• Journal of The Korean Ophthalmological Society
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• v.60 no.2
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• pp.144-151
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• 2019

Purpose: Intravitreal aflibercept, ranibizumab, bevacizumab, and dexamethasone are the most widely used drugs in the treatment of diabetic macular edema (DME). The aim of this study was to compare the efficacy and safety of anti-vascular endothelial growth factors and dexamethasone for the treatment of DME. Methods: There were nine previous systematic reviews on this topic; we updated these high-quality reviews. Seven studies were added to two studies following a literature search. Efficacy outcomes were 1) average improvement in visual acuity, 2) proportion of patients who experienced an improvement in vision (an increase in best-corrected visual acuity (BCVA) of ${\geq}15$ in the Early Treatment Diabetic Retinopathy Study [ETDRS]), and 3) proportion of patients who experienced worsening vision (a decrease in BCVA of ${\geq}15$ in the ETDRS). Safety outcomes included systemic adverse events and ocular-related adverse events. Results: The mean difference in the BCVA for ranibizumab versus bevacizumab treatment was 0.16 (95% confidence interval [CI]: -0.02, 0.34), and that for ranibizumab versus aflibercept was -0.08 (95% CI: -0.26, 0.10). The mean difference in the change of BCVA for aflibercept versus ranibizumab was -0.20 (95% CI: -0.40, -0.01), and that for aflibercept versus bevacizumab was -0.34 (95% CI: -0.53, -0.14). Other efficacy outcomes showed similar trends, and there was no significant difference between treatments. There was also no significant difference in both systemic and ocular adverse events rates between the treatments. Conclusions: In DME patients, the efficacy of aflibercept was found to be higher with respect to BCVA changes compared with ranibizumab or bevacizumab. However, there were no significant difference in terms of visual acuity improvement or visual acuity of more than 15 letters, nor in terms of anti-vascular endothelial growth factors (as a safety outcome).

• Journal of Korean Society of Transportation
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• v.24 no.3 s.89
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• pp.63-71
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• 2006

There were many theories to suggest the indicators that evaluate stability and reflect the plan in mixed traffic street in all traffic modes This Paper analyzed residential street of Suwon City adopting time-space occupancy index among these indicates. Three survey street. congregated into apartment house. were selected to analyze this and pictured by video camera over one hour. and the length of these street were 76m, 55m, and 34m each, and major street by each region, comparably high in Pedestrians and pass vehicles, were selected. Basic datum to calculate time-space occupancy index and time-space occupancy index per person was gathered through video analysis. i.e Parameters for pedestrians, cars, bicycles, average speed of bicycles, and parking car. There are some limitation to analyze LOS of mixed traffic street in all traffic modes, not pedestrian mall. Therefore this paper presented evaluation standard of LOS. In conclusion. the aim of this paper is to suggest modeling based on guidelines for evaluating LOS of mixed traffic street in all traffic modes. It is estimated that this will be influencing indicates for improving pedestrian environment, and Planning mixed traffic street in future.

• The Journal of the Korea Contents Association
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• v.21 no.9
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• pp.704-713
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• 2021

The purpose of this study was to evaluate the relative weight of infectious disease vulnerability indicators that affect the occurrence and spread of infectious diseases in local communities. For this, the infectious disease vulnerability indicators were classified as facilities vulnerable to spread, vulnerable groups of infections, social vulnerable conditions, and response capabilities based on literature and case review, and the relative weights among indicators were determined using Analytic Hierarchy Process(AHP) by 22 experts. As a result of the analysis, the weight of each sector was found to be the highest in the facilities vulnerable to spread, and the overall weight was highest in the following order: sickbed securing rate(1st), density of religious facilities(2nd), medical personnel rate(3rd), elderly person ratio(4th), and entertainment establishment density(5th). These results can be used to prepare the supporting data necessary for the establishment of infectious disease response policies of local governments.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.1
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• pp.1-8
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• 2015

Wind power systems have gained much attention due to the relatively high reliability, good infrastructures and cost competitiveness to the fossil fuels. Advances have been made to increase the power efficiency of wind turbines while less attention has been focused on structural integrity assessment of structural sub-systems such as towers and foundations. Among many parameters for integrity assessment, the most perceptive parameter may be the induced horizontal displacement at the hub height although it is very difficult to measure particularly in large-scale and high-rise wind turbine structures. This study proposes an indirect displacement estimation scheme based on the combined use of inclinometers and accelerometers for more convenient and cost-effective measurements. To this end, (1) the formulation for data fusion of inclination and acceleration responses was presented and (2) the proposed method was numerically validated on an NREL 5 MW wind turbine model. The numerical analysis was carried out to investigate the performance of the propose method according to the number of sensors, the resolution and the available sampling rate of the inclinometers to be used.

• Proceedings of the Safety Management and Science Conference
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• 2013.04a
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• pp.501-516
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• 2013

우리나라는 비약적인 산업기술발전을 통해 선진국 진입을 눈앞에 두고 있다. 하지만 선진국 진입에 있어 크게 세 가지의 걸림돌이 있다. 첫째로는 세계시장 진입의 장벽, 둘째로 제조물책임법(PL법) 대응방안 미흡, 셋째로는 고객신뢰 및 자원의 한계 이다. 이러한 한계점으로 인하여 신뢰성경영시스템의 필요성이 대두되고 있으며 국내의 신뢰성경영시스템의 활성화는 필수 요소로 다가오고 있다. 본 논문에서는 신뢰성경영시스템의 활성화와 이를 위한 지표개발의 필요성 및 개발 방향성을 제시해보고자 한다.

