• Journal of The Korean Society of Inherited Metabolic disease
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• v.4 no.1
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• pp.54-60
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• 2004

• Proceedings of the KTCVS Conference
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• 1993.06a
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• pp.92-92
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• 1993

• Clinical and Experimental Pediatrics
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• v.53 no.2
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• pp.163-166
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• 2010

Purpose : Leigh syndrome is a typical type of mitochondrial disease. This study was conducted to analyze the types of ophthalmologic symptoms and results of funduscopy conducted in the ophthalmologic examination of patients with Leigh syndrome. Methods : Funduscopy was conducted on 24 subjects, who were chosen among those diagnosed as having mitochondrial respiratory chain complex defect and who were clinically suitable for the criteria of Leigh syndrome. Their clinical features, ophthalmologic symptoms, and ophthalmologic examination results were retrospectively analyzed. Results : Of the 24 patients with Leigh syndrome, 11 developed ophthalmologic symptoms and no abnormal finding was observed in 13. The most frequent abnormal finding was visual disturbance in 5 patients. Funduscopy revealed abnormal findings in 17 patients; retinal pigmentation was the most frequent abnormality and was seen in 9 patients. Conclusion : Funduscopy can be an important screening test to find ophthalmologic abnormalities among patients with mitochondrial disease (MD), including those patients whose ophthalmologic symptoms are inconspicuous. It is predicted that an improved screening test can be made in the future that will identify risk factors related to ophthalmologic symptoms.

• Laboratory Medicine Online
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• v.7 no.4
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• pp.163-169
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• 2017

Background: An automated immunohematology analyzer, DAYMATE M (DAY Medical, Switzerland), has been recently developed. The potential of this analyzer to improve test results has been evaluated. Methods: A total of 300 blood samples from Seoul St. Mary's hospital and Incheon St. Mary's hospital were tested for ABO and RhD typing. In addition, 336 antibody screening test (AST) samples and 82 patients treated with hematopoietic stem cell transplantation (HSCT) were included. AST results by DAYMATE M were compared with those obtained by a manual method using DS-Screening II (Bio-Rad Laboratories, Switzerland) and red blood cells from Selectogen (Ortho-Clinical diagnostics Inc., USA). Results: Of the 300 patients enrolled, 87, 73, 79, and 61 had type A, B, O, and AB blood, respectively. The concordance rate was 99.9% for cell typing and 97.0% for serum typing. One discordant case was classified as type B instead of AB, and six discordant serum-typing cases were type A, but classified as type AB. Among the 336 AST samples, the concordance rate was 93.2%. From 136 positive cases, six were discordant. Within the 82 HSCT-treated patients, the concordance rate for ABO blood typing was 92.2%. Among the six discordant cases, DAYMATE M typed four cases as donor type where the standard method typed them as the recipient blood type. Conclusions: The DAYMATE M automated immunohematology analyzer performs reliably for ABO and RhD typing, as well as for ASTs and on samples from patients treated with HSCT.

• Proceedings of the Korea Information Processing Society Conference
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• 2007.11a
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• pp.161-164
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• 2007

최근 인터넷과 멀티미디어 기술이 발달함에 따라 이미지 데이터의 양이 급속히 증가하고 있다. 증가하는 이미지를 효과적으로 관리하고 검색하기 위해 내용기반 이미지 검색에 대한 연구가 활발히 진행되고 있다. 대부분의 내용 기반 이미지 검색 시스템은 색상, 모양, 질감 특징을 이용한 유사도-기반검색에 초점을 맞추고 있다. 따라서 본 논문에서는 이미지에 나타나는 주요 색상과 색상의 공간적 특성을 포함하는 픽셀샘플링, 그리고 이미지의 외형적 변경에 강인함을 갖는 불변 모멘트 값을 이용한 내용기반 이미지 검색 시스템을 제안한다. 첫 번째 유사성 검사 단계에서는 이미지의 영역별로 가중치를 부여하여 추출한 대표색상을 사용하여, 유사하지 않은 이미지를 제거하여 검색대상의 수를 줄이며, 두 번째 유사성 검사 단계에서는 첫 번째 단계에서 선별된 후보 이미지에 색상의 공간적 정보를 포함한 픽셀샘플링을 이용하여 색상의 공간적인 위치까지 유사한 이미지만을 선별한다. 두 번째 유사성 검사단계에서 이미지가 외형적으로 변형된 유사이미지의 검출이 어려운 점을 보완하는 방법으로 이미지의 불변 모멘트를 이용하여 검색의 정확성을 높인다. 제안한 이미지 검색 방법은 10000개의 다양한 이미지로 구성된 데이터베이스에서 검색을 효율성을 실험하였다.

