• Tunnel and Underground Space
• /
• v.14 no.4
• /
• pp.248-260
• /
• 2004

Damage in brittle rock due to stress increase starts from initiation of microcracks, and then results in failure by forming macro failure planes due to propagation and coalescence of these discrete cracks. Conventionally, continuum approaches using macro-failure criteria or a number of elasto-plastic models have been major solution to implement rock damage and failure. However, actual brittle failure processes can be better described in phenomenological approach if initiation and propagation of discrete fractures are explicitly considered. This study presents damage and failure process of rock using a boundary element code, FRACOD, which has been developed to model fracturing process of rocks. Through a series of numerical uniaxial compressive tests, the feasibility of the developed model was verified, and realistic rock failure process was reproduced considering scale effects in rocks. In addition, the fracturing process and the corresponding rock damage in the vicinity of deep shaft in rock mass were presented as an application of this approach. This approach will be expected to contribute to finding better engineering solutions for the analysis of stability problems in brittle rock masses.

• Applied Microscopy
• /
• v.33 no.4
• /
• pp.299-313
• /
• 2003

The aim of the present study was to assess the role of protein kinase C (PKC) in the development of cardiac injury following scald burn. Sprague-Dawley rats were induced a scald burn a 15% total body surface area. Phorbol 12-myristate 13-acetate (PMA, 2 mg/kg) and bisindolylmaleimide (BIS, 0.05 mg/kg) were immediately administered i.p. after burn injury. 5 h and 24 h later, heart was removed and examined biochemical assay, ultrastructural changes and stereological analysis. The activity of serum aspartate aminotransferase was significantly increased at 5h (p<0.01) and 5h+BIS (p<0.001) after burn compared with that of control. The activity of serum creatinine was significantly decreased in PMA-treated groups after burn compared with postburn 5 h. PMA caused a decrease in MPO activity and induced wavy fibers in cardiac myocytes at postburn 5 and 24h. BIS induced contraction band, separation of intercalated disk and abnormal mitochondria in cardiac myocytes at postburn 5 and 24h. In stereological analysis, treatment of rats with PMA increased volume density of myofibril and mitochondria compared with postburn 5 and 24h. Our data suggest that the activation of PKC in scald burned heart decreases inflammation and protects the myocardium.

• Cement
• /
• s.61
• /
• pp.58-63
• /
• 1975

1) 본연구논문은 Zement-Kalk-Gips 1975년도 8월호에 게재된 TH Chavatal씨의 $\ulcorner$Systematische Versucke zur Hydrophbierung des Gipses$\lrcorner$를 번역 발췌한 것으로 요약하면 다음과 같다. 2) 현재 사용가능한 agent 중에서 가장 효과적인 것을 선택하여 석고에 장기 배수성을 가지게 하는 것이 가능한가의 여부에 대한 실험 결과이다. 3) 원필자의 실험은 28일간 계속되었으며 $\alpha$형 및 $\beta$형 반수석고에 대해 물의 흡수, 강도변화, 체적의 감소 및 표면의 손상 등에 대해 계통적으로 실험하였다. 4) $\alpha$형 및 $\beta$형 반수석고에 대해 어떤 agent도 안전히 배수성을 가지게 할 수는 없었으며 이 두 석고의 물에 대한 저항은 거의 대동소이하였다.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
• /
• 2002.10a
• /
• pp.295-300
• /
• 2002

To establish an optimum condition in the surface treatment and curing process will be an important parameters for the fabrication of multilayered hybrid composite materials, A17075/CFRP (CARALL : carbon fiber reinforce aluminum laminates). Effects of carbon fiber direction and thickness variation in tensile strength were investigated. And impact damage behavior of carbon fiber reinforce plastic (CFRP) and CARALL were investigated also, it was found that a partial stress increase in order of epoxy adhesive, A17075, CFRP. And the partial stress of CFRP carried out a great portion of applied stress. The impact damage resistance of CARALL was higher than that of CFRP. This is because both side Al sheet of CARALL absorb a great of impact damage.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.3 no.5
• /
• pp.38-46
• /
• 1995

In this paper, an experimental study on the effects of the impact damage and the perforation characteristic of CFRP laminates with different fiber stacking orientation and ply number was done through an observation of interrelations between the impact energy vs. transmitted energy and the impact energy vs. absorbed energy per unit volume. The velocities of the ball before or after impact are measured by the high-speed camera. And when CFRP laminates are subjected to tranverse impact by a steel ball(${\phi}10$), the delamination shapes generated by impact damage are observed by using SAM (Scanning acoustic Microscope).

