• Title/Summary/Keyword: 실패양상

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Breast Conservation Therapy Versus Mastectomy - Preliminary Results of Pattern of Failure and Survival Rate in Early Breast Cancer (조기유방암에서 유방보존치료와 유방전절제술의 치료결과 및 실패양상 비교)

  • Kim Yeon-Sil;Yoon Sei-Chul;Chung Su-Mi;Ryu Mi-Ryeong;Jung Sang-Sul;Choi Ihl-Bohng
    • Radiation Oncology Journal
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    • v.22 no.2
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    • pp.115-123
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    • 2004
  • Purpose : This retrospective study was conducted to compare early preliminary results of breast conservation therapy (BCT) with mastectomy In early breast cancer. Materials and Methods : We evaluated 171 women with AJCC stage I and II breast cancer who had been treated at Kangnam St. Mary's Hospital from March 1989 to August 1996. Eighty-eight patients underwent mastectomy and 85 patients did conservative surgery with breast irradiation. in the BCT group, all patients received whole breast irradiation to a total dose of 45$\~$50 Gy/5$\~$6 wks, followed by a boost to the original tumor site at least 60 Gy. Chemotherapy was administered to 29 (34.1$\%$) patients in BCT and 40 (45.5$\%$) in mastectomy, with various sequencing of surgery and/or radiation. We compared survival rate, patterns of failure in each treatment group and the prognostic factors that had a significant effect on treatment failure. The median follow-up time was 63 months (19$\~$111 months). Log rank test was used to estimate the prognostic factors for treatment failure. Results : Overall survival, disease free survival, locoregional recurrence and distant metastasis rates were not significantly different between the two treatment groups. During the follow-up period, 11 patients (12.5$\%$)in the mastectomy group and 10 patients (11.8%$\%$ in the BCT group were failed. Six local recurrences occurred after mastectomy and 5 after BCT Five patients fatted at distant site in mastectomy and 4 in BCT. Of the local recurrence cases, five of 6 mastectomy patients and 3 of S BCT patients were alive with no evidence of disease after salvage surgery and/or chemoirradiation. Our results indicated that the major influence on survival was distant metastasis. Unfortunately, control of distant metastasisis was not frequently achieved. Even with salvage systemic therapy or radiotherapy, most of distant metastasis patients died or had uncontrolled disease in both treatment groups: only one of 4 BCT patients and none of mastectomy patients were alive without disease. There was no apparent difference in the incidence rate of contralateral breast cancer and non-breast 2$^{nd}$ primary tumor between the two treatment groups. Univariate Log-rank test identified the N stage and the involved axillary LN number as distinct prognostic factors that were highly predictive of treatment failure in both treatment groups. Additionally, marginal status in BCT and histologic nuclear grade In the mastectomy group were risk factors for treatment fallure (p < 0.05). Concousion : Although further careful follow-up is necessary to confirm the trends evident In this serles, it would appear that patterns of failure and survival rate following conservative surgery and radiotherapy in early breast cancer are similar to those following mastectomy. The great majority of patients with local recurrence had an exellent salvage rate in both treatment groups. Therefore, these preliminary short term results support BCT as an equally effective management for early breast cancer as an alternative to mastectomy.

Analysis of Treatment Failure after Curative Radiotherapy in Uterine Cervical Carcinoma (자궁경부암에 있어서 방사선치료 후의 치료실패 분석)

  • Chai, Gyu-Young;Kang, Ki-Mun;Lee, Jong-Hak
    • Radiation Oncology Journal
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    • v.19 no.3
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    • pp.224-229
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    • 2001
  • Purpose : The aim of this study is to analyze the treatment failure patterns and the risk factors for locoregional or distant failure of uterine cervical carcinoma treated with radiation therapy. Materials and methods . A retrospective analysis was undertaken of 154 patients treated with curative radiation therapy in Gyeongsang National University Hospital from April 1989 through December 1997. According to FIGO classification, 12 patients were stage IB, 24 were IIA, 98 were IIB, 1 were IIIA, 17 were IIIB, 2 were IVA. Results : Overall treatment failure rate was $42.1\%$ (65/154), and that of complete responder was $31.5\%$ (41/130). Among 65 failures, 25 failed locoregionally, another 25 failed distantly, and 15 failed locoregionally and distantly. Multivariate analysis confirmed tumor size (>4 cm) as risk factor for locoregional failure, and tumor size (>4 cm), pelvic lymph node involvement as risk factors for distant failure. Conclusion : On the basis of results of our study and recent published data of prospective randomized study for locally advanced uterine cervical carcinoma, we concluded that uterine cervical carcinoma with size more than 4 cm or pelvic lymph node involvement should be treated with concurrent chemoradiation.

