• Journal of the Society of Cosmetic Scientists of Korea
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• v.48 no.3
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• pp.197-212
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• 2022

This study was conducted to empirically analyze the effects and interactions among beneficial bacteria, commensal bacteria, and acne bacteria, which are factors in the skin microbiomes, on detrimental bacteria by 289 people, who are 20 to 49 years old among Koreans. As a result of multiple regression models using bio big data of skin microbiomes, when the difference in skin microbiomes according to the sex and age of the subjects was controlled, the beneficial bacteria showed a negative (-) effect on the detrimental bacteria, while the commensal and acne bacteria showed a positive (+) effect. Particularly, the negative (-) effect of beneficial bacteria on detrimental bacteria was different through interaction with acne bacteria according to the level of commensal bacteria. These results demonstrate that the activation of beneficial bacteria inhibits detrimental bacteria, and the effect of skin microbiomes on detrimental bacteria is balanced with skin microbiomes through interaction with independent influence. Therefore, it is suggested that when studying skin microbiomes products to help the proliferation of beneficial bacteria and to create a skin environment that inhibits detrimental bacteria in the personalized cosmetics manufacturing industry, it is necessary to consider the independent effects and interactions among skin microbiome factors together.

• Computational Structural Engineering
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• v.4 no.3
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• pp.129-135
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• 1991

This paper reports the application study of the ground reinforcement under a buried pipeline subjected to differential settlement via a finite element modeling. The soil-reinforcement interaction helps to minimize the differential settlement between the adjoining pipe segments. The settlement pattern and deformation slope of a pipeline have been evaluated for a boundary condition at the joint between a rigid structure and a pipeline. The analysis results are compared for both non-reinforced and reinforced cases to numerically evaluate the stress transfer mechanism and the effectiveness of the soil reinforcement for restraining the settlement of the pipeline.

• Journal of Life Science
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• v.28 no.4
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• pp.488-495
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• 2018

The p53 gene plays a critical role in the transcriptional regulation of cellular response to stress, DNA damage, hypoxia, and tumor development. Keeping in mind the recently discovered manifold physiological functions of p53, its involvement in the regulation of cancer is not surprising. In about 50% of all human cancers, inactivation of p53's protein function occurs either through mutations in the gene itself or defects in the mechanisms that activate it. This disorder plays a crucial role in tumor evolution by allowing the evasion of a p53-dependent response. Many recent studies have focused on directly targeting p53 mutants by identifying selective, small molecular compounds to deplete them or to restore their tumor-suppressive function. These small molecules should effectively regulate various interactions while maintaining good drug-like properties. Among them, the discovery of the key p53-negative regulator, MDM2, has led to the design of new small molecule inhibitors that block the interaction between p53 and MDM2. Some of these small molecule compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, more personalized anti-carcinogenic medicines. Here, we review the structural and functional consequences of wild type and mutant p53 as well as the development of therapeutic agents that directly target this gene, and compounds that inhibit the interaction between it and MDM2.

• The Korean Journal of Zoology
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• v.17 no.1
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• pp.5-16
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• 1974

In order to see the single effect and interaction of potassium chloride(KCI) and calcium the chloride ($CaCl_2$) on the development of Drosophila melanogaster, the emergence rates of the five strains of the flies were examined from the media containing 0.0M, 0.5M, 0.1M, 0.2M, of $CaCl_2$ or KCI plus various concentrations of KCI or $CaCl_2$, and the results are presented as follows: 1. The emergence rate of D. melanogaster is not significantly different among strains but strikingly different among concentrations of KCI or $CaCl_2$; the emergence rate decreases as concentration of KCI or $CaCl_2$ increases. 2. The inhibitory effect of $CaCl_2$ on the emergence rates is greater than that of KCI, implying that the resistibility of the flies to KCI is greater than to $CaCl_2$. 3. The addition of small amount of $CaCl_2$ or KCI to KCI or $CaCl_2$ media counteracts the inhibitory effect of KCI or $CaCl_2$, but the addition of a little greater amounts of $CaCl_2$ or KCI to the KCI or $CaCl_2$ media enhance the inhibitory effect of the salts. 4. Thus, there may be some interaction of $K^+$ and $Ca^++$ ions in the inhibitory effect on the development(emergence rates) of Drosophila melanogaster.

• Sleep Medicine and Psychophysiology
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• v.5 no.1
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• pp.80-87
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• 1998

Objectives : The purpose of this study was to investigate the relationship among anger expression mode, depression, and blood pressure. Method : Eight hundred sixty-eight male military draftees were asked during the examination procedure to answer Spielberger's Anger Expression Inventory, MMPI Repression Scale, and Beck Depression Inventory(BDI). Blood pressures, weight, and height were also measured. Results : 1) No significant difference was found in the anger-in and anger-out subscales of Spielberger Anger Expression Inventory, MMPI Repression Scale, and BDI between the hypertensives and the normotensives. 2) No significant difference of blood pressure was found between the groups determined by upper and lower 25% of each of the above scales and inventory. 3) The interaction effect of anger-in and anger-out on depression was found to be significant. Conclusion : These findings suggest that there is no relationship among anger-in, anger-out, depression, and blood pressure in young male military draftees. Interestingly, ambivalence of anger expression, i.e. the interaction of anger-in and anger-out, was found to be an important factor related to depression.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2017.05a
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• pp.724-729
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• 2017

The interaction between the flow of the nozzle and the acoustic motion in the combustion chamber acts as an important factor in suppressing combustion instability where nozzle damping effect can be evaluated by nozzle admittance. In this study, Modified Impedance Tube experiment is implemented to predict the acoustic nozzle damping effect. The experimental admittances are compared to numerical admittances values which are calculated from one-dimensional linearized Euler equation of Crocco's theory. As a result, it was possible to identify qualitatively the tendency between increasing and decreasing parts. Also, Efficient frequency bands of nozzle attenuation can be predicted.

