• KSBB Journal
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• v.21 no.3
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• pp.212-219
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• 2006

The purpose of this study was to develop a assay system of host cell-derived residual proteins in final pharmaceutical products. Accurate and simple assay system for host cell-derived proteins(HCPs) is very important test item in pharmaceutical qualification control. In this study, methods for quantification of residual HCPs in recombinant anti-GPIIbIIIa antibody were developed using a process-specific immunoligand assay which was based on the Enzyme linked Immunosorbent assay(ELISA) system. The assay had a detection limit of 10.8 ng/ml of HCPs with a product concentration of 1 mg/ml. The practical implication of these results is that the developed ELISA system can be used for HCPs qualification control and this system will be applicable to develop another ELISA system of different antibody drug.

• Journal of Korean Society of Transportation
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• v.31 no.1
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• pp.3-13
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• 2013

This paper reviews the characteristics of dilemma zone by analysing the influence exerted by actual location of intersection traffic signal on behaviour of drivers approaching signalized intersection in urban area. The analysis of approach speed was based upon a 'before and after' comparison, measured at three sites where the locations of traffic signals were changed. The study demonstrated that, when traffic signal changed to yellow, the scales of dilemma zone were narrowed in case of stopping cars by moving up the starting point of the dilemma zone due to lowered spot speed. On the other hand, in case of passing cars, the end points of dilemma zone were moved further out to the rear due to increased spot speed. Therefore, changing traffic signal locations could make an impact to increase intersection safety through reducing the scales of dilemma zone. This study also found that, in cases involving vehicles with similar approach speeds, spot speeds could be differentiated following the change of signal locations due to the fact that there can be greater differences in both braking point and deceleration rate. Thus, when considering the appropriate measuring of dilemma zone, 'spot speed' rather than 'approach speed' appeared to be more appropriate criterion.

• KIPS Transactions on Computer and Communication Systems
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• v.3 no.10
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• pp.323-328
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• 2014

ZigBee based on the most vulnerable part of u-Healthcare system that uses the ZigBee communication is the wireless section. ZigBee communication sectors to identify vulnerabilities in this paper, we propose to compensate. ZigBee has been raised from the existing vulnerabilities organize and ZigBee also uses the 64bit address that uniquely identifies a vulnerability that was defined as exposure. And to prevent the exposure of a unique identifying address was used to address a temporary identification. ZigBee security services, the proposed system during the Network Key for encryption only use one mechanism of Residential Mode is used. Residential Mode on all nodes of the entire network because they use a common key, the key is stolen, your network's security system at a time are at risk of collapse. Therefore, in order to guard against these risks to the security policy Network Key updated periodically depending on the method used to. The proposed evaluation and comparative analysis of the system were exposed in the existing system can hide the address that uniquely identifies a public key Network Key also updated periodically, so that leaks can occur due to reduced risk.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.32 no.5
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• pp.333-340
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• 2019

Tests using a middle velocity propulsion impact machine (MVPIM) were performed to verify the impact resistance capability of sandwich concrete panels (SCP) in a modular liquefied natural gas (LNG) outer tank, and numerical models were constructed and analyzed. $2{\times}2m$ specimens with plain sectional characteristics and specimens including a joint section were used. A 51 kg missile was accelerated above 45 m/s and impacted to have the design code kinetic energy. Impact tests were performed twice according to the design code and once for the doubled impact speed. The numerical models for simulating impact behaviors were created by LS-DYNA. The external steel plate and filled concrete of the panel were modeled as solid elements, the studs as beam elements, and the steel plates as elasto-plastic material with fractures; the CSCM material model was used for concrete. The front plate deformations demonstrated good agreement with those of other tests. However the rear plate deformations were less. In the doubled speed test for the plain section specimen, the missile punctured both plates; however, the front plate was only fractured in the numerical analysis. The impact energy of the missile was transferred to the filled concrete in the numerical analysis.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.5
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• pp.263-270
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• 2021

In this study, a reliability-based design optimization of a 130-m class fixed-type offshore platform, to be installed in the North Sea, was carried out, while considering environmental, material, and manufacturing uncertainties to enhance its structural safety and economic aspects. For the reliability analysis, and reliability-based design optimization of the structural integrity, unity check values (defined as the ratio between working and allowable stress, for axial, bending, and shear stresses), of the members of the offshore platform were considered as constraints. Weight of the supporting jacket structure was minimized to reduce the manufacturing cost of the offshore platform. Statistical characteristics of uncertainties were defined based on observed and measured data references. Reliability analysis and reliability-based design optimization of a jacket-type offshore structure were computationally burdensome due to the large number of members; therefore, we suggested a method for variable screening, based on the importance of their output responses, to reduce the dimension of the problem. Furthermore, a deterministic design optimization was carried out prior to the reliability-based design optimization, to improve overall computational efficiency. Finally, the optimal design obtained was compared with the conventional rule-based offshore platform design in terms of safety and cost.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.520-528
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• 2021

