• Analytical Science and Technology
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• v.29 no.6
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• pp.277-282
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• 2016

British Pharmacopoeia (BP 2013), the United States Pharmacopoeia (USP 39) and the Korean Pharmacopoeia (KP XI) contain monographs for the quality control of raw diosmin using high performance liquid chromatography (HPLC). However, official monographs detailing pharmaceutical formulations for diosmin are not available in foreign pharmacopoeias. In the KP XI, ultraviolet-visible (UV-Vis) spectroscopy-which is less specific than HPLC-is reported for the testing of diosmin capsules. In this study, we present an alternative HPLC assay for such testing that is more specific than UV-Vis methods. Method validation was performed to determine linearity, precision, accuracy, system suitability, and robustness. The linearity of calibration curves in the desired concentration range was high ($r^2$>0.999), while the RSDs for intra- and inter-day precision were 0.15-0.29 % and 1.05-1.74%, respectively. Accuracies ranged from 101.2-103.2 %, while the retention time and peak area RSDs were 0.37 % and 0.06 %, respectively. Additionally, the plate number and asymmetry factor values for diosmin were 3591.293 and 1.35, respectively. Since the intermediate-precision and robustness of the assay were satisfactory, this method will be a valuable addition to the Korean Pharmacopoeia (KP XI).

• Journal of Life Science
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• v.27 no.11
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• pp.1357-1368
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• 2017

The purpose of this study was to investigate the anti-obesity and anti-inflammation effect of the cheonggukjang (a soybean paste fermented for only a few days) in diet induced obesity mice. Weight gain was significantly decreased in the mice fed cheonggukjang compared High Fat Diets (HFD). The HFD plus cheonggukjang (CGJ) were also effective in improving the lipid metabolism. The levels of plasma triglyceride, cholesterol, ALT, AST, leptin, glucose, and insulin were significantly lower in CGJ than HFD group (p<0.05). The adiponectin level of CGJ group was significantly increased compared to the HFD group (p<0.05). In the CGJ group, the mRNA expression of adipogenic genes in the liver and adipose tissues, which are transcription factors crucial for adipogenesis, were significantly suppressed (p<0.05). The number of $CD11b^+F4/80^+$ T cells, $Gr-1^{int}CD11b^{high}$ cells, and $Gr-1^{int}CD11b^{high}$ cells were significantly higher in HFD group than CGJ group (p<0.05). The size of adipocyte was significantly reduced in CGJ group compared to HFD group. In addition, the contents of liver lipid droplets were significantly downregulated in the CGJ mice than HFD mice (p<0.05). Collectively, these data suggest the novel function of cheonggukjang in modulating adipogenesis through an immune function-alteration involving downregulation of adipogenic transcription factors and macrophage activation.

• Journal of the Institute of Convergence Signal Processing
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• v.8 no.4
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• pp.237-243
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• 2007

In this paper, we propose the Real-time Dead-Pixel Detection and Compensation System for mobile camera and its hardware architecture. The CMOS image sensors as image input devices are becoming popular due to the demand for miniaturized, low-power and cost-effective imaging systems. However a conventional Dead-Pixel Detection Algorithm is disable to detect neighboring dead pixels and it degrades image quality by wrong detection and compensation. To detect dead pixels the proposed system is classifying dead pixels into Hot pixel and Cold pixel. Also, the proposed algorithm is processing line-detector and $5{\times}5$ window-detector consecutively. The line-detector and window-detector can search dead pixels by using one-dimensional(only horizontal) method in low frequency area and two-dimensional(vertical and diagonal) method in high frequency area, respectively. The experimental result shows that it can detect 99% of dead pixels. It was designed in Verilog hardware description language and total gate count is 23K using TSMC 0.25um ASIC library.

• Fire Science and Engineering
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• v.25 no.6
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• pp.168-177
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• 2011

The combustion test for real box of AC outdoor unit has been performed in this study in order to estimate the fire hazard in multi-system type of AC outdoor unit which is currently used for commercial use. The result showed that in test, there was explosion inside of AC outdoor unit, and flame erupted and fire spread through upper side grill. And then this fire burnt the combustibles such as wires, electronic control board, heat exchange copper plate and plastics etc inside the unit, refrigerant gas pipe was burst due to fire, and accelerated the explosion and flame eruption to outside while the refrigerant was erupting. It is found in this test that the maximum heat release rate of AC outdoor unit is 5,830 kW, the maximum internal temperature measured with infrared camera and thermocouple is $1,201^{\circ}C$, maximum ambient temperature is $881^{\circ}C$, and flame rose higher than about 5 m. It is concluded that the fire in AC outdoor unit cause fire to combustibles around the unit, and may give big damage by generating the secondary fire. It is expected that the result obtained from the test on the real object may be applied to fire realization of AC outdoor unit and estimation of fire spreading to the combustibles around in the future computer simulation.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.19 no.5
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• pp.162-177
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• 2020

