• Journal of Korean Society of Industrial and Systems Engineering
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• 제19권39호
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• pp.129-142
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• 1996

The early diagnosis has an very important role in curing dementia. But there was not the effective method to diagnose it until now. In this paper we analyzed the EEG of Alzheimer's disease patients and normal groups by nonlinear methods. In the analysis we calculated the correlation dimensions $D_2$ and the largest Lyapunov exponent $L_1$. We found that patients with Alzheimer's disease have significantly lower $D_2$ and TEX>$L_1$ than normal groups. It means that brains injured by Alzheimer's disease have electrophysiological inactive elements and have decreased chaotic behaviour. We propose the nonlinear analysis of the EEG as a useful tool for the early diagnosis of Alzheimer's disease.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제18권1호
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• pp.202-209
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• 2017

South Korea is becoming an aging society, increasing the population with dementia. This study analyzed the characteristics of the trend of dementia patients by utilizing 12 years' worth of data from five V hospitals within metropolitan cities. The results show that there has been an 11.3 times increase in the total number of new dementia patients in these five hospitals from 410 in 2003 to 5,048 in 2014; and among them, the rate of increase was highest in P hospital with a 30.3 times increase. Conversely, there has been a 6-times increase in D hospital, illustrating a noticeable gap between these hospitals. Overall, these hospitals have shown an enormous increasing ratio. In an analysis according to age, it's been shown that those aged between 75 and 84 showed the highest prevalence, and most patients, approximately 93.5%, were 65 years or older, while 20.2% were 85 years or older, showing a high ratio of elderly among dementia patients. In an analysis by type of dementia, it's been shown that Alzheimer's was the most prevalent with 44.4%, followed by unspecified dementia with 33.3%, and vascular dementia with 20.4%. As evident by the outcome of the study, there's been a drastic increase in the number of dementia patients in the past 12 years; since the prevalence of dementia was shown to be higher with older age, it is expected that the number of dementia patients will rise further in these five hospitals, where there's a high ratio of elderly patients. More elaborate and continuous plans are necessary for the management of dementia patients following the growing number of dementia patients.

• Investigative Magnetic Resonance Imaging
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• 제14권2호
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• pp.103-114
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• 2010

Purpose : To generate a Korean specific brain template, especially in patients with Alzheimer's disease (AD) by optimizing the voxel-based analysis. Materials and Methods : Three-dimensional T1-weighted images were obtained from 123 subjects who were 43 cognitively normal subjects and patients with 44 mild cognitive impairment (MCI) and 36 AD. The template and the corresponding aprior maps were created by using the matched pairs approach with considering differences of age, gender and differential diagnosis (DDX). We measured several characteristics in both our and the MNI templates, including in the ventricle size. Also, the fractions of gray matter and white matter voxels normalized by the total intracranial were evaluated. Results : The high resolution template and the corresponding aprior maps of gray matter, white matter (WM) and CSF were created with the voxel-size of $1{\times}1{\times}1\;mm$. Mean distance measures and the ventricle sizes differed between two templates. Our brain template had less gray matter and white matter areas than the MNI template. There were volume differences more in gray matter than in white matter. Conclusion : Gray matter and/or white matter integrity studies in populations of Korean elderly and patients with AD are needed to investigate with this template.

• The Korean Journal of Health Service Management
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• 제9권3호
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• pp.255-266
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• 2015

Objective : The aim of this study was to examine the effects of the Home-based Multi-component Activity Program (Home-MAP) for the maintenance activities of daily living (ADL) for patients with mild Alzheimer's disease (AD) and on caregiver burden for caregivers. Methods : Nine mild AD patients and family caregivers. The Home-MAP was performed 1d/wk, for a total of 10 times over 10 weeks. Results : After the 10 sessions, participants' motor and process skills scores on the AMPS were found to have significantly improved (p=.028 and p=.028, respectively). The BPSD frequency score on the R-MBPC was found to be significantly reduced (p=.017). The BPSD symptoms related to caregiver reaction score on the R-MBPC and distress score on the NPI-Q were significantly reduced (p=.039 and p=.018, respectively). Conclusions : The Home-MAP appears to have contributed to the improvement of patients' capabilities in performing in ADL, to a reduction of BPSD, and to a reduction of burden related to BPSD.

• Phonetics and Speech Sciences
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• 제5권1호
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• pp.27-38
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• 2013

Healthcare providers in Korea are using conservative pharmacological treatment for Alzheimer's disease (AD) to delay the progress of the disease or to mitigate its behavioral and neurological symptoms. However, there is a growing need for interventions using practical non-pharmacologic treatment, as the effects of pharmacological treatments has faced limitations. This research provided a cognitive rehabilitation program to 3 AD patients and used a multiple baseline design across subjects to examine the effects. Performing reality orientation therapy (ROT) for 1 cycle (4 weeks) resulted in a slight increase in accuracy and responsiveness on an orientation task, mainly with patients with mild cases of AD. Also, in the sub-domain of the Korean-Mini Mental Status Examination performed to examine changes in cognitive ability, there were minimal changes in place orientation. In functional communication, however, there were no significant differences before and after the intervention. In conclusion, we found that ROT was an effective intervention for improving accuracy and responsiveness in the orientation of patients with mild cases of AD. In future studies, the effect of non-pharmacological interventions can be evaluated more reliably by examining the interaction effects of sample size, length of the intervention, outcome measurements, and pharmacological intervention.

