• Proceedings of the Korea Contents Association Conference
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• 2018.05a
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• pp.407-408
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• 2018

본 연구는 여성노인을 대상으로 안구운동 훈련을 적용하여 인지기능에 어떠한 영향을 미치는지 알아보고자 하였다. 대상자는 65세 이상 여성 노인 8명을 선정하였고 안구운동은 급속안구운동을 4주 동안 적용하여 사건관련 전위 중 P300을 활용하여 그 변화를 측정하였다. 그 결과 p300의 전위값은 유의하게 상승하였고, 잠복기는 유의하게 짧아졌다. 결론적으로 여성노인에게 적용한 급성안구운동은 뇌의 긍정적 변화를 나타내 인지기능 향상에 영향을 준다는 것을 알 수 있었다.

• Korean Journal of Psychosomatic Medicine
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• v.15 no.2
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• pp.73-80
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• 2007

Anumber of prior studies have reported eye movement dysfunction in patients with dementia. The eye movement test which is non-invasive can evaluate the local brain function quantitatively. Therefore, it can be a useful method for characterizing regional brain abnormalities of patients with dementia. The aim of this paper is to review the literatures on eye movement abnormalities in dementia patients. Saccade system dysfunctions in Alzheimer disease include increased latency, reduced accuracy, and increased antisaccade error rates. Patients with frontotemporal dementia showed impaired reflexive saccade inhibition and increased latency and errors of antisaccade task. And delayed initiation of voluntary saccades, slow saccades, and increased errors and latency on antisaccade task were found in Huntington's disease. Patients with Parkinson’s disease dementia and dementia with Lewy bodies have characteristics of impaired in both reflexive saccade execution and complex saccade performance. However, there were few reports of abnormal eye movements in Creutzfeldt-Jakob disease; they could be found at the later stages after symptoms of dementia came to be evident, and secondary to cerebellar and vestibular involvement. Slowing of saccades and hypometric saccades might precede the supranuclear limitation of vertical gaze in PSP. Dysfunction of voluntary eyelid movements was a characteristic finding of PSP as well. In conclusion, patients with dementia can show various abnormal eye movements and they are related with cortial and subcortical brain dysfunctions. The research on localization of brain relevant to each symptom can promise more clinical implications of eye movement of dementia.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.3
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• pp.103-109
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• 2008

Purpose: This review illustrates an importance of oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation in association with eye disease, especially of cataract, and discusses an important role of lipid peroxide as a mediator of oxidative stress-related ocular dysfunction. Methods: Oxidative stress, resulted from the cellular production of ROS and RNS, is known to cause various forms of cellular damages such as protein oxidation, DNA breaks, apoptosis, and lipid peroxidation. These damages can be developed to human diseases. Accumulating evidence strongly suggests that continuous or constant exposure of eye tissues to oxidative stress is a main cause of cataractogenesis. Therefore, we investigated the action of oxidative stress in ocular dysfunction. Results: The ocular lens is continuously attacked by ROS inevitable generated from the process of cellular metabolism and the chronic exposure to ultraviolet. Excessive generation of ROS, resulting in degradation, oxidation, crosslinking and aggregation of lens proteins, is regarded as an important factor in development of cataract. Conclusions: These oxidative stress and oxidant/antioxidant imbalance produces the excess ROS which can lead to eye dysfunction. Even though known results, it should be noted that there is limited information on the molecular mechanism which can be better defined with the interrelation of oxidative stress and optic abnormalities.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.2
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• pp.177-184
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• 2012

