• Journal of Life Science
• /
• v.32 no.1
• /
• pp.23-28
• /
• 2022

CopA3 (LLCIALRKK), an antimicrobial peptide isolated from the Korean dung beetle, has been shown to suppress apoptosis in various cell types. CopA3 inhibits not only bacterial toxin-induced colonocyte apoptosis but also 6-hydroxy dopamine-induced neural cell apoptosis. Our recent study revealed that CopA3 directly binds to caspases (key regulators of apoptosis) and inhibits the proteolytic cleavage required for their activation. But molecular mechanisms underlying CopA3-mediated inhibition of apoptosis in multiple cell types remain unknown. Here we assessed possible effects of CopA3 on expression of survivin, which is known to inhibit apoptosis. In HT29 human colonocytes, CopA3 exposure markedly upregulated survivin expression in a concentration- and time-dependent manner. RT-PCR revealed that CopA3-mediated upregulation of survivin was attributable to increased gene transcription, and further showed that CopA3 also increased expression of Sp1, one of many transcription factors known to be involved in transcription of the survivin gene. Notably, blocking Sp1 by treatment with the Sp1 inhibitor, tolfenamic acid, significantly reduced CopA3-mediated upregulation of survivin. These results collectively suggest that CopA3 induces Sp1 expression, which in turn is involved in upregulation of survivin in human colonocytes. These novel findings establish another pathway for explaining the anti-apoptotic effects of CopA3 against various cellular apoptosis systems.

• Journal of IKEEE
• /
• v.16 no.2
• /
• pp.95-101
• /
• 2012

A novel approach for the reconstruction of 3D building model from aerial image data is proposed in this paper. In this approach, a Centroid Neural Network (CNN) with a metric of line segments is proposed for connecting low-level linear structures. After the straight lines are extracted from an edge image using the CNN, rectangular boundaries are then found by using an edge-based grouping approach. In order to avoid producing unrealistic building models from grouping lined segments, a hierarchical grouping method is proposed in this paper. The proposed hierarchical grouping method is evaluated with a set of aerial image data in the experiment. The results show that the proposed method can be successfully applied for the reconstruction of 3D building model from satellite images.

• The Journal of Internal Korean Medicine
• /
• v.43 no.2
• /
• pp.274-282
• /
• 2022

Introduction: This study reports the effect of herbal medicine (Samulanshin-tang-gamibang) and acupuncture on complete atrioventricular (AV) block. Case presentation: A 63-year-old female with complete AV block was experiencing dyspnea, palpitation, dizziness, headache, bradycardia, and insomnia, and she was treated with Samulanshin-tang-gamibang and acupuncture for 12 days. To evaluate the treatment, a numeric rating scale (NRS) and the New York Heart Association (NYHA) functional classification was used. The patient's NRS scores decreased from 6 to 2 for dyspnea and palpitation and from 5 to 1 for dizziness and headache. Her NYHA Class improved from Class II to Class I. No side effects were observed during treatment. Conclusion: This study suggests that herbal medicine and acupuncture may be effective in relieving symptoms caused by complete AV block. However, the long-term effects of the treatment were not observed, and so further studies are still needed.

• Journal of Chest Surgery
• /
• v.31 no.5
• /
• pp.441-450
• /
• 1998

The medullospinal tract cells are known to play an important role in the control of the cardiovascular activities. To clarify the modes of action of the neurotransmitters on these cells, glutamate, GABA(${\gamma}$-aminobutyric acid) and bicuculline were applicated iontophoretically into the rostral ventrolateral medulla in adult cats anesthetised with ${\alpha}$-chloralose. Followings are the results obtained : 1. The spontaneous activities of the cardiac-related neurons in rostral ventrolateral medulla (RVLM) were increased by the glutamate and decreased by the GABA. 2. Bicuculline, an antagonist of GABA, alone didn't increase the frequency of the action potentials, but could reverse the cellular response to the GABA, simultaneously applicated. 3. GABA seemed to decrease the peak as well as the basal discharge of the neurons in RVLM, but hardly changed their periodicities. 4. The cellular responses of RVLM evoked by the peripheral nerve stimulation could be inhibited by the iontophoretically released GABA. In conclusion, GABA seemed to act as an inhibitory neurotransmitter on the cardiac- related neurons in RVLM of the cats anesthetized with ${\alpha}$-chloralose. But the maintenance of the periodicities of these cells after the application of bicuculline suggested that the afferent activity of the baroreceptor didn't play a key role in the spontaneous activities of the RVLM neurons.

