• Journal of Digestive Cancer Research
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• 제10권1호
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• pp.31-38
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• 2022

Ulcerative colitis (UC) exhibits chronic intestinal inflammatory conditions with cycles of relapse and remission. The incidence is rapidly growing in Asian countries including South Korea possibly due to changes in lifestyles. Although the etiology of inflammatory bowel disease is inconclusive, gut microbiota composition is considered a critical factor involved in the pathogenesis of UC. The overgrowth of pathogenic bacteria evokes hyper-immune responses in gut epithelium causing tissue inflammation and damage. Also, failure to regulate gut epithelium integrity due to chronic inflammation and mucus depletion accelerates bacterial translocation aggravating immune dysregulation. Gut microbiota composition responds to the diet in a very rapid manner. Epidemiological studies have indicated that the risk of UC is associated with low plant foods/high animal foods consumption. Several bacterial strains consistently found depleted in UC patients use plant food-originated dietary fiber producing short chain fatty acids to maintain epithelial integrity. These bacteria also use mucus layer mucin to keep gut microbiota diversity. These studies partly explain the association between dietary modification of gut microbiota in UC development. Further human intervention trials are required to allow the use of specific bacterial strains in the management of UC.

• 한국식품영양과학회지
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• 제36권8호
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• pp.975-982
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• 2007

본 연구는 H. pyroli 억제능을 지닌 김치 유래 유산균인 Pediococcus pentosaceus MD1을 가지고 궤양 예방효과를 지닌 김치를 개발하기 위한 선행연구로서 독성평가 실험을 수행하고자 4주 반복 투여 독성시험을 실시하였다. 본 시험에서 설정한 최고 용량 투여군인 2,000 mg/kg에서도 일반증상관찰, 체중변화, 사료섭취량 및 물 섭취량을 측정한 결과, 모두에서 시험물질과 관련된 유의성 있는 변화가 관찰되지 않았다. 또한 혈액학적, 혈액생화학적 검사 및 장기의 육안적 관찰 및 장기 중량변화에서도 대조군과 유의성이 있는 차이를 보이는 항목이 없었으며, 모두 정상범위를 벗어나지 않아 시험물질에 기인하는 이상소견을 발견할 수 없었으므로, 최대 무해 용량은 2,000 mg/kg 이상일 것으로 추정되었다. 이상의 결과 4주 반복 투여 독성시험 결과 H. pyroli 억제능을 지닌 유산균인 Pediococcus pentosaceus MD1은 저독성물질로 판정되었으며, 유산균이 기능성식품 소재로서의 안전성 확인을 통하여 소비자들에게 소화성 궤양 예방효과를 지닌 안전하고 차별화된 경쟁력 있는 김치를 개발할 수 있을 것으로 사료된다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제8권2호
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• pp.164-171
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• 2005

목 적: 건강한 만삭아로 출생한 신생아에서 상부위장관 출혈의 임상적 특징, 위내시경 소견, 연관된 위험요소 등을 알아보고자 하였다. 방 법: 2002년 1월부터 2003년 12월까지 을지의과대학교 을지병원 신생아 중환자실에 토혈 혹은 혈변을 주소로 입원하여 위내시경상 출혈성 위염 또는 궤양으로 진단된 9명의 환아들을 대상으로 산전인자, 모체인자, 분만소견, 내시경 소견, 예후 등을 후향적으로 조사하였다. 결 과: 1) 9명의 환아 중 원내 출생아는 5명(5명/3,734명)으로 발생률은 0.13%였고, 모두 적정체중 만삭아로 출생 시 가사소견은 없었다. 2) 산모들의 병력상 산전에 위염, 소화성 궤양, 제산제 복용 등의 기왕력, 위장관 질환의 가족력은 없었고, 분만과정 중 특이소견 없었다. 3) 토혈, 혈변, 반복되는 구토가 주증상이었으며, 출생 후 $4.4{\pm}3.8$일에 발생하였고, 입원 시 활력증후는 양호하였고, 혈액검사소견도 정상이었다. 내시경 검사상 출혈성 위염이 6예, 위궤양이 3예였다. 4) 모든 환아는 $H_2$ 수용체 차단제 치료와 보존적 치료을 실시하였고, 치료 시작 후 $0.9{\pm}0.3$일 이내에 임상증상은 호전되었다. $H_2$ 수용체 차단제는 $18.6{\pm}5.0$일 치료하였으며 추적관찰상 증상이 재발된 환아는 없어서 추적 내시경은 실시하지 않았다. 결 론: 만삭아에서 출혈을 동반한 상부위장관 점막질환은 대부분 예후가 양호하여 임상증상이 호전된 경우에는 추적 위내시경 검사는 불필요한 것으로 사료된다.

