• Journal of Korean Ophthalmic Optics Society
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• v.9 no.2
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• pp.211-221
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• 2004

The purpose of this study is to evaluate the distribution and change of curvature of the anterior corneal surface with age in emmetropia. 504 subjects who have emmetroia with good naked vision of at least 0.6-1.0 (spherical equivalent: +0.75D- -0.75D) participated in this study. The 504 subjects into 8 groups with 10 year interval from 3-year to 83-year, and their corneal curvatures were analyzed using manual keratometry. The results are as follows. In individual analysis: First, regression analysis of corneal curvature radius with age has given an equation: Y = -0.003x + 7.796 (r = -0.26). The average corneal curvature radii was measured to be $7.68{\pm}0.25mm$ at 38.3-year and range was 6.98-8.54 mm. Second, frequency of corneal curvature radius were obtained in 36% between 7.61 and 7.80 mm, 78% between 7.41 and 8.00 mm, 96% between 7.21 and 8.20 mm, 100% between 6.98 and 8.54 mm. Third, as for the comparison of corneal curvature radius with respect to sex, The mean value of male (n = 304, mean: 37.6-year $7.72{\pm}0.24mm$, Range: 7.09-8.54 mm) is larger than that of female (n = 200, mean: 39.3-year $7.62{\pm}0.24mm$, Range: 6.98-8.42 mm) by 0.1mm (p<0.01). In groups analysis: First, regression analysis of corneal curvature radius with age has given an equation: $Y=-0.0066x^2+0.0227x+7.7282$ (r = -0.90). Second, vertical and horizontal curvature radius decreased with age (p < 0.01). Especially the decrease of horizontal curvature radius were more pronounced than the decrease of vertical (horizontal:10-70 age group: 0.38 mm decrease, vertical:10-70 age group: 0.20 mm decrease). Third, difference between steep and flat meridian (astigmatism) progressively decreased with age. (low age group:0.18 mm difference, high age group: 0.08 mm difference). Fourth, the corneal curvature radius of male was larger than female's in total groups(p < 0.01). Consequently, the change of corneal curvature radius with age progressively decreased in all conditions (mean, vertical, horizontal, male, and female) and this change was more outstanding in horizontal rather than in vertical.

• Journal of Korean Ophthalmic Optics Society
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• v.10 no.3
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• pp.205-213
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• 2005

To evaluate the reliability of binocular vision measurements by phorometry. 90 students volunteered to participate in this study. 25 subjects were males, and 65 were females, they ranged in ages from 21 to 30 years. All subjects had normal ocular and systematic health, and all of them had at least 1.0 visual acuity with their best correction. At negative relative convergence(NRC) measurement in distance, the percentage of subjects is included in expected value(blur point/break point/recovery point) was 78%/61%/67%, divergence excess(DE) was 9%/31%/33%, and divergence insufficience(DI) was 13%/8%/9%, respectively. And positive relative convergence(PRC) measurement, includes expected value was 20%/46%/39%, convergence excess(CE) was 22%/14%/16%, and convergence insufficience(CI) was 35%/40%/45%. AC/A ratios of 42 subjects were normal. 38 were low, and the rest of them high. A low AC/A ratio is usually the result of a small vergence response in relation to accommodation. Negative relative convergence(NRC) at near, includes expected value was 26%/29%/44%, divergence excess(DE) was 61%/33%/24%, and divergence insufficience(DI) was 3%/38%/32%. And PRC at near, includes expected value was 33%/40%/31%, convergence excess(CE) was 61%/23%/42%, and convergence insufficience(CI) was 6%/37%/27%. For the near point of convergence(NPC) test, 58% of their subjects had a break of ${\leq}8cm$ with the accommodative target. In case of NRA(PRA) measurement, the expected value was 41%(33%). Accommodative insufficiency (AI) was 33%(43%), and accommodative excess(AE) was 26%(24%), respectively. AE was related to respectively low values of NRA. AI and CE are associated with high value of NRA, and the dysfunction of convergence excess combined with AE was related to a normal-high values of NRA. PRA in AI was related to a low value, wheres the dysfunction are associated with high values of PRA.

