• Journal of the Earthquake Engineering Society of Korea
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• v.9 no.5 s.45
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• pp.1-10
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• 2005

This study proposes a fatigue reliability evaluation procedure for steel-composite high-speed railway bridge based on dynamic analysis and investigates the effectiveness of Tuned Mass Damper(TMD) in terms of the extension of fatigue life of the bridge. For the fatigue reliability evaluation, the limit state is determined using S-N curve and linear fatigue-damage accumulation. Dynamic analyses are peformed repeatedly to consider the uncertainties of train-velocity and damping ratio of the bridge. The distribution of random variables related to fatigue damage for the intended service life is then statistically estimated from analytical results. Finally, the fatigue reliability indices are obtained by means of the Advanced First-Order Second-Moment (AFOSM) method. Through numerical simulation of a steel-composite bridge of 40m span, the effectiveness of TMD on fatigue life of the bridge is examined and the results are presented.

• Journal of Chest Surgery
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• v.35 no.7
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• pp.501-510
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• 2002

Background: The various pathogeneses of acute respiratory distress syndrome have been suggested but not established yet. In the present study, the role of group II phospholipase $A_2$($PLA_2$) in the pathogenesis of gut ischemia-reperfusion(I/R) induced acute lung injury (ALI), especially in the pulmonary oxidative stress with infiltration of neutrophils was investigated. Material and Method: To induce ALI, reperfusion of mesentery was done for 120 min after clamping of superior mesenteric artery for 60 min in Sprague-Dawley rats that weighed about 300g. To exmaine the role of group II $PLA_2$ in ALI, especially endothelial injury associated with the action of neutrophils, lung myeloperoxidase activity, lung leak index, bronchoalveolar lavage fluid protein were measured, and pulmonary $PLA_2$ activity changes in gut I/R were also measured. The role of group II $PLA_2$in the neutrophilic generation of free radicals was assessed by inhibiting group II $PLA_2$ with rutin, manoalide and scalaradial. Furthermore, to verify the oxidative stress in the lung, histologic and free radical detecting cytochemical electron microscopy were done. Result: After reperfusion, ALI was developed with accumulation of neutrophils in the lung, which was confirmed by the increase of myeloperoxidase activity, lung leak index and bronchoalveolar lavage protein (p<0.001). The pulmonary and intestinal group II $PLA_2$ activities significantly increased after gut I/R which were reversed by rutin(p<0.001). In vitro, cytochrome-c reduction assay denoted the inhibitory effects of rutin, scalaradial and manoalide on the production of free radicals from isolated human neutrophils. Histologically, neutrophilic accumulation and pericapillary edema in the lung after gut I/R was detected by light microscopy which was suppressed by rutin. In $CeCl_3$ cytochemical electron microscopy, the increased production of hydrogen peroxide in the lung after gut I/R was confirmed and also the production of hydrogen peroxide was decreased by rutin. Conclusion: On the basis of these experimental results, the inhibition of group II $PLA_2$ seemed to mitigate gut I/R-induced ALI by suppressing the production of free radicals from the infiltrated neutrophils. Collectively, group II $PLA_2$ seems to play a crucial role in gut I/R-induced ALI by neutrophilic oxidative stress.

• Journal of Korean Society of Steel Construction
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• v.19 no.2
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• pp.211-221
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• 2007

A structural reliability analysis of fatigue truck model for fatigue failure of highway steel bridges was performed by applying the Miner's fatigue damage rule expressed as a function of various random variables affecting fatigue damage. Among the variables, the statistical parameters for equivalent moment, impact factor, and loadometer were obtained by analyzing recently measured domestic traffic data, whereas the parameters on fatigue strength, girder distribution factor, and headway factor of the measured data available in the literature were used. The effects of various fatigue truck models, fatigue life, ADTT, fatigue detail category, loadometer, and gross vehicle weight of fatigue truck on the reliability index of fatigue damage were analyzed. It is expected that the analytical results presented herein can be used as a basic background material in the calibration of both fatigue design truck and fatigue load factor of LRFD specification.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.4
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• pp.349-354
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• 2023

Sunscreen is a product that protects against ultraviolet rays by blocking and scattering ultraviolet rays, and has now become a daily necessity beyond cosmetics. Applying sunscreen is a common and easy way to prevent skin damage caused by ultraviolet rays. Due to its significance, the evaluation of sunscreen has evolved since its regulation by the FDA in 1978, progressing to standardized methods established by ISO. Additionally, to assess the loss of sunscreen due to activities such as water exposure or sweating, the Ministry of Food and Drug Safety in Korea and ISO have established protocols for evaluating the water-resistant sun protection factor (SPF). However, existing evaluations of water resistance have been mainly confined to test methods involving plain water, and methods accounting for the impact of seawater during activities like beach leisure, sports, and recreation are yet to be established. Based on the existing guidelines for testing the water-resistant UV protection index, this study compared the water-resistant UV protection index in water, artificial seawater (salt water) and natural seawater (sea water) to evaluate the UV protection index in real-world situations such as marine leisure, sports, and leisure activities. Through these results, we were able to compare the differences between water resistance sun protection index tests in ordinary water, artificial seawater, and natural seawater, and suggest a method for water resistance sun protection index tests using natural seawater.

• Journal of the Korean Society of Radiology
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• v.12 no.2
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• pp.253-260
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• 2018

Diffusion tensor images were obtained to investigate the damage of brain white matter in non-smokers and an adequate drinking group (less than 10 points) selected by scores of the Korean versions of alcohol use disorders identification test questionnaire. Factional anisotropy (FA) values, according to the variables of age and body mass index (BMI), were not statistically significant in all regions of the brain white matter after measurement of factional anisotropy (FA) values by the tract-based spatial statics (TBSS) method. In other words, age and body mass index (BMI) do not significantly affect the microstructural changes of the brain white matter.

