• The Journal of Internal Korean Medicine
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• v.28 no.3
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• pp.442-452
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• 2007

Objectives : The purpose of this study was to investigate the toll-like receptor (TLR)-4 mediated anti-inflammatory effects of extract from Shigyungbanha-tang (SBT) on the peritoneal macrophage. Methods : To evaluate of TLR-4 mediated inflammatory of SBT. we examined NO and cytokine production in TRL-4 ligand (LPS : lipopolysaccharide) induced macrophages. Furthermore, we examined its molecular mechanism using western blot. Results : Extract from SBT itself does not have any cytotoxic effect in the peritoneal macrophages. Extract from SBT reduced LPS-induced nitric oxide (NO). tumor necrosis factor-alpha ($TNF-{\alpha}$), interleukin (IL)-6 and IL-12 production in peritoneal macrophages. SBT inhibited degradation of inhibitor kappa B-alpha ($I{\kappa}B-{\alpha}$) in the TLR-4 mediated peritoneal macrophages. Conclusions : These results suggest that SBT inhibits NO and cytokines production through inhibiting nuclear factor-kappaB (NF-${\kappa}$B) activation in peritoneal macrophage and that SBT may be beneficial oriental medicine for inflammation.

• The Journal of Internal Korean Medicine
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• v.26 no.1
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• pp.229-235
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• 2005

Pneumonia is an inflammation that forms at the mesopulmonum and alveolus that is also an acute infection with fever and cough. It is difficult for doctors to diagnose pneumonia in elderly patients, due to the variety of symptoms. For this reason, it, with its complications, is a major cause of death for the elderly. In this case, improvement was seen in an elderly patient diagnosed with pneumonia by X-ray, and by using Si-Kyung-Ban-Ha-Tang-Ka-Mi-Bang as a way of Kong-Bo-Kyum-Si, because in this case pneumonia was presumed Dam-Yel-Ong-Pye and Ki-Eum-Yang-Huh due to the weakness associated with old age. This thesis proposes that the elderly are better treated differently from other pneumonia patients due to the weakness that comes with old age.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.6
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• pp.1349-1357
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• 2009

This study was performed to investigate the effects of Shigyungbanha-tang(SGT) on the lipopolysaccharide(LPS) induced acute lung injury(ALI) in mice. 1 and 24 h before LPS intratracheal instillation, control group was taken distilled water orally. Treated groups was taken each concentrate SGT(2.5 g/kg, 6.7 g/kg) by orally as same times. Normal group was not instilled with LPS and was taken distilled water. 24 h after LPS intratracheal instillation, lung histology was performed in inflated-fixed lungs in 3 mice of each groups. The other mice of each groups, bronchoalveolar lavege fluids(BALF) was obtained to measure proinflammatory cytokines(TNF-$\alpha$, IL-$1{\beta}$, IL-6) and blood sample was obtained to measure white blood cell(WBC). In vitro, the effect of SGT($100\;ug/m{\ell}$, $500\;ug/m{\ell}$, $1000\;ug/m{\ell}$) on the release of RANTES, TARC induced by TNF-$\alpha$ and IL-4 in human alveolar epithelial cell(A549) was examined. Histopathologically, SGT prevented LPS-induced lung injury. SGT decreased protein, TNF-$\alpha$, IL-$1{\beta}$ and IL-6 according to concentrations. In vitro, $500\;ug/m{\ell}$, $1000\;ug/m{\ell}$ concentrate SGT suppressed the expression of RANTES and TARC on A549 cells. On the basis of these results, SGT had a markedly anti-inflammatory effect in a clinically relevant model of ALI. Nevertheless, further investigations are required to determine the potential clinical usefulness of SGT in the adjunctive therapy of ALI.

• The Journal of Internal Korean Medicine
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• v.37 no.2
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• pp.352-360
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• 2016

Objective: This study reports on traditional Korean medicine therapy used for pneumonia among elderly patients.Method: Two patients diagnosed with pneumonia were treated with herbal medicine and acupuncture, as well as cupping along the back. We checked chest X-rays, coughing and sputum on the visual analogue scale (VAS), and lab evaluations in order to evaluate the effectiveness of the treatment.Results: Following treatment with traditional Korean medicine therapy, VAS scores for coughing and sputum decreased and the chest X-rays and inflammation markers improved.Conclusion: Traditional Korean medicine therapy treatment appears to be effective for treating pneumonia in elderly patients.

• The Journal of Internal Korean Medicine
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• v.39 no.3
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• pp.443-449
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• 2018

Objective: This case reports the management of a patient with bronchiectasis treated with Sikyungbanha-tang, an herbal extract covered by national health insurance. Methods: Twice a year, the patient was treated for a 30-day period with the herbal extract Sikyungbanha-tang. History-taking and a chest X-ray (CXR) were used to evaluate the effects. Results: Following treatment with herbal medicine, the patient's complaints of symptoms decreased, and improvement was shown on CXR. Conclusions: Sikyungbanha-tang in herbal extract form in insured herbal extracts has effects on the management of bronchiectasis patients.

• The Journal of Internal Korean Medicine
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• v.44 no.2
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• pp.97-106
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• 2023

Objective: This study addressed the case of a cerebral infarction patient with recurring aspiration pneumonia. Methods: A patient diagnosed with cerebral infarction with recurring aspiration pneumonia was treated with Korean medicine therapies, including herbal medication (Shigyungbanha-tang-gami), acupuncture, electro-acupuncture, and moxibustion combined with antibiotics for 31 days. To evaluate the therapeutic effect, we checked chest X-rays, lab evaluations, the number of night suctions, and body temperature. Results: After treatment, chest X-rays and inflammation markers improved. In addition, the number of night suctions decreased, and the body temperature was normalized. Aspiration pneumonia recurred. However, the intensity of the symptoms gradually weakened, and the recovery speed increased. Conclusion: These results suggest that Korean medicine therapies, including Shigyungbanha-tang-gami combined with antibiotics, have a beneficial effect on recurring aspiration pneumonia, an additional disease related to cerebral infarction.