• Journal of Applied Biological Chemistry
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• v.64 no.3
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• pp.299-307
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• 2021

Accumulation of amyloid beta (Aβ) and oxidative stress are the most common reason of Alzheimer's disease (AD). In the present study, we investigated the cognitive improvement effects of butanol (BuOH) fraction from Momordica charantia in Aβ_25-35-induced AD mouse model. To develop an AD mouse model, mice were received injection of Aβ_25-35, and then orally administered BuOH fraction from M. charantia at doses of 100 and 200 mg/kg/day during 14 days. In the T-maze and novel object recognition test, administration of BuOH fraction from M. charantia L. at doses of 100 and 200 mg/kg/day improved spatial ability and novel object recognition by increased explorations of novel route and new object. In addition, BuOH fraction of M. charantia-administered groups improved learning and memory abilities by decreased time to reach hidden platform in Morris water maze test. Oral administration of BuOH fraction from M. charantia significantly inhibited lipid peroxidation and nitric oxide levels in the brain, liver, and kidney compared with Aβ_25-35-induced control group. These results indicated that BuOH fraction of M. charantia improved Aβ_25-35-induced cognitive impairment by attenuating oxidative stress. Therefore, M. charantia could be useful for protection from Aβ_25-35-induced cognitive impairment.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2002.02a
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• pp.585-591
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• 2002

국내에서 개발된 연속식 현미조절기를 이용한 현미 가수처리 여부에 따른 도정수율의 변화를 알아보기 위해 경남 진주 농협 미곡종합처리장, 경기 여주의 미곡종합처리장 및 경기 용인의 농협 미곡종합처리장에서 검증실험을 실시하였다. 현미의 조절을 위한 가수처리 여부에 관한 실험 결과를 요약하면 다음과 같다. 1. 조질에 따른 현미 함수율의 측정값과 예측값의 차이는 진주, 여주의 경우는 각각 0.07%, 0.13%로 미소하게 나타났으며, 용인의 경우는 0.18%로 예측값이 낮게 나타났다. 2. 쇄미 발생량을 분석한 결과, 진주 농협의 경우 2.85 kg, 여주 농협의 경우 5.47 kg, 용인 농협의 경우 5.47 kg 감소되는 것으로 나타났다. 3. 도정수율 변화는 진주농협 1.21 %, 여주 0.87%, 용인 농협 1.00%의 상승을 보였다.

• Journal of the Korean Geographical Society
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• v.33 no.1
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• pp.93-107
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• 1998

The purpose of this paper is to examine the change in the regional characteristics of Y${\={o}}$ju as its economic base has been shifted. From Chosun Dynasty to the mid 1960s, Y${\={o}}$ju had been known as a core of rice production, utilizing favorable natural conditions and well developed river transportation system, with commercial and administrative functions. From the mid 1960s to the mid 1980s, Y${\={o}}$ju had been excluded from the process of the national industrilization, which made Y${\={o}}$ju remain lagged. The transportation system was blocked and the industrial investment in this area was prevented by a variety of restrictive laws. Since the mid 1980s, Y${\={o}}$ju entered into a prosperous are as the land transportation system began to be dramatically improved and some of the restrictions were alleviated. Tecently, diversification and commercialization in the agricultural sector have progressed in land use. In the manufacturing sector, Y${\={o}}$ju becomes a core of the pottery industry in tems of the total amount of its production.

• Journal of the Economic Geographical Society of Korea
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• v.7 no.2
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• pp.283-296
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• 2004

This study aims at explaining locality of living space which is changing drastically by exploring change of land utilization, living space and condition in Yeo-ju, an agricultural area around Seoul. The conclusions are as follows. 1. Agricultural land utilization tends to decrease, while civic land utilization tends to increase. 2. Change of living space due to transportation development is remarkable. Big ferry town (Yeoju-town) grew to a city, while small ferry town fell away. 3. In villages on slow urbanization, houses or lands are deserted. 4. In villages, there has been increasing number of recreational farm for urbanite. 5. In 80% of villages, there has been an increasing number of part-time farmers. 6. Most serious social problem in Yeo-ju is incompetence in agricultural activity after UR. In sum, Yeoju is now an area where the pace of urbanization is very tardy. However, this area, as an changeable area just before speedy urbanization, is expected to be urbanized drastically on condition that transportation develop. When plans suitable for this town are set up, Yeoju is expected to be a comfortable city.

