• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.9
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• pp.1325-1333
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• 2014

Sasang constitutional medicine is a Korean traditional medicine in which individuals are classified into four constitutional types, Taeyangin, Taeumin, Soyangin, and Soeumin. To develop new functional Saengsik products, we investigated the immunostimulatory activities of raw materials of Saengsik (milled rice, barley, Job's tears, soybean, adzuki bean, millet, eggplants, radish, carrot, Lentinus edodes, Agaricus bisporus, and Auricularia auricula-judae) and Saengsik products (Mix 1~6) in primary immune cells (lymphocytes and macrophages) isolated from blood of Taeumin, Soyangin, and Soeumin types. Increased cell proliferation as well as NO and TNF-${\alpha}$ protein production by immune cells treated with extracts of materials of Saengsik and Saengsik products were measured as immunostimulatory parameters. We chose milled rice, adzuki bean, radish, and Lentinus edodes to study the immunostimulatory activity of Teaumin, barley, soybean, eggplants, and Agaricus bisporus to study the immunostimulatory activity of Soyangin, as well as Job's tears, adzuki bean, carrot, and Auricularia auricula-judae to study the immunostimulatory activity of Soeumin. The mixtures (Mix 1~6) were made with different kinds and ratios of Saengsik materials based on the immunostimulatory activities of Saengsik materials. The immunostimulatory activity of Taeumin was highest in Mix 2 (rice 60%, adzuki bean 20%, radish 10%, and Lentinus edodes 10%) extract-treated immune cells among all six mixtures. The immunostimulatory activity of Soyangin responded best to Mix 4 (barley 60%, soybean 20%, eggplants 10%, and Agaricus bisporus 10%) among the six extracts (Mix 1~6). The increased immunostimulatory activity of Mix 6 (Job's tears 60%, adzuki bean 20%, carrot 10%, and Auricularia auricula-judae 10%)-treated immune cells was higher than the other five extracts (Mix 1~5). Accordingly, Mix 2, Mix 4, and Mix 6 may be useful as mixtures for Saengsik products having personalized immunostimulatory activities.

• Korean Journal of Ecology and Environment
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• v.51 no.1
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• pp.29-39
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• 2018

Long-term variation of zooplankton community and species composition was studied from 2003 to 2014 in a deep reservoir, Lake Soyang, in monsoon climate region, Korea. In addition, we examined the correlation with environmental factors. Annual precipitation of watershed showed a large variation in the $705{\sim}1,779mm\;yr^{-1}$ and more than 70% of it was being concentrated from June to September. The water quality of Lake Soyang was shown a clearly seasonal variations and particularly turbid water flowing into the lake during rainy season was the most important environmental factors. Zooplankton community in Lake Soyang showed a significant difference before and after 2006. Zooplankton biomass has shown a large increase and also showed a change in the zooplankton community structure since 2006. The of zooplankton showed positive correlation with temperature and BOD, Chl. a, TP concentration. These results are considered that nutrient and organic matter contained in the turbid water influences the increase in zooplankton biomass and species composition. However, water quality was limited to account for the increase in biomass of zooplankton. For example, increase of small zooplankton density (rotifer; Keratella cochlearis, Polyarthra vulgaris) in spring which is dominated by diatoms (large size; Melosira, Synedra etc.) is considered as a bottom-up effect by the microbial loop. And increased density of crustaceans in autumn was considered a top-down effects by the relationship between predator and prey of microzooplankton and mesozooplankton. In other words the inflow of allochthonous organic matter during rainy season also affected to zooplankton food web in Lake Soyang. In conclusion, biomass, diversity and long-term variations of zooplankton in Lake Soyang were determined by physico-chemical factors but also it is considered that biological interactions is important.

• Journal of Sasang Constitutional Medicine
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• v.9 no.1
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• pp.13-24
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• 1997

• 한국생태학회:학술대회논문집
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• 1998.05a
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• pp.64.2-64.2
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• 1998

• Journal of Food Hygiene and Safety
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• v.31 no.2
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• pp.126-131
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• 2016

This study examined the immunostimulatory activities on a 70% ethanol extract of raw garlic (RG) and steamed garlic (SG) grown in Korea, Japan, and America using primary immune cells isolated from the blood of Soyangin, Taeumin, and Soeumin volunteers. The Soeumin showed the highest cell proliferation, NO and $TNF-{\alpha}$ production from the immune cells treated with a 70% ethanol raw garlic extract (RGE), followed Taeumin, and Soyangin. The constitution differences were not observed for the same ethanol streamed garlic extract (SGE) and the SGE showed stronger immunostimulatory activities than RGE. The immunostimulatory activities of RG and SG showed a significant difference among countries and the immunostimulatory activities were the highest in RG and SG grown in Korea, followed by RG and SG grown in Japan, RG and SG grown in America. The effect of RGE and SGE on antioxidant activity showed similar trends.

