• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2011.07a
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• pp.454-455
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• 2011

미토콘드리아의 수송은 치매, 다형성 경화증, 알츠하이머병 등의 신경성 질환과 관련하여 활발하게 연구되고 있다. 하지만 미토콘드리아 영상의 경우 일반 영상에 비해 노이즈(noise)가 많고 초당 프레임 수(frame-persecond)가 낮기 때문에 분석이 쉽지 않다. 이에 따라 미토콘드리아의 수송 통로인 축색돌기(axon)를 사전에 검출하고자 하는 연구들이 진행되고 있다. 본 논문에서는 이러한 배경을 바탕으로 미토콘드리아 영상에서 축색돌기를 자동으로 분리, 검출해내는 알고리즘을 제안한다. 배경이 비해 밝게 착색되어 있다는 미토콘드리아의 특성을 이용하여 축색돌기를 구분하는 데에 최대 화소값 기법(maximum intensity)과 혈관 증폭 필터(vessel enhancement filter)를 이용한다. 두 기법을 통해 얻은 축색돌기의 파편들은 로젠펠드 세선화(rosenfeld thinning)와 선형 보간법(linear interpolation)을 이용하여 연결되고 최종적인 검출 결과를 얻어낸다. 제시된 실험결과는 영상에서 전체적인 축색돌기가 성공적으로 검출되고 있음을 보여준다.

• Korean Journal of Adult Nursing
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• v.24 no.4
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• pp.398-405
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• 2012

Purpose: The purpose of this study was to develop spaced retrieval training as a nursing intervention for patients having an mild alzheimer's disease and to determine the effects of the program on their memory and cognitive function across training sessions. Methods: A non-equivalent control group pre test-post test design was used in this study. Participants were recruited from a local community: 14 patients were allocated into experimental group and 12 patients were allocated into control group. The experimental group was asked to participate in spaced retrieval training over 4 weeks, with seven times a week and 1 hour a session based. The study was conducted from June 20, 2011 to July 17, 2011. Data was analyzed with descriptive statistics, $x^2$-test and t-test using the SPSS/WIN 19.0 program. Results: After spaced retrieval training, the experimental group showed significant increases in scores for memory (t=12.40, p<.001) and cognitive function (t=7.69, p<.001) in comparison to the control group. Conclusion: Spaced retrieval training was effective in increasing cognitive function and memory of patients having mild alzheimer's disease. Therefore spaced retrieval training could be benefit the mild alzheimer's disease.

• Journal of Oriental Neuropsychiatry
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• v.14 no.2
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• pp.43-59
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• 2003

Object : This study was designed to assess the protective effects of Jowiseungchungtang on cognitive decline of the patients with early DAT[Dementia of Alzheimer Type]. Method : 15 patients with early DAT and 10 healthy elderly subjects were measured by using auditory ERP and K-DRS, and after 9 months again. During 9 months the patients with early DAT were administered with Jowiseungchungtang. Result : 1. The score of K-DRS increased in two group but it was not significant. 2. The latency of ERP P300 component increased in 2nd test of the normal group, but did not increase in 2nd test of patients group. 3. The amplitude of ERP P300 component showed the significant difference in electrode location in patients group, but it did not show any typical property. Conclusion : The results suggest that Jowiseungchungtang may have protective effects on cognitive decline in the patients with early DAT.

• Journal of Oriental Neuropsychiatry
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• v.16 no.1
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• pp.43-66
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• 2005

Object : This study was designed to asses the protective effects of Kunneo tang on cognitive decline of the patients with early DAT. Method : Before administered with Kunneotang, 16 patients with early DAT were measured by auditory ERP, MMSE-K and K-DRS. During 12 months the patients with early DAT were administered with Kunneotang. After 12months the patients were measured by the same examinations again. Result : 1. The total score of MMSE-K decreased but it was not significant. 2. The total score of K-DRS increased but it was not significant. Among the five criteria(attention, memory, initiation/perseveration, construction, conceptualization), Initiation/perseveration score signifcantly decreased and there were no significant differences in the other scores. But, memory mean score had a tendency to increase. 3. The latency of ERP P300 component increased but it was not significant and the amplitude of ERP P300 component showed the significant difference. Conclusion : The results suggest that Kunneotang may have protective effects on cognitive decline in the patients with early DAT.