The perception of traffic environment based on various sensors in autonomous driving system has a direct relationship with driving safety. Recently, as the perception model based on deep neural network is used due to the development of machine learning/in-depth neural network technology, a the perception model training and high quality of a training dataset are required. However, there are several realistic difficulties to collect data on all situations that may occur in self-driving. The performance of the perception model may be deteriorated due to the difference between the overseas and domestic traffic environments, and data on bad weather where the sensors can not operate normally can not guarantee the qualitative part. Therefore, it is necessary to build a virtual road environment in the simulator rather than the actual road to collect the traning data. In this paper, a training dataset collection process is suggested by diversifying the weather, illumination, sensor position, type and counts of vehicles in the simulator environment that simulates the domestic road situation according to the domestic situation. In order to achieve better performance, the authors changed the domain of image to be closer to due diligence and diversified. And the performance evaluation was conducted on the test data collected in the actual road environment, and the performance was similar to that of the model learned only by the actual environmental data.

• Journal of Digital Convergence
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• v.16 no.10
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• pp.351-356
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• 2018

Changes in vocal cords due to aging can change the frequency of speech, and the speech signals of the elderly can be automatically distinguished from normal speech signals through various analyzes. The purpose of this study is to provide a tool that can be easily accessed by the elderly and disabled people who can be excluded from the rapidly changing technological society and to improve the voice recognition performance. In the study, the gender of the subjects was reported as sex analysis, and the number of female and male voice samples was used equally. In addition, the gender analysis was applied to set the voices of the elderly without using voices of all ages. Finally, we applied a review methodology of standards and reference models to reduce gender difference. 10 Korean women and 10 men aged 70 to 80 years old are used in this study. Comparing the F0 value extracted directly with the waveform and the F0 extracted with TF32 and the Wavesufer speech analysis program, Wavesufer analyzed the F0 of the elderly voice better than TF32. However, there is a need for a voice analysis program for elderly people. In conclusions, analyzing the voice of the elderly will improve speech recognition and synthesis capabilities of existing smart medical systems.

• Korean Chemical Engineering Research
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• v.50 no.2
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• pp.353-357
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• 2012

The new qualitative and quantitative analytical method for hydrocarbon compounds in DME-LPG blending fuel, mixing dimethyl ether (DME) with liquefied petroleum gas (LPG), by using gas chromatography (GC) was investigated. It is difficult to analyze all components of DME-LPG blending fuel by using single column in GC due to consisting of the non-polar LPG and the polar DME which is oxygen-containing compound. Therefore, it has been introduced the Deans switching system, which are useful for analyzing mixtures of a very different nature and/or target analytes in very complex matrix. This technique is to control the pressure between two columns and to selectively change the path of effluent flows to either one of two columns. As a result, we found that DME and LPG can be completely separated at the different columns and the determination of all hydrocarbon compounds in DME-LPG blending fuel can be achieved to this method qualitatively and quantitatively during the operation of one injection. In addition, this method can be applied to the determination of trace components of by-product, such as methanol, methyl formate and ethyl methyl ether, which will be derived from DME synthesis process.

• Korean Chemical Engineering Research
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• v.46 no.5
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• pp.1002-1007
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• 2008

The purpose of this paper studied the optimal hydrogen production condition of plasma reforming system to operate the PEMFC. Plasma reforming reactor used with Ni catalyst reactor at the same time, So $H_2$ concentration increased. Also the WGS and PrOx reactor were designed to remove CO concentration under 10 ppm, because CO has effect on catalyst poisoning of PEMFC. The maximum $H_2$ production condition in plasma reforming system was S/C ratio 3.2, $CH_4$ flow rate 2.0 L/min, catalytic reactor temperature $700{\pm}5^{\circ}C$ and input power 900 W. At this time, the concentration of produced syngas was $H_2$ 70.2%, CO 7.5%, $CO_2$ 16.2%,$CH_4$ 1.8%. The hydrogen yield, hydrogen selectivity and $CH_4$ conversion rate were 56.8%, 38.1% and 92.2% respectively. The energy efficiency and specific energy requirement were 37.0%, 183.6 kJ/mol. In additional, The experiment of $CO_2/CH_4$ ratio proceeded. Also WGS reactor experiment was proceeding on optimum condition of plasma reactor and the exit concentration were $H_2$ 68%, CO 337 ppm, $CO_2$ 24.0%, $CH_4$ 2.2%, $C_2H_4$ 0.4%, $C_2H_6$ 4.1%. At this time, experiment result of PrOx reactor were $H_2$ 51.9%, CO 0%, $CO_2$ 17.3%.