• Journal of Korean Medical classics
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• v.18 no.4 s.31
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• pp.44-48
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• 2005

소위(所謂) 심풍열증시상화치성이혈조(心風熱證是相火熾盛而血操), 인기음수다(引起飮水多), 습열울체어혈분적결흉병(濕熱鬱滯於血分的結胸病). 인이(因而), 흉중수기불능하강(胸中水氣不能下降), 유차가견류사소양병적결흉증상(由此可見類似少陽病的結胸證象), 이차재체표용역조성잉유부진소산적풍열사(而且在體表容易造成仍有不盡消散的風濕邪). 여차병황하(如此病況下), 심장지열영향소장이출현(心臟之熱影向小腸而出現), 뇨수빈이부창(尿雖頻而不暢), 혹뇨량소이소편불리(或尿量少而小便不利). 종상소술(綜上所述), 여하요약기내용(如下要略其內容). 1. 도적강기탕시적합용어소양인소양병습열결흉(導赤降氣湯是適合用於少陽人少陽病濕熱結胸). 2. 기병증수속어혈분증(其病證雖屬於血分證), 인잉유표증(因仍有表證), 고의겸용발산지제(故宜兼用發散之齊). 3. 여겸유안양등(如兼有眼痒等) 간담병증(肝膽病證), 환령가기타처방. 4. 해방대소화계통허약(該方對消化系統虛弱), 겸유수족냉(兼有手足冷), 훈차(暈車), 전두통(前頭痛), 장염(腸炎) 등적환아(等的患兒), 기효과흠가(其效果欠佳). 5. 유차가지(由此可知), 도적강기탕시침대심유습열(導赤降氣湯是針對心有濕熱), 위야유열(胃也有熱), 잉유표증(仍有表證), 부겸유간담병증적환아료효호(不兼有肝膽病證的患兒療效好). 여유소시호탕증(如有小柴胡湯證), 즉선용시호지제이해제해증(則先用柴胡之劑而解除該證), 연후재변증(然後再辨證), 재산시해치법적원칙(才算是該治法的原則).

• Journal of Sasang Constitutional Medicine
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• v.17 no.1
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• pp.155-161
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• 2005

1. Objectives The purpose of this study was to investigate the effects of administration of Indongdeungjikolpi-tang on the Soyangin Jungso(中消). 2. Methods To heal the Soyangin Jungso, we used Indongdeungjikolpi-tang(忍冬藤地骨皮湯). 3. Results Jungso of a Soyangin patient responded well to the treatment with Indongdeungjikolpi-tang. 4. Conclusions This case-study shows an efficient results by using Indongdeungjikolpi-tang in treatment of Soyangin Jungso(Diabetes Mellitus).

• Journal of Sasang Constitutional Medicine
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• v.14 no.2
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• pp.138-146
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• 2002

1. Background and Purpose 1 intented to be helpful to treat diabetes through a clinical study of lndongdeungjikolpitang effect of soyangm 2. Methods I studied 6 patients with middle diabetes who were diagnosed by Soyangin at department of Sasang constitutional Medicine in Dongeui Oriental Hospital during 1 year from August. 2001 to July. 2002. and then I investigated the clinical symptoms of the diabetics and analyzed level of examination after administration of lndongdeungjikolpitang 3. Results and Conclusion lndongdeungjikolpitang was administered to six diabetic patients, So-yang-in for 8 weeks. The symptoms such as frequent hunger(P<0.05), decrease of body weight(P<0.05) have improved after the treatment. As results, level of HbAlC(P<0.05), total protein(P<0.05) and blood pressure(P<0.05) significantly decreased after administration of Indongdeungjikolpitang.

• Journal of Sasang Constitutional Medicine
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• v.10 no.1
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• pp.143-160
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• 1998

PURPOSE This studied the biomechanical body segment parameters of Korean adults with reference to Sasang Constitutional Medicine(SCM). We anlyzed the characteristics of Sasang constitution through Body Measurement, Immersion Method, and Reaction Board Method. SUBJECT Subjects were 72 persons. There were made 49 and Female 23. Mean age was . And There were Taeumin 30, Soyangin 17, and Soeumin 25. METHOD The items of Body Measurement were 51. Limbs were measured right side. Volume was gained with Immersion Method and Weight was calculated with the density equation for limbs from Drills and Contini. Center of Mass was gained with Reaction Board Method. RESULT 1. In Body Measurement there were the significant differences with each constitution of man's circumference. 2. In Volume there were the significant differences between Taeumin and Soeumin in mand. And the volume rate of head and neck, hand, and foot was the lowest in Taeumin, but the highest in Soeumin. 3. In center of mass Soyangin was higher than others.

• Journal of Sasang Constitutional Medicine
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• v.12 no.1
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• pp.186-200
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• 2000

The purpose of this research was to investigate the effects of Indongdeungjikolpitang water extract(IJTE) on the complication of diabetes. IJTE did not affect the level of blood glucose in alloxan- or streptozotocin-induced hyperglycemic mice, but inhibited the motility of gastrointestine. IJTE inhibited the writhing syndrome induced by acetic acid, the permeability of evans blue into peritoneal cavity induced by acetic acid, the paw edema induced by histamine, and the formation of cotton pellet granuloma. IJTE increased the cell viability of thymocytes and splenocytes. IJTE decreased the release of ${\gamma}-interferone$(${\gamma}-IFN$) and interleukin-2(IL-2), but did not affect the release of interleukin-4(IL-4) from murine thymocytes. IJTE increased the release of IL-4 and decreased the release of tumor necrosis $factor-{\alpha}$($TNF-{\alpha}$) and $interleukin-1{\beta}$($IL-1{\beta}$), but did not affect of ${\gamma}-IFN$ and IL-2 from murine splenocytes. IJTE decreased the release of $TNF-{\alpha}$ and $IL-1{\beta}$ from murine peritoneal macrophages. IJTE decreased the production of niric oxide(NO) from murine peritioneal macrophages and increased the phagocytic activity of murine peritoneal macrophages. These results suggest that IJTE has an anti-inflammatory action via the inhibition of $TNF-{\alpha}$, $IL-1{\beta}$ and NO production from immune cells.