• Tuberculosis and Respiratory Diseases
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• v.61 no.4
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• pp.374-383
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• 2006

Background: Ethyl pyruvate (EP) is a derivative of pyruvate that has recently been identified by both various in vitro and in vivo studies to have antioxidant and anti-inflammatory effects. The aim of this study was to determine the effect of EP on lipopolysaccharide (LPS)-induced acute lung injury (ALI). Methods: 5 weeks old, male BALB/c mice were used. ALI was induced by an intratracheal instillation of LPS 0.5mg/Kg/$50{\mu}L$ of saline. The mice were divided into the control, LPS, EP+LPS, and LPS+EP groups. In the control group, balanced salt solution was injected intraperitoneally 30 minutes before or 9 hours after the intratracheal instillation of saline. In the LPS group, a balanced salt solution was also injected intraperitoneally 30 minutes before or 9 hours after instillation the LPS. In the EP+LPS group, 40mg/Kg of EP was injected 30 minutes before LPS instillation. In the LPS+EP group, 40mg/Kg of EP was injected 9 hours after LPS instillation. The TNF-$\alpha$ and IL-6 concentrations in the bronchoalveolar lavage fluid (BALF), and that of NF-$\kappa$B in the lung tissue were measured in the control, LPS and EP+LPS groups at 6 hours after instillation of saline or LPS, and the ALI score and myeloperoxidase (MPO) activity were measured in all four groups 24 and 48 hours after LPS instillation, respectively. Results: The TNF-$\alpha$ and IL-6 concentrations were significantly lower in the EP+LPS group than in the LPS group (p<0.05). The changes in the concentration of these inflammatory cytokines were strongly correlated with that of NF-$\kappa$B (p<0.01). The ALI scores were significantly lower in the EP+LPS and LPS+EP groups compared with the LPS group (p<0.05). In the EP+LPS group, the MPO activity was significantly lower than the LPS group (p=0.019). Conclusion: EP, either administered before or after LPS instillation, has protective effects against the pathogenesis of LPS-induced ALI. EP has potential theurapeutic effects on LPS-induced ALI.

• International Journal of Highway Engineering
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• v.5 no.1 s.15
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• pp.1-10
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• 2003

The objective of pavement design, just as with the design of other structures, is to obtain the most economical designs at specified levels of reliability. Methods that yield designs with different levels of reliability are undesirable, and over the course of time design approaches in the U.S. and Europe have converged toward the Load and Resistance Factor Design (LRFD) format in order to assure uniform reliability. At present the LRFD format has been implemented in concrete, steel, wood and bridge design specifications. In this paper, reliability theories are used to illustrate the development of an LRFD format for Mechanistic-Empirical (M-E) design of flexible pavements as an alternative of its reliability module. It is shown in this paper that ten candidate pavement sections designed with a reliability level using the AASHTO design guide (1986) do not have uniform structural reliability in terms of pavement mechanistic distress such as fatigue cracking and the uniform reliability can be achieved by using the LRFD format.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.5
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• pp.543-553
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• 2023

This study was conducted to propose a simple method to evaluate the load-carrying capacity of RC slab bridges, which have been most frequently constructed in Korea. A number of RC slab bridges have been considerably deteriorated associate with the long service year. However, since these bridges are not included in the 1st and 2nd class infrastructures due to their short span length, they have been relatively neglected compared to other bridge types in terms of safety management. In the previous theoretical study, a process (draft) was proposed for evaluating the damage of RC slab bridges using the relationship between the displacement response ratio and the stiffness reduction rate derived by the measured displacement and natural frequency. In this paper, to verify the validity of the proposed damage evaluation process (draft), the results to the actual bridges were compared with the safety grade and the Matsui's deterioration index. In addition, to enhance the practical applicability of the existing process (draft), an improved method approximately evaluating the load-carrying capacity using only the measured natural frequency was presented. If an error of 10% of the load-carrying capacity is allowed, it is judged that the proposed damage evaluation process can be appropriately used not only for evaluating the safety of RC slab bridges, but also for determining priorities for their maintenance.

• Tunnel and Underground Space
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• v.20 no.1
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• pp.65-72
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• 2010

Crack-controlled blasting method which utilizes notched charge hole has been proposed in order to achieve smooth fracture plane and minimize the excavation damage zone. In this study, the blast models, which have a notched charge hole, were analyzed using dynamic fracture process analysis software to investigate the effect of the geometry of a notched charge hole and decoupling indexes of the charge hole on crack growth control in blasting. As a result, crack extension increased and damage crack decreased with the notch length. Ultimately, stress increment factors and resultant fracture patterns with different notch length and width were analyzed in order to examine the effect factors on the crack growth controlling in rock blasts using a notched charge hole.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.2
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• pp.149-156
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• 2017

Nuclear fuel requires high reliability and safety and therefore contains debris filtering devices to prevent failure-inducing debris from entering it. The debris filtering performance of nuclear fuel is one of the most important factors for fuel integrity. Therefore, the performance must be evaluated and the measurement must be reasonable. In this study, a calculation method of the comprehensive filtering efficiency using the weighted mean was proposed to establish a standard filtering efficiency index. To confirm the suitability of the proposed method, representative debris specimens were selected and the filtering efficiency with the weighted mean was compared with the efficiency of the arithmetic mean. The weighting factor of the weighted mean was introduced to produce a fair evaluation. In addition, the analysis of the debris filtering mechanism was performed according to the size of debris specimens, and the main dimensions of the filtering feature for commercial nuclear fuel.