• Investigative Magnetic Resonance Imaging
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• v.1 no.1
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• pp.114-118
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• 1997

Purpose: Functional MR imaging is the method of demonstrating changes in regional cerebral blood flow produced by sensory, motor, and any other tasks. Functional MR of visual cortex is performed as a patient stares a photic stimulation, so adaptable photic stimulation is necessary. The purpose of this study is to evaluate whether the size of photic stimulator can affect the degree of visual cortex activation. Materials and Methods: Functional MR imaging was performed in 5 volunteers with normal visual acuity. Photic stimulator was made by 39 light-emitting diodes on a plate, operating at 8Hz. The sizes of photic stimulator were full field, half field and focal central field. The MR imager was Siemens 1.5-T Magnetom Vision system, using standard head coil. Functional MRI utilized EPI sequence (TR/TE= 1.0/51. Omsec, matrix $No.=98{\times}128$, slice thickness=8mm) with 3sets of 6 imaging during stimulation and 6 imaging during rest, all 36 scannings were obtained. Activation images were obtained using postprocessing software(statistical analysis by Z-score), and these images were combined with T-1 weighted anatomical images. The activated signals were quantified by numbering the activated pixels, and activation a index was obtained by dividing the pixel number of each stimulator size with the sum of the pixel number of 3 study using 3 kinds of stimulators. The correlation between the activation index and the stimulator size was analysed. Results: Mean increase of signal intensities on the activation area using full field photic stimulator was about 9.6%. The activation index was greatest on full field, second on half field and smallest on focal central field in 4. The index of half field was greater than that of full field in 1. The ranges of activation index were full field 43-73%(mean 55%), half field 22-40 %(mean 32%), and focal central field 5-24%(mean 13%). Conclusion: The degree of visual cortex activation increases with the size of photic stimulator.

• The Journal of Korean Society for Radiation Therapy
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• v.8 no.1
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• pp.19-27
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• 1996

I. Project Title A Study of Brachytherapy for intraocular tumor II. Objective and Importance of the project The eye enucleation or external-beam radiation therapy that has been commonly used for the treatment of intraocular tumor have demerits of visual loss and in deficiency of effective tumor dose. Recently, brachytherapy using the plaques containing radioisotope-now treatment method that decrease the demerits of the above mentioned treatment methods and increase the treatment effect-is introduced and performed in the countries, Our purpose of this research is to design suitable shape of plaque for the ophthalmic brachytherapy, and to measure absorbed doses of Ir-192 ophthalmic plaque and thereby calculate the exact radiation dose of tumor and it's adjacent normal tissue. III. Scope and Contents of the project In order to brachytherapy for intraocular tumor, 1. to determine the eye model and selected suitable radioisotope 2. to design the suitable shape of plaque 3. to measure transmission factor and dose distribution for custom made plaques 4. to compare with the these data and results of computer dose calculation models IV. Results and Proposal for Applications The result were as followed. 1. Eye model was determined as a 25mm diameter sphere, Ir-192 was considered the most appropriate as radioisotope for brachytherapy, because of the size, half, energy and availability. 2. Considering the biological response with human tissue and protection of exposed dose, we made the plaques with gold, of which size were 15mm, 17mm and 20mm in diameter, and 1.5mm in thickness. 3. Transmission factor of plaques are all 0.71 with TLD and film dosimetry at the surface of plaques and 0.45, 0.49 at 1.5mm distance of surface, respectively. 4. As compared the measured data for the plaque with Ir-192 seeds to results of computer dose calculation model by Gary Luxton et al. and CAP-PLAN (Radiation Treatment Planning System), absorbed doses are within ${\pm}10\%$ and distance deviations are within 0.4mm Maximum error is $-11.3\%$ and 0.8mm, respectively. As a result of it, we can treat the intraocular tumor more effectively by using custom made gold plaque and Ir-192 seeds.

• Journal of Korean Ophthalmic Optics Society
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• v.8 no.2
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• pp.169-175
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• 2003

This research reviewed that 83 male subjects. 89 female subjects of middle and high school visited D Optical shop at the downtown of Daegu more than twice from January, 1999 to January, 2003 and obtained the following results by using the visual acuity prescription of them for which D Optical shop was keeping. 1. The classification of correction power for 190 myopia eyes was examined (87 male eyes, 103 female eyes) showed 89 eyes(46.82%) between $0.25D{\leq}3.00D$, 86 eyes(45.26%) between $3.25D{\leq}6.00D$, 15 eyes(7.89%) for over 6.25D. 2. The kind of 154 astigmatism subjects(79 male eyes, 75 female eyes) was direct astigmatism 83.77%, reverse astigmatism 11.69%, oblique astigmatism 4.55%. The cylindrical correction power for astigmatic eyes was 61 eyes(39.61%) between $0.25D{\leq}0.50D$, 60 eyes(38.96%) between 0.50D<1.00D, 121 eyes(78.57%) for less than 1.06D, 6 eyes(0.65%) for over 3.00D. 3. The variation of spherical power showed 161 eyes(46.80%) between $0.00D{\leq}0.50D$, 109 eyes(31.69%) between $0.51D{\leq}1.00D$, 17 eyes(4.94%) for over 2.01D variation. 4. The variation of astigmatic power showed 92 eyes(59.74%) between $0.00D{\leq}0.50D$, 39 eyes(25.32%) between $0.26D{\leq}0.50D$, 10eyes (6.49%) between $0.51D{\leq}0.75D$, 13 eyes(8.44 %) for over 0.76D astigmatic variation. 5. The variation of equivalent spherical power showed 137 eyes(39.83%) between $0.00D{\leq}0.50D$, 126 eyes(36.63%) between $0.51D{\leq}1.00D$, 40 eyes(11.63%) between $1.01D{\leq}1.50D$, 21 eyes(6.10%) between $1.51D{\leq}2.00D$, 20 eyes(5.81%) for over 2.01D variation.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.2
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• pp.195-200
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• 2011

