• Annals of Clinical Neurophysiology
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• v.4 no.1
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• pp.63-66
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• 2002

Blepharospasm and apraxia of lid opening(ALO) are non-paralytic causes of involuntary eyelid closure. Clinically it is difficult to differentiate blepharospasm and ALO, and these two conditions are sometimes associated. We report a case of pretarsal blepharospasm presenting as apraxia of lid opening. 55-year-old woman was noted to have voluntary eye opening difficulty. We synchronously record the electromyographic(EMG) from the levator palpebrae superioris and the orbicularis oculi muscles in this patient. This results suggested that she has a variant of blepharospasm due to abnormal contraction in the pretarsal orbicularis oculi.

• Korean Journal of Head & Neck Oncology
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• v.32 no.2
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• pp.61-64
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• 2016

There are various types of malignancy in eyelid, such as squamous cell carcinoma, melanoma, and sarcoma. These malignant tumors have potential of metastasis by regional lymph node drainage. The lymph node around parotid gland has been known as a common site of regional lymph node metastasis. The rarity of malignant tumors in the periorbital area makes it difficult to determine the optimal extent of treatment. We report a case of parotid metastasis after eyelid cancer operation in a 60-year-old man.

• Development and Reproduction
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• v.14 no.2
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• pp.91-97
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• 2010

FOXL2 is a winged-helix/forkhead (FH) domain transcription factor, and mutations in FOXL2 gene are responsible for blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). BPES is an autosomal dominant genetic disease. BPES type I patients exhibit both premature ovarian failure (POF) and eyelid malformation, while only the eyelid defect is observed in BPES type II. FOXL2-null ovaries showed a blockage of granulosa cell differentiation, suggesting that FOXL2 plays an essential role for proper ovarian folliculogenesis. Previously, we screened for FOXL2-interacting proteins and identified steroidogenic factor-1 (SF-1) which is known to be required for gonad development and transactivates steroidogenic enzymes including CYP19. In the present study, we demonstrated that FOXL2 transactivates CYP19 and stimulated the transcriptional activation of CYP19 induced by SF-1. In contrast, FOXL2 mutants found in BPES type I and II exhibited compromised abilities to enhance CYP19 induction mediated by SF-1. Thus, this study provides a functional difference between wild-type FOXL2 and its mutants which may aid to understand pathophysiology of BPES elicited by FOXL2 mutations.

• Journal of Veterinary Clinics
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• v.21 no.1
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• pp.76-79
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• 2004

A five-day old female Thoroughbred foal appealed mild edema and pain of a lower eyelid on left eye. She was diagnosed with a typical entropion which clinical signs were inward rolling of the eyelid edge and excess lacrimation. Modified Hotz-Celsus technique that resect and suture only skin was operated. Result was very successful without recurrence of entropion and other complications. We conclude this method is of value for permanent correction of severe entropion in young foals.

• Journal of Veterinary Clinics
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• v.14 no.2
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• pp.365-369
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• 1997

A ten-year-old holstein cow was presented because of prolapse of the third eyelid and apparent hyperplasia of the right lower eyelid. Historical findings included increased appetite as well as polyuria and polydipsia for about two weeks. The most remarkable fadings on physical examination were a large periocular proliferative tissue and bleeding. Surgical incision was used both as a biopsy and therapeutic tool in holstein cow with mass. Histopathological examination of the mass revealed squamous cell carcinoma. Blood and milk tests of patient with squamous cell carcinomatosis were peformed, but normal values.

• Journal of Veterinary Clinics
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• v.31 no.4
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• pp.319-321
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• 2014

A 12-year-old mixed breed male dog was referred to Chonbuk National University Animal Medical Center with unilateral left epiphora. Magnified ophthalmic examination revealed a very small tissue mass on the palpebral conjunctiva of the left eye. The mass was surgically removed and microscopic examination confirmed moderate papillary hyperplasia of the squamous epithelium without viral cytopathic effects. Based on the histology, the mass was diagnosed as a non-viral squamous papilloma. After removal of the mass, the epiphora was completely solved. This case report describes the non-viral squamous papilloma arising from the conjunctiva in a dog with epiphora.

