• Korean Journal of Biological Psychiatry
• /
• v.22 no.2
• /
• pp.40-46
• /
• 2015

Neuroglial cells are fundamental for brain homeostasis and defense to intrinsic or extrinsic changes. Loss of their function and over-reactivity to stimuli contribute to the aging of brain. Alzheimer's disease (AD) could be caused by more dramatic response in neuroglia associated with various chemokines and cytokines. Neuroglia of the AD brain shares some phenotypes with aging neuroglia. In addition, neuroglial activation and neuroinflammation are commonly showed in neurodegeneration. Thus neuroglia would be a promising target for therapeutics of AD.

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2021.07a
• /
• pp.317-320
• /
• 2021

본 연구는 주기적인 알츠하이머 병의 중증도 모니터링을 위해 스마트 인솔을 통한 보행 특징 추출과 머신러닝 기반 중증도 분류의 성능에 대해 살펴보았다. 최근 고령화가 가속화되는 추세에 있어 치매 환자가 급증하고 있으며, 중증도가 심해질수록 필요한 치료 비용 및 노력이 급증하기 때문에 조기 진단이 최선의 치료 전략으로 보여진다. 환자 친화적이고 저비용의 관성 측정 장치가 내장된 스마트 인솔만을 사용하여 다양한 보행 실험 패러다임에서 환자의 보행 특징을 추출하고, 이를 알츠하이머 병의 중증도 진단을 위한 머신러닝 기반 분류기를 훈련시켜 성능을 평가한 결과, 숫자세기와 같이 뇌에 부하를 주는 하위 작업이 포함된 복합 보행을 측정한 데이터셋을 사용하여 훈련된 분류 모델이 일반 걷기 데이터셋을 사용한 모델보다 성능이 높게 나타나는 것이 관찰되었다. 본 연구는 안전하고 환경적 제약이 적은 방법을 사용하여 시기 적절한 진단뿐만 아니라 주기적인 중증도 모니터링 시스템의 일환으로 활용될 수 있을 것이다.

• Journal of the Korean Society of Radiology
• /
• v.81 no.3
• /
• pp.488-500
• /
• 2020

Accumulating evidence suggests that Alzheimer's disease (AD) is not only caused by accumulation of abnormal proteins, including amyloid and tau, but is also closely associated with abnormalities in the microvascular environment including the blood-brain barrier (BBB), both of which lead to neuroinflammation and neurodegeneration. Application of in vivo magnetic resonance imaging (MRI) has recently increased to assess BBB permeability in AD and related diseases. Here, we provide a narrative review of BBB permeability-related pathology in Alzheimer dementia and recent MRI research on BBB permeability changes in AD and related diseases. Furthermore, we briefly introduce the measurement of BBB permeability using MRI and its methodological issues.

• Korean Journal of Psychosomatic Medicine
• /
• v.26 no.2
• /
• pp.119-126
• /
• 2018

Objectives : The aim of this study is to investigate correlation between degree of white matter hyperintensities (WMH) and neurocognitive function along with behavioral and psychological symptoms of dementia (BPSD) in Korean patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods : Participants were 115 elderly subjects diagnosed with Alzheimer's disease or mild cognitive impairment in this retrospective study. WMH in brain MRI were rated with standardized visual rating scales (Fazekas scales) and the subjects were divided into two groups according to Fazekas scale. Cognitive function was evaluated with Korean version of the consortium to establish a registry for Alzheimer's Disease (CERAD-K), and BPSD was evaluated with Korean neuropsychiatric inventory (K-NPI). Independent t-test was performed to analyze the relationship between the degree of WMH and neurocognitive functions & BPSD. Results : Especially, the group with high severity of WMH showed significantly lower language fluency (p<0.05). In addition, the group with high severity of WMH showed significantly higher score in K-NPI. Conclusions : There was a significant association between WMH and neurocognitive test related with executive function. Moreover, WMH seems to affect BPSD severity. Evaluation of WMH would provide useful information in clinical settings.

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2022.07a
• /
• pp.333-335
• /
• 2022

