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Screening of Potential Compounds Promoting BDNF Production in Noradrenergic Locus Coeruleus Neurons  

전홍성 (조선대학교 자연과학대학 생물과학부)
Publication Information
KSBB Journal / v.18, no.3, 2003 , pp. 207-210 More about this Journal
Abstract
The locus coeruleus (LC) contains about half of the total number of noradrenergic neurons in the brain and those noradrenergic neurons from the LC innervate entire brain regions. The LC is a major common target region in several neurodegenerative disorders such as Alzheimer's, Pakinson's and Huntington's diseases. The brain-derived neurotrophic factor (BDNF) regulate neuronal cell survival and differentiation of central nervous system neurons, including LC noradrenergic neurons. In this study, various small molecules and growth factors were tested as candidates to promote the production of BDNF in LC noradrenergic neuronal cells. The molecules tested include neuropeptides, cytokines, growth factors, neurotransmitters, and intracellular signaling agents. Four small molecules or growth factors, FGF8b, BMP-4, forskolin, and dibutyryl cGMP, were found to increase the release of BDNF in LC noradrenergic neurons. Especially, BMP-4 significantly enhanced BDNF production over 2.5-fold in LC noradrenergic neurons.
Keywords
Locus coeruleus; BDNF; BMP-4; FGF8b; forskolin;
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