• The Korean Society of Law and Medicine
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• v.24 no.2
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• pp.147-196
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• 2023

Advances in brain science have made it possible to stimulate the brain to treat brain disorder or to connect directly between the neuron activity and an external devices. Non-invasive neurotechnologies already exist, but invasive neurotechnologies can provide more precise stimulation or measure brainwaves more precisely. Nowadays deep brain stimulation (DBS) is recognized as an accepted treatment for Parkinson's disease and essential tremor. In addition DBS has shown a certain positive effect in patients with Alzheimer's disease and depression. Brain-computer interfaces (BCI) are in the clinical stage but help patients in vegetative state can communicate or support rehabilitation for nerve-damaged people. The issue is that the people who need these invasive neurotechnologies are those whose capacity to consent is impaired or who are unable to communicate due to disease or nerve damage, while DBS and BCI operations are highly invasive and require informed consent of patients. Especially in areas where neurotechnology is still in clinical trials, the risks are greater and the benefits are uncertain, so more explanation should be provided to let patients make an informed decision. If the patient is under guardianship, the guardian is able to substitute for the patient's consent, if necessary with the authorization of court. If the patient is not under guardianship and the patient's capacity to consent is impaired or he is unable to express the consent, korean healthcare institution tend to rely on the patient's near relative guardian(de facto guardian) to give consent. But the concept of a de facto guardian is not provided by our civil law system. In the long run, it would be more appropriate to provide that a patient's spouse or next of kin may be authorized to give consent for the patient, if he or she is neither under guardianship nor appointed enduring power of attorney. If the patient was not properly informed of the risks involved in the neurosurgery, he or she may be entitled to compensation of intangible damages. If there is a causal relation between the malpractice and the side effects, the patient may also be able to recover damages for those side effects. In addition, both BCI and DBS involve the implantation of electrodes or microchips in the brain, which are controlled by an external devices. Since implantable medical devices are subject to product liability laws, the patient may be able to sue the manufacturer for damages if the defect caused the adverse effects. Recently, Korea's medical device regulation mandated liability insurance system for implantable medical devices to strengthen consumer protection.

• Journal of Korean Tunnelling and Underground Space Association
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• v.17 no.3
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• pp.403-413
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• 2015

This paper presents the cutter bit damage due to the rotation speed of shield TBM cutter head in the mixed ground. The efficient of cutter bits and disk cutter are very important for tunnelling in mixed ground. In particular, this research is focused on the performance of cutter bits during excavation in mixed ground which is consist of the weathered soil and rock formation. In order to carry out this research, the experimental works are prepared performed by using the scaled shield TBM cutter bits evaluation machine developed. The mixed ground is prepared considering with a scale effect of tunnel size. Three different rotation speeds of shield TBM cutter head (i.e. 2, 3, 4 rpm) are applied in the experimental work. The drag forces acting on the cutter bits are measured at each cutter bit during rotation of cutter head. It is also analysed the variation of drag forces due to the rotation speed of shield TBM cutter head. The results of this research are clearly shown that the drag forces acting on the cutter bits are jumped up at the boundary between weathered soil and rock. It is also indicated that the jamping drag forces are increased with increasing the rotation speed of the cutter head. It is found from the research that the higher rotation speed of shield TBM cutter head will be high risk in the mixed ground. It is, therefore, suggested that the use of lower rotation speed of shield TBM cutter head is recommended for reducing the cutter bit damage in practice.

• Journal of Bio-Environment Control
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• v.28 no.4
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• pp.328-334
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• 2019

Shading paint (water-soluble) is one of the temperature control agents inside of a greenhouse in summer. Plastic film rain shelter is a unique system in Korean, prevents disease development vineyards, but it causes the heat inside a shelter in summer. Shading paint treatment with different shading rates (15, 25, and 35%) outside of plastic rain shelter avoided excessive heat inside. Shading paint influenced sunlight under plastic rain shelter in a different manner at each treatment. 35% of shading paint treatment reduced 45% of PPFD (Photosynthesis Photon Flux Density) than non-treatment control. Shading paint had the significance of efficiency to reduce the temperature under plastic rain shelter. 35% of shading paint treatment reduced $2^{\circ}C$ of bunch temperature than non-treatment control. However, shading paint treatment had not to control lower than ambient temperature. 35% of shading paint treatment is available to prevent excessive heat damage and poor fruit quality under plastic film rain shelter in summer in Korean vineyards.