• Journal of Yeungnam Medical Science
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• 제10권1호
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• pp.144-156
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• 1993

Octreotide는 somatostatin 동족체로서 8개의 aminoacid로 구성된 합성 polypeptide이다. 이는 외분비선과 내분비선, 특히 위의 분비기능과 췌장분비 기능을 억제하는 작용이 강하며 somatostatin에 비하여 체내 반감기가 길고 장기에 대한 선택성이 높기 때문에 소화성 궤양에 의해 유발되는 출혈, 급성췌장염, 그리고 소화기관의 분비선에 나타나는 종양의 치료에 대한 적용이 시도되고 있다. 저자등은 somatostatin이 말초 교감신경에 존재하며, 신경전달인자 또는 신경조정인자로서 작용할것이라는 보고와 임상적용시 혈압과 심박동수를 감소시킨다는 보고에 흥미를 가지고 그 유도체인 octreotide가 말초 교감신경에 미치는 작용을 관찰하기 위하여 다음과 같은 실험을 하였다. 흰쥐 (Sprague-Dawley)의 전립선 부위 정관 절편을 적출 근편 실험조에 현수하여 등척성 장력을 측정하였다. 흰쥐 적출정관은 전기장 자극(duration : 1 mSec, voltage: 50 V, frequency: 5 Hz or 30 Hz, train: 10 Sec)에 대하여 first phasic component (FPC)와 second tonic component (STC)로 구성된 수축 반응을 나타내었으며, 이러한 수축반응은 tetrodotoxin($10^{-6}M$) 전처치로 소실되었다. Octreotide는 전기장 자극에 의해 유발되는 수축 반응을 FPC, STC 모두 농도의존적으로 억제하였다. 그리고 24 시간 전에 reserpine(1 mg/kg, IP)을 전처치하여 norepinephrine을 고갈시킨 흰쥐에서 적출한 정관 절편과 beta-gamma-methylene ATP를 전처치하여 퓨린성 수용체를 탈감작시킴으로써 ATP의 작용을 배재한 정관절편의 전기장 유발 수축을 공히 억제하였다. 이러한 octreotide의 모든 수축 억제 작용들은 5 Hz의 전기장 자극을 가하였을 때, 30 Hz의 전기장 자극을 가하였을 때 보다 더 강하게 나타났다. 그러나 octreotide는 정관 절편의 기본장력에는 영향을 미치지 않았으며, 외부에서 첨가한 norepinephrine과 ATP에 의해 유발되는 수축반응에는 영향을 미치지 않았다. 이상의 결과로 미루어 보아 octreotide는 흰쥐적출 정관의 교감신경성 신경원으로부터 ATP와 norepinephrine의 유리를 억제함으로써 그 수축성을 억제하는 것으로 사료된다.

• 대한간호학회지
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• 제21권2호
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• pp.230-246
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• 1991