• Journal of Wetlands Research
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• v.20 no.2
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• pp.173-180
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• 2018

The utilization of TOC(Total organic carbon), a new environmental standard, was evaluated for 30 lakes in the Nakdong River Basin, which is used for drinking and agricultural usage. The active use of water resources begins with securing satisfactory water quality. Since this allows people and nature to maintain stability of quality, water quality standards are being tightened to ensure good water quality. In order to improve the pollution level of organic matter in lakes in the living environment, it is important to use the appropriate organic substance index. The relationship between the newly introduced TOC and the existing COD(Chemical oxygen demand) in the targeted lake was positively correlated with the possibility of replacing the TOC with COD. However, the environmental grade standard using TOC is better than the environmental grade standard using COD, so it has the same effect as that of the grade of water quality using TOC as an organic substance factor. This indicates the limitation of TOC to directly replace existing COD when trying to determine or improve the quality level using organic indicators of lakes. Therefore, in order to secure the qualitative safety of the lake, it is required to strengthen environmental standards of TOC in terms of water quality grade. In addition, the correlation between TOC and COD shows a great difference depending on the utilization characteristics of the lake. This requires clear scientific identification, and it requires continuous monitoring of COD that has been used to accumulate indicators of lake organic matter.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.1
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• pp.29-34
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• 2015

The objective of this study was to obtain data on the safety-in-use of nano calcium as a dietary supplement by assessing its acute and subacute oral toxicities in female and male Sprague-Dawley rats. A single oral dose of 5,000 mg/kg of nano calcium did not result in mortality or significant changes in the general behavior and gross appearance of the internal organs of rats. For subacute toxicity study, nano calcium was administered orally at a dose of 1,000 mg/kg daily for 14 days. There were no significant differences in organ weights between control and treated groups of both sexes. Hematological analysis and blood chemistry revealed no toxic effects of nano calcium. Pathologically, neither gross abnormalities nor histopathological changes were observed. These results show that nano calcium possesses very low toxicity as indicated in a rat model.

• Journal of the Korea Institute of Building Construction
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• v.10 no.1
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• pp.181-191
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• 2010

Lightweight panels are currently used in many ways, such as inner walls of the skyscrapers and residential buildings in Korea. Moreover there has been an increasing of interest in developing construction method and quality improvement as many buildings became higher, because there are more advantages like constructability, finishability, and economic efficiency, etc. than previous heavy weight concrete wall. It is necessary to analyze the characteristics and evaluate the performance of lightweight panels when selecting proper methods and materials to building characteristics and builder's demand. However, there doesn't exist systematic data with a classification of lightweight panels' type and performance. The purpose of this study is to classify domestic lightweight panels by both type of exterior board and construction method, and also to evaluate each performance by surveying user's opinion.

• Journal of the Korea Institute of Building Construction
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• v.11 no.2
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• pp.189-199
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• 2011

Installation of a proper root barrier in a green roof system is very important in order to protect the concrete slab of roof and the root penetration in the waterproofing layer. To select the proper root barrier materials and methods, it is necessary to understand the environmental conditions affecting the waterproofing-root barrier system in green roof construction site. Therefore, we suggested as the environmental performance indexes four kinds of performance requirements; root penetration, chemical attack by chemical agent or fertilizer, load impact by soil depth and size of plant, and water pressure. The related four test methods were suggested for the inspection of these performance indexes. In this research, we could suggest for kinds of test methods as standard test methods to evaluate the environmental performance of waterproofing-root barrier for greening roof system.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.16 no.2
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• pp.69-77
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• 2021

연구 배경 최근 한국 및 중국에서 근골격계 질환에 대한 도침술의 활용이 늘고 있다. 하지만 현재까지의 임상연구는 대부분 증례보고 형태에 그치거나, 충분한 근거가 확보되지는 않은 실정이다. 우리는 요천추신경병증환자의 치료에 있어 도침치료와 통상한의치료와의 비교를 통해 도침치료의 유효성, 안전성, 경제성 평가를 시행하기 위해 본 연구를 기획하게 되었다. 연구 방법 본 연구는 예비임상 연구로, 다기관에서 진행되며, 무작위대조군, 활성 대조군을 통한 2개군 병행집단 연구로 평가자 맹검을 시행하게 된다. 이 연구에서는 총 50명의 요천추신경병증 환자를 대상으로 2개군으로 균등하게 분배하여 도침술 또는 통상한의치료를 시행하게 된다(각군당 25명). 도침술 그룹의 경우 협척혈에 도침치료를 시행 받게 되며, 통상 한의치료군은 연구자 판단하에 도침술을 제외한 적절한 한의치료를 시행 받게 된다. 두 개의 그룹은 주당 2회씩 총 3주간 치료를 받게 된다. 일차 유효성 평가는 요통으로 인한 기능장애를 평가하기 위한 Oswestry disability index를 통해 시행한다. 이차 유효성 평가지표로는 numeric rating scale, European Quality of Life 5-Dimension 5-Level, short-form McGill Pain Questionnaire, Roland-Morris Disability Questionnaire scores를 시행하게 된다. 고찰 본 예비임상연구의 결과는 추후 있을 요천추신경병증에 대한 도침치료 및 한의통상치료 비교효과 연구의 유효성, 경제성평가 본 임상연구를 위한 기초 정보 및 가능성을 확인하고 적절한 대상자수 산정에 도움이 될 것이다.