• Therapeutic Science for Rehabilitation
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• v.12 no.3
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• pp.61-77
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• 2023

Objective : This study analyzed the correlation between cognitive function and oral health-related quality of life (OHQoL). Methods : Demographic and clinical characteristics were extracted and utilized for subjects aged 45 years or older who participated in the 8th Korean Longitudinal Study on Aging in 2020. The dependent variable was the Geriatric Oral Health Assessment Index, and the independent variable was the level of cognitive function classified by the Mini-Mental State Examination scores. The analysis method used inverse probability of treatment weighting (IPTW). Then, the association between cognitive function and OHQoL was analyzed by multiple regression analysis. Results : Among the participants, 4,367 (71.40%) had normal cognition, 1,155 (18.89%) had moderate cognitive impairment, and 594 (9.71%) had severe cognitive impairment. As a result of analysis by applying IPTW, there was a negative correlation between the cognitive function group and OHQoL (normal vs. moderate: β = -2.534, p < .0001; normal vs. severe: β = -2.452, p < .0001). Conclusion : After propensity score matching, mild cognitive impairment showed a more negative association than severe cognitive impairment. Therefore, patients with cognitive impairment require oral health management education to improve OHQoL regardless of the level of cognitive impairment.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.5
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• pp.543-553
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• 2023

This study was conducted to propose a simple method to evaluate the load-carrying capacity of RC slab bridges, which have been most frequently constructed in Korea. A number of RC slab bridges have been considerably deteriorated associate with the long service year. However, since these bridges are not included in the 1st and 2nd class infrastructures due to their short span length, they have been relatively neglected compared to other bridge types in terms of safety management. In the previous theoretical study, a process (draft) was proposed for evaluating the damage of RC slab bridges using the relationship between the displacement response ratio and the stiffness reduction rate derived by the measured displacement and natural frequency. In this paper, to verify the validity of the proposed damage evaluation process (draft), the results to the actual bridges were compared with the safety grade and the Matsui's deterioration index. In addition, to enhance the practical applicability of the existing process (draft), an improved method approximately evaluating the load-carrying capacity using only the measured natural frequency was presented. If an error of 10% of the load-carrying capacity is allowed, it is judged that the proposed damage evaluation process can be appropriately used not only for evaluating the safety of RC slab bridges, but also for determining priorities for their maintenance.

• Journal of the Korea institute for structural maintenance and inspection
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• v.17 no.1
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• pp.10-20
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• 2013

Because of the defect in design, damage in using period, and deterioration in long term exposure to severe environmental condition, degradation of performance in RC (Reinforced Concrete) structures has occurred. This paper contains durability performance evaluation in railway bridges which covers eight districts through field investigation. For the target structures, durability performance is evaluated and the critical problems in use are derived. Additionally, service lifes for the deteriorated structures are evaluated through Durability-Environment index method based on the results from field investigation, and the results are compared with those from the condition assuming the structures without defect, damage, and deterioration. The target structures which consist of RC T girder, PSC girder, RC box, and Rahmen are investigated and the critical damage patterns are derived. They are evaluated to be cracks in PSC girder end, flexural cracks in PSC girder, crack around EPT anchor, and flexural cracks in RC T girder and RC box. The reasons for the critical patterns are also investigated. This study can be utilized for the repair planning considering the different district and the structure types.

• The Journal of Engineering Geology
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• v.12 no.2
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• pp.151-166
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• 2002

Groundwater development as a means of acquiring subsidiary water resource is very important for the persistent security of water resource. Nowadays, pneumatic fracturing technology which was developed in the advanced countries is applied for increasing pumping rate and eliminating contaminants. This study gives an experimental data to clarify permeability characteristics of the single discontinuity which is newly developed or increased in aperture by the pneumatic fracturing or damage propagation of the natural barrier for the nuclear waste disposal. On the basis of understanding the relationship between permeability and hydraulic aperture the result could apply as one of the basic data for researches concerned with increasing pumping rate and eliminating contaminants. Hydraulic aperture is decreased exponentially with increasing confining pressure and proportioned to permeability in the same confining pressure. Especially, with the increasing aperture permeability of coarse- and medium- grained granite shows the more rapid increasing than that of fine- grained granite.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.10 no.2
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• pp.212-219
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• 1999