• Journal of Oriental Neuropsychiatry
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• 제14권2호
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• pp.43-59
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• 2003

Object : This study was designed to assess the protective effects of Jowiseungchungtang on cognitive decline of the patients with early DAT[Dementia of Alzheimer Type]. Method : 15 patients with early DAT and 10 healthy elderly subjects were measured by using auditory ERP and K-DRS, and after 9 months again. During 9 months the patients with early DAT were administered with Jowiseungchungtang. Result : 1. The score of K-DRS increased in two group but it was not significant. 2. The latency of ERP P300 component increased in 2nd test of the normal group, but did not increase in 2nd test of patients group. 3. The amplitude of ERP P300 component showed the significant difference in electrode location in patients group, but it did not show any typical property. Conclusion : The results suggest that Jowiseungchungtang may have protective effects on cognitive decline in the patients with early DAT.

• Journal of Oriental Neuropsychiatry
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• 제16권1호
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• pp.43-66
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• 2005

Object : This study was designed to asses the protective effects of Kunneo tang on cognitive decline of the patients with early DAT. Method : Before administered with Kunneotang, 16 patients with early DAT were measured by auditory ERP, MMSE-K and K-DRS. During 12 months the patients with early DAT were administered with Kunneotang. After 12months the patients were measured by the same examinations again. Result : 1. The total score of MMSE-K decreased but it was not significant. 2. The total score of K-DRS increased but it was not significant. Among the five criteria(attention, memory, initiation/perseveration, construction, conceptualization), Initiation/perseveration score signifcantly decreased and there were no significant differences in the other scores. But, memory mean score had a tendency to increase. 3. The latency of ERP P300 component increased but it was not significant and the amplitude of ERP P300 component showed the significant difference. Conclusion : The results suggest that Kunneotang may have protective effects on cognitive decline in the patients with early DAT.

• Journal of Oriental Neuropsychiatry
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• 제30권3호
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• pp.287-293
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• 2019

Objectives: The purpose of this study was to report the clinical effectiveness of the complex Korean medicine therapy on a patient with BPSD (Behavioral and Psychological Symptoms of Dementia) due to suspected Alzheimer's disease. Methods: We experienced an age 73 female who complained of a depressive mood, insomnia, and accompanying symptoms such as abnormal behavior. During treatment, the patient received acupuncture and herbal medicine. The clinical effects were evaluated through KGDS (Korean Form of Geriatric Depression Scale) and subjective statements of the patient. Results: After the complex Korean medicine therapy, the treatments ameliorated overall symptoms that the patient complained about. The patient was more positive and slept better after the treatment. No specificities or adverse effects were reported during treatment. Conclusions: This study suggests the possibility of treating patients with BPSD with complex Korean medicine therapy.

• Annual Conference on Human and Language Technology
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• 한국정보과학회언어공학연구회 2022년도 제34회 한글 및 한국어 정보처리 학술대회
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• pp.47-52
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• 2022

환자와 주변인들에게 다양한 문제를 야기하는 치매와 조현병 진단을 위한 모델을 제안한다. 치매와 조현병 진단을 위해 프로토콜에 따라 녹음한 의사와 내담자 음성 시료를 전사 작업하여 분류 태스크를 수행하였다. 사전 학습한 언어 모델의 MLM Head를 이용해 분류 태스크를 수행하는 Prompt 기반의 분류 모델을 제안하였다. 또한 많은 수의 데이터 수를 확보하기 어려운 의료 분야에 효율적인 Few-Shot 학습 방식을 이용하였다. CLS 토큰을 미세조정하는 일반적 학습 방식의 Baseline과 비교해 Full-Shot 실험에서 7개 태스크 중 1개 태스크에서 macro, micro-F1 점수 모두 향상되었고, 3개 태스크에서 하나의 F1 점수만 향샹된 것을 확인 하였다. 반면, Few-Shot 실험에서는 7개 태스크 중 2개 태스크에서 macro, micro-F1 점수가 모두 향상되었고, 2개 태스크에서 하나의 F1 점수만 향상되었다.

• Journal of Integrative Natural Science
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• 제16권2호
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• pp.61-67
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• 2023

Human body ages differently due to environmental, genetic and pathological factors. DNA methylation patterns also differs depending on various factors such as aging and several other diseases. The aging clock model, which uses these differences to predict age, analyzes DNA methylation patterns, recognizes age-specific patterns, predicts age, and grasps the speed and degree of aging. Aging occurs in everyone and causes various problems such as deterioration of physical ability and complications. Alzheimer's disease is a disease associated with aging and the most common brain degenerative disease. This disease causes various cognitive functions disabilities such as dementia and impaired judgment to motor functions, making daily life impossible. It has been reported that the incidence and progression of this disease increase with aging, and that increased phosphorylation of Aβ and tau proteins, which are overexpressed in this disease and accelerates epigenetic aging. It has also been reported that DNA methylation is significantly increased in the hippocampus and entorhinal cortex of Alzheimer's disease patients. Therefore, we calculated the biological age using the Epi clock, a pan-tissue aging clock model, and confirmed that the epigenetic age of patients suffering from Alzheimer's disease is lower than their actual age. Also, it was confirmed to slow down aging.