Pain is a subjective and multidemensional concept. Therefore the patient's expression of pain have been referedl to the best believable indicator of pain condition but the support data obtained from the patient considered cultural difference is a deficient condition in determinded on the precise nursing diagnosis. The purpose of this reasearch was to understand multiple pain reponses in cultural difference and sensitivity, to encourage communication between medical teams, and to provide the foundation data of on data of precise nursing assessment for the patient in pain. The research problem was to grasp pain express pattern of Korean peptic ulcer patients. The subjects were 20 peptic ulcer patients in medical unit or OPD of twp university hospitals in Seoul. Data were collected from September 7th to 22nd, 1990 by intensive interviews. Interviews were done by the researcher and all were tape - recorded. The Data analysis was done by Phenomenological method from Van Kaam. Validity assured by confirmation of the internal consistency of the statements and catigory by nursing collegue in educational and clinicions in medical care. From the emic data, 96 descriptive statements were organized in 18 theme cluster. The results of study were summerized as follows. 1. Pain Express Pattern cluster of Peptic Ulcer Patients were “Pain as clogging”, “shallow pain”, “pain as pressing”, “nauseating pain”, “pain as smarting”, “pain as pulling”, “pain as pricking”, “pain as bursting”, “wrenching pain”, “excising pain”, “uncontrollable pain for mind and body”, “awakening pain”, “pain as hollowing” and the other cluster. As above mentioned, Pain Express Pattern of Peptic Ulcer Patient appeared diversely in verbal and they were propered to Korean culture. Therefore they will provide for the foundation data of precise nursing assessment.

• Journal of Preventive Medicine and Public Health
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• 제32권4호
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• pp.427-434
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• 1999

Objectives: This study was conducted to determine, by reviewing the literature, whether treatment of Helicobacter pylori infection in patients with non-ulcer dyspepsia affects symptoms. Methods: We retrieved the literature using MEDLINE search, with nonulcer dyspepsia and Hericobacter pylori and treatment as key words, which were reported from 1984 to 1998, and manual literature search. The criteria for inclusion was as follows; 1) The paper should have confirmed nonulcer dyspepsia as case definition. 2) The paper should have peformed a randomized, blind trial. 3) Confirmation of Helicobacter pylori eradication should be done 4 weeks after treatment. 4) studies with no information on measurement of symptoms after treatment were not accepted. The percentage of patients with symptom improvement after eradication therapy for Helicobacter pylori infection was calculated. Cumulative odds ratio was compared by fixed effect model and random effect model as sensitivity and funnel plot was used to evaluate publication bias. Results: The overall effect size of symptom improvement was calculated by cumulative odds ratio. Cumulative odds ratio of random effect model was 4.16(95% CI: 1.55-11.19). Before integrating each effect sizes into common effect size, the homogeneity test was conducted and random effect model was selected(Cochran's Q=41.08 (d.f=10, p<0.001)). The heterogeneity across studies was evaluated and the different methodological aspects of studies led to differences between study results Conclusions: The results suggest that the eradication of Helicobacter pylori in patients with non-ulcer dyspepsia results more symptom improvement. In studios that shows the opposite results there are methodological aspects explaining the heterogeneity.

• Journal of Preventive Medicine and Public Health
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• 제32권2호
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• pp.200-205
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• 1999

Objectives: This study was carried out to investigate the aluminum concentrations in blood, urine and drinking water, the factors which affect the concentrations and the role of silicon in patients who were taking antacid containing aluminum. Methods: We selected 122 peptic ulcer patients as cases and 144 healthy examinees as controls. Blood, urine, and drinking water were collected from the each study subject and we measured aluminum concentrations as well as silicon concentrations in the specimens. The factors including silicon affect on the aluminum concentrations were also analyzed, Results: 1. The mean duration of antacid administration was 12 months, and the mean daily and total amount of aluminum administration were 0.9 g and 304 g per each patient, respectively. 2. The blood and urine aluminum concentrations were significantly higher in the case. 3. The blood silicon concentration was significantly lower in the control group, and the urine silicon concentration was significantly higher in the case. 4. Urine aluminum concentration was significantly correlated with blood aluminum concentration (r=0.18), and urine silicon concentration was correlated with blood aluminum (r=0.19) and urine aluminum concentrations (r=0.13). 5. The longer the duration of antacid administration and the larger the total and daily amount of aluminum in the antacid were, the higher urine aluminum and silicon concentrations were, but not to a statistically significant degree. Conclusions: Blood and urine aluminum concentrations were higher in the ulcer patients. The authors suggest that follow-up studies of the patients who administered antacid with high aluminum content for long duration should be done.