본 논문에서는 기존에 두 가지 모델이 필요했던 작업을 하나의 모델로 처리할 수 있는 자연어 처리 아키텍처를 제안한다. 단일 모델로 알츠하이머 환자의 언어패턴과 대화맥락을 분석하고 두 가지 결과인 환자분류와 챗봇의 대답을 도출한다. 일상생활에서 챗봇으로 환자의 언어특징을 파악한다면 의사는 조기진단을 위해 더 정밀한 진단과 치료를 계획할 수 있다. 제안된 모델은 전문가가 필요했던 질문지법을 대체하는 챗봇 개발에 활용된다. 모델이 수행하는 자연어 처리 작업은 두 가지이다. 첫 번째는 환자가 병을 가졌는지 여부를 확률로 표시하는 '자연어 분류'이고 두 번째는 환자의 대답에 대한 챗봇의 다음 '대답을 생성'하는 것이다. 전반부에서는 셀프어탠션 신경망을 통해 환자 발화 특징인 맥락벡터(context vector)를 추출한다. 이 맥락벡터와 챗봇(전문가, 진행자)의 질문을 함께 인코더에 입력해 질문자와 환자 사이 상호작용 특징을 담은 행렬을 얻는다. 벡터화된 행렬은 환자분류를 위한 확률값이 된다. 행렬을 챗봇(진행자)의 다음 대답과 함께 디코더에 입력해 다음 발화를 생성한다. 이 구조를 DementiaBank의 쿠키도둑묘사 말뭉치로 학습한 결과 인코더와 디코더의 손실함수 값이 유의미하게 줄어들며 수렴하는 양상을 확인할 수 있었다. 이는 알츠하이머병 환자의 발화 언어패턴을 포착하는 것이 향후 해당 병의 조기진단과 종단연구에 기여할 수 있음을 보여준다.

• Korean Journal of Clinical Laboratory Science
• /
• v.54 no.4
• /
• pp.249-255
• /
• 2022

Alzheimer's disease (AD) represents a major public health concern and has been identified as a research priority. Clinical research evidence supports that the core cerebrospinal fluid (CSF) biomarkers for AD, including amyloid-β (Aβ42), total tau (T-tau), and phosphorylated tau (P-tau), reflect key elements of AD pathophysiology. Nevertheless, advances in the clinical identification of new indicators will be critical not only for the discovery of sensitive, specific, and reliable biomarkers of preclinical AD pathology, but also for the development of tests that facilitate the early detection and differential diagnosis of dementia and disease progression monitoring. The early detection of AD in its presymptomatic stages would represent a great opportunity for earlier therapeutic intervention. The chance of successful treatment would be increased since interventions would be performed before extensive synaptic damage and neuronal loss would have occurred. In this study, the importance of developing an early diagnostic method using cognitive decline biomarkers that can discriminate between normal, mild cognitive impairment (MCI), and AD preclinical stages has been emphasized.

• Speech Sciences
• /
• v.15 no.2
• /
• pp.111-118
• /
• 2008

We identified the characteristic impairmants of linguistic semantic memory in patients with prodromal Alzheimer's disease(AD) and mild AD. To elucidate the earliest changes of semantic language function in subjects with AD, performances on confrontation naming test and verbal fluency task were compared among patients with AD patients (n=20), mild AD patients (n=27) and healthy elderly controls (n=20). Tasks in this study included the confrontation naming test of Test of Lexical Processing in Aphasia(TLPA/Japanese) and one-minute verbal fluency task (semantic/ phonetic categories). The results were as follows: 1) Performances of the prodromal AD group showed the comparable to those of the control group on the confrontation naming test, 2) In the semantic/phonetic verbal fluency tasks, the performances of the control group were better than those of the prodromal AD and mild AD groups, but no significant differences were shown between the prodromal AD and the mild AD group.

• Korean Journal of Biological Psychiatry
• /
• v.17 no.4
• /
• pp.194-202
• /
• 2010

Alzheimer's disease(AD) is the most common neurodegenerative disorder and constitutes about two thirds of dementia. Despite a lot of effort to find drugs for AD worldwide, an efficient medicine that can cure AD has not come yet, which is due to the complicated pathogenic pathways and progressively degenerative properties of AD. In its early clinical phase, it is important to find the subtle alterations in synapses responsible for memory because symptoms of AD patients characteristically start with pure impairment of memory. Attempts to find the target synaptic proteins and their pathogenic pathways will be the most powerful alternative strategy for developing AD medicine. Here we review recent progress in deciphering the role of target synaptic proteins related to AD in hippocampal glutamatergic synapses.

• Science & Technology Policy
• /
• v.1 no.1 s.1
• /
• pp.13-13
• /
• 1991

노인성 알츠하이머 병의 원인 물질 발견 / 고려 인삼 중 Saponin 피부 노화 방지에 효용 입증 / 인공 합성 항암제 제조법 특허 / 마·일·유럽, IMS를 국제 공동 개발하기로 / HDTV용 디지털 VTR 세계 최고밀도 구현 / 창 유리를 TV안테나로

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
• /
• v.14 no.5
• /
• pp.403-412
• /
• 2021

Alzheimer's disease (AD) is the most common cause of dementia, showing progressive neurodegeneration. Although oral medications for symptomatic improvement still take a huge part of treatment, there are several limitations caused by pharmacology-based real world clinic. In this respect, non-pharmacologic treatment for AD is rising to prominence. Transcranial direct current stimulation (tDCS) is a one of the non-invasive neuromodulation technique, using low-voltage direct current. In terms of safety, tDCS already has been proven through numerous previous reports. This review focused on behavioral, neurophysiologic and histopathologic improvement by applying tDCS in AD rodent models, thereby suggesting reliable background evidence for human-based tDCS study.