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A Study on Vibration Characteristics for Misfiring Condition of Large Marine Diesel Engines using Accelerometer Signal (가속도 신호를 이용한 대형 선박용 디젤엔진의 착화실패 상태에 대한 진동 특성 연구)

  • Seo, Jong-Cheol;Kim, Sang-Hwan;Kim, Jung-Sung;Lee, Don-Chool
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2010.05a
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    • pp.578-579
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    • 2010
  • 최근 내연 기관에서 엔진상태 및 잠재적인 결함의 발견을 위해 연료분사, 실린더 내 연소과정, 실린더 내부와 피스톤 마모상태, 흡 배기 밸브 및 과급기 (turbocharger) 등의 상태 모니터링을 통해서 결함에 대한 진단 및 경향관리에 대한 연구들이 진행되고 있다. 본 연구에서는 기 개발된 선박용 대형디젤엔진에 대한 상시 모니터링 시스템을 이용하여 엔진상태 및 잠재적인 결함을 진단하고자 하였으며, 일차적으로 가속도 신호를 이용하여 실린더 내 연소과정에서 정상적인 상태와 착화실패에 따른 진동 양상을 비교 분석하였다. 신호 분석 기법으로 시간-주파수 분산 기법들은 충격파 신호인 엔진 폭발신호를 분석하는데 적합하였으며, 그 기법들 중 Short Time Fourier Transform 기법과 Wavelet Transform 기법을 이용하였다.

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Repetition and Inertia of Policy Failure -Focusing on the Case of Yangyang International Airport (정책실패의 반복과 관성에 관한 연구: 양양국제공항 사례를 중심으로)

  • Heo, Hyeok;Choi, Seonmi
    • The Journal of the Korea Contents Association
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    • v.18 no.12
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    • pp.456-467
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    • 2018
  • This study analyzed the repeated causes of policy failure focusing on Yangyang International Airport cases. Yangyang International Airport, which opened in 2002, was built with about 360 billion won, but it is considered as a representative example of policy failure of local airports. According to the policy failure theory, the failure factors of Yangyang International Airport are anlyzed by rationalistic, political, and environmental complexity viewpoint. The results are as follows. First, from a rationalist point of view, Yangyang Airport failed to achieve the policy goal of securing passengers and revitalizing local economy, This is due to the pressure of politics and the lack of geographical infrastructure. Second, the failure of the stakeholders to resolve conflicts in the flow of politics can be seen as the conflict between the airline and the airport, and the failure to reconcile conflicts between the government and the airports on the low cost airline permits and subsidies. Third, from the viewpoint of environmental complexity, Yangyang International Airport can be regarded as a failure to adapt to environmental changes such as the opening of nearby expressways and railway lines, and the sharp decline of Chinese tourists. This study sugeests the establishment of an independent organization that can prevent unreasonable business promotion by politics in the case of large scale national projects, the linkage with the surrounding infrastructure and related businesses in the case of transportation facilities such as airports and railways, and institutionalization of cooperative governance for coordinating conflict among stakeholders.

A Study on Aspects of Reproduction of Contents Archetype (콘텐츠의 원형 재현의 양상 연구)

  • Lee, Jae Hong
    • Journal of Korea Game Society
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    • v.16 no.1
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    • pp.73-82
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    • 2016
  • With a rapid development of smart devices, the consumption of digital media contents has become much faster. As a result, there has been a rising demand for diverse stories, and cultural archetypes have been reproduced to crate these stories. An archetype is an act inherent in collective unconsciousness. Since it is a prototype stemming from imagination and experiences, the distortion or deterioration of the archetype could even threaten the identity of national tradition. This study analyzed western contents which have been successful and domestic ones that have failed in the reproduction of their archetype, investigated aspects in the reproduction of cultural archetypes and reviewed future storytelling methodology.

Yagisawa on Peacocke and van Inwagen

  • Kim, Seahwa
    • Korean Journal of Logic
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    • v.16 no.1
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    • pp.45-59
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    • 2013
  • In his book Worlds and Individuals: Possible and Otherwise, Takashi Yagisawa Yagisawa argues that his own theory is better than Lewis's theory by showing that his own theory can deal with important objections to modal realism more successfully than Lewis's. In particular, Yagisawa claims that by adopting modal tenses, he can respond to many important objections to modal realism in a uniform way. In this paper, I argue that Lewis can also successfully respond to Peacocke's objection in an exactly parallel way to Yagisawa's by distinguishing existence at the actual world from existence at other possible worlds and that Yagisawa's response to van Inwagen's objection does not succeed. I conclude that Yagisawa fails to show that his own theory is better than Lewis's.

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