• Korean Journal of Psychosomatic Medicine
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• v.30 no.2
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• pp.155-164
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• 2022

Objectives : A growing body of evidence links type 2 diabetes (T2D) with a neurodegenerative disease (ND) such as Alzheimer's disease and Parkinson's disease. The purpose of this study is to investigate the relationship between NDs and the development of T2D by comparing the incidence of T2D in a group of various NDs (ND group) and control group. Methods : A population-based 10-year follow-up study was conducted using the Korean National Health Information Database for 2002-2015. We used a retrospective cohort study design to investigate the association of ND with T2D occurrence. The study population included ND (n=8,814) and control (n=37,970) groups, all aged 60 years or over. The Kaplan-Meier method was used to estimate the risk of developing T2D as a function of time. Cox proportional hazards regression models were used to evaluate the relationship between ND and T2D. Results : T2D was developed in a significantly higher percentage of patients in the ND group (53.6%) than in the control group (44.7%). The ND group increased the risk of T2D (HR, 1.43; 95% CI, 1.38-1.47). About one-third of patients in both groups were additionally diagnosed with another ND before the occurrence of T2D during a 10-year follow-up period. When compared to those who did not have another ND during the follow-up period, the incidence of T2D in those who were additionally diagnosed with another ND was higher in both the ND and control groups. Conclusions : The ND group had about 1.4 times higher risk of developing T2D than the control group. Our results showed a positive association between ND and T2D.

• Proceedings of the Zoological Society Korea Conference
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• 1998.10b
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• pp.76-76
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• 1998

No Abstract, See Full Text

• Journal of the Korean Orthopaedic Association
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• v.56 no.4
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• pp.283-293
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• 2021

Degenerative disc disease has traditionally been thought of as low back pain caused by changes in the nucleus pulposus and annulus fibrous, in recent studies, however, changes in the upper and lower endplates cause degeneration of the disc, resulting in mechanical pressure, inflammatory reactions and low back pain. Recently, the bone marrow of the vertebral body-endplate-nucleus pulposus and annulus fibrous were considered as a single unit, and the relationship was explained. Once the endplate is damaged, it eventually aggravates the degeneration of the bone marrow, nucleus pulposus, and annulus fibrosus. In this process, the compression force of the annulus fibrosus increases, and an inflammatory reaction occurs due to inflammatory mediators. Hence, the sinuvertebral nerves and the basivertebral nerves are stimulated to cause back pain. If these changes become chronic, degenerative changes such as Modic changes occur in the bone marrow in the vertebrae. Finally, in the case of degenerative intervertebral disc disease, the bone marrow of the vertebral body-endplate-nucleus pulposus and annulus fibrous need to be considered as a single unit. Therefore, when treating patients with chronic low back pain, it is necessary to consider the changes in the nucleus pulposus and annulus fibrosus and a lesion of the endplate.

• KSBB Journal
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• v.18 no.3
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• pp.207-210
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• 2003

The locus coeruleus (LC) contains about half of the total number of noradrenergic neurons in the brain and those noradrenergic neurons from the LC innervate entire brain regions. The LC is a major common target region in several neurodegenerative disorders such as Alzheimer's, Pakinson's and Huntington's diseases. The brain-derived neurotrophic factor (BDNF) regulate neuronal cell survival and differentiation of central nervous system neurons, including LC noradrenergic neurons. In this study, various small molecules and growth factors were tested as candidates to promote the production of BDNF in LC noradrenergic neuronal cells. The molecules tested include neuropeptides, cytokines, growth factors, neurotransmitters, and intracellular signaling agents. Four small molecules or growth factors, FGF8b, BMP-4, forskolin, and dibutyryl cGMP, were found to increase the release of BDNF in LC noradrenergic neurons. Especially, BMP-4 significantly enhanced BDNF production over 2.5-fold in LC noradrenergic neurons.

• Development and Reproduction
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• v.13 no.2
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• pp.63-77
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• 2009

The neuronal ceroid-lipofuscinoses (NCLs) are a kind of neurodegenerative storage disorders. The NCLs are charecterizated by accumulation of autofluorescent lipofuscin or lipopigment in the brain. All NCL group belongs to in lysosomal storage disorders (LSDs), except Northern epilepsy. NCLs are the most common group of progressive neurodegenerative disorders in childhood, with an incidence as high as I in 12,500 live births. Four main clinical types have been described based on the onset age : infantile, late infantile, juvenile and adult types. Clinical symptoms of NCLs include loss of vision, seizures, epilepsy, progressive mental retardation and a premature death. Although mutation causes neurodegeneration in NCLs, the molecular mechanism by which mutation leads to neurodegeneration remains unclear. In this paper, we review the characteristics of these NCLs.

