• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.2
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• pp.223-237
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• 2009

본 임상연구는 임상연구 모집 공고를 통하여 모집된 대상자 중 Atopic Dermatitis Research Group (2005) 한국인 아토피 피부염 진단기준에 따라 아토피 피부염으로 판정되고 현재 약물(한약, 양약)치료나 외용제 치료를 하고 있지 않은 만 5$\sim$50세의 아토피 피부염 환자를 대상으로 하였다. 피험자들을 이중맹검, 블록무작위배정하여 시험군과 대조군으로 나누어 6주간의 시험기간 동안 육안적 평가, 혈액학적 검사, 피부측정 장비를 통한 기기적 평가를 시험 전후에 실시하여, 시험군에 사용된 제품이 대조군 사용된 제품에 비하여 얼마나 효과적으로 아토피 피부염으로 손상된 피부 장벽을 회복하는지 관찰하였다. 본 임상시험을 통해 'Atomento solution & cream'이 손상된 피부장벽을 회복시키고 피부 보습력을 증가시켜 아토피 피부염에 효과적이었으며, 인체에 이상반응이나 부작용 없이 안전하게 사용될 수 있음을 확인하였다.

• 건강소식
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• v.35 no.4
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• pp.30-31
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• 2011

살랑살랑 불어오는 봄바람은 아토피 피부염에는 가장 큰 적이다. 소아기의 아토피 피부염은 손이나 발목이 접히는 부위의 피부가 건조하고 두꺼워지는 것으로 나타나다. 그리고 눈주위의 홍반, 귀 주위의 피부 균열, 손이나 발의 습진도 흔하게 생긴다.

• Prospectives of Industrial Chemistry
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• v.22 no.1
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• pp.3-11
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• 2019

최근 화장품 산업은 제약사들을 중심으로 기업들이 보유한 바이오 및 의약 기술을 접목하여 기능성 화장품 개발에 주목하고 있다. 화장품과 의약품의 경계가 무너지고 코스메슈티컬이 화장품 산업의 블루오션 시장으로 각광받고 있다. 특히 현대병으로 알려진 고질적 피부질환 아토피성 피부 인구가 늘면서 아토피 기능성 스킨케어 시장이 급부상하고 있다. 98년부터 시작된 아토피 관련 시장은 국내 약국 아토피성 화장품 시장 100억 원을 포함해 현재 700억원대로 급성장하고 있어 앞으로 확고한 수익 시장으로 자리잡을 것이라 전망되고 있다. 현 사회에서 심각한 문제로 인식되는 아토피 피부를 치료할 수 있는 다양한 화장품 제품들이 급증하고 있으므로, 본 기획에서는 아토피 화장품 시장의 현황, 동향 및 전망을 분석하여 살펴보고자 한다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.32 no.2 s.57
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• pp.93-97
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• 2006

Staphylococcus aureus is found on the skin of $78{\sim}100%$ of children and adults with atopic dermatitis (AD) but only on the skin of $2{\sim}25%$ of healthy subjects. It is known that S. aureus and their endotoxins as superantigen have important roles in the exacerbation and prolongation of AD. This study was carried out for the detection of S. aureus in the skin of AD, age, sex, outbreak age of AD, treatment duration, aggravation season, and the relation of ooze and S. aureus. Most patients (84%) with AD show colonization of the skin with S. aureus and there is a correlation between the degree of colonization and the serous exudate. It seems likely that the inhibition of S. aureus is associated with improvement in the skin of AD patients.

• Journal of the Korea Convergence Society
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• v.7 no.4
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• pp.67-73
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• 2016

The purpose of this study was to examine the effects of Lespedeza Caneata (LC) extracts on atopic dermatitis. For the experiment, mice were divided into a normal group, an AD group, and AD-LC groups (100 mg/Kg, 300 mg/Kg, and 500 mg/Kg). For the AD and AD-LC groups, 1% DNCB $200{\mu}{\ell}$ was applied at a hair-removed site for 2 weeks, and then 0.1% DNCB $150{\mu}{\ell}$ was applied every 2 days for 4 weeks. Skin thickness is a symptom of atopic dermatitis, and in this experiment, the AD group had the thickest skins, and the AD-LC group (500 mg/Kg) had the same skin thickness as the normal group. Mast cells show inflammatory reaction, and in this experiment, the AD group had the largest number of mast cells. Collagen fibers are usually observed on normal skins, and in this experiment, the AD-LC group (500 mg/Kg) had a uniform level of those fibers. Based on the study results, it turned out that LC extracts have the anti-atopic efficacy improving keratinization, erosion, and uredo.