• Tuberculosis and Respiratory Diseases
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• v.50 no.1
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• pp.67-75
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• 2001

Background : Two tumor suppressor genes, p53 and p16, which have different roles in controlling the cell cycle and inducing apoptosis, are frequently inactivated during carcinogenesis including lung cancer. Single tumor suppressor gene therapies using either with p53 or p16 have been studied extensively. However, there is a paucity of reports regarding a combined gene therapy using these two genes. Methods : The combined effect of p53 and p16 gene transfer by the adenoviral vector on the growth of lung cancer cell lines and its interactive mechanism was investigated. Results : An isobologram showed that the co-transduction of p53 and p16 exhibited a synergistic growth in hibitory effect on NCI H358 and an additive effect on NCI H23. Cell cycle analysis demonstrated the induction of a synergistic G1/S arrest by a combined p53 and p16 transfer. This synergistic interaction was again confirmed in a soft agar confirmed in a soft agar clonogenic assay. Conclusion : These observations suggest the potential of a p53 and p16 combination gene therapy as another potent strategy in cancer gene therapy.

• Journal of the Korean Society of Food Culture
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• v.5 no.4
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• pp.425-430
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• 1990

The taste describing terms of Monosodium glutamate(MSG) was surveyed by questionnaires, and the sensory threshold value of MSG solution was compared to those of other basic taste substances. The effects of MSG addition to the other basic tastes were also evaluated. From the 96 responders, the taste of MSG itself was expressed as greasy(58%) or nauseous(24%), but the taste expected when MSG was added to food was expressed as sapidity and relish(79%). From the sensory evaluation, the panel expressed greasy, bitter or sweet at the absolute threshold level(0.002 M) of MSG solution, but changed to greasy and salty at the recognition threshold level(0.006 M). When MSG was added to salt solution, it expanded the salty taste, but with citric acid solution it suppressed the sourness. When MSG was added to sugar solution, it expanded sweet taste at the lower concentration of MSG(0.01 M), but suppressed the sweet taste as MSG concentration increased.

• The Korean Journal of Pharmacology
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• v.28 no.2
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• pp.147-162
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• 1992

The objectives of the present experiments were to characterize the effects of the peptides belonging to the pancreatic polypeptide family on the contractility of cerebral arteries and to observe the interactions of these peptides with the cyclic nucleotide activators and the potassium channel openers. Dogs of either sex, $20{\sim}30\;Kg$ in weight, were sacrificed. Basilar and middle cerebral arteries from brain were isolated and prepared for myography in the PSS equilibrated with 95% $O_2$ and 5% $CO_2$ at $37^{\circ}C$. The endothelial cells of the spiral strips were removed by CHAPS solution (0.3% w/v, 15 seconds). 1. PP, PYY and NPY contracted the arterial strips concentration-dependently with a rank order of potency of PYY>NPY>PP. These peptides were 20 to 200 times more potent than norepinephrine, and only PYY showed a greater potency than 5-HT. 2. Cyclic nucleotide activators, forskolin (for cAMP) and sodium nitroprusside (for cGMP) reduced the basal tone and inhibited the PP-, PYY- and NPY- induced contractions by concentration-dependent manners. Forskolin was more potent in reducing basal tone than sodium nitroprusside. 3. Potassium channel openers, RP 49356, P 1060 and BRL 38227 reduced the basal tone concentration-dependently and tended to inhibit the PP-, PYY- and NPY- induced contractions. Notably, BRL 38227 with low concentration $(0.1\;{\mu}M)$ enhanced the contractions induced by those peptides while P 1060 inhibited the contractions concentration-dependently. 4. The combinations of the cyclic nucleotide activators and the potassium channel openers were slightly additive in reducing the basal tone. P 1060 and BRL 38227 enhanced the relaxant effect of sodium nitroprusside significantly. On the PYY-induced contration $(0.1\;{\mu}M)$, $K^+$ channel openers tended to inhibit the inhibitory actions of forskolin and sodium nitroprusside. P 1060 and BRL 38227 antagonized the inhibitory action of sodium nitroprusside significantly. The results of the present study may be summarized that in canine cerebral arteries, not only NPY but also PYY may play a role in a cerebrovascular spasm, and intracellular concentration of either cAMP or cGMP may be involved in the mechanism of vasoconstrictive actions of these peptides, which may be affected either positively or negatively by a $K^+$ channel opener.

• The Journal of the Korea Contents Association
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• v.16 no.8
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• pp.322-331
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• 2016

This study aims to investigate interaction effects of self-esteem with self-resilience on adolescents' anger and to suggest for teaching method. For research, Anger, self-esteem, self-resilience was measured to total of 419 adolescents. The collected data were analyzed by multiple regression analysis and hierarchical regression analysis. The results, Firstly, anger were negatively influenced by the emotion regulation, diversity of Interests and interest, self-esteem in schools. Secondly, anger-in was negatively influenced by the self-esteem in schools, self-esteem in social, emotion regulation. Thirdly, anger-control was positively influenced by the emotion regulation, self-esteem in family. Fourthly, interaction effects of the self-esteem and self-resilience was statistically confirmed on anger. Fifthly, interaction effects of the self-esteem and self-resilience was statistically confirmed on anger-control.