 일반 기업들에 비해 경쟁력을 갖춘 기업을 찾아보기 어려운 것이 현실이다. 이에 벤처기업들은 도태되지 않고 생존하기 위해경쟁력을 강화시킬 수 있는 다양한 전략을 구사하고 있다. 벤처기업은 하나의 비즈니스 생태계 내 유기적 생명체로서 진화하기 위해 제품이나 산업의 수명주기와 마찬가지로 창업기, 초기 성장기, 고도 성장기, 성숙기, 쇠퇴기 등의 정형화된 단계를 거친다. 따라서 벤처기업은 무차별적인 전략을 통해 기업의 생존 및 성장을 도모 하는 것이 아니라 해당 기업이 놓인 수명주기 단계별로 전략, 조직 구조, 의사결정방식, 통제유형 등을 상이하게 판단하고 이에 적절한 전략을 수행해야 한다. 예를 들어, 동일 생산요소를 투입하더라도 이를 적용할 수 있는 지식이 있는 경우 더 높은 가치 창출이 가능(Aghion & Howitt, 1992) 하지만 창업 초창기의 기업은 고도 성장기의 기업보다 보유한 지식 수준 및 경험이 상대적으로 낮기 때문에 다양한 협력을 필요로 한다. 그러나 현재의 여러 선행연구들은 기업이 처한 상황을 고려하지 않은 단편적인 대처 방안이거나 혹은 부분적인 방법론을 제공하는 수준에 그치고 있다는 한계가 있다(이병헌 외, 2014). 따라서 본 연구에서는 '2016년 벤처기업정밀실태조사' 데이터를 기반으로 기업의 외부 협력 정도 및 벤처기업 지원제도 활용 정도가 경쟁력과 성과에 미치는 영향이 기업의 수명주기별로 상이하다고 보고 관련 전략 프레임워크를 제시하고자 한다.

• Journal of the korean academy of Pediatric Dentistry
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• v.34 no.3
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• pp.513-518
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• 2007

Loss of multiple teeth by multiple dental caries, traumatic influence or hereditable disease can cause many problem in children. Using removable appliance can be used for treatment of this problem. But conventional removable appliance has limits of retention by wire-clasp, non esthetic appearance, difficulty in pronunciation by its volume. Flexible denture using $Valplast^{(R)}$ system could be a excellent partial denture for restorarion in child because of various advantage such as retention from soft tissue, natural esthetic aspect, biocompatibility, durability to compare with conventional acrylic appliance. The present case report describe properties and consideration of flexible denture using Valplast $system^{(R)}$ in comparison with conventional acrylic appliance and report successful restoration of child using Valplast $system^{(R)}$.

• The korean journal of orthodontics
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• v.28 no.3 s.68
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• pp.353-370
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• 1998

This study was conducted to investigate the changes in the structural parts of the craniofacial skeleton subsequent to chincap therapy in the juvenile skeletal Class III patients. The subject consisted of 29 Korean children(14 males, 15 females) who had skeletal Class III malocclusion and were undergone chincap therapy from the beginning of the treatment (and an auxilliary upper removable appliance, if necessary). The control group was composed of 21 children(10 males, 11 females) with skeletal Class III malocclusion who had no orthodontic treatment. Cephalometric data at the mean age of 7 and 2 years later were analyized by finite element method, and compared between groups by independent group t-test(p<0.05). The results of the present study were as follows; 1. There were no significant changes in the cranial base, posterior face, upper anterior face, ramus, chin and soft tissues by the chincap therapy. 2. The mandibular body showed significant differences in the minimum extention ratio and the overall shape ratio. This means that the vertical direction of growth was retarded by the chincap therapy. 3. The major direction of the growth in the maxillary basal bone was significantly more horizontal in the experimental group, which suggests that the vertical growth of maxilla was inhibited. 4. There was statistical difference in the major direction of the growth of the anterior face between groups. This may be due to the significant difference in the major direction of growth of the lower anterior face, supposed to be resulted from the mandibular rotation and/or displacement by the chincap therapy. The change in the oral functional space seemed to be caused by the same reason. 5. From the standpoint of these results, the retardation of growth, the changes of the growth direction and the morphological changes could be accepted partly, but the major effect of the chincap seems to be the rotation and the displacement of the mandible.

• Journal of dental hygiene science
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• v.8 no.2
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• pp.89-96
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• 2008

Effects of sodium fluoride exposure on the amelogenesis during fetal formation were investigated using 11 days rat incisor of control group and two experimental groups. According to results of morphological analysis using an electron microscope, enamel organ in the rat incisor consisted of presecretory, secretory, and maturation zone, especially maturation zone had ruffle-ended ameloblasts (rAB) that additionally supply inorganic ions and smooth-ended ameloblasts (sAB) that remove water and organic compounds. Such a histological composition was same in fetal and adult rats. According to experimental results using calcein (green fluorescence) in order to reveal the modulation cycle of ameloblast, modulation cycle of experimental group decreased on an average one time than control group, as increase of density of sodium fluoride indicated that thickness of smooth-ended ameloblast decreased. Also ratio of thickness on sagittal total length of sAB increased than rAB in experimental groups than control group. In total length of teeth, an injected 100 ppm sodium fluoride group was similar control group but as injected 200 ppm group became short. In experimental group, thickness of sAB and rAB became narrow to the tip of cutting edge. According to concentration of sodium fluoride grows, the modulation cycle and total length of teeth were decreased, finally it prevented teeth growth.

• Journal of the korean academy of Pediatric Dentistry
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• v.47 no.1
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• pp.17-24
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• 2020

The purpose of this study was to evaluate the accuracy and precision of the three-dimensional (3D) imaging system of children's facial soft tissue by comparing linear measurements. The subjects of the study were 15 children between the ages of 7 and 12. Twenty-three landmarks were pointed on the face of each subject and 16 linear measurements were directly obtained 2 times using an electronic caliper. Two sets of 3D facial images were made by the 3D scanner. The same 16 measurements were obtained on each 3D image. In the accuracy test, the total average difference was 0.9 mm. The precision of 3D photogrammetry was almost equivalent to that of direct measurement. Thus, 3D photogrammetry by the 3D scanner in children had sufficient accuracy and precision to be used in clinical setting. However, the 3D imaging system requires the subject's compliance for exact images. If the clinicians provide specific instructions to children while obtaining 3D images, the 3D device is useful for investigating children's facial growth and development. Also the device can be a valuable tool for evaluating the results of orthodontic and orthopedic treatments.