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http://dx.doi.org/10.14478/ace.2011.22.1.091

The Effect of Anti-atopic Cosmetic in Hairless Mice  

Kwon, Taek Kwan (Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University)
Lim, Kun Bin (FineCo Ltd., Bio Venture Plaza)
Kim, Jin-Chul (Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Applied Chemistry for Engineering / v.22, no.1, 2011 , pp. 91-97 More about this Journal
Abstract
The efficacies of anti-atopic preparations were investigated in hairless mice suffering from 2,4-dinitro-chlorobenzene (DNCB)-induced atopic dermatitis-like lesion. Solid lipid nanoparticle (SLN) containing ceramide and astaxanthin was prepared by a melt-homogenization method using Aminsoft-CT 12 (Cocoyl glutamate) as an emulsifier. And then, the SLNs were coated with silk fibroin (SF) by taking advantage of an electrostatic interaction between the surface of SLNs and SF. SLNs were included in lotion (FL) and cream (FC) types of preparations. Anti-atopic efficacies of the preparations were investigated in terms of appearance of skin surface, spleen index, serum IgE level, and serum cytokine level. SLN-containing preparations suppressed IgE production and IL-4 expression, but promoted $IFN-{\gamma}$ expression.
Keywords
ceramide; astaxanthin; atopic dermatitis (AD); immunoglobulin E; cytokine;
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1 K. D. Cooper, J. Invest. Dermatol., 102, 128 (1994).   DOI   ScienceOn
2 N. A. Soter, Allergy, 44, 16 (1989).   DOI
3 M. Uehara, R. Izukura, and T. Sawai, Clin. Exp. Dermatol., 15, 264 (1990).   DOI
4 Y. M. Donald and M. Leung, J. Allergy Clin. Immunol., 105, 860 (2000).   DOI   ScienceOn
5 X.-F. Qi, D.-H. Kim, Y.-S. Yoon, J.-H. Li, D. Jin, Y.-K. Deung, and K. J. Lee, J. Ethnopharmacol., 123, 195 (2009).   DOI   ScienceOn
6 L. K. Poulsen, C. M. Reimert, C. Bindslev-Jensen, M. B. Hansen, and K. Bendtzen, Int. Arch. Allergy Immunol., 106, 55 (1995).   DOI   ScienceOn
7 J. Y. Ahn, L. R. Im, J. H. Kim, J. H. Park, D. K. Kim, and Y. M. Lee, Kor. J. Pharmacogn., 40, 218 (2009).
8 Y. A. Hannun and L. M. Obeid, Trends Biochem. Sci., 20, 73 (1995).   DOI   ScienceOn
9 S. L. Chamlin, J. Kao, I. J. Frieden, M. Y. Sheu, A. J. Fowler, J. W. Fluhr, M. L. Williams, and P. M. Elias, J. Am. Acad. Dermatol., 47, 198 (2002).   DOI   ScienceOn
10 M. A. Linan-Cabello, J. Paniagua-Michel, and P. M. Hopkins, Aquac. Nutr., 8, 299 (2002).   DOI   ScienceOn
11 Y. M. A. Naguib, J. Agric. Food Chem., 48, 1150 (2000).   DOI   ScienceOn
12 S. Sakai, T. Sugawara, K. Matsubara, and T. Hirata, J. Biol. Chem., 284, 28172 (2009).   DOI   ScienceOn
13 M. J. Kang, J. Y. Eum, M. S. Jeong, S. E. Choi, S. H. Park, H. I. Cho, C. S. Cho, S. J. Seo, M. W. Lee, and Y. W. Choi, Biol. Pharm. Bull., 33, 10 (2010).
14 S. M. Cho, H. Y. Lee, and J.-C. Kim, J. Am. Oil. Chem., 84, 859 (2007).   DOI   ScienceOn
15 S. Haug, A. Roll, P. Schmid-Grendelmeier, P. Johansen, B. Wuthrich, T. M. Kundig, and G. Senti, Curr. Probl. Dermatol., 33, 144 (2006).
16 K. Matsumoto, K. Mizukoshi, M. Oyobikawa, H. Ohshima, Y. Sakai, and H. Tagami, Skin Res. Technol., 11, 209 (2005).   DOI   ScienceOn
17 D. W. Kim, J. Y. Park, G. Y. Na, S. J. Lee, and W. J. Lee, Int. J. Dermatol., 45, 698 (2006).   DOI   ScienceOn
18 M. Loden, H. Olsson, T. Axell, and Y. W. Linde, Br. J. Dermatol., 126, 137 (2006).
19 T. Agner, Contact Dermatitis, 25, 108 (2006).
20 H. Jyonouchi, S. Sun, Y. Tomita, and M. D. Gross, J. Nutr., 125, 2483 (1995).
21 C. Walker, M. K. Kagi, P. Ingold, P. Braun, K. Blaser, C. A. F. M. Bruijnzeel-Koomen, and B. Wuthrich, Exp. Allergy, 23, 145 (2006).