• Journal of Veterinary Clinics
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• v.32 no.1
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• pp.105-107
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• 2015

A 4-year-old Thoroughbred gelding was referred to Chonbuk National University Animal Medical Center with inability to blink and drooping lower lip on the right side after traumatic accident. Through clinical examination, the horse was diagnosed as right-sided facial nerve paralysis. Acupuncture treatment was performed to treat the facial nerve paralysis. The selected acupoints were ST3, ST5, ST7, ST9, SI17, CV24 and Yintang. At the end of the $2^{nd}$ weeks of electroacupuncture treatment, the palpebral reflex was normally recovered. One month after the therapy, symmetry of the face was completely accomplished without the drooping lower lip. This case shows that electroacupuncture should be considered as an effective therapy for the traumatic facial nerve paralysis in horse.

• Archives of Plastic Surgery
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• v.35 no.4
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• pp.471-479
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• 2008

Purpose: Sunken eyelid is a deformity of upper eyelid due to atrophy of periocular fat tissue, loss of skin elasticity. It causes the skin retraction of eyelid and unfavorable fold. Sunken eyelid occurs from the results of natural aging process, facial trauma, complication of previous periocular surgery, etc. We acquired a satisfied correction of sunken eyelid and unfavorable fold using autologous fat injection only. The aim of this study is a assessment of autologous fat injection for correction of sunken eyelid accompanied with unfavorable fold. Methods: From August 2002 to March 2006, we performed 37 cases of correction of sunken eyelid with unfavorable fold using autologous fat injection. They were all females with ages ranged from 23 to 63. Fat was harvested from lower abdomen and centrifuged with Coleman system. Multi-layered injection of purified fat was done from orbital fat layer to orbicularis oculi muscle. Results: Overall, improvement of sunken eye and unfavorable fold was observed in the majority of the patients. Discomfort of eye opening was improved in 24 patients. The average injection volume was 1.33 mL in right eyelid, 1.31 mL in left eyelid at first injection. Second injection was done in patients who absorption of injected fat was noted with. No specific complications were observed. Conclusion: Natural and attractive upper eyelid was acquired from fat injection only in sunken eyelid with unfavorable fold. To the authors' knowledge, it is desirable for sunken eyelid accompanied with unfavorable fold to be treated with autologous fat injection at first. Although some shortcomings are substantial, autologous fat injection is easy and effective method for correction of unfavorable fold in sunken eyelid without specific complication.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.17 no.3
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• pp.103-108
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• 2017

Kabuki syndrome is a rare congenital disorder that causes multiple birth defects and mental retardation. Mutation of the lysine methyltransferase 2D (KMT2D) gene is the primary cause of Kabuki syndrome. We report a 4-year-old Korean girl diagnosed with Kabuki syndrome based on distinctive facial features (eversion of the lower lateral eyelid, arched eyebrows, depressed nasal tip, prominent ears), skeletal anomalies, short stature, and molecular analysis, which revealed a novel frameshift mutation in the KMT2D gene. A 4-year-old patient had a past history of congenital cardiac malformations (coarctation of the aorta, ventricular septal defect, atrial septal defect, patent ductus arteriosus), subclinical hypothyroidism and dysmorphic features at birth including webbed neck, short fingers, high arched palate, micrognathia and horseshoe kidney. She showed unique facial features such as a long palpebral fissure, long eyelashes, arched eyebrows with sparseness of the lateral third, broad nasal root, anteverted ears, and small mouth. Her facial features suggested Kabuki syndrome, and genetic analysis discovered a novel heterozygous frameshift mutation (c.4379dup, p.Leu1461Thrfs*30) in exon 15 of the KMT2D gene. The diagnosis of our 4-year-old patient was made through thorough physical examination and history taking, and genetic testing. It is challenging to diagnose patients with Kabuki syndrome at birth, since the characteristic facial features are expressed gradually during growth. Clinical suspicion aroused by regular follow-ups may lead to earlier diagnosis and interventions.

• Journal of Veterinary Clinics
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• v.16 no.1
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• pp.189-192
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• 1999

Tarsorrhaphy is widely used to protect the cornea, reduce evaporation of tears, and facilitate reepithelialization of the ocular surface. However, a dilemma ensues in patients when frequent neurological evaluations and postoperative examinations are needed. The modified temporary tarsorrhaphy in this study was simple to perform, provided stable eyelid closure, and could be opened and closed as needed. It could be easily reversed with minimal complications of the eyelid and it allowed the surgeon to control traction of the bolsters in all of 45 dogs with corneal epithelial defects. Also, The globe could be examined without further anesthesia, sutures, and pain at any time after surgery. It was concluded that this modified method might be effective for evaluation of the corneal healing process and useful for ocular surface reconstruction clinically.