• 건강소식
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• v.29 no.12 s.325
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• pp.24-25
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• 2005

아토피 피부염이란? '아토피'란 말은 어원상 이상한 반응이라는 뜻을 가지고 있다. 아토피 피부염은 얼굴, 팔이 접히는 부위, 무릎 뒤 부위에 흔히 발생하는 습진성 질병이다. 대체로 전신의 피부가 건조하고 거칠게 느껴지며 심한 가려움증을 동반한다. 처음 발생하는 연령은 90% 이상이 2세 이하지만 최근 들어 정신적 스트레스의 영향인 듯 성인에게서도 나타나고 있다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.4
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• pp.361-369
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• 2020

Atopic dermatitis (AD) is a common and multifactorial inflammatory skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. AD has a complex etiology that includes genetic, immunological, and environmental factors that cause skin barrier abnormalities and immune dysfunctions. Sophora flavescens (SF) has been used in traditional Chinese medicine, but little research has been conducted on its anti-AD efficacy. In this study, we evaluated the effect of SF extract (SFE) on improving skin barrier function and immune abnormalities, which are the main symptoms of AD. SFE has the capacity to enhance the formation of cornified envelope (CE) that plays an important role in the skin barrier function. In addition, it was confirmed that SFE increased the expression of hyaluronic acid related to skin moisture. The effect of SFE against Staphylococcus aureus (S. aureus), which increases specifically in AD lesions, confirmed that SFE inhibited the production of pro-inflammatory cytokines induced by S. aureus. Furthermore, SFE was shown to inhibit the expression of pro-inflammatory cytokines induced by substance P (SP), the cause of skin neurogenic inflammation. These results demonstrate that SFE could be one of potential candidate agent for the treatment of AD by improving the skin barrier function and immune responses.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2009.05a
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• pp.201-204
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• 2009

미용 향장분야에서 많이 사용되고 있고, 소염작용, 진통효과, 면역증진작용, 강장작용이 있다고 알려진 저먼 카모마일, 라벤더, 샌달우드, 호호바 등의 혼합 아로마 오일을 NC/Nga 생쥐의 피부에 도포하여 생쥐의 피부조직내 염증세포와 mast cell 의 변화를 파악하여 아토피 피부염에 대한 효과를 검증하였다. 그 결과 아로마 혼합오일인 CLS 가 아토피 피부염의 주증상인 표피세포의 각질화와 mast cell의 감소에 영향을 주어 아토피 피부염에 효과가 있을 것으로 사료된다.

• Korean Journal of Clinical Laboratory Science
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• v.49 no.4
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• pp.395-400
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• 2017

Atopic dermatitis is a chronic inflammatory skin disease caused by a variety of genetic and environmental factors, dysregulation of immunological response, as well as dysfunction of the skin barrier proteins. The purpose of this study is to develop an ELISA kit suitable for evaluating the expression of skin barrier proteins. Proteins were obtained from the skin via AriNo and D-Squame patches. The efficiency of protein collection from the skin, using the Arino patch, was shown to be more effective than using D-Squame; while the efficiency of lysis using 0.1% Triton-X100 was higher than that of other lysis solutions, including 0.1 M Tris-HCL, 0.1% Tween-20, and 5 mM KOH. Recombinant skin barrier proteins, such as filaggrin and involucrin, were produced by molecular biological methods. Monoclonal antibodies against filaggrin and involucrin were produced by immunization of mice, fusion of spleen cells and myeloma cells, as well as a selection of antibody-producing hybridoma cells. The filaggrin expression in the skin of subjects suffering from atopic dermatitis was lower than that in normal mice. Involucrin expression was not altered between normal individuals and subjects with atopic dermatitis. These findings contribute to an elucidation of the importance of the skin barrier protein expression in atopic dermatitis and the development of a diagnostic kit for atopic dermatitis.

• Applied Chemistry for Engineering
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• v.22 no.1
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• pp.91-97
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• 2011

The efficacies of anti-atopic preparations were investigated in hairless mice suffering from 2,4-dinitro-chlorobenzene (DNCB)-induced atopic dermatitis-like lesion. Solid lipid nanoparticle (SLN) containing ceramide and astaxanthin was prepared by a melt-homogenization method using Aminsoft-CT 12 (Cocoyl glutamate) as an emulsifier. And then, the SLNs were coated with silk fibroin (SF) by taking advantage of an electrostatic interaction between the surface of SLNs and SF. SLNs were included in lotion (FL) and cream (FC) types of preparations. Anti-atopic efficacies of the preparations were investigated in terms of appearance of skin surface, spleen index, serum IgE level, and serum cytokine level. SLN-containing preparations suppressed IgE production and IL-4 expression, but promoted $IFN-{\gamma}$ expression.