Purpose: We analyzed the influence of myopic's eye-glasses wearing on myopia progress after cycloplegic refraction. Methods: The 33 people (66 eyes) were school children from 8 years to 12 years having no experience eye-glasses wearing, they were taken cycloplegic refraction at the 100th, the 200th and 300th days in order to evaluate myopia progression. We investigated the eye-glasses wearing group (experimental group, 32 eyes) and the non-eye-glasses wearing group (control group, 34 eyes). The eye-glasses power of the experimental group were -0.50 D, -0.75 D, -1.00 D, -1.25 D and -1.50 D. We compared experimental group with control group for myopia progress according to period, age, and refraction error and investigated the myopia progress according to the eye-glasses power of experimental group. Results: At the 300th day from the first cycloplegic refaction, spherical equivalent for the experimental group increased as -1.03${\pm}$0.43 D (t=13.36, p<0.001) and for the control group increase as -0.61${\pm}$0.35 D (t=10.05, p<0.001) and two groups were statistical difference. Myopia power for experimental group increased 60.75%, for control group increased 56.66% at the 300 days. According to eye-glasses power increased 41.19${\pm}$15.25% at -1.50 D, 36.74${\pm}$19.29% at -1.25 D, 56.57${\pm}$20.21% at -1.00 D, 87.26${\pm}$49.38% at -0.75 D and 106.69${\pm}$59.60% at -0.50 D. Conclusions: The myopia power for the eye-glasses wearing group was 0.46 D faster than the non-eye-glasses wearing group at the 300th day from the first cycloplegic refraction. We will consider the effect of non-eye-glasses wearing to protect the progressing myopia and prescribe the under correction for school children having no experience eye-glasses wearing.

• Journal of Korean Ophthalmic Optics Society
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• v.5 no.1
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• pp.131-138
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• 2000

We compared the study of refractive error of the eyes done in 1998 with that reported three years ago at any high school in the north Kyungki. From the these data, the distribution of ammetropia was investigated. The study of refractive error for high school students was also compared with those reported before for the Adults and the middle school student. When the refractive error is refered to spherical equivalent, the 40.6% of the whole students examined above had emmetropia and the other part of them(59.4%) turned out to be ammetropia which is classified to 46.4% belonged to myopia and 13.0% belonged to hyperpia. The ratio of emmetropia for the students in 1998 is 4.4% lower, and the ratio of hyperopia is 4.3% lower, but the ratio of myopia for the students in 1998 is 8.7% higher than that for the student in 1995. In the kind of refracive error, it is classified that a simple myopia is shown to highest ratio as a 23.6% of 6143 eyes examined, a compound myopic astigmatism to the next high ratio as a 17.4%, a simple myopic astigmatism as 10.9%, a simple hyperopic astigmatism as 9.8%, a simple astigmatism as 7.1%, a compound hyperopic astigmatism as 2.2%, a mixed astigmatism as a 1.8%, respectively. The percentage of an astigmatism is a 69.6% of total eyes examined if Cyl-0.25 Dptr is included to an astigmatism. On the other hand. The percentage of an astigmatism is a 45.0% of total eyes examined if Cyl-0.25 Dptr is excluded to an astigmatism. In the kind of astigmatism, the number of students had an astigmatism with the rule is about 5.6 times than that of astigmatism against the rule. From the result of comparison the right eye with the left eye, the right eye of the students had more a myopic refractive error than the left eye, which is same as adults' case.