Objective：This study is designed to get clinical guidelines for management of children with TBI by examining neuropsychiatric sequelae of TBI, determining whether the severity of TBI, type of treatment, and enviornmental factors are related to those sequelae, and defining the adequacy of public psychological tests as evaluating tools for them. Method：This is chart review of 47 children, aged 5 to 14 years, referred to a psychiatric outpatient clinic for neuropsychiatric evaluation at least 6 months after TBI. Data on the initial GCS score, associated injury, treatment type, and duration of hospital stay are obtained from medical records. EEG, MRI, intelligent test, and several psychological tests are administrated at the point of assessment. Results：1) Cognitive symptoms outnumber externalizing behavioral, emotional, and somatic symptoms, with no significant differences of frequencies of those 4 categorical symptoms between mild injury group and moderate to severe group. 2) Children treated with non-surgical method(p<0.01) complain more cognitive symptoms than the others. 3) Behavioral symptoms are related to younger age(p<0.05), and to anticonvulsant medication(p<0.05). 4) Children with associated injury complain emotional symptoms more frequently(p<0.05). 5) More somatic symptoms are presented by children with no medication(p<0.05), and with higher I.Q(p<0.05). 6) Low I.Q is correlated to low GCS score (p<0.05). Cognitive impairment is confirmed in 25 in 42 children complaining cognitive symptoms though I.Q test and BGT, whose hospital stay is longer than the others(p<0.05). 7) emotional disturbance is confirmed in 22 in 25 children showing emotional problems through psychological tests, who complain cognitive symptoms more frequently(p<0.05). Conclusion：This findings suggest that even mild TBI children need to be followed-up and treated as complaining neuropsychiatric symptoms over 6 months after injury, and shorter hospital stay is recommended for cognitive and emotional status of children, and for better evaluation of neuropsychiatric sequelae of TBI, more specific tests should be included in neuropsychological test tools.

• Tuberculosis and Respiratory Diseases
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• v.52 no.3
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• pp.219-229
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• 2002

Background : Sepsis-induced acute lung injury (ALI) is caused by many cellular and humoral mediators induced by an endotoxin. Histamine, which is widely distributed in the lungs and has been considered as an important mediator of sepsis. It increases P-selectin expression on the endothelial cell surfaces and induces IL-8 secretion. Therefore, an endotoxin-induced histamine may be related to neutrophil-mediated ALI by inducing the migration and activation of neutrophils in the lung tissue. However, the role of endogenous histamine in endotoxin ALI has not been clarified. The purpose of this study was to investigate how endotoxin-induced ALI is influenced by endogenous histamine and to identify the possible mechanism of action. Materials and Methods : The study consisted of 4 groups using Sprague-Dawley rats : 1) control group, where the rats were infused intratracheally by normal saline, 2) an endotoxin group, where lipopolysaccharide (LPS) was administered intratracheally 3) the $H_2$ receptor antagonist-treated group ($H_2$ group) and 4) the $H_1$ receptor antagonist-treated group ($H_1$ group), where $H_2$-receptor blocker (ranitidine) and $H_1$-receptor blocker(pyrilamine) were co-treated intravenously with the intratracheal administration of an endotoxin. The lung leak index using $I^{125}$-BSA, the total protein and LDH concentration in the lung lavage fluid, myeloperoxidase(MPO) activity in the lung tissue, the pathologic score and the total number of neutrophils, TNF-$\alpha$, IL-$1{\beta}$ and IL-10 in lung lavage (BAL) fluid were measured in each group as the indices of lung injury. Results : Compared to the control group, the endotoxin group exhibited significant increases in all lung injury indices. Significant reductions in the endotoxin-mediated increases in lung leak index (p<0.05) were observed in both the $H_1$ and $H_2$ groups. In addition the total protein (p<0.05) and LDH concentration (p<0.05) in the BAL fluid were also lower in the $H_2$ group compared to the endotoxin group. However, there was no change in the MPO activity in the lung tissue, the pathologic score and the total number of neutrophils in the BAL fluid in both the $H_2$ and $H_1$ groups compared to the endotoxin group. The increases in TNF-$\alpha$ IL-$1{\beta}$ and IL-10 concentrations in the BAL fluid observed in the endotoxin group were not reduced in the $H_2$ and $H_1$ groups. Conclusion : Antihistamine attenuated the enhanced alveolar-capillary permeability induced by the endotoxin via the $H_2$ receptor. However the attenuating mechanism may not be related to the pathogenesis of neutrophil dependent lung injury.

• Environmental Analysis Health and Toxicology
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• v.23 no.3
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• pp.171-178
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• 2008

수백여 종의 개별물질이 불완전 연소 혹은 유기물의 열분해로 인해 발생되는 다환방향족 탄화수소(PAHs)는 환경에서 중요한 오염원이 되고 있다. 본 연구는 다양한 바이오마커를 이용하여 수서생태계에 벤조피렌(benzo[a]pyrene)과 같은 다환방향족 탄화수소의 영향을 분석하였고, 이에 대한 통합적 결과 모델을 도출하였다. 즉, 잉어(Cyprinus carpio)를 이용하여 여러 농도의 벤조피렌(3, 12, $34{\mu}g/L$, 측정농도 기준)에 10일간 노출시킨 다음, DNA single-strand break, ethoxyresorufin-O-deethylase (EROD), acetylcholine esterase (AChE)와 vitellogenin (VTG)의 농도를 측정하였다. 벤조피렌은 잉어의 DNA 손상을 유도하였고, 낮은 농도에서 EROD와 VTC의 유의적인 활성을 보였으나, 신경전달물질과 관련이 깊은 AChE 효소활성에는 영향을 미치지 않았다. 이 결과를 star plot를 이용하여 통합 및 분석하였으며, 노출농도에 따른 통합 반응지수(integrated biomarker response value: IBR)로 나타내었다. 이런 다양한 바이오마커의 결과들은 벤조피렌에 대한 어류의 영향과 수생태 모니터링 자료로 이용 가능할 것으로 여겨지며, 통합반응지수는 생태위해성평가에서 유용한 도구로 쓰일 가치가 있는 것으로 평가된다.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.322-322
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• 2018