• Korean Journal of Clinical Pharmacy
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• v.29 no.1
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• pp.1-8
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• 2019

Background: Alzheimer's dementia is the most common dementia. However, recently, choline alfoscerate is prescribed for treating Alzheimer's dementia, although it is not a treatment for this disease. Purpose: To analyze the prescription patterns of choline alfoscerate as a dementia treatment for patients with Alzheimer's disease and to analyze, as well as the factors affecting choline alfoscerate prescription. Method: The 2016 HIRA-NPS data was used in this study. The code of Alzheimer's dementia is F00 in the ICD-10 disease classification code. We analyzed the demographic, clinical, and regional characteristics associated with donepezil, rivastigmine, galantamine, memantine, and choline alfoscerate prescriptions. All statistical and data analyse were conducted by SAS 9.4 and Excel. Results: For patients with Alzheimer's disease, choline alfoscerate was the second most prescribed after donepezil. Analysis results showed that choline alfoscerate was more likely to be prescribed to men than to women, and more likely to be prescribed by local health centers than by medical institutions. Moreover, choline alfoscerate was highly likely to be prescribed at neurosurgical departments, among medical departments. Conclusions: This study confirmed that choline alfoscerate was prescribed considerably for patients with Alzheimer's dementia. Further studies valuating its clinical validity should be performed to clarify whether choline alfoscerate prescription is appropriate for treating Alzheimer's dementia.

• Journal of Oriental Neuropsychiatry
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• v.30 no.3
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• pp.287-293
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• 2019

Objectives: The purpose of this study was to report the clinical effectiveness of the complex Korean medicine therapy on a patient with BPSD (Behavioral and Psychological Symptoms of Dementia) due to suspected Alzheimer's disease. Methods: We experienced an age 73 female who complained of a depressive mood, insomnia, and accompanying symptoms such as abnormal behavior. During treatment, the patient received acupuncture and herbal medicine. The clinical effects were evaluated through KGDS (Korean Form of Geriatric Depression Scale) and subjective statements of the patient. Results: After the complex Korean medicine therapy, the treatments ameliorated overall symptoms that the patient complained about. The patient was more positive and slept better after the treatment. No specificities or adverse effects were reported during treatment. Conclusions: This study suggests the possibility of treating patients with BPSD with complex Korean medicine therapy.

• 한국노년학
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• v.28 no.4
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• pp.925-940
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• 2008

As the proportion of old people in contemporary societies steadily increases, the influence on cognitive rehabilitation strategy of the memory deficit associated with normal and pathological aging grows greater as well. This paper reviewed the current memory rehabilitation techniques for older adults. In the first part of this article, human memory systems as a framework for understanding memory aging were considered. In the second part, research findings concerning memory performance in normal aging and Alzheimer's disease were reviewed. Finally, recent evidence for the kinds of memory rehabilitation procedures with proven efficacy were offered. The existent memory rehabilitation technique have focused on prompt of residual explicit memory, use of preserved implicit memory, utilization of memory external memory aids. A suggestion of memory training based on brain plasticity as a novel approach is offered.

