• Journal of Yeungnam Medical Science
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• v.14 no.1
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• pp.13-20
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• 1997

관상피내암종의 조직학적 분류에 있어서 그 기준으로써 공통적으로 사용된 소견은 핵등급, 면포형 괴사 및 성장유형이었다. 그러나 최근의 분류(Tavassoli, 1992; Tavassoli and Man, 1995; Poller 등, 1994; Holland 등, 1994; Silverstein 등, 1995; Millis, 1996)에서는 핵등급과 면포형 괴사만을 분류의 기준으로 사용하고 있고 성장유형은 포함시키지 않는 경향이 있는 것 같다. 이는 관상피내암종의 성장유형은 너무나 다양하고 혼합형으로 자라는 경우가 많아 관찰자간의 재현성이 떨어지고, 이와 반대로 핵등급이나 면포형 괴사는 관찰자간의 재현성이 비교적 높을 뿐만 아니라 여러 가지 생물학적 표지자와도 관련이 잘 지워지기 때문으로 생각한다. 관상피내암종의 분류나 등급매김에 있어서는 연구자마다 사용하는 용어가 다르고 그들이 정한 등급의 기준이 서로 다르나 대체로 세 등급으로 나뉘어짐을 알 수 있었다. 한편, 국내에서는 유방의 관상피내암종에 대한 연구가 미흡한 실정이므로 이에 대한 지속적인 자료의 축적과 연구가 필요하리라 생각한다.

• Tunnel and Underground Space
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• v.30 no.5
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• pp.462-472
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• 2020

Rock classification is fundamental discipline of exploring geological and geotechnical features in a site, which, however, may not be easy works because of high diversity of rock shape and color according to its origin, geological history and so on. With the great success of convolutional neural networks (CNN) in many different image-based classification tasks, there has been increasing interest in taking advantage of CNN to classify geological material. In this study, a feasibility of the deep CNN is investigated for automatically and accurately identifying rock types, focusing on the condition of various shapes and colors even in the same rock type. It can be further developed to a mobile application for assisting geologist in classifying rocks in fieldwork. The structure of CNN model used in this study is based on a deep residual neural network (ResNet), which is an ultra-deep CNN using in object detection and classification. The proposed CNN was trained on 10 typical rock types with an overall accuracy of 84% on the test set. The result demonstrates that the proposed approach is not only able to classify rock type using images, but also represents an improvement as taking highly diverse rock image dataset as input.

• Journal of Chest Surgery
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• v.29 no.9
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• pp.1031-1035
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• 1996

International Ass ciation for the Study of Lung Cancer(IASLC) recommended the following classification of small cell lung carcinoma(SCLC) : (1) Small cell carcinoma (2) Mixed small cell/large cell carcinoma (3) Combined small cell carcinoma. Combined small cell carcinomas contain a squamous cell carcinoma or adenocarcinoma component. The prognostic significance of these elements is not known, but since the frequency and extent of non-small cell elements are considerably greater in posttherapy and autopsy tissues, it is possible that the non-SCLC elements are more resistant to therapy than the SCLC cells. Metaplasia & dysplasia of the bronchial surface epithelium are frequently observed in the bronchial biopsy specimens that contain small cell carcinoma of the lung. We report a case of combined small cell carcinoma with squamous element associated with microinvasive squamous cell carcinoma of the bronchial surface epithelium in 68 year old male patient, stage was IIIa. The two lesion are not connected n serial sections.

• Journal of Gastric Cancer
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• v.6 no.2
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• pp.91-96
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• 2006

Purpose: Cancer is a genetic disease caused by alterations in key regulators of cell growth and cell turnover, We investigated apoptotic cell death and cell proliferation in gastric adenomas and adenocarcinomas. Materials and Methods: The TdT-mediated dUTP-biotin nick end labelling (TUNEL) method and immunohistochemistry for Ki-67 were peformed, using paraffin-embedded tissues of 41 gastric adenomas and 100 gastric adenocarcinomas. These results were compared with histopathologic parameters. Results: The Ki-67 labelling index was higher in adenocarcinomas than in adenomas and the apoptotic index was higher in adenomas than in adenocarcinomas. There were no significant difference between the apoptotic index/Ki-67 labelling index and clinicopathological parameters. Conclusion: We propose that cell proliferation is more closely associated with gastric adenocarcinomas than apoptosis is, but that neither has any clinical significance as a prognostic factor in gastric adenocarcinomas. (J Korean Gastric Cancer Assoc 2006;6:91-96)

• The Journal of Engineering Geology
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• v.15 no.4 s.42
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• pp.463-473
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• 2005

Because of using the same rating ranges for every rock types the RMR or the Q-system could not usually consider local geological characteristics They also could not present sufficiently the engineering anisotropy of rocks. The canonical correlation analysis was carried out with 3 kinds of face mapping data obtained from granite, sedimentary rock and phyllite in order to clarify a discrepancy between rock types. According to analysis results, as a type of rocks changes, RM factors have different influences on the total rating of RMR.

