• Title/Summary/Keyword: 연골

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Microarray Analysis of Gene Expression in Chondrosarcoma Cells Stimulated with Bee Venom (봉독이 연골육종세포의 유전자 발현에 미치는 영향에 대한 Microarray 연구)

  • Yin, Chang-Shik;Koh, Hyung-Gyun
    • Journal of Pharmacopuncture
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    • v.7 no.2
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    • pp.19-28
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    • 2004
  • 봉독은 관절염 치료를 비롯한 여러 질환에 그 응용범위가 넓어지고 있으며 기전규명과 새로운 치료효과 개발을 위한 연구가 필요하다. 연골의 파괴는 진행된 각종 관절병증의 공통 병리기전이며 연골세포의 기능이상은 이 기전에 중요한 의미를 지닌다. 사람 연골세포의 특성을 유지하고 있는 HTB-94 연골육종세포를 배양하고 봉독을 처치했을 때의 유전자 발현양상을 microarray를 이용하여 관찰하였다. 대조군에 비해 4배 이상 발현의 차이가 있는 경우를 유의한 것으로 보았을 때 microarray의 344개 유전자중 봉독처치시 발현이 증강되는 유전자는 없었으며 발현이 억제되는 유전자는 interleukin 6 receptor, interleukin 1 alpha, tissue inhibitor of metalloproteinase 1, matrix metalloproteinase 1, tumor necrosis factor (ligand) superfamily, members 4, 8 and 12, and caspases 2, 6, and 10등 35개가 관찰되었다. Microarray를 통한 유전자발현 분석을 통해 관절염에 대한 봉독치료의 기전을 시사하는 유용한 자료를 얻을 수 있었으며 앞으로 보다 넓은 범위에 대한 연구가 필요할 것이다.

Arthroscopic Treatment of Infectious Chondrolysis of Femoral Head - A Case Report - (대퇴골두 감염성 연골 용해증의 관절경적 처치 - 1례 보고 -)

  • Moon, Young Lae;Yoon, Tae Hyun;Kim, Chan Sang
    • Journal of the Korean Arthroscopy Society
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    • v.3 no.2
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    • pp.142-145
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    • 1999
  • Chondrolysis of the femoral head s characterized by progressive destruction of the articular cartilage, resulting secondary joint space narrowing and stiffness. It is usually regarded as an idiopathic disease, but it can be produced by sequelae of an infection, trauma, or prolonged immobilization. We report a case of chondrolysis of femoral head in 45-year-old male, caused by infection and treated by arthroscopic management.

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Case Report on Medial Discoid Meniscus (내측 원판형 연골의 증례 보고 -1예 보고-)

  • An, Hyug-Su;Cho, Young-Ho;Kim, Dong-Young;Yun, Hee-Min;Park, Ho-Won
    • Journal of the Korean Arthroscopy Society
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    • v.11 no.1
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    • pp.50-53
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    • 2007
  • Although the lateral discoid meniscus of the knee has been observed frequently, the medial discoid meniscus has very rarely been reported in the literature. A 22-year-old female patient was diagnosed as having a medial discoid meniscus with horizontal tear by means of magnetic resonance image and arthroscopy. The patient was treated by arthroscopic partial meniscectomy.

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Ultrasonographic Findings of a Chondrolipoma Arising from the Left Supraclavicular Region: A Case Report (좌측 쇄골 상부에서 발생한 연골 지방종의 초음파 소견: 증례 보고)

  • Noh Hyuck Park;Yoon Yang Jung
    • Journal of the Korean Society of Radiology
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    • v.82 no.4
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    • pp.943-947
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    • 2021
  • Chondrolipomas, which are lipomas with chondroid metaplasia, are rare benign soft tissue tumors with no relevant epidemiological reports or radiological information. A limited number of lipomas with osteo/chondroid differentiation have been reported in the literature between 1960 and 2008. Moreover, only few studies have described the radiologic findings of chondrolipomas. Herein, we present a case of chrondrolipoma arising from the left supraclavicular region in a 77-year-old female.

