• Journal of Korean Medical classics
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• v.18 no.3 s.30
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• pp.17-26
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• 2005

음양오행설시한의학적기본원리(陰陽五行說是韓醫學的基本原理). 오행포괄목(五行包括木), 화(火), 토(土), 금(金), 수(水), 기상호간구유상생여상극적관계(其相互間具有相生與相克的關係), 인기유불급이보지(因其有不及而補之), 태과이억지적작용(太過而抑之的作用), 고상능유지평형(故常能維持平衡), 인체의차원리(人體依此原理), 역능불급이보지(亦能不及而補之), 태과이억지(太過而抑之). 재차문중주요연구(在此文中主要硏究), 화과성시유수래억제이조절평형적원리(火過盛時由水來抑制而調節平衡的原理). 오행중수배속어신(五行中水配屬於腎), 신주전신지수액(腎主全身之水液). 이신지수액(而腎之水液), 우분화위오종부동형태적오액(又分化爲五種不同形態的五液), 분별배속어오장(分別配屬於五臟). 인차(因此), 연구신수분화위부동형태지오액적과정화분별배속어오장적원리(硏究腎水分化爲不同形態之五液的過程和分別配屬於五臟的原理), 기능설명해제인체중과성적열이유지평형적도리(旣能說明解除人體中過盛的熱而維持平衡的道理).

• Proceedings of the Membrane Society of Korea Conference
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• 1999.10b
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• pp.23-26
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• 1999

• The Journal of Engineering Geology
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• v.3 no.3
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• pp.241-252
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• 1993

Lead bas been found in the groundwater in Door County, Wiscorsin, with temporally and spatially irregular distribution in concentration. Correlation coeffidents were calculated among lead indicators in groundwater(frequency of lead detections, mean and maximum concentration of lead detections) and seven independent variables(stucture and geographic factors of wells, hydrogeological factors at lead-arsenate mixing sites and the level of soil contamination) which are possibly related to the lead level in groundwater. The significance of relationships was determined statistically by a t-test at the 90% confidence level, and indicated that the spatially located lead-arsenate mixing sites provided the lead in groundwater in the study area. A total of 112 groundwater samples were collected from 5 house wells with previous lead detects. Lead was detected in partides on ifiter papers with $0.45{\;}\mu\textrm{m}$ pore size, but not in filtrates. The result of chemical analysis for lead indicates that lead is associated with partides in groundwater in Door County. Subsequently, the irregular distribution of lead in the county results from the transport of particulate lead along the advective groundwater movement through the preferential pathways sucn as vertical and bedding-plane joints.

• Childhood Kidney Diseases
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• v.2 no.2
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• pp.178-182
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• 1998

Purpose : The conventional Whitaker test assesses the renal pelvic pressure response to a constant infusion rate of 10 mL/min in adult and 5 mL/min in children. We evaluated whether the infusion rate,5 mL/min is appropriate during Whitaker test in children. Materials and Methods : The study included 3 children with unilateral hydronephrosis, whose diuretic renography results were equivocal to define the presence of urinary obstruction. The kidneys were perfused at increasing flow rates from lmL/min. Results : There were intrapelvic pressure increases $26\;cmH_2O$ at 3 mL/min, $50\;cmH_2O$ at 2 mL/min and $80\;cmH_2O$ at 3 mL/min infusion rate, respectively. There was no need to increase the infusion rate over 4 mL/min to get a positive Whitaker test. Conclusion : Our experience with Whitaker test at variable low flow rates (1-5 mL/min) confirmed its usefulness in differentiating obstructive from nonobstructive uropathy. We recommend the increasing infusion rate from 1 mL/min during Whitaker test in children.

• Clinical and Experimental Pediatrics
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• v.51 no.8
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• pp.879-885
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• 2008

Purpose : The human lung fibroblast may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, which are important in airway remodeling. Vascular endothelial growth factor (VEGF) induces mucosal edema and angiogenesis. Thymus and activation regulated chemokine (TARC) induces selective migration of T helper 2 cells. We investigated whether human lung fibroblasts produced VEGF and TARC, and the effects were augmented with the co-culture of fibroblasts and human bronchial smooth muscle cells (HBSMC), and whether dexamethasone can inhibit the proliferation and the release of VEGF in lung fibroblasts. Methods : Human lung fibroblasts were cultured with and without HBSMC, growth-arrested in serum-deprived medium, and pretreated with dexamethasone for 16 hours. After 24-hour stimulation with platelet derived growth factor-BB (PDGF-BB) and/or transforming growth factor-${\beta}$ (TGF-${\beta}$), culture supernatant was harvested for assays of VEGF and TARC. Cell proliferation was assayed using BrdU cell proliferation ELISA kit. Results : 1) The release of VEGF was significantly increased after stimulation with TGF-${\beta}$, and its release was augmented when co-stimulated with PDGF and TGF-${\beta}$. 2) VEGF release induced by PDGF or TGF-${\beta}$ was inhibited by dexamethasone. 3) There was no synergistic effect on the release of VEGF when human lung fibroblasts were co-cultured with HBSMC. 4) Dexamethasone did not suppress human lung fibroblasts proliferations. 5) Neither TGF-${\beta}$ nor PDGF induced TARC release from lung fibroblasts. Conclusion : Human lung fibroblasts may modulate airway remodeling by release of VEGF, but they have no synergistic effects when co-cultured with HBSMC. Dexamethasone suppresses VEGF release, not proliferation of lung fibroblast.

• Parasites, Hosts and Diseases
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• v.30 no.2
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• pp.101-112
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• 1992

The natural killer cell activity of splenocytes and TBC, active NK cells, recycling capacity of natural killer cells were observed by means of both the 51Cr-release cytotoxicity assay and single cell cytotoxicity assay against YAC-1. CSH/HeJ mice were infected intranasally with $1{\times}10^4{\;}or{\;}1{\times}10^5$ trophosoites of pathogenic Acanthamoeba culbertsoni. The infected mice showed mortality rate of 34% in $1{\times}10^4$ group and 65% in 1{\times}10^5 group, and mean survival time was $16.40{\pm}3.50$ {\;}and{\;}3.20{\pm}4.09$ days respectively. The cytotoxic activity of natural killer cells of the 2 groups was significantly higher than that of non-infected mice from the 12th hour to the 2nd day after infection, showing the highest on the first day. On the l0th day after infection, the cytotoxic activity of natural killer cells was significantly suppressed as compared with that of the control. There was no significant difference in NK cell cytotoxicity between two infected groups. The targetbinding capacity and active NK cells of natural killer cells in $1{\times}10^5$ trophosoite infected mice was significantly increased on the 12th hour and the first day after infection as compared with the control group. Maximal recycling capacity (MRC) was not changed during the observation period. The present results indicated that the elevation of natural killer cell activity in the mice infected with A. culbertsoni was due to elevation of target.binding capacity and increased active NK cells of natural killer cells, and not due to the maximal recycling capacity of the individual NK cell, and there was no difference between two experimental dose groups.