• Journal of the Korea Convergence Society
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• v.10 no.5
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• pp.95-102
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• 2019

This study was to investigate the effect of eye movement and intentional finger movement on cognitive ability. Normal adult subjects were randomly divided into two groups: saccadic eye movement(SEM) and intentional finger movement(IFM). After 2 weeks of intervention, Digit span was used for short-term memory test and N-back was used for working memory test. As a result, the short-term memory of the IFM group increased significantly over time, and the follow-up test showed difference between group. The IFM group's the execution time, the error count and the accuracy rate of n-back item showed significant effects over time. The SEM group's the execution time and the accuracy of n-back item showed significant effects over time. In conclusion, the IFM method, which is a multiple stimulus that can activate the cerebral cortex more extensively than the single stimulus SEM, may be more useful as an intervention method of cognitive function improvement.

• Journal of the Korean Institute of Telematics and Electronics
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• v.18 no.4
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• pp.12-20
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• 1981

In this paper, Band-limlted Gaussian Random Noise and PRBS(pseudo random hinary sequence) are used as a test signals to estimate the dynamic characteristics of the ocuiomotor system. Eye movements of the human subject are measured by E.O.G(electro-oculography) and the control characteristics of the oculomotor system are studied by random signal an-alysis based on the statistical communication theory. The conclusions are summerized as follows. (1) From the frequency response, the gain curve rises slightly at the regions of 0.7~0.9 Hz and 1.8~2 Hz due to the saccades which are occurred during usual tracking. (2) The average rate of information transfer by the oculomotor control system is 1.24 bits/sec, being calculated from the power spectral density and the cross spectral density for the Gaussian random input.

• Journal of Korean Elementary Science Education
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• v.31 no.3
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• pp.358-371
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• 2012

The main purpose of this study was to examine elementary teachers' visual attention that appears in science textbook tables. This paper proposed that teachers' cognitive effectiveness can be different by the presence or absence of the title of tables. The eye fixation data of participants are collected by the eye tracker apparatus. Participants in this study were 10 elementary school teachers and the table on the 2007 revised science textbooks were selected as experimental stimuli. Information about eye-fixations are recorded when subjects are given 4 tables by eye tracker. Eye-fixation time as well as the ratio and the number of fixation can be obtained by using the eye tracker but also we can acquire a significant conclusion through these outcomes. As the result of the experiment, it took less time to interpret in the presence of the title than in the absence of it. However, this result is only effective only for the interpretation of simple stimulus; the presence of title does not influence on fixation time in the analysis of complicated stimulation. This study showed that it is better to insult the title in the tables because it helps teachers to recognize contents of the tables effectively.

• Korean Journal of Biological Psychiatry
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• v.15 no.4
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• pp.288-296
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• 2008

Objectives : We investigated the association of Val108/158Met polymorphism on catechol-O-methyl transferase(COMT) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenia patients. Methods : We measured SPEM in 217 Korean schizophrenia patients(male 116, female 101) and divided them into two groups, one was a good SPEM function group and the other was a poor SPEM function group. Then we analyzed Val108/158Met polymorphism on COMT gene. We compared the differences of genotype and allele distributions of the polymorphism on COMT gene between the two groups. Results : The natural logarithm value of signal/noise ratio(Ln S/N ratio) of the good SPEM function group was $4.39{\pm}0.33$(mean${\pm}$s.d.) and that of poor SPEM function group was $3.17{\pm}0.71$. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the Val108/158Met polymorphism on COMT gene between the two schizophrenic groups. Conclusions : The results suggest that Val108/158Met polymorphism on COMT gene is not related to SPEM function abnormality in schizophrenia.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.3
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• pp.263-268
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• 2010