• International Journal of Highway Engineering
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• v.1 no.1
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• pp.107-119
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• 1999

The joints in the jointed concrete pavement provide a control against transverse or longitudinal cracking at slab, which may be caused by temperature or moisture variation during or after hydration. Without control of cracking, random cracks cause more serious distresses and result in structural or functional failure of pavement system. However, joints nay cause distresses due to its inherent weakness in structural integrity. Thus, the evaluation at joint is very important. and the joint-related distresses should be evaluated reasonably for economic rehabilitation. The purpose of this paper was to develop an evaluation system at joints of jointed concrete pavement using finite element analysis program, ILLI-SLAB, and nondestructive testing device. FWD. To develop an evaluation system for JCP, a sensitivity analysis was performed using ILLI-SLAB program with a selected variables which might affect fairly to on the performance of transverse joints. The most significant variables were selected from precise analysis. An evaluation charts were made for jointed concrete pavement by adopting the field FWD data. It was concluded that the variables which most significantly affect to pavement deflections are the modulus of subgrade reaction(K) and the modulus of dowel/concrete interaction(G), and limiting criteria on the performance of joints at JCP are 300pci. 500,000 lb/in. respectively. Using these variables and FWD test, a charts of load transfer ratio versus surface deflection at joints were made in order to evaluate the performance of JCP. Practically, Chungbu highway was evaluated by these evaluation charts and FWD field data for jointed concrete pavement. For Chungbu highway, only one joint showed smaller value than limiting criterion of the modulus of dowel/concrete interaction(G). The rest joints showed larger values than limiting criteria of the modulus of subgrade reaction(K) and the modulus of dowel/concrete interaction(G).

• Radiation Oncology Journal
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• v.5 no.1
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• pp.49-58
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• 1987

Hypertermia for the treatment of cancer has been introduced for a long time and the biological effect for the use of hyperthermia to treat malignant tumors has been well established and encouraging clinical results have been obserbed. Unfortunately, however, the engineering or technical aspects of hyperthermia for the deep seated tumors has not been satisfactory. We developed the radiofrequency capactive hyperthermia device (Greenytherm-GY8) in cooperation with Yonsei Cancer Center and Green Cross Medical Corporation. It was composed with $8{\sim}10MHz$ RF generator, capacitive electrode, matching system, cooling system, temperature measuring system and control PC computer. The thermal profile was investigated in agar phantom, animals and in human tumors, heated with capactivie RF device. Deep and homogeneous heating could be achieved in a large phantom of 25cm diameter and 19cm thick when heated with a pair of 23cm diameter electrodes, coupled to both bases of the phantom, when the size of the two electrodes was not the same, the region near the smaller electrode was preferentially heated. It was, therefore, possible to control the depth of heating by choosing proper size of electrodes. Therapeutic temperature $(42^{\circ}C{\sim}43^{\circ}C)$ could be obtained in the living animal experiments. Indications are that deep heating of humn tumors might be achieved with the capacitive method, provided that subcutaenous fat layer is cooled by temperature controlled bolus and large size of electrodes.

• Journal of the Korean Geosynthetics Society
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• v.15 no.1
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• pp.21-35
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• 2016

It is a current trend that the concrete track is applied for high speed railway. In the case of the railway embankment constructed on soft ground, the damage to concrete track which is sensitive to settlement such as distortion and deflection could be caused by very small amount of long term settlement. Pile Supported Embankment method can be considered as the effective method to control the residual settlement of the railway embankment on soft ground. The Geosynthetics is used inside of the embankment to maximize the arching effect transmitting the load of the embankment to the top of the piles. But, PHC piles that are generally used for bridge structures are also applied as the pile supporting the load of embankment concentrated by the effect of the Geosynthetics. That is very low efficiency in respect of pile material. So, in this study, the cast in place concrete pile was selected as the most suitable pile type for supporting the embankment by a case study and the optimum mixing condition of concrete using a by-product of industry was induced by performing the mixing designs and the compressive strength designs. And it is shown that the cast in place pile with the optimum mixing condition using the by-product of industry is 2.8 times more efficient than the PHC pile for the purpose of Pile Supported Embankment by the finite element analysis method.

• Tunnel and Underground Space
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• v.16 no.2 s.61
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• pp.179-188
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• 2006

The vibration or/and noise generated by blast operations might cause not only structural damage to properties but mentally also to humans and animals. For that reason, maximum permitted vibration and noise levels are set by sensitivities of structures and they are used for the management of blast vibration. It is known that the fish lived in water are more sensitive to vibration than land animals, and thus the adverse impact of the blasting on fish farms should be very concerned. This study investigated the vibration and noise levels at a large eel farm located some 840 meters of the blasting site through the large real-scale experiments of blastings, prior to conducting the actual blasting. As a result, it was found that the noise met the requirement to be within maximum permitted level, while the ground vibration exceeded the permitted vibration. Accordingly, the impact of the excess vibration was investigated by an existing empirical method and verified by a new three dimensional numerical analysis. In this study, such an inspection process was briefly described, and a method was suggested for the examination of possible adverse effects from blasting on vibration-sensitive structures like the eel farm. The study also introduced a design method that controls the blast effects - ground vibration and noise.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2016.11a
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• pp.164-164
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• 2016