In this study, we attempted to derive major management factors related to the quality control of formwork and identified differences in the perceptions of construction engineers, construction managers, and field workers about the importance and performance of the derived factors. As a result of the study, 18 management factors related to the formwork were derived. Among the derived factors, the field workers placed importance on the factors that influence the detailed process of the formwork, while construction engineers placed importance on the factors related to the judgment of the progress and completion of the construction. The construction managers placed importance on the factors that affect the quality of the building frame. Based on the results of this study, it is expected that a plan to improve the quality of formwork that accepts the various opinions of each participant will be established.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.2
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• pp.681-693
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• 2019

Multi-use ophthalmic solutions are used many times after opening; therefore, there is a high possibility of decreased quality during use. This study was conducted to determine the recommended use period of multi-use ophthalmic solutions based on evaluation of the stability by comparing stability evaluation regulations of the USA, EU and Korea We selected four types of multi-use ophthalmic solutions (Olopatadine (Olo), Fluorometholone (Flu), Dorzolamide (Dor), Timolol (Timol)) that are frequently marketed in Korea and evaluated their stability during storage according to the actual usage method after opening. The Olo had a decrease in assay and preservative content at 2 months after opening, while Flu showed a significant difference from day 28 after opening. For Dor, significant differences were observed from day 14 after opening in the assay and impurity test item and Timol showed a significant difference from day 28 after opening. Based on the results of the stability test Olo and Flu should only be used within 28 days of opening, while Dor and Timol should be used within 14 days of opening. Therefore, we suggest that regulations system related use periods of multi-use ophthalmic solutions designed as aseptic preparations should be improved based on the results of stability tests after opening.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.8
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• pp.604-609
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• 2019

A variety of complaints about road signs have occurred for various reasons, such as new road facilities, new road signs such as road name signs, and an increase in nearby important facilities. In addition, there are many road signs that are in violation of road sign regulations. The basic principles of road signs, the connectivity of guide names, the location suitability, and a consistent road sign guidance system have not implemented. To solve these problems, various errors were investigated on major road signs on eight national highways, including direction signs, distance signs, boundary signs, and route signs. In addition, we classified the errors on road signs by grade to give them maintenance priority. We also analyzed the error status of signs for each route and grade. Based on the data, the problems of the road signs were derived, and an improvement plan is discussed. Based on this research, more systematic installation and management of road signs through cooperation between the government and local governments could increase the efficiency of road signs, as well as provide safer and more convenient road sign guidance systems for road users.

• Korean Journal of Construction Engineering and Management
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• v.20 no.1
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• pp.32-40
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• 2019

This study analyzed operating condition and the problems of damage compensation insunace (property insurance) for qualified architect and derived some suggsetions for improvement. The Certified Architects Act requires all building design and construction supervision to buy property insurance. This study proposes following suggestions to solve problems of current architect property insurance. Firstly, we need to increase the insurance purchasing rate of damage compensation insurance for qualified architect. It is necessary to clearly specify the matters concerning the submission of insurance policies by the architects, which is currently carried out by the Minister's official letter, in the form of official announcement. Secondly, proper insured amount should be adjusted. In order to insured substantial compensation capacity, total amount of insurance should be enlarged. Thirdly, the insurance period should be extended to one year after completion of building to allow compensation for accidents due to design negligence. Generally, the design defect can mostly be identified within one year after completion. Fourthly, insurance coverage should be extended. In the long run, it is essential to enlarge the scope of the security not only to property damage but also to human losses. Finally, an accident record sharing system should be established among insurance companies, so that proper insurance premiums or discounts can be made based on the system.

• Journal of the Korean Geosynthetics Society
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• v.17 no.4
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• pp.21-28
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• 2018

Despite a number of studies on consolidation behavior that have been carried out in the Nakdong River estuary in Busan, these are focused on the prediction of final settlement during ground improvement process, and there is almost no research on the long-term settlement occurring after that. For the practical study on the long-term settlement, the field monitored settlement data that measured over 10 years in the Busan new port facilities area were used, and the final settlement and predicted time-settlement line were constituted by hyperbolic function. As a result, the measured settlements depend on the thickness of clayey soils, and the pattern were similar to each other and good agreement with the predicted time-settlement line using hyperbolic method. Also, the settlement in the lower non-improved layer occupied 62-76% of total settlement. Information about above results would be quite helpful to understand the long-term settlement behaviors as well as the non-improved layer's settlement is more careful consideration needed at design phase.