우리나라의 기후는 대부분 지역의 강수량이 약 1,350mm 이상의 습윤지역이다. 하계 집중형 강수형태로, 우리나라는 연강수량의 50%이상이 여름철(6월~9월)에 집중된다. 또한 제방이 제 기능을 발휘할 수 있는 시기도 6~9월이 되기 때문에 이전에 제방의 적절한 점검과 보강이 이루어져야 홍수와 태풍과 같은 자연재해를 막을 수 있다(Cha et al, 2010). 제방이 제 기능을 발휘하기 위해서는 홍수나 범람 등에 얼마나 견딜 수 있는지를 알아야 한다. 그러기 위해서는 무엇보다도 제방이 자연재해로부터 손상을 입게 되는 원인과 과정, 하천수의 침투로 인한 제체내부의 역학적 거동 등에 대한 충분한 이해와 지식을 함양해야 한다. 본 연구에서는 하천 제방에 대한 홍수취약성을 평가하는 새로운 기법을 기후변화에 따라 달라지는 하천의 수위변화를 고려하여 제방의 취약성 변화 정도를 파악해보고자 한다. 이를 위해 미래 기후변화 시나리오를 기반으로 대상유역의 홍수량을 산정하여 홍수위를 구하고 제방의 2차원 지하수침투 모형인 SEEP/W를 이용하여 침투거동을 분석함으로써 침투안정성을 평가하였다. 대상지역은 한강 본류 서울 구간으로 선정하여 대표 제방을 선정한 후, 대표 제방의 현재 계획홍수위와 기후변화를 고려한 홍수위를 고려하여 제방의 안전율을 분석하였다. 제방의 취약성 분석에 필요한 인자를 도출하고 이를 활용하여 기후변화 시나리오에 따른 제방의 수위변화를 고려한 제방의 취약성 분석을 실시하였으며 분석결과를 본 연구자가 기 개발한 제방홍수취약성지수(Levee Flood Vulnerability Index, LFVI) 값을 이용하여 제방의 취약성에 미치는 영향을 분석하였다.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.62 no.3
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• pp.184-192
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• 2017

Rice flours from five rice (Oryza sativa L.) varieties with different amylose content were prepared by both wet and dry milling processes. The moisture content of wet-milled rice flours (WMR) was approximately three-times higher than that of dry-milled rice flours (DMR). Water absorption index (WAI), water solubility index (WSI), and swelling power (SP) increased in proportion to temperature. The WAI, WSI and SP values of DMR were higher than those of WMR. Baeokchal (BOC), which is a waxy rice cultivar, had a significantly high WSI value. Pasting properties of DMR, except for the BOC cultivar, resulted in an increase in peak, trough, final, and setback viscosities. The levels of resistant starch in four cultivars, except for Dodamssal (DDS), were under 1%, irrespective of the milling process, whereas the resistant starch contents of DMR and WMR in DDS were 9.18% and 6.27%, respectively. In vitro digestibility of WMR was higher than that of DMR, and the estimated glycemic index of the rice flour varieties ranged from 57.6 to 81.3. Damaged starch content of WMR was less than that of DMR; in addition, a negative correlation was observed between the amylose and damaged starch contents of WMR. These results suggest that the properties of rice flour vary depending on the milling method and flour variety, and could be a reference for selecting the appropriate processing method.

• Applied Biological Chemistry
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• v.33 no.4
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• pp.301-306
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• 1990

The Physical and chemical properties or dry acorn starch(DS), detannined acorn starch (DTS) and defatted and detannined acorn starch(Drn) were investigated. Ail acorn starch sample, observed by a scanning electron microscope, showed a hemispherical shape ud its size was about $5{\sim}10{\mu}m$ in diameter. It had a little change on the pasting temperature of DS, DTS and DFTS but peak viscosity of DTS was somewhat higher than that of n. Flow behavior of gelatinized starch pastes showed a pseudoplastic behavior and flow behavior index was lower than unit. The consistency coefficient showed concentraion and temperature dependency. The activation energies of DS, DTS and DFTS were $2.09{\sim}3.58Kcal/g\;{\cdot}\;mol and time dependent characteristic of acorn starch samples showed thixotrpic behavior.