• Journal of Korean Ophthalmic Optics Society
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• v.21 no.2
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• pp.127-135
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• 2016

Purpose: The present study was aimed to investigate the effect of excessive near work by using a smartphone on subjective symptoms and accommodative and convergent function in their 40s. Methods: A total of 40 subjects(male, 10; female, 30; age, $43{\pm}7.2year$) in their 40s who have monocular and binocular visual acuities of 0.8 and 1.0, respectively, were divided into presbyopia group and non-presbyopia group. The subjects were asked to watch a movie on the screen of smartphone for 30 minutes. Their accommodative amplitude and facility, and relative accommodation were measured and compared before and after the use of smartphone. Changes in fusional vergence and near heterophoria by using smartphone were also evaluated. Furthermore, the change of subjective symptoms was surveyed using a questionnaire. Results: The presbyopia in mid-40s reported discomfort in an order of asthenopia, blur and dryness after the use of smartphone. Accommodative function and non-strabismic binocular function were generally decreased. Accommodative functions such as monocular accommodative amplitude, and relative accommodation were significantly decreased after smartphone use, and the change of phoria was observed as a result of decreased convergence and divergence. Negative fusional vergence was also significantly reduced. On the other hand, non-presbyopia in mid-40s reported discomfort in an order of asthenopia, dryness and blur, and only accommodative amplitude among the accommodative functions was significantly reduced. Significant reduction of negative fusional vergence was also observed. Conclusion: From the results, it was confirmed that the subjective discomfort of mid-40s after smarphone use might be related to whether presbyopia or not. It was due to not only the reduction of accommodative function but also the overall deterioration of visual function including heterophoria and fusional vergence. Therefore, it suggests that the accurate determination of the cause based on the overall visual functional tests such as heterophoria, fusional vergence as well as the decrease of accommodation due to the aging may be necessary when the mid-40s feels discomfortable symptoms by near work.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.1
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• pp.67-74
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• 2012

Purpose: The purpose of this study to evaluate visual acuity and refractive state and measure and analyze the components of eye's optical system in children and teenagers. Methods: With subjects of 124 (230 eyes) children and teenagers who had no eye diseases, correlation between the correlation between refractive errors and component's of eye's optical system was investigated. The spherical equivalent power of cycloplegic clinical refraction or manifest clinical refraction(SE), corneal power(CP), corneal radius(CR), axial length(AL), anterior chamber depth(ACD) and axial length to corneal radius (AL/CR) ratio were measured and analysed. Results: the SE was negatively correlated with the AL(r = -0.80, p = 0.00), the ACD(r = -0.35, p = 0.00) and the CR(r = -0.11, p=0.00) and positively correlated with the CP(r = +0.11, p=0.00). The AL was positively correlated with the AL/CR ratio (r = +0.84, p = 0.00), the ACD(r = +0.47, p=0.00) and the CR(r = +0.38, p = 0.00) and negatively correlated with the CP(r = -0.38, p=0.00). The CR was negatively correlated with CP(r = -1.00, p = 0.00), the AL/CR ratio(r = -0.19, p = 0.00) and the ACD(r = -0.06, p = 0.39). The CP was positively correlated with the AL/CR ratio(r = +0.19, p = 0.00) and the ACD(r = +0.06, p = 0.39). The ACD was positively correlated with the AL/CR ratio(r = 0.53, p = 0.00). Conclusions: the highest change of refractive errors was shown that the AL/CR ratio was a very important indicator for diagnosing the refractive errors of the children and teenagers.

• Clinical and Experimental Pediatrics
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• v.46 no.3
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• pp.277-283
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• 2003

Purpose : Craniopharyngiomas are often accompanied by severe endocrine disorders. Although there is universal growth hormone deficiency(GHD), the resulting growth pattern is very heterogeneous. We report the growth and endocrine outcome of 44 children with craniopharyngioma, with emphasis on initial symptoms, growth before and during growth hormone(GH) treatment and spontaneous growth in spite of GHD. Methods : We performed a retrospective study of 44 children treated at our centre between 1984 and 2002. Results : About 30% of patients had symptoms suggesting endocrine disorder at diagnosis. After surgery, multiple endocrinopathies were almost universal. Before GH therapy, height velocity was $8.00{\pm}2.71cm/yr$ in the normal growth group(n=11) and $1.79{\pm}1.10cm/yr$ in the subnormal growth group(n=7) during the first year and during the second year, $6.76{\pm}2.49cm/yr$ and $2.29{\pm}1.33cm/yr$, respectively. There was no difference of body mass index(BMI) change between before and after surgery in the two groups. Height standard deviation score(SDS) was $-1.46{\pm}0.74$ in the normal growth group and $-0.43{\pm}0.97$ in the subnormal growth group. Before GH treatment height SDS was $-1.31{\pm}1.25$ and BMI was $20.46{\pm}3.60$. During GH treatment, height SDS increased to $-0.60{\pm}1.37$ in the first, and to $-0.41{\pm}1.54$ in the second year(P<0.05), but BMI did not change significantly. Conclusion : The endocrine morbidity could develop in most children with craniopharyngioma before and after the operation and should be managed properly. Although all treated patients benefit from GH therapy, further studies are necessary to find out the possible mechanism of growth regulation in normally growing children, despite GH deficient.