• Proceedings of the KSAR Conference
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• 2004.06a
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• pp.269-269
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• 2004

배아줄기 세포는 신경퇴행성 질환의 치료 수단으로 많은 가능성을 가지고 있는 것으로 알려져 있다. 본 연구에서는 중풍 동물모델에서 수중미로 학습을 이용하여 중풍 치료제로서 인간배아줄기 세포의 인지 및 기억력 장애에 대한 기능 회복의 효능을 검토하였고, 인간배아줄기 세포의 신경세포 보호효과를 규명하기 위하여 면역조직화학 염색법을 이용하여 해마내의 세포사멸을 측정하였으며, 인지 및 기억증진의 작용을 규명하기 위하여 아세틸콜린성 신경세포의 활성도를 측정하였다. (중략)

• Journal of the Korean Orthopaedic Association
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• v.54 no.3
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• pp.203-210
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• 2019

The aim of this review was to evaluate minimally invasive lateral lumbar interbody fusion on the latest update. Lumbar interbody fusion was introduced recently. This study performed, a literature review of the indications, clinical outcomes, fusion rate, and complications regarding recently highlighted minimally invasive lateral lumbar interbody fusion. The indications of lateral lumbar interbody fusion are similar to the conventional anterior and posterior interbody fusion in degenerative lumbar diseases. In particular, lateral lumbar interbody fusion is an effective minimally invasive surgery in spinal stenosis, degenerative spondylolisthesis, degenerative adult deformity, degenerative disc disease and adjacent segment disease. In addition, the clinical outcomes and fusion rates of lateral lumbar interbody fusion are similar compared to conventional lumbar fusion. On the other hand, non-specific complications including hip flexor weakness, nerve injury, vascular injury, visceral injury, cage subsidence and pseudohernia have been reported. Lateral lumbar interbody fusion is a very useful minimally invasive surgery because it has advantages over conventional anterior and posterior interbody fusion without many of the disadvantages. Nevertheless, nonspecific complications during lateral lumbar interbody fusion procedure remain a challenge to be improved.

• Journal of the Korean Applied Science and Technology
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• v.35 no.1
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• pp.194-204
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• 2018

This study was to investigate the effect of the extract(KP-HE) from Kalopanax pictus(KP) fermented with Hericium erinaceum(HE) mycelium on oxidative modification of neurofilament-L(NF-L) which is closely related to neurodegenerative disorders. The oxidative modification of NF-L was induced by AAPH producing peroxyl radicals in solution, and KP, HE, and KP-HE was investigated. KP and HE did not protect NF-L against peroxyl radical-mediated NF-L modification whereas KP-HE significantly prevented NF-L modification induced by peroxyl radical. KP-HE inhibited the formation of dityrosine in oxidative modification of NF-L and stimulated the peroxyl radical scavenging activity. The effects of KP, HE, and KP-HE on the modification of NF-L by tetrahydropapaveroline(THP), a neurotoxin found in patients with Parkinson's disease was investigated. KP-HE also prevented THP-mediated NF-L modification as compared to KP and HE. In addition, KP-HE significantly inhibited the formation of dityrosine in oxidative modified NF-L and enhanced the inhibition of reactive oxygen species(ROS) was generated by THP. The results suggested that KP-HE can contribute to protected cell from oxidative stress was induced by ROS and neurotoxin. Therefore, KP-HE could potentially be used as a valuable functional food ingredient to prevent neurodegenerative disorders.

• The Journal of Korean Physical Therapy
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• v.16 no.2
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• pp.1-16
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• 2004

The purpose of this paper is to review changes in articular cartilage properties from the joint immobilization. Joint immobilization is accompanied not only by many disorders including rheumatologic disorders, degenerative disorders, trauma and fracture but treatment for disorders. Articular cartilage are sensitive to mechanical events. Immobilization is associated with cartilage degradation that may cause joint pain and reduced range of motion. An understanding of the effects of immobilization on the articular cartilage will help to plan of physical therapy program

• Journal of Pharmacopuncture
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• v.6 no.1
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• pp.13-13
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• 2003

1. 도입 및 배경 Lou Gehrig 병이라고 알려져 있는 근위축성 측삭경화증은 중추신경계 중 운동신경의 퇴행성 변화에 의한 진행성 질환이다. 이 병은 근육의 마비와 약화, 강직의 진행과 더불어 언어장애, 연화장애, 호흡장애가 동반된다. ALS는 환자나 가족들에게 엄청난 고통을 주는 질환으로 이병은 발병 후 3-5년 내에 약 $75\%$가 사망한다. 그리고 연하장애가 주된 증상이거나 고령에서 발병하였을 때에는 생존기간이 더욱 단축되는 경향을 나타낸다. 그리고 치명적인 호흡장애로 인해 대부분 사망하게 된다. 현재 의학계에서는 이 병의 원인도 알고 있지 못하고, 증상에 대한 아무런 치료방법도 제시하지 못하고 있는 실정이다. 2. 역학 원발성 운동신경원성 질환의 발생률은 100,000당 약 7명이고, ALS는 이 중 약 $65-85\%$를 차지한다. 전 세계적으로 1년에 약 2-4명/100,000이 발생하고 있으며 시간이 경과할수록 점차 증가하고 있는 추세이다. 3. 연구방법 EMG나 Biopsy 등을 통해 신경과 전문의가 ALS로 진단한 환자 중 상지대학교 부속한방병원에서 3개월 이상 입원치료를 받은 환자 18명을 대상으로 임상연구를 진행하였고, 설문조사는 외래에 내원한 환자 중 설문에 응답한 환자 28명을 포함한 총 46명의 환자들을 대상으로 시행하였다. 치료방법은 침, 약침, 봉약침, 한약 등을 환자의 체질을 고려하여 변증에 따라 적용하였고, 환자의 상태 변화는 ALSFRS(ALS Functional Rate Scale)를 사용하여 관찰하였다. 4. 결과 본 연구결과 ALS의 치료에 한의학적 치료방법은 유효한 것으로 나타났다. 특히 본 질환이 시간이 경과하면서 $100\%$ 악화되는 질환임을 감안한다면 한의학적 치료를 통해 약 $40\%$의 환자에서 몸의 상태나 언어장애, 만성적 피로 등이 호전되었고, 근력도 증가되는 결과를 나타내었다.