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.11 no.6
• /
• pp.107-114
• /
• 2012

Fracture of brittle material due to dynamic load such a particle impact has been reported by many researchers as the fracture behavior by variation of stress for a short minute. Especially, the brittle material, such a ceramic, applied to the structural component of machine, is considered as the important project. In order to evaluate the improvement of impact resistance, the particle impact test for the $Al_2O_3-TiO_2$ coated glass is practiced. And then, the damage variation according to the impact energy of steel ball was evaluated. There was a large improvement by the ceramic coating on the surface of a glass substrate. The damage volume was especially imported to evaluate damage behavior in quantity. These data were plotted on logarithmic coordinate and experimental equations were induced by data analysis based on test results. And the variation of critical energy for crack initiation was analyzed with critical impact energy when each crack occurs.

• Progress in Medical Physics
• /
• v.25 no.2
• /
• pp.79-88
• /
• 2014

The dose distributions within the real volumes of tumor targets and critical organs during internal target volume-based intensity-modulated radiation therapy (ITV-IMRT) for liver cancer were recalculated by applying the effects of actual respiratory organ motion, and the dosimetric features were analyzed through comparison with gating IMRT (Gate-IMRT) plan results. The ITV was created using MIM software, and a moving phantom was used to simulate respiratory motion. The doses were recalculated with a 3 dose-volume histogram (3DVH) program based on the per-field data measured with a MapCHECK2 2-dimensional diode detector array. Although a sufficient prescription dose covered the PTV during ITV-IMRT delivery, the dose homogeneity in the PTV was inferior to that with the Gate-IMRT plan. We confirmed that there were higher doses to the organs-at-risk (OARs) with ITV-IMRT, as expected when using an enlarged field, but the increased dose to the spinal cord was not significant and the increased doses to the liver and kidney could be considered as minor when the reinforced constraints were applied during IMRT plan optimization. Because the Gate-IMRT method also has disadvantages such as unsuspected dosimetric variations when applying the gating system and an increased treatment time, it is better to perform a prior analysis of the patient's respiratory condition and the importance and fulfillment of the IMRT plan dose constraints in order to select an optimal IMRT method with which to correct the respiratory organ motional effect.

• The Journal of Korean Society for Radiation Therapy
• /
• v.34
• /
• pp.43-50
• /
• 2022

Objective: The purpose of this study is to choose a treatment plan and equipment to maximize tangential irradiation to protect the normal brain tissues as much as possible during total scalp irradiation. Subjects and Methods: After zoning the total scalp of a phantom and selecting a target area for treatment, the study made a Helical TomoTherapy(HT) plan, a Helical TomoTherapy with a Complete Block(HTCB) plan, and a Volumetric Modulated Arc Therapy(VMAT) plan. All of these plans made sure that the volume of a treatment plan with 95% of a prescription dose(40 Gy) would not exceed 95% of the entire volume and that Dmax would not be more than 110% of the prescription dose. The therapy plans compared doses among organs at risk of damage including the brain. Doses in the brain tissues were assessed based on the volumetric criteria for normal tissues in Emami et al. Results: HT, HTCB, and VMAT had a dose of 21.68 Gy, 13.75 Gy, and 20.89 Gy, respectively, in brain tissues at D_33%, a dose of 7.06 Gy, 3.21 Gy, and 7.84 Gy, respectively, at D_67%, and a dose of 3.14 Gy, 1.75 Gy, and 3.84 Gy, respectively, at D_100%. They recorded a Dmean of 16.64 Gy, 11.78 Gy, and 16.64 Gy, respectively. These results show that the overall dose was low in the HTCB plan. When the volume of a low dose was calculated based on 5 Gy, they recorded 87%, 49%, and 96%, respectively, in V_5Gy. In addition, the maximum dose in the remaining organ(brain stem, hippocampus, and both lenses) except for the optic pathway was the lowest in HTCB Conclusion: The findings demonstrate that TomoTherapy with a complete block minimized a dose in organs at risk of damage including the brain and hippocampus on both sides and accordingly reduced the probability of side effects such as radiation-induced brain injuries and a resulting decrease in neurocognitive functions. In addition to total scalp irradiation, if additional studies on ring targets treated in various areas are conducted to establish the benefits of tangential irradiation, it is believed that TomoTherapy using Complete Block can be used to maximize tangential irradiation in treatment planning.