• Journal of radiological science and technology
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• v.37 no.4
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• pp.267-272
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• 2014

It is well known that low body mass index and younger age are associated with high breast density. Mammographic dense breast has been reported both as a cause of false-negative findings on mammography and as an indicator of increased breast cancer risk. The purpose of this study was to evaluate the association between breast density and body mass index. Furthermore, we considered proper screening method of breast cancer in Korean women. The study was performed on 496 women who underwent health checkup in a university hospital. Age and body mass index were negatively associated with breast density respectively. In postmenopausal women, age and body mass index showed statistically significant association with breast density. Therefore, we should consider sensitive additional method for breast cancer screening especially in younger age and underweight women.

• The Journal of Korean Academy of Sensory Integration
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• v.13 no.1
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• pp.23-31
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• 2015

Objective : The aim of this study was to investigate the correlation between problem drinking and sensory processing features in college students. Methods : From April to June in 2015, mentally healthy 162 college students were completed the questionnaire for problem drinking and sensory processing features. Both Adolescent/Adult Sensory Profile and Alcohol Use Disorder Identification Test-Korean were used as measurements for correlation. Results : Depends on the existence of the problem drinking, there was no statistical differences between groups in sensory processing features. In group of problem drinking, the result indicated the positive correlation between problem drinking and sensory processing feature (r=.195). Conclusion : Problem drinking had significant relationship with sensory sensitivity. Therapists should understand the features of college students with problem drinking. It would be desirable to develop a proper evaluation and intervention programs for these people.

• Stress
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• v.26 no.4
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• pp.277-289
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• 2018

Background: The purpose of this study is to develop a short form of the normal depression scale for individual use in the school, health, industry, organization, and counseling settings, based on the original normal depression scale (17 items). Methods: To achieve this purpose, we selected five items from the original test and analyzed data using Mplus 7.4 and SPSS 21.0. Results: The normal depression scale-short form consists of 5 items. The reliability of the short form (test-retest reliability) was good. The content validity and internal structure validity (1 factor model) were verified. The cut score between normal and dysfunctional depression was determined to be 18. Conclusions: The normal depression scale-short form for individual screening is verified to have good reliability and validity, so it is expected to be useful to perform quick screening of normal depression in the practical settings.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.18 no.2
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• pp.35-42
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• 2018

Purpose: To follow up Korean patients with metabolic and endocrine disorders ascertained by Korea Genetics Research Center, and assess the long-term effectiveness of extended newborn screening program in Korea. Methods: From January 2000 to December 2017, tandem mass spectrometry and fluoroimmunoassay were employed in extended newborn screening (NBS). The NBS program obtained dried blood spots from 283,626 babies, 48 hours after birth, and screened for galactosemia, congenital hypothyroidism (CH), congenital adrenal hyperplasia (CAH), and 50 preventable inborn errors of amino acid, fatty acid, and organic acid metabolism. Results: 28 cases of amino acid disorders, 75 cases of organic acid disorders, 27 cases of fatty acid disorders, 51 cases of urea cycle disorders, 127 cases of CH, 14 cases of CAH, and 15 cases of galactosemia were ascertained through NBS and subsequent confirmatory laboratory tests. Patients with amino acid metabolic disorders, galactosemia, CH, or CAH were more likely to have a better long-term outcome if detected early. Early management of MSUD led to much better outcome in over 90%. Despite early intervention, 32% of other organic acidemia cases still resulted in developmental delay and neurological problems. Fatty acid disorders showed varied results; those with EMA and MCAD had a good outcome, but those with VLCAD had serious neurological problems and considerably higher mortality. 75% with UCD experienced serious neurological complications and higher mortality. Conclusion: The nation-wide NBS program must be accompanied by comprehensive long-term management and physician and family education of inborn errors of metabolism for a better outcome.

• Women's Health Nursing
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• v.10 no.2
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• pp.150-161
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• 2004

The importance of screening or repeat screening for cervical and breast cancer is well known to decrease the chance of death from cancer. Few data is avaliable regarding factors associated with participation in cervical and breast cancer screening and repeat screening examinations. This study was to investigate the associations of demographic factors, health status and cancer risk recognition, attitude to cancer screening, health behaviors, and inhibiting or facilitating factors to cervical and breast cancer screening with participation in the screening tests. Data was collected with self-administrated questionnaires from 342 women, aged 40 to 69 years. The cancer screenings were classified into have had or never groups and repeat or not repeated groups. In the case of cervical and breast cancer screening, the have had group was 90 (26.3%), and 82 (24.0%) and the repeat group was 17 (5.0%), and 13 (3.8%) respectively. According to logistic regression analysis, age (<60 vs ${\geq}60$ : OR=3.25, 95% CI=1.27-8.26), breast cancer screening (Do vs Don't : OR=14.49, 95% CI=7.46-27.78) and other person's cancer (Yes vs No : OR=4.27, 95% CI=1.01-18.05) were statistically significantly associated with participation in screening for cervical cancer. Regular exercise (Do vs Don't : OR=2.76, 95% CI=1.30-5.88) and cervical cancer screening (Do vs Don't : OR=13.70, 95% CI=7.09-26.32) were statistically significantly related to participation in screening for breast cancer.