The Outcome of Anterior Cruciate Ligament Reconstruction in Patients with Meniscal Injury (반월판 연골 손상이 동반된 환자에서 전방 십자 인대 재건술의 임상적 결과)

  • Lee Kwang Won;Park Jae Guk;Jung Yu Hun;Kim Byung Sung;Kim Ha Yong;Choy Won Sik
    • Journal of the Korean Arthroscopy Society
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    • v.7 no.2
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    • pp.160-168
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    • 2003
  • Purpose : To analyze the anterior stability and functional results after the arthroscopic ACL reconstruction and meniscectomy based on meniscus status at the time of surgery. Materials and Methods : From October 1997 to October 2002, 78 patients (male 64 female 14) were treated by arthroscopic ACL reconstruction and meniscectomy and followed more than 12 months (range, $12\~72$ months, average: 32 months). Average age was 32 years old (range, $18\~57$ years old). We divided the patients into 4 groups; Both menisci was intact (BMI, control group), lateral meniscus removed (LMR), medial meniscus removed (MMR) and both menisci removed (BMR). Anterior passive displacement (objective stability) was estimated using KT-2000 arthrometer under the loading of 15lb,20lb and 30lb and evaluated anterior drawer test, Lachman test, range of motion, thigh circumference. Functional evaluation system of IKDC, OAK and Lysholm knee score was used. Results : Average anterior displacement under the loading of 30lb were 2.47 mm, 2.96 mm, 2.96 mm and 3.57 mm in each group(BMI, LMR, MMR, BMR) and it was statistically significant difference (p<0.05). There is no statistically significant difference in average anterior displacement under the loading of 15lb and 20lb in each group but it has showed decreasing tendency in meniscal removed groups. The mean anterior displacement was within 3 mm in 21 cases, 15 cases, 24 cases and 12 cases (total 72 cases, $94\%$) under the loading of 15lb and 20 cases, 15 cases, 24 cases and 11 cases (total 70 cases, $91\%$) under the loading 20lb of in each group and postoperative knee joint stability has showed increasing tendency (p>0.05). The mean score was 94.5, 93.2, 92.2 and 90.4 points in each group and 71 cases $(91\%)$ were more than excellent or good with a OAK score and fair results were noted 4 cases in both meniscal removed group. There were 65 cases $(83\%)$ with a Lysholm knee score more than excellent or good, and IKDC grading were more than normal or nearly normal in 74 cases $(95\%)$ except 4 cases (2 cases in MMR group and 2 cases in BMR group). Conclusion : Long-term anterior stability and functional results of a successful ACL reconstruction affected by tile status of the menisci at the time of surgery and KT-2000 arthrometer was good for estimation of objective follow up.

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Chondroblastoma of the carpal scaphoid (A Case Report) (수근부 주상골의 연골모세포종 (증례 보고))

  • Chung, Kyung-Chil;Kim, Key-Yong;Choi, Jang-Suk;Seo, Seung-Suk;Kim, Kyoung-Whan
    • The Journal of the Korean bone and joint tumor society
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    • v.11 no.2
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    • pp.194-198
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    • 2005
  • Chondroblastoma is relatively rare benign neoplasm with predilection for the epiphysis of long bones. Benign chondroblastomas of bone compromise approximately 1% of benign bone tumors in several reported series. Chondroblastoma in the carpus is extremely rare in english literature. We report the case of a chonroblastoma in the carpal scaphoid.

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Ultrasonographic evaluation of extrusion of medial meniscus of the knee -A Case Report- (초음파를 이용한 슬관절 내측 반월상 연골 탈출의 진단 -1례 보고-)

  • Kim, Jung Man;Song, Chol
    • The Journal of Korean Orthopaedic Ultrasound Society
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    • v.1 no.1
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    • pp.14-17
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    • 2008
  • Meniscal extrusion is defined as a distance of 3 mm or more between the peripheral border of the meniscus and the edge of the tibial plateau on the coronal plane, associated with degeneration or tear of meniscus, effusion, osteophyte, osteoarthritis. There are many advantages of ultrasonography, including cost, dynamic real-time assessment. We evaluated a patient with anteromedial mass of the knee by ultrasonography, which was proved to be the extrusion of medial meniscus. We report a case of extrusion of medial meniscus evaluated by ultrasonography with review of the related literatures.

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Synovial Chondromatosis of the Temporomandibular Joint :A Case Report (악관절에 발생한 연골종증 증례)

  • Koh, Se-Wook
    • Journal of Dental Rehabilitation and Applied Science
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    • v.25 no.3
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    • pp.237-242
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    • 2009
  • the primary diagnosis of synovial chondromatosis of temporomandibular joint is extremely rare. often many months, or even years pass before the diagnosis is confirmed. synovial chondromatosis is an uncommon disease of cartilage transformation of synovial membrane with formation of loose bodies within the joint space. a 28-year-old women had experienced pain of the left TMJ area at mastication. Radiographs of the left TMJ revealed calcified loose bodies in superior temporomandibular joint space. treatment consisted of removal of calcified loose bodies and synovail membrane. after surgery, pain of Lt temporomandibular area at mastication disappeared. until present after surgery there have been no recuurence of symptoms.