Purpose: In this study, the effect of the eye movement direction on visual function related to accommodation was investigated when playing computer games for a certain period of time. Methods: Total 60 subjects in 20s who had the visual acuity of 1.0 or higher without any ocular disease and accommodative dysfunction were asked to play computer games separately in horizontal and vertical directions for 40 and 90 minutes and then measured their accommodative amplitude, accommodative facility, accommodative lag and relative accommodations. Thevisual function when not doing the computer game was regarded as a control value, and further compared and analyzed. Results: The accommodative amplitude, accommodative facility, accommodative lag and relative accommodations showed the tendency of decrease after the computer game for 40 minutes, and more reduced values of the visual functions were shown when the computer game extended up to 90 minutes except positive relative accommodation. Positive relative accommodation had a tendency to increase slightly after the computer game for 90 minutes. Meanwhile, the change of the visual functions was primarily influenced by the eye movement in horizontal direction rather than by the eye movement in vertical direction during computer game when analyzed by the direction of eye movement. Conclusions: Over all accommodative functions tended to decrease with the extended VDT working time by computer game, and the frequent eye movement in horizontal direction during VDT tasks could be the main cause of eyestrain since the eye movement in horizontal direction rather than vertical direction significantly affected the change of accommodative function.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.1
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• pp.37-43
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• 2013

Purpose: The present study was conducted to investigate whether the directions of eye movement in playing computer games for certain period affected the change of near point of convergence (NPC) and fusional reserve (FR) or not. Methods: Total 40 subjects in 20s who have the visual acuity of 1.0 or higher without any ocular disease and accommodative dysfunction were asked to successively play computer games. After the subjects were moving eyes in horizontal and vertical directions for 40 and 90 minutes, their horizontal fusional reserves, vertical fusional vergence and near point of convergence were measured. Results: The near point of convergence showed a tendency to be receded after computer gaming in the horizontal and vertical directions, and both of horizontal and vertical fusional reserves were significantly reduced. The range of declined fusional reserves and receded near point of convergence after computer gaming for 90 minutes was smaller than those after computer gaming for 40 minutes. The change of binocular vision was affected by the horizontal eye movement rather than the vertical movement when analyzed by the direction of eye movement. Conclusions: This study revealed that the change in FR and NPC was different along with dominant direction of eye movement during visual display terminal (VDT) tasks. Therefore, the adjustment of VDT working time is required to prevent the dysfunction of binocular vision according to the dominant direction of eye movement during VDT task.

• Proceedings of the ESK Conference
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• 1995.04a
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• pp.145-154
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• 1995

복잡한 생산시스템 속에서 빠른 속도로 제품을 생산하기 위해서 도입된 신형 고성 능 기계류의 경우에는 검사 작업자가 제품의 결점을 검출하기가 매우 어렵다. 검사작 업을 위해서 충분한 시간이 주어진다면 정확하게 처리할 수 있겠지만, 실제로는 많은 제약이 있다. 이러한 관점에서 검출오류의 결과에 대한 중요성은 증가되고 있다. 본 연구에서는 검사작업의 개인차에서 비롯하는 작업자의 결점검출방법에 관하여 살펴보고자 한다. 이를 위해서, 먼저 피실험자를 대상으로 두가지 작업방법, 즉 기능적 검사(functional search)를 하는 작업자와 지형적 검사(topographic search)를 하는 작업자로 나누어 실험을 하였다. 또한 이들이 검사작업을 하는 동안 일어나는 안구운동(eye movements)의 몇가지 요인을 측정하여 시각검사작업에 영향을 미치는 안구운동요인을 파악하고자 한다.

• Journal of Korean Ophthalmic Optics Society
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• v.5 no.1
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• pp.139-146
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• 2000

Once refractive error of the eye was fully corrected, Maddox rod was used to investigate binocular vision function. When the deviations of subjects' eyes were measured, orthophoria. without any horizontal deviations, was found in 10%, esophoria in 55% and exophoria in 34% of the patients. Esodeviation of the eye was found to be greater than exo-deviation by 11%. This is also refracted in deviations found to be greater than $4{\Delta}$ diopter magnitude where esophoria was 23% and exophoria was 9%. Thus for the patients to achieve comfortable binocular vision function, binocular vision anomalies need to be considered in spectacle prescription. In examining ocular anomalies of corrected refractive error, the deviation of the eye differed from under corrected refractive power to over corrected refractive power. There was a decrease in exophoria and an increase in esophoria, with over correction. This was thought to be due to accommodation. Furthermore, calculated AC/A ratio was found to vary from 1.25 to 6.61 and its relationship to refractive error could not be determined.