• Radiation Oncology Journal
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• v.15 no.4
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• pp.369-377
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• 1997

Purpose : This study was Performed to identify the histopathologic feature by the reevaluation of the Pathologic specimen of the cervical tumors and to evaluate the clinical findings and the treatment results of the patients with small cell carcinoma of the cervix treated by radiotherapy. Materials and Methods : 2890 patients with cervical carcinoma received radiotherapy at the Department of Radiation Oncology. Yonsei Cancer Center, Yonsei University College of Medicine between October 1981 and April 1995. Of the 2890 patients in this data base, sixty were found to have small cell carcinomas $(2.08\%)$. Among them thirty six patients were transferred from other hospitals. the biopsy specimens of those Patients were not available. So we could review the slides of the other twenty four patients who were diagnosed at our hospital. Twenty four patients with small cell carcinoma of the cervix were analyzed retrospectively based on the assessment of H & E staining and other four immunohistochemical stains for neuroendocrine differentiation (neuron specific enolase, chromogranin. synaptophysin and Grimelius stain). And we also evaluate the Patients and tumor characteristics. response to radiation. patterns of failures, 5 year overall and disease free survival rates. Results : Thirteen tumors were neuroendocrine carcinomas(13/24 = $54.2\%$) and eleven tumors were squamous carcinomas, small cell type (11/24 = $47.8\%$) based on the assessment of H & E staining and other four neuroendocrine marker studies. So we classified the Patients two groups as neuroendocrine carcinoma and small cell type of squamous carcinoma, Among the 13 neuroendocrine carcinomas, five were well to moderately differentiated tumors and the other eight were Poorly differentiated or undifferentiated ones. The median age was 54 years old (range 23-79 years). Eight Patients had FIGO stage IB disease, 12 had stage 11, 3 had stage III and one had stage IV disease, Pelvic lymph node metastases were found in five Patients $(20.8\%)$. three of them were diagnosed by surgical histologic examination and the other two were diagnosed by CT scan. There was no difference between two histopathologic groups in terms of patients and tumor characteristics. response to radiation. 5 year overall and disease free survival rates. However the distant metastases rate was higher in neuroendocrine carcinoma Patients (6/13:$46.2\%$) than in small cell type of squamous carcinoma Patients (2/11:$18.2\%$), but there was no statistically significant difference because of the small number of patients (P>0.05). Conclusion : More than half of the small cell carcinoma of the cervix patients were neuroendocrine carcinoma (13/24 : $54.1\%$) by reevaluation of the biopsy specimen of the cervical tumors. The tendency of distant metastases of the neurolndocrine carcinoma was greater than those of the small cell type of squamous carcinoma $(46.2\%\;vs.\;18.2\%)$. But there were no differences in the patients and tumor characteristics and other clinical treatment results in both groups. These data suggest that radical local treatment such as radiotherapy or radical surgery combined with combination systemic cytotoxic chemotherapy might provide these patients with the best chance for cure.

• Journal of the Korean Society of Radiology
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• v.81 no.6
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• pp.1424-1435
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• 2020

Purpose The purpose of this study was to evaluate the usefulness of multiphasic CT and ¹⁸F-fluorodeoxyglucose (FDG) PET/CT for the differentiation of combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA) from hepatocellular carcinoma (HCC). Materials and Methods From January 2007 to April 2016, 93 patients with pathologically confirmed HCC (n = 84) or cHCC-CCA (n = 9) underwent CT and PET/CT imaging. Contrast enhancement patterns were divided into three types based on the attenuation of the surrounding liver parenchyma: type I (early arterial enhancement with delayed washout), type II (early arterial enhancement without delayed washout), and type III (early hypovascular, infiltrative appearance, or peripheral rim enhancement). Results cHCC-CCAs (89%) had a higher PET/CT positive rate than did HCCs (61%), but the PET/CT positive rate did not differ significantly (p = 0.095). Among the 19 cases of the type II enhancement pattern, 3 (21%) of 14 HCCs and 4 (80%) of 5 cHCC-CCAs were PET/CT positive. cHCC-CCAs had a significantly higher PET/CT positive rate (p = 0.020) in the type II enhancement pattern. Conclusion The PET/CT positive rate of cHCC-CCA was significantly higher than that of HCC in lesions with a type II enhancement pattern. The ¹⁸F-FDG PET/CT can be useful for the differentiation of cHCC-CCA from HCC in lesions with a type II enhancement pattern on multiphasic CT.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2007.06a
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• pp.241-247
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• 2007