Purpose: Eye movements and fixation ability are an important procedure to obtain external information and essential means of clear vision. The purpose of this study was to determine the reading performance such as reading time and number of fixations when random text was viewed at varying distances. Methods: Twenty two presbyopes were participated. All subjects were screened for their suitability to participate in the study by clinical examination, and none of the participants had previously worn contact lenses and no previous experience of wearing any types of presbyopic vision correction except single vision. The reading time and number of fixations were recorded using eye tracker while each subjects was waring four vision corrections which included single vision for distance (SV), bifocal spectacle lenses (BIF), progressive addition lenses (PAL), and monovision (MV). The reading material was presented at distance and near distance. Results: Reading time and number of fixations for near stimulus were significantly different among vision correction used in this study (p<0.001). In particular, wearing SV required longer reading time and produced longer fixation duration for near text. However, reading distance text was similarity performed across vision corrections tested and there was no statistical difference found for either reading time and number of fixations. Conclusions: Wearing presbyopic vision correction is advantageous for reading task of near stimuli, but not having near correction such as wearing SV could result in longer reading time and higher number of fixation due to lacks of accommodative ability for near task. For the future studies, it would be interesting to examine the performance of reading both at adapted and unadapted stages as examining only unadapted wearers was limitation of this study.

• Korean Journal of Biological Psychiatry
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• v.6 no.1
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• pp.119-124
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• 1999

This study was done to examine whether cigarette smoking improved smooth pursuit eye movement(SPEM) abnormalities in chronic schizophrenic inpatients. Fifteen schizophrenic and twelve alcoholic subjects abstained from their usual cigarette smoking for a minimum of nine hours and their baseline performances during the constant velocity smooth pursuit tasks were assessed. Then, the subjects smoked as much as they desired in a 10 minutes period and were retested immediately after smoking and 15 minutes after smoking. Electrooculographic recordings during the eye movements were converted and saved as digitized files. Power spectral density curves and natural logarithm value of signal/noise(Ln S/N) ratios were computed from them. In the schizophrenic patients, Ln S/N ratios increased significantly immediately after smoking compared to baseline. But, Ln S/N ratios showed no statistically significant changes after 15 minutes compared to baseline. In alcoholic subjects, Ln S/N ratios showed no statistically significant changes immediately after smoking and after 15 minutes compared to baseline. In conclusion, SPEM was improved in schizophrenic patients immediately after smoking and we hypothesized that nicotinic receptor dysfunction maybe a candidate mechanism for smooth pursuit eye movement abnormalities in schizophrenia.

• Korean Journal of Biological Psychiatry
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• v.23 no.4
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• pp.148-156
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• 2016

Objectives According to previous studies, the cannabinoid receptor 1 (CNR1) gene could be an important candidate gene for schizophrenia. Some studies have linked the (AAT)n trinucleotide repeat polymorphism in CNR1 gene with the risk of schizophrenia. Meanwhile, smooth pursuit eye movement (SPEM) has been regarded as one of the most consistent endophenotypes of schizophrenia. In this study, we investigated the association between the (AAT)n trinucleotide repeats in CNR1 gene and SPEM abnormality in Korean patients with schizophrenia. Methods We measured SPEM function in 167 Korean patients with schizophrenia (84 male, 83 female) and they were divided according to SPEM function into two groups, good and poor SPEM function groups. We also investigated allele frequencies of (AAT)n repeat polymorphisms on CNR1 gene in each group. A logistic regression analysis was performed to find the association between SPEM abnormality and the number of (AAT)n trinucleotide repeats. Results The natural logarithm value of signal/noise ratio (Ln S/N ratio) of the good SPEM function group was $4.34{\pm}0.29$ and that of the poor SPEM function group was $3.21{\pm}0.70$. In total, 7 types of trinucleotide repeats were identified, each containing 7, 10, 11, 12, 13, 14, and 15 repeats, respectively. In the patients with $(AAT)7$ allele, the distributions of the good and poor SPEM function groups were 18 (11.1%) and 19 (11.0%) respectively. In the patients with $(AAT)_{10}$ allele, $(AAT)_{11}$ allele, $(AAT)_{12}$ allele, $(AAT)_{13}$ allele, $(AAT)_{14}$ allele and $(AAT)_{15}$ allele, the distributions of good and poor SPEM function groups were 13 (8.0%) and 12 (7.0%), 4 (2.5%) and 6 (3.5%), 31 (19.8%) and 35 (20.3%), 51 (31.5%) and 51 (29.7%), 36 (22.2%) and 45 (26.2%), 9 (5.6%) and 4 (2.3%) respectively. As the number of (AAT) n repeat increased, there was no aggravation of abnormality of SPEM function. Conclusions There was no significant aggravation of SPEM abnormality along with the increase of number of (AAT)n trinucleotide repeats in the CNR1 gene in Korean patients with schizophrenia.