• Journal of Nutrition and Health
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• v.35 no.8
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• pp.880-885
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• 2002

This study was performed to determine the antimicrobial and anticarcinogenic activities of the Momordica charantia L. (MC) on several microorganisms and human cancer cell lines. In the paper disk test, its antimicrobial activity was increased in proportion to its concentration. Among the various solvent fractions of Momordica charantia L., the ethylether partition layer (MCMEE) showed the strongest antimicrobial activity. Also, the ethylacetate partition layer (MCMEA) and the butanol partition layer (MCMB) showed antimicrobial activity. We also determined the cytotoxicity and chemopreventive effect of Momordica charantia L. extract and fractions on human cancer cells. The experiment was conducted to determine the cytotoxicity of Momordica charantia L. partition layers on HepG2, HeLa and MCF-7 cells by MTT assay. Among the various partition layers of Momordica charantia L., MCMEE and MCMEA showed strong cytotoxic effects on all cancer cell lines. The chemopreventive effect of the quinone reductase induced activities of HepG2 cell, the hexane partition layer (MCMH) at a dose of 50 $\mu\textrm{g}$/mL was 3.62 times more effective compared with the control values of 1.0. Therefore, based on these studies, Momordica charantia L. may be developed into a potentially useful cancer chemopreventive agent.

• Journal of the Korea Convergence Society
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• v.13 no.5
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• pp.97-102
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• 2022

In this study, the antibacterial effect of silkworm extract and Momordica charantia extract on S. mutans and F. nucleatum was investigated. S. mutans or F. nucleatum and 0%, 2%, 4%, 8% concentration of silkworm powder or Momordica charantia powder extract were added to the BHI liquid medium and cultured, and the sample was measured at an optical density of 600nm. As a result, S. mutans, the absorbance value was significantly decreased only in 8% of the silkworm extract, and the absorbance value was significantly decreased in all concentrations in the Momordica charantia extract. The absorbance of F. nucleatum was significantly decreased in a concentration-dependent manner in both the silkworm extract and the Momordica charantia extract. This suggests the possibility that silkworm extract and Momordica charantia extract can be used as materials for the prevention and treatment of oral diseases.

• Korean Journal of Food Science and Technology
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• v.50 no.4
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• pp.430-436
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• 2018

This study aimed to analyze charantin and lutein from fresh bitter melon (FBM) for their antioxidant and ${\alpha}$-glucosidase inhibitory activities. We subsequently compared our results with charantin and lutein content of pickled bitter melon (PBM11, PBM13, PBM51, and PBM53), obtained by brining (1 and 5% salt) and blanching (1 and 3 min). Charantin, lutein, $\text\tiny{L}$-ascorbic acid, and total polyphenolic content in FBM were $777.92{\pm}27.59$, $16.87{\pm}2.07$, $94.78{\pm}0.61$, and $22.07{\pm}0.74mg$ catechin equivalents/g on dry basis, respectively. Antioxidant activity of 5 mg/L FBM extract was $31.76{\pm}0.42%$ in ABTS assay and $56.19{\pm}2.39%$ in DPPH assay; ${\alpha}$-glucosidase inhibitory activity of 0.5 mg/L FBM extract was $55.60{\pm}1.34%$. Charantin and lutein content of all PBM samples were higher than control without brining and blanching treatments, those in PBM53 being $375.63{\pm}9.03$ and $4.07{\pm}0.40mg/100g$, respectively. These showed that brining and blanching in pickling process were very effective in retaining charantin and lutein in bitter melon.

• Applied Microscopy
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• v.39 no.4
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• pp.355-363
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• 2009

The purpose of this study was to demonstrate the effect of Momordica Charantia L. water extracts, one of the natural chelator, on the biochemical and enzyme activity changes in the rats liver and kidney caused by lead acetate. Rat approximately 250 g in weight were grouped into the control, lead acetate treated, and the Momordica Charantia L. boiling water extracts treated after lead acetate groups. Lead acetate (1,000 ppm) and Momordica Charantia L. water extracts (5%, 10%) were delivered drinking water. Serum AST, ALT and BUN were measured, histological alteration of liver and kidney were examined by light microscopy. Momordica Charantia L. extract group was decreased serum AST, ALT and BUN level induced by lead. Optical observations of liver tissue, lead group were observed necrosis of hepatic cells and infiltration of inflammatory cells, but Momordica Charantia L. extract group was observed only slight infiltration of inflammatory cells around the central vein. Optical observations of kidney tissue, lead acetate induced atrophy and necrosis of glomerulus and infiltration of inflammatory cell around renal tubule. For the group treated with Momordica charantia L. extract, the glomerulus was similar to the control, some around the renal tubule was observed infiltration of inflammatory cells. In conclusion, Momordica Charantia L. water extract may protect the lead-induced toxicity on liver and kidney.