• The Korean Journal of Pain
• /
• v.10 no.1
• /
• pp.93-96
• /
• 1997

Block of superior hypogastric plexus has been advocated as a useful technique in the palliation of various of pelvic pain syndromes. This technique has been performed under fluroscopic or CT guidance using bilateral placement of needles. We performed a modification of transdiscal approach with the patient in oblique position permitting successful superior hypogastric plexus block using a single needle placed under fluoroscopic guidance. Our experience suggest transdiscal approach performed in oblique position allows easier, safer, and more accurate needle placement for superior hypogastric plexus block.

• Journal of KSNVE
• /
• v.6 no.5
• /
• pp.535-540
• /
• 1996

공장내 소음을 형성하는 각종 발생 형태 및 소음원, 전달 형식의 분류에 따라 특성을 간략히 살펴보았다. 각 소음원 및 전달 경로의 특성을 확실히 이해하면, 혀ㅌ상을 파악하는 작업이나 소음제어 대책을 수립하는데 있어서 매우 효과적으로 대처할 수 있다. 일반적으로 공장소음 대책은 음원대책과 전달경로상의 방지 대책을 생각할 수 있는데 음원대책으로는 공장에서 사용하는 기계중 저소음 기계를 선정 하도록 권장해야하고, 일단 설치된 소음 발생원 기계에 대해서는 철저하게 차음, 흡음 조치를 취하여야 한다. 공장내부 소음 발생원에 대해서는 흡음재료를 사용하여 소음을 흡수하고 차음별을 설치하여 음의 차단에 신경 써야한다. 한편 기계 작동상의 주의, 작업 공장의 개선, 낮과 밤의 작업시간 등을 조절하여 인근 주민과 작업자 스스로에 대한 소음 피해를 막고, 피해를 입은 자에 대해서는 법적으로 보상조치하는 제도와 관리 감독이 철저히 지켜져야 한다. 끝으로 공장내.외부의 소음을 정확하게 측정 분석하여 작업장 내의 소음을 최대한으로 제거하여 쾌적한 작업장의 분위기를 만들 어야 할 것이다.

• The Korean Journal of Pain
• /
• v.18 no.2
• /
• pp.208-209
• /
• 2005

Interstitial cystitis is an extremely painful and distressing condition, characterized by severe suprapubic pain, which increases with bladder filling and is relieved by voiding. The daily frequency of micturition may approach 100 times, but no incontinence is observed. The symptoms persist throughout the night, which consequently affects sleep. The etiology of this condition is still unknown, but includes infection, autoimmune response, allergic reaction, neurogenic inflammation, epithelial dysfunction and inherited susceptibility. Herein, a case of interstitial cystitis, with severe symptoms, which was successfully treated with lumbar sympathetic block, is reported.

• The Korean Journal of Pain
• /
• v.18 no.2
• /
• pp.259-262
• /
• 2005

Facial blushing is a personally disabling condition, which can result in emotional disturbance and be an impediment to social life. Although numerous treatment options exist, including beta blocker, cognitive behavioral therapy and sympathetic neurolysis, no generally accepted form of treatment has been established. Herein, we report two cases of successful reduction of facial blushing following the administration of beta blocker and a minor tranquillizing antianxiety drug.

• Journal of Pharmaceutical Investigation
• /
• v.1 no.1
• /
• pp.30-33
• /
• 1971

Comparative studies were made on the analgesic effect of salicylamide, used individually and combined with parasympatholytics (propantheline and atropine) and antihistaminics (tripelennamine, diphenhydramine) as regards the analgesic effect (in thermal contact method) were examined by its oral administration with each combined drug to mouse (three assumption cross-over test), and the following effects were found. 1. The increasing order of the parasympatholytics to the analgesic effect of salicylamide is as follows: propantheline>atropine. 2. The increasing order of the antihistaminics to the analgesic effect of salicylamide is as follows: chlorpheniramine>diphenhdramine>tri pelennamine. In the ratio '1 : 1' salicylamide to parasympatholytics and antihistaminics, the analgesic effect of salicylamide was more increase than the other ratio in this study.

• The Korean Journal of Pain
• /
• v.11 no.1
• /
• pp.116-118
• /
• 1998

Stellate ganglion block(SGB) is frequently performed in pain clinics. Facial palsy produces asymmetry of the face, lagophthalmos and incomplete eyelid closure. Exposure keratitis and eyeball pain can be induced by prolonged lagophthalmos. SGB was performed on a 51-year-old female patient who had exposure of keratitis and eyeball pain due to facial nerve palsy after an operation for chronic otitis media. After 31 stellate ganglion blocks, eyeball pain and keratitis nearly subsided. SGB is an effective method to treat lagophthalmos caused by facial nerve palsy.