• The Journal of Korean Society for Radiation Therapy
• /
• v.28 no.1
• /
• pp.65-75
• /
• 2016

Purpose : By analyzing seroma volume changes in the patients who underwent Partial breast radiation therapy after breast conserving surgery, we try to contribute to the improvement of radiotherapy effect. Materials and Methods : Enrolled 20 patients who underwent partial breast radiation therapy by ViewRay MRIdian System were subject. After seeking for the size of the removed sample in the patients during surgery and obtained seroma volume changes on a weekly basis. On the Basis of acquired volume, it was compared with age, term from start of the first treatment after surgery, BMI (body mass index) and the extracted sample size during surgery. And using the ViewRay MRIdian RTP System, the figure was analyzed by PTV(=seroma volume + margin) to obtain a specific volume of the Partial breast radiation therapy. Results : The changes of seroma volume from MR simulation to the first treatment (a week) is 0~5% in 8, 5~10% in 3, 10 to 15% in 2, and 20% or more in 5 people. Two patients(A, B patient) among subjects showed the biggest change. The A patient's 100% of the prescribed dose volume is 213.08 cc, PTV is 181.93 cc, seroma volume is 15.3 cc in initial plan. However, while seroma volume decreased 65.36% to 5.3 cc, 100% of the prescribed dose volume was reduced to 3.4% to 102.43 cc and PTV also did 43.6% to 102.54 cc. In the case of the B patient, seroma volume decreased 42.57% from 20.2 cc to 11.6 cc. Because of that, 100% of the prescribed dose volume decreased 8.1% and PTV also did to 40%. Conclusion : As the period between the first therapy and surgery is shorter, the patient is elder and the size of sample is smaller than 100 cc, the change grow bigger. It is desirable to establish an adaptive plan according to each patient's changes of seroma volume through continuous observation. Because partial breast patients is more sensitive than WBRT patients about dose conformity in accordance with the volume change.

• Radiation Oncology Journal
• /
• v.26 no.4
• /
• pp.271-279
• /
• 2008

Purpose: To evaluate the efficacy of a belly-board device (BBD) in reducing the volume of small bowel during four-field pelvic irradiation. Materials and Methods: Twenty-two cancer patients (14 uterine cervical cancer, 6 rectal cancer, and 2 endometrial cancer) scheduled to receive pelvic irradiation were selected for this study. Two sets of CT images were taken with and without the belly-board device using the Siemens 16 channel CT scanner. All patients were set in the prone position. The CT images were transferred to a treatment planning system for dose calculation and volume measurements. The external surfaces of small bowel and the bladder were contoured on all CT scans and the 4-pelvic fields were added. The dose-volume-histogram of the bladder and small bowel, with and without the BBD, were plotted and analyzed. Results: In all patients, the total small bowel volume included in the irradiated fields was reduced when the BBD was used. The mean volume reduction was 35% (range, $1{\sim}79%$) and was statistically significant (p<0.001). The reduction in small bowel volume receiving $10{\sim}100%$ of the prescribed dose was statistically significant when the BBD was used in all cases. Almost no change in the total bladder volume involved was observed in the field (<8 cc, p=0.762). However, the bladder volume receiving 90% of the prescribed dose was 100% in 15/22 patients (68%) and $90{\sim}99%$ in 7/22 patients (32%) with the BBD. In comparison, the bladder volume receiving 90% of the prescribed dose was 100% in 10/22 patients (45%), $90{\sim}99%$ in 7/22 patients (32%), and $80{\sim}89%$ in 5/22 patients (23%) without the BBD. When the BBD was used, an increase in the bladder volume receiving a high dose range was observed Conclusion: This study shows that the use of a BBD for the treatment of cancer in the pelvic area significantly improves small bowel sparing. However, since the BBD pushed the bladder into the treatment field, the bladder volume receiving the high dose could increase. Therefore it is recommended to be considerate in using the BBD when bladder damage is of concern.