• Journal of Bio-Environment Control
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• v.25 no.1
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• pp.71-75
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• 2016

The experiment was carried out to examine the effects of planting date on the growth and marketable yield of bitter gourd grown in rain-shield plastic houses. Bitter gourd cv 'Dragon' seedlings were separately transplanted during the months of June, July and August, 2015. The training method of all plants was made with four lateral vines and pinching the main vine. Lateral length of plants exhibited no significant difference between each planting date. However, bitter gourd planted in June had significantly higher main stem diameter than those treatments planted on August. The application of planting date was found effective in increasing marketable yield and number of fruits. June, as a planting date, had the highest marketable yield (6,439kg/10a), whereas bitter gourd planted in August had the lowest yield (870kg/10a) which were also consistent in terms of the number of fruits. Fruit length and diameter had no significant differences as affected by treatments. Therefore, planting date of bitter gourd in June was effective in increasing yield of fruit in rain-shield plastic house conditions.

• Journal of the Daesoon Academy of Sciences
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• v.33
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• pp.91-145
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• 2019

This study aims to reveal that Daesoon Jinrihoe Yeoju Headquarters Temple Complex is a sacred place of Gaebyeokgongsa (the Reordering Works of the Great Opening) through the logic of the energy of form in Feng-Shui studies. The Headquarters Temple Complex can illuminate the lamp of coexistence, emerge as a place for cultivation, and support the era of human nobility with Gucheonsangje (the Supreme God of the Ninth Heaven) as an object of faith. Virtuous Concordance of Yin and Yang, Harmonious Union between Divine Beings and Human Beings, the Resolution of Grievances for Mutual Beneficence, and Perfected Unification with Dao are the mission statements of this great site. For this purpose, it is necessary to investigate the headquarters according to integral Feng-Shui Theory. Doing so can provide proof that the geographic location, landscape, yin-yang harmonizing, and flowing veins of terrestrial energy at Headquarters Temple Complex are all profoundly auspicious. At the same time, this data also allows further study into the interactions of dragon-veins, energy hubs, surrounding mountains, and watercourses, which reveal how Daesoon Jinrihoe Yeoju Headquarters Temple Complex promotes the basic works of propagation, edification, and cultivation and three societal works of charity aid, social welfare, and education for the purpose of global propagation, saving beings, and building an earthly paradise by reforming humanity and engaging in spiritual civilization. This must be done on site with proper Feng-Shui in order to open up the era of human nobility upon the Great Opening of the Later World. As the center of the religious order, Daesoon Jinrihoe, Yeoju Headquarter Temple Complex has the general Feng-Shui characteristic of Baesanimsu (a back supported by a mountain and a front facing water). Through discussing the Feng-Shui of Daesoon Jinrihoe's Yeoju Headquarters Temple Complex as the center of humankind's resolution of grievances for mutual beneficence, this study would explore growth-supporting land that delivers future rewards through Feng-Shui symbolism and the ethical practice of grateful reciprocation of favors for mutual beneficence. This exploration will reveal how the geographical features and conditions of the Yeoju Headquarters Temple Complex make it a place fit for spiritual cultivation. It is a miraculous luminous court surrounded by mountains, where auspicious signs in eight directions gather. Its veins of terrestrial energy harmonize with clean water energy as it is affectionately situated within its natural environment. Its location corresponds with the Feng-Shui theory of dragon-veins, energy hubs, surrounding mountains, and watercourses. Thus, with regards to the Feng-Shui of Daesoon Jinrihoe's Yeoju Headquarters Temple Complex, this study examines the flows of mountains and waters and focuses on how the site is based on the logic of Feng-Shui. More generally, the geographical features of the surrounding mountains are likewise examined. An analysis of the relationship between Poguk (布局) of Sasinsa (animal symbols of the four directions, four gods, including blue dragon of the east, red phoenix of the south, white tiger of the west, and black tortoise of the north) and the location will be provided while focusing on the Yeoju Headquarters Temple Complex. This study supports the feasibility of further Feng-Shui studies of the Yeoju Headquarters Temple Complex based on traditional geomancy books that focusing on Hyeonggi (Energy of Form) Theory.