• Journal of Biomedical Engineering Research
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• v.22 no.6
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• pp.487-496
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• 2001

In this study, a galvanic stimulator providing bipolar mode controlled by a PIC(peripheral interface controller) was constructed to evaluate vestibular function The maximum load and maximum current intensity of the constant current source were 3$k\Omega$ and 5mA. respectively. and it could Produce DC, sine wavers. or Pulse waves. Eve movements of 20 normal subjects by galvanic stimulation were analyzed using a commercial videooculogragh. During stimulating with DC for 30 sec. we recorded the response of eye movement with current intensity of 0.75. 1 2, and 3 mA. Nystagmus occurred to all the subjects when the galvanic stimulus intensity was larger than 2 mA. Average SPV(slow Phase eye movement velocity) and the number of nystagmus increased from 7.1 to 4.8 deg/sec and from 17 to 48, respectively, when the stimulus current increased from 0.75 to 3 mA. All the fast eye movement of the nystagmus were the direction of the negative electrode. The asymmetry which means the difference between right- and left-eye movements decreased when the stimulus intensity increased. It is expected that this study would be useful in evaluating vestibular function and in studying basic Physiology mechanism of vestibular ocular reflex by galvanic stimulus .

• Korean Journal of Biological Psychiatry
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• v.14 no.3
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• pp.184-193
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• 2007

Objectives:There is increasing evidence that the cerebellum plays an important role in cognition and psychiatric symptoms as well as motor coordination. The concept of cognitive dysmetria has been making cerebellar function in schizophrenia the focus of current studies. In other words, disruption in the corticocerebellum-thalamic -cortical circuit could lead to disordered cognition and clinical symptoms of schizophrenia. The purposes of this study were to determine cerebellar dysfunction in male schizophrenic patients semiquantitatively with ICARS and to investigate the clinical and cognitive correlates of ICARS in patients. Methods:We compared the scores of cerebellar neurologic sign using ICARS in 47 male patients with a DSM-IV-TR diagnosis of schizophrenia with 30 gender and age-matched healthy control subjects. The semiquantitative 100-point ICARS consists of 19 items divided into 4 unequally weighted subscores:posture and gait disturbances, kinetic functions, speech disorders and oculomotor disorders. All subjects were also assessed with cognitive function test. Cognitive functions were evaluated by Korean-Mini Mental Status Examination (K-MMSE), Verbal fluency test, and Clock drawing test. The patients were administered Korea version of Positive and Negative Symptom Scale(K-PANSS) to assess the symptom severity. Results:Schizophrenic patients had significantly higher scores on the ICARS than control subjects with posture and gait disturbances, kinetic functions, and oculomotor disorders. They also showed more significant impairments in cognitive function tests than control subjects. There was a significant correlation between ICARS and negative symptoms of patients. In cognitive function test, Clock drawing test was significantly associated with negative symptoms. In addition, Clock drawing test was negatively correlated with the total score of ICARS. Conclusion:In this study, we confirmed that schizophrenic patients have significant impairments in cognitive and cerebellar function, and that those were related with negative symptoms of schizophrenic patients. These results support a role of the cerebellum in schizophrenia. It is meaningful that we used a structured, and reliable procedure for rating neurological soft signs, ICARS. We hope that future prospective studies using a similar design help that rate of neurological sign should have been visible with the progression of illness.

• Journal of the korean academy of Pediatric Dentistry
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• v.39 no.2
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• pp.161-165
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• 2012

Lowe syndrome, also known as oculocerebrorenal syndrome, is a rare genetic disorder involving eyes, kidney, brain and musculoskeletal system, and occurs predominantly in males. The patient with Lowe syndrome is characterized with congenital cataracts, glaucoma, prominent forehead, thin and sparse hair, mental and growth retardation, muscular hypotonia, renal dysfunction, and metabolic bone disease. We have experienced a 10-year-old boy with Lowe syndrome who had poor oral hygiene and trouble for teeth brushing. To manage his behavior and systemic metabolic disorder, sedation was performed during dental care. Excessive calculus formation in this patient is caused by both medication and lack of ability to maintain oral hygiene. The dental management of those patients has to be focused on prevention due to difficulties in dental treatment and dangers of general anesthesia for the Lowe syndrome.