항만 및 해양 구조물은 육상과는 비교할 수 없을 정도로 가혹한 해수 환경에서 사용되며 계속적으로 부식 손상을 받는다. 따라서 강구조물이 장기적으로 안전하게 사용되기 위해서는 적절한 방식은 물론 철저한 유지관리가 필수적이다. 한편, 현재 해양환경 중 항만, 조선, 해양산업 등에 많이 이용되는 강구조물은 이에 대응하기 위하여 일반적으로 도장방식이나 음극방식이 사용되고 있다. 음극방식은 피방식체를 일정전위로 음극 분극하는 원리로써 외부전원을 인가하거나 비전위의 금속을 희생양극으로 연결하여 방식하는 방법이다. 이와같이 해수 중 음극방식을 실시할 경우 해수 중 용존하는 많은 이온들 중에서 특히 $Ca^{2+}$ 이나 $Mg^{2+}$ 이온이 탄산칼슘, 수산화마그네슘을 주성분으로하는 화합물로 형성된다. 이렇게 생성된 전착막은 산소 확산을 방지하는 물리적 장벽을 형성하고 부식율을 감소시키는 것으로 보고되고 있다. 그러나 전착막은 소지 금속과의 결합력이 불균일 함은 물론 막을 형성하는데 있어서 장시간이 소요된다는 단점이 있다. 따라서 본 연구에서는 해수 중 음극방식 응용 원리에 의해 전착막을 형성하고, 석출속도, 밀착성 및 내식특성을 향상시키기 위해 해수 중 기체를 용해시켜 제작한 막의 특성을 분석-평가하였다. 본 연구에 사용된 기판(substrate)은 일반구조용 강(SS400)을 사용하였으며, 면적은 $70mm{\times}30mm$, 두께는 1 mm로 제작하여 실험을 진행하였다. 외부전원은 정류기(Rectifier, xantrex, XDL 35-5T)를 사용하여 3 및 $5A/m^2$ 의 조건으로 인가하였고, 양극은 Carbon Rod를 사용하였다. 이때 해수에 주입한 이산화탄소의 양은 0.5 NL/min 였다. 각 조건별로 제작된 전착막에 대해 외관관찰, 석출량, 모폴로지, 조성원소 및 결정구조 분석을 실시하였고, 밀착성 및 내식특성을 평가하기 위해 테이핑 테스트(Taping Test, JIS K 5600-5-6)와 3.5 % NaCl 용액에서 전기화학적 양극 분극 시험을 진행하였다. 시간에 따른 전착막의 외관관찰 결과 전류밀도의 증가와 함께 상대적으로 많은 피막이 형성되었고, 용해시킨 기체에 의해 더 치밀하고 두터운 피막이 형성됨을 확인할 수 있었다. 성분 및 결정구조 분석 결과 $Mg(OH)_2$ 성분의 Brucite 및 $CaCO_3$ 성분의 Calcite 구조 및 Aragonite 구조를 확인하였으며, 용해시킨 기체의 영향으로 $CaCO_3$ 성분의 Aragonite 구조가 상대적으로 많이 검출되었다. 이는 해수 중 용해된 이산화탄소의 영향으로 인해 풍부한 ${CO_3}^{2-}$ 이온이 형성되고 용액 pH를 낮게 유지시켜 Ca 화합물 형성이 용이한 환경이 조성되는 것으로 판단된다. 밀착성 및 내식성 평가를 실시한 결과 해수중 용해시킨 기체에 의해 제작한 시편의 경우 견고하고 화학적 친화력이 높은 Aragonite 결정이 표면을 치밀하게 덮어 전해질로부터 산소와 물의 침입을 차단하는 역할을 하여 기체를 용해시키지 않은 $3A/m^2$ 및 $5A/m^2$ 보다 비교적 우수한 밀착성 및 내식 특성을 보이는 것으로 사료된다.

• Radiation Oncology Journal
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• v.25 no.4
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• pp.242-248
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• 2007

Purpose: To study the effect of recombinant human epidermal growth factor (rhEGF) on oral mucositis induced by cisplatin and radiotherapy in a mouse model. Materials and Methods: Twenty-four ICR mice were divided into three groups-the normal control group, the no rhEGF group (treatment with cisplatin and radiation) and the rhEGF group (treatment with cisplatin, radiation and rhEGF). A model of mucositis induced by cisplatin and radiotherapy was established by injecting mice with cisplatin (10 mg/kg) on day 1 and with radiation exposure (5 Gy/day) to the head and neck on days $1{\sim}5$. rhEGF was administered subcutaneously on days -1 to 0 (1 mg/kg/day) and on days 3 to 5 (1 mg/kg/day). Evaluation included body weight, oral intake, and histology. Results: For the comparison of the change of body weight between the rhEGF group and the no rhEGF group, a statistically significant difference was observed in the rhEGF group for the 5 days after day 3 of. the experiment. The rhEGF group and no rhEGF group had reduced food intake until day 5 of the experiment, and then the mice demonstrated increased food intake after day 13 of the of experiment. When the histological examination was conducted on day 7 after treatment with cisplatin and radiation, the rhEGF group showed a focal cellular reaction in the epidermal layer of the mucosa, while the no rhEGF group did not show inflammation of the oral mucosa. Conclusion: These findings suggest that rhEGF has a potential to reduce the oral mucositis burden in mice after treatment with cisplatin and radiation. The optimal dose, number and timing of the administration of rhEGF require further investigation.