• 대한한방내과학회지
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• 제21권4호
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• pp.597-604
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• 2000

Objective : his study was carried out to investigate the effect of Dansameum (DS) on the gastrohemorrhagic lesion induced by ammonia in rats. Methods : Rats were pretreated with DS extract 25 mg/kg for 10 days and then were given amonia through gastric tube. The animals were killed 1 hr after amonia treatment. Results : DS extract siginificantly reduced the gastrohemorrhagic lesion score, the gastric lipid peroxide level, the gastric urease activity, the gastric myeloperoxidase activity, the gastric acid phosphatase activity, xanthine oxidase activity and type conversion, and increased the gastric glutathione level considerably. In photomicrographs of stomach tissue in rat, we could see the gastrohemorrhagic lesion induced clearly. conclusions : These results suggest that DS extract may be effective in peptic ulcer.

• 한국미생물·생명공학회지
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• 제38권4호
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• pp.405-413
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• 2010

무화과는 뽕나무 과에 속하며 세계에서 가장 오래된 과일 중 하나이고, 국내에서는 주로 소화장애, 염증성궤양 그리고 가려움증 등에 사용되어 왔다. 본 연구에서는 무화과 잎을 메탄올로 추출한 후 임상진료실에서 분리된 메티실린 내성 황색포도상구균(MRSA)에 대한 항균활성을 보았다. 그 결과 분리된 MRSA 1-20에서 최소억제농도 (MIC)는 2.5 mg/mL에서 20 mg/mL 농도로 측정되었으며, 최소살균농도(MBC)는 5 mg/mL에서 20 mg/mL 농도로 관찰되었다. Oxacillin이나 ampicillin과 병용투여 시 4-8배 이상의 MIC/MBC농도가 감소되었으며, FICI 값도 0.0375-0.5이하로 병용효과를 나타내었다. 더불어 메탄올추출물 단독 사용시 보다 항생제와 병용투여 시 빠른 사멸효과를 보였다. 결론적으로 무화과 잎이 메티실린 내성 황색포도상구균에 항균활성을 나타냄을 확인하였으며, 메티실린 내성 황색포도상구균 감염에 천연 치료제로서의 가능성을 확인하였다.

• 한국식품영양과학회지
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• 제27권1호
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• pp.132-140
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• 1998

This study aimed to verify the nutritional and curative effects of protein hydroysate and optimal ratio between protein and protein hydroysate as nitrogen source in rats with cysteamine-induced duodenal ulcer. Duodenal ulcer rat model was established by intraperitoneal injections of cysteamine. Sprague-Dawley, female rats weighing approximately 200g were intrapertionealy injected twice cysteamine(13mg/100g BW) at intervals of 3hours per day. This procedure was repeated 3 times at intervals of 3 days. Animals fed on 10% casein diet for injection periods. After last injection, 5 kinds of kiets (the ratio of casein and casein hydrolysate was 100 : 0(C100), 75 : 25(CH 25), 50 : 50(CH 50), 25 : 75(CH 75), 0 : 100(CH 100)) were given. The rate were sacrificed after feeding diet, 1, 3, 5 days. Ulcer index, hexosamine content of stomach and duodeum, gastric motility, trypsin activity, blood glutathione, plasma total protein, albumin, amino-N, urinalry urea nitrogen, creatinine, hydroxyproline and retention rate of nitrogen were analyzed for nutritional effects of diet treatments. There were no differences among diet groups in the view of the growth and diet treatments. There difference of ulcer curation by diet was appeared after 3 days. The ulcer indexes of C100 and CH 25 of 3, 5 days were significantly higher than those of CH 50, CH 75 and CH 100. This result was the same as hexosamine content of stomach, plasma protein, albumin concentration and nitrogen retention rate. The more casein hydrolysate diet had, the lower trypsin activity was. The more casein gydroysate diet had, the higher excretion of hydroxyproline was. These results show that protein hydrolysate can be applied in diet therapy for the patients with gastronitestinal ulcer. It suggests that it has curative effect of diet when nitogen sources include at least over than 50% of protein hydrolysate.