• Proceedings of the Safety Management and Science Conference
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• 1999.11a
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• pp.343-343
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• 1999

아크용접은 산업전반에 걸쳐 그 생산기반에 없어서는 안될 필수기술로써 자동차 및 조선, 항공우주산업에 이르기까지 경제기반에 미치는 파급효과가 매우 크다. 그러나 이 아크용접을 하게 되면 각종 가스와 미세입자로 이루어진 흄이 발생하게 되는데 이들은 작업자들의 건강에 많은 영향을 미치는 것으로 보고되어 있다. 용접흄에는 용접재료 및 용접공정에 따라 다양한 유해원소가 포함되어 있고 그 종류에 따라 인체에 미치는 잠재적 독성효과도 매우 광범위하다. 최근 국내에서는 용접사들 중에 용접흄에 포함된 중금속 중 Mn중독에 의한 파킨스씨병 환자들과 Cr중독에 의하여 콧속 연골에 구멍이 뚫리는 비중격천공(鼻中隔穿孔) 환자들이 직업병으로 판정 받아 산재요양이 승인된 사례가 있다. 이러한 계기로 인하여 용접사들의 용접기피 현상이 심화되고 작업환경에 대한 법적규제는 선진 외국뿐만 아니라 국내에서도 한층 엄격하게 강화되고 있는 실정이다. 따라서 이제는 작업자와 사용자 모두 용접흄에 대한 인식의 전환이 요구되는 때이며 여러 분야에서 이러한 용접흄에 대한 연구가 활발히 진행되어야 한다. 해외에서는 이미 용접흄에 대한 연구가 활발히 진행되어 왔으나 국내의 경우는 매우 미비한 상태이며 용접산업의 미래 영향력이나 필요성을 고려할 때 국내에서도 적극적인 관심을 가져야 할 부분으로 판단된다. 본 연구에서는 아크용접공정에서 발생하는 흄의 특정 중금속 성분이 인체에 치명적인 악영향을 미치는 것에 착안하여 여러 종류의 용접재료에서 발생되는 용접흄의 중금속 분포를 조사하여 비교하였다. 이것은 향후 용접재료별 및 용접공정별 발생되는 흄의 유해원소를 저감시킬 수 있고 또한 각종 유해원소의 노출기준 및 평가기준을 마련할 수 있는 기초data로써 도움이 되리라 사료된다.동, 공정중재고가 줄어드는 결과를 보였고, 가동률 수준이 높을수록 ORR 방법간의 차이가 크게 나타났다. 그리고 부하평준화 기능은 Order Release 정책의 유효성에 별 영향을 주지 않는 것으로 나타났다. 결론적으로, Order Release 방법은 우선순위규칙간의 성능차이를 줄이거나, 대체할 수 통제 기법이라기보다는 우선순위규칙을 보완하여 공정중재고와 작업현장에서의 리드타임, 리드타임의 편차를 줄여주는 역할을 한다고 볼 수 있다. 그리고, 계획시스템이 존재하여 계획오더가 일정기간간격으로 이송되는 환경에서 특히 유용하다는 결론을 얻었다. 알 수 있었다. 것인데, 제조업에서의 심각한 고비용, 저효율 문제 를 해결하기 위해 필수적으로 도입해야만 하는 실정이다. 또한 소비자의 다양한 요구로 인 하여 제품의 종류와 사양면에서 심한 변동을 보이는 시장 수요에, 신속한 정보처리로 대응 하는데도 크게 기여하고 있다. 이에 본 연구에서는, 자동차 Job Shop의 동기화 생산방식을 지원하는 동기화 생산시스템의 구축 모델을 제시하고자 한다.과로 여겨지며, 또한 혈청중의 ALT, ALP 및 LDH활성을 유의성있게 감소시키므로서 감잎 phenolic compounds가 에탄올에 의한 간세포 손상에 대한 해독 및 보호작용이 있는 것으로 사료된다.반적으로 홍삼 제조시 내공의 발생은 제조공정에서 나타나는 경우가 많으며, 내백의 경우는 홍삼으로 가공되면서 발생하는 경우가 있고, 인삼이 성장될 때 부분적인 영양상태의 불충분이나 기후 등에 따른 영향을 받을 수 있기 때문에 앞으로 이에 대한 많은 연구가 이루어져야할 것으로 판단된다.태에도 불구하고 [-wh]의미의 겹의문사는 병렬적 관계의 합성어가 아니라 내부구조를 지니지 않은 단순한 단어(min

• Journal of Life Science
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• v.15 no.4 s.71
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• pp.590-594
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• 2005

In this study, the wastewater treatment was conducted to evaluate the removal efficiency of total nitrogen from synthetic wastewater in the F-STEP PROCESS $(anaerobic{\rightarrow}\;oxic\;{\rightarrow}\;anoxic)$ with loess ball as support metrics. The average removal efficiencies of total nitrogen and ammonia nitrogen were $83.0\%\;and\;84.4\%$, respectively. The average nitrification efficiency at the oxic area was $60.9\%$ in the pH range of effluent water between 4.8 and 6.0. On the other hand, in the case of pH range of effluent water between 6.5 and 7.5, the denitrification efficiency at the anoxic area was $96.3\%$. The average concentration of COD was 12.8 ppm and the removal efficiency of COD in the F-STEP PROCESS were $96.3\%$. In the case of SS, the average concentration was $7.0\%$ at the effluent.