• Korean Journal of Psychosomatic Medicine
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• v.29 no.1
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• pp.67-76
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• 2021

Objectives : The aim of this study was to compare activities of daily living (ADLs) according to degenerative changes in brain [i.e., medial temporal lobe atrophy (MTA), white matter hyperintensities] and to examine the association between neurocognitive functions and ADLs in Korean patients with dementia due to Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods : Participants were 111 elderly subjects diagnosed with AD or MCI in this cross-sectional study. MTA in brain MRI was rated with standardized visual rating scales (Scheltens scale) and the subjects were divided into two groups according to Scheltens scale. ADLs was evaluated with the Korean version of Blessed Dementia Scale-Activity of daily living (BDS-ADL). Neurocognitive function was evaluated with the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease assessment packet (CERAD-K). Independent t-test was performed to compare ADLs with the degree of MTA. Pearson correlation and hierarchical multiple regression analyses were performed to analyze the relationship between ADLs and neurocognitive functions. Results : The group with high severity of the MTA showed significantly higher BDS-ADL scores (p<0.05). The BDS-ADL score showed the strongest correlation with the word list recognition test among sub-items of the CERAD-K test (r=-0.568). Findings from the hierarchical multiple regression analysis revealed that the scores of MMSE-K and word list recognition test were factors that predict ADLs (F=44.611, p<0.001). Conclusions : ADLs of AD and MCI patients had significant association with MTA. Our study, which identifies factors correlated with ADLs can provide useful information in clinical settings. Further evaluation is needed to confirm the association between certain brain structures and ADLs.

• Korean Journal of Psychosomatic Medicine
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• v.24 no.2
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• pp.184-190
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• 2016

Objectives : This study analyzed the differences of body mass index(BMI) in Korean patients with Alzheimer's diseases(AD), Mild Cognitive Impairment(MCI), and healthy controls to verify whether low BMI is associated with cognitive impairment. Furthermore, this study also sought to examine any association between BMI and Mini Mental State Examination-Korean version(MMSE-K), Clinical Dementia Rating(CDR), and Global Deterioration Scale(GDS). Methods : A total of 257 subjects were included in the study. History taking, mental status examination, physical examination and neurocognitive function test were carried out for the diagnosis of AD and MCI. The subjects' demographic data and presence of diseases were also surveyed. The overall cognitive function and severity of diseases were assessed using MMSE-K, GDS, and CDR. Results : The order of BMI was found to be healthy controls>MCI>AD, with statistically significant differences among the groups. The order of MMSE-K scores was similar, with healthy controls>MCI>AD in statistically significant differences. The healthy controls had the lowest CDR and GDS scores, and AD patients had the highest scores. There was a significant positive correlation between BMI and MMSE scores(r=0.238, p=0.000). BMI was negatively correlated with CDR(r=-0.174, p=0.008) as well as with GDS(r=-0.233, p= 0.000). Conclusions : Measuring BMI of patients with AD or MCI is expected to be meaningful in that BMI could be a clinical indicator of AD. We expect this to be beneficial for the diagnosis, prevention, and therapeutic approach of AD and also expect large-scale, long-term longitudinal studies to follow.

• Journal of agriculture & life science
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• v.44 no.4
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• pp.45-55
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• 2010

In this study, the acetylcholinesterase (AChE) inhibition and neuronal cell protective effects of water, 100% methanol and dichlromethane extracts from garlic were investigated. We found that dichloromethane extract of garlic resulted in a dose-dependent manner on AChE inhibition ($IC_{50}$: $36.1{\mu}g/mL$). In cell viability assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide (MTT), cell viabilities of water, 100% methanol and dichlromethane extracts were lower (almost under 40%) than amyloid ${\beta}$ protein ($A{\beta}$)-induced neurotoxicity. Because $A{\beta}$ is also known to increase neuronal cell membrane breakdown, neuronal apoptosis was further confirmed by lactate dehydrogenase (LDH) and neutral red uptake (NRU) assay. Water extract presented relative protection against $A{\beta}$-induced membrane damage in LDH assay. However all garlic extracts showed significant problem with decrease of cell viability in NRU assay, especially at dichloromethan extract. To determine active compounds in column fractions (98:2 fraction) from dichloromethane extract which showed significant AChE inhibitory effect, we performed HPLC and LC-MS analysis. It was supposed that garlic may contain allyl methyl disulfide, diallyl monosulfide, and diallyl disulfide as active compounds.