자궁 경부 세포진 영상의 핵 추출을 위해서는 영상의 배경과 핵 그리고 세포질 영역의 구분이 중요하다. 또한 정상 세포핵과 암종 세포핵의 구분 및 인식을 위해서는 세포핵들의 형태학적 특징을 이용한 분류 기준을 세워야한다. 본 논문에서는 자궁 경부 세포진 영상에서 세포핵의 후보 영역과 핵을 추출하기 위해 현미경 400배율 확대 사진을 획득하는 과정에서 훼손된 컬러 영상을 복원하기 위한 방법으로 Lighting Compensation을 적용하여 영상을 보정한다. 그리고 배경 영역과 세포핵 영역을 구분하기 위해 영상의 R,G,B 영역의 히스토그램의 분포를 이용하여 배경을 제거한다. 배경이 제거된 영상을 그레이 영상으로 변환 한 후, 히스토그램 명암도의 값을 이용하여 세포핵 영역과 세포질을 분류하여 세포핵 영역을 추출한다. 그리고 Kapur 방법을 적용하여 세포핵 영역의 엔트로피 누적확률을 구한 후, 영상을 이진화 한다. Kapur 방법이 적용된 이진화 영상에서 세포핵 영역의 중심과 주위 화소를 비교하는 $3\times3$ 마스크를 적용하여 영상의 미세한 잡음을 제거 한 후, 8방향 윤곽선 추적 알고리즘을 적용하여 최종적으로 세포핵 영역을 추출한다. 추출된 세포핵의 영역을 분류 및 인식하는 과정으로 세포의 외각의 방향성 정보, 핵의 크기, 그리고 면적 비율의 특징을 이용하여 퍼지 소속 함수를 설계한 후, 소속 함수의 소속도를 구하고 퍼지 추론 규칙을 적용하여 자궁 경부 세포진 영상에서 정상 세포핵 및 암종 세포핵을 인식한다.

• Journal of Gastric Cancer
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• v.9 no.2
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• pp.46-50
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• 2009

During carcinogenesis, precancers (premalignant lesions) are the morphologically identifiable lesions that precede invasive cancers. In theory, the successful treatment of precancers would result in the eradication of most human cancers. Despite the importance of these lesions, there has been no effort to list and classify all of the precancers. In 2001, the NCI sponsored a workshop on the classification of precancers. When considering all the possible classes of precancers, it is worth noting that not all precancers are neoplastic. In fact, precancers need not progress to cancer, and precancerous lesions often have a high rate of regression. Thus, the following five classes were adopted: 1) acquired microscopic precancers; 2) acquired large lesions with microscopic atypia; 3) Precursor lesions occurring with inherited hyperplastic syndromes that progress to cancer; 4) acquired diffuse hyperplasias and diffuse metaplasias; and 5) currently unclassified entities. In this review paper, precancerous lesions of the stomach are classified and their clinical significance is described.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1993.05a
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• pp.93-93
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• 1993

We analyzed retrospectively 100 cases of floor of mouth cancer, treated at Korea Cancer Center Hospital from Jan. 1985 to Dec, 1992. The most prevalent age group were 6th, 1th decades, the sex ratio was M:F =4.6:1. 95 patients were smoker, 73 patients smoked more than 1 pack per day. 51 patients were heavy drinker (So-ju more than 1 B/day). Histopathologically, the squamous cell carcinoma (95 cases) was most common, followed by the adenoid cystic carcinoma (4 cases), mucoepidermoid carcinoma (1 case). The most common clinical staging was stage IV, and lymph node metastasis were 71 cases, histopathologically. Distant metastasis were 2 cases, multiple primary cancer was 1 case. 5 years survival rates according to treatment modality were 71.4% in operation only group that were almostly in early stage, 0% in radiation therapy group that were almostly in advanced stage, 32.5 % in combination therapy with operation and radiation therapy.