• Korean Journal of Biological Psychiatry
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• v.25 no.4
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• pp.101-109
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• 2018

Objectives According to previous studies, the Chromogranin B (CHGB) gene could be an important candidate gene for schizophrenia which is located on chromosome 20p12.3. Some studies have linked the polymorphism in CHGB gene with the risk of schizophrenia. Meanwhile, smooth pursuit eye movement (SPEM) abnormality has been regarded as one of the most consistent endophenotype of schizophrenia. In this study, we investigated the association between the polymorphisms in CHGB gene and SPEM abnormality in Korean patients with schizophrenia. Methods We measured SPEM function in 24 Korean patients with schizophrenia (16 male, 8 female) and they were divided according to SPEM function into two groups, good and poor SPEM function groups. We also investigated genotypes of polymorphisms in CHGB gene in each group. A logistic regression analysis was performed to find the association between SPEM abnormality and the number of polymorphism. Results The natural logarithm value of signal/noise ratio (Ln S/N ratio) of good SPEM function group was $4.19{\pm}0.19$ and that of poor SPEM function group was $3.17{\pm}0.65$. In total, 15 single nucleotide polymorphisms of CHGB were identified and the genotypes were divided into C/C, C/R, and R/R. Statistical analysis revealed that two genetic variants (rs16991480, rs76791154) were associated with SPEM abnormality in schizophrenia (p = 0.004). Conclusions Despite the limitations including a small number of samples and lack of functional study, our results suggest that genetic variants of CHGB may be associated with SPEM abnormality and provide useful preliminary information for further study.nwhile, smooth pursuit eye movement (SPEM) abnormality has been regarded as one of the most consistent endophenotype of schizophrenia. In this study, we investigated the association between the polymorphisms in CHGB gene and SPEM abnormality in Korean patients with schizophrenia. MethodsZZWe measured SPEM function in 24 Korean patients with schizophrenia (16 male, 8 female) and they were divided according to SPEM function into two groups, good and poor SPEM function groups. We also investigated genotypes of polymorphisms in CHGB gene in each group. A logistic regression analysis was performed to find the association between SPEM abnormality and the number of polymorphism. ResultsZZThe natural logarithm value of signal/noise ratio (Ln S/N ratio) of good SPEM function group was $4.19{\pm}0.19$ and that of poor SPEM function group was $3.17{\pm}0.65$. In total, 15 single nucleotide polymorphisms of CHGB were identified and the genotypes were divided into C/C, C/R, and R/R. Statistical analysis revealed that two genetic variants (rs16991480, rs76791154) were associated with SPEM abnormality in schizophrenia (p = 0.004). ConclusionsZZDespite the limitations including a small number of samples and lack of functional study, our results suggest that genetic variants of CHGB may be associated with SPEM abnormality and provide useful preliminary information for further study.

• Therapeutic Science for Rehabilitation
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• v.13 no.1
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• pp.9-21
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• 2024

Objective : The purpose of this study was to confirm the characteristics and quality of a single-subject research that conducted interventions to improve activities of daily living (ADL) in stroke patients. Methods : 'Stroke,' 'activities of daily living,' and 'single-subject studies' were searched as keywords among papers published in the last 15 years between 2009 and 2023 among Research Information Sharing Service, DBpia, and e-articles. A total of nine papers were examined for the characteristics and quality before analysis. Results : The independent variables applied to improve ADL included constraint-induced therapy, mental practice for performing functional activities, virtual reality-based task training, subjective postural vertical training without visual feedback, bilateral upper limb movement, core stability training program, traditional occupational therapy and neurocognitive rehabilitation, smooth pursuit eye movement, neck muscle vibration, and occupation-based community rehabilitation. Assessment of Motor and Process Skills was the most common evaluation tool for measuring dependent variables, with four articles, and Modified Barthel Index and Canadian Occupational Performance Measure were two articles each. As a result of confirming the qualitative level of the analyzed papers, out of a total of nine studies, seven studies were at a high level, two at a moderate level, and none were at a low level. Conclusion : Various types of rehabilitation treatments have been actively applied as intervention methods to improve the daily life activities of stroke patients; the quality level of single-subject studies applying ADL interventions was reliable.