• Proceedings of the Korean Information Science Society Conference
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• 2011.06c
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• pp.98-101
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• 2011

코호트연구는 특정 집단을 계속 추적해 가면서 과거의 행동이 미래에 어떠한 영향을 미치는가에 대하여 알아보는 역학적 연구이다. 짧게는 2개월에서 길게는 수십 년에 걸쳐서 진행 된다. 일반적으로 식사조사 프로그램을 이용하여 연구대상자들에 대한 식사조사기록을 저장하게 되는데, 이러한 기록들은 수십 년에 해당하는 결과를 장기간 지속적으로 저장하고 보존하여야 한다. 하지만, 현존하는 식사조사 프로그램들은 대부분 운영체제 및 시스템에 종속적이기 때문에 운영체제가 변경되면 프로그램도 같이 변경되어야 하는 문제점을 가지고 있다. 이는, 장기간의 식사조사기록을 보관하여 연구를 하는 코호트연구에 있어서는 심각한 문제이다. 때문에, 장기보존을 위해서는 장기보존 시스템을 구축할 필요성이 존재하며, 각 식사조사 프로그램은 장기보존시스템과 연동 할 수 있는 식사조사 기록 생성 시스템이 필요하다. 따라서 본 논문에서는 OAIS(Open Archival Information System) 참조 모델의 SIP와 METS(Metadata Encoding and Transmission Standard)를 이용하여 식사조사기록을 장기 보존 관리 하는 시스템에 적용할 수 있는 식사 조사기록 생성 시스템을 제안 한다. 제안한 시스템은 XML 패키지를 이용하여 식사조사기록을 생성하는 인터페이스를 제공한다.

• Journal of Environmental Health Sciences
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• v.19 no.4
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• pp.67-82
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• 1993

This study was performed to investigate the preventive effect of KDD against lead toxicity. KDD of 133, 266, 532 and 1,064 mg/kg were administered twice to the rats of Sprague-Dawley strain and then 300 mg/kg lead acetate was given to times, respectively. 1. The accumulation effects of KDD against to lead showed the changes of lead concentration by time variation. But, no statistical significance were showed on 8 and 10 weeks for kidney, spleen, 8 weeks for liver, and 4, 6 and 8 weeks for duodenum. In the femur, statistical significance existed during the whole experimental period. The relatively high concentration of lead detected in the feces of the experimental group means that KDD facilitated excretion of lead. 2. The histopathological effect of KDD against lead showed cytomegaly, karyomegaly, inclusion body, urinary cast and hemosiderin of kidney in the experimental group I (Pb 300 mg/kg). Recovery of KDD administrated group was inclined to increase by KDD concentration. But, spleen's histopathological recovery of KDD aginst to lead did not show as much as kidney. In conclusion, this study revealed the preventive effect of KDD against lead toxicity and its mechanism inferred to facilitate lead excretion in feces following hinderance of lead absorption in the gastric-intestine and organs.

• Journal of Society of Preventive Korean Medicine
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• v.12 no.3
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• pp.1-8
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• 2008

Background : 'Yangsaeng' means health preservation concept in TKM(Traditional Korean Medicine). Health promotion using by traditional medicine was increased recently, but, has little measurement tools in evaluating traditional health care program. This study accomplished to analyze internal consistency reliability by Hong-Cheon survey data Method : Internal consistency reliability analysis within survey items Result : There was little reliability in mind and sexual life yangsaeng factor(Cronbach's alpha value 0.325, 0.273), higher reliability in lifestyle yangsaeng factor(0.718). And reliability was various within items according to age and health insurance type.

• Journal of Society of Preventive Korean Medicine
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• v.5 no.1
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• pp.31-40
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• 2001

Legal permissible limit of herbal drugs metal level in Korea is define 'less 30.0ppm in total(except mineral drugs)' including Pb Hg Cd As Cr Ni etc. This limit has a lot of problems in several factors, that is, not divide hazard and essential elements, not consider high and low toxic effect in each metal, not calculate dose-response relationship and average health behavior in Korean etc. As a that result, It has strong limits and weakness in the basic toxicology and Oriental medicine. To improve and correct these factors, We need to several new approach as like below. It must be radical study following problems in short and middle-long period in the future, toxic metal and essential element must be divide to basic toxicology and also be diverse toxic effect. But mineral drugs that included a amount of severe toxic metals is being used as active prescription drug until now. If toxic, safety and side-effect of metals will be considered, mineral drugs must prohibit instantly or use at least after examined toxic effect. But one of the most important things about herbal drugs contamination, all people and department (government, farmer and trader, oriental medicine doctors and association) will be participate cooperative and collection for preventive or the least contamination in herbal drugs.

• Herbal Formula Science
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• v.30 no.3
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• pp.205-210
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• 2022

Conventional pharmacology has followed the notion of the reductionist 'single target selective drug paradigm'. Network pharmacology has made conventional pharmacology newer while meeting the challenges of this era. Conventional pharmacological methods have not solved the problems of Korean Medicine. For this reason, Network pharmaco- logy needs urgently and desperately for Korean medicine research. However, the information on drug interactions in herbal medicines is complex and less known. There are still some hurdles before network pharmacology emerges, one factor which constitutes Korean medicine research. There is a need to look for solutions other than inheriting the network pharmacology to solve problems that Korean medicine has before. The way of 'in silico' research should be the best to meet this challenge. With the help of 'in silico' research, there might have been emerged new findings of experimental data in Korean Medicine. If 'herbalomics' has been close to foundation through the 'in silico' method, it will contribute to the formation of modern Korean medicine and, simultaneously, come to a foundation for revitalizing exchanges with orthodox Western medicine. Eventually, it ends with a significant profitable and healthy result for the patients.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.11 no.1
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• pp.21-27
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• 2017

To guarantee the effectiveness of the HACCP(Hazard analysis and critical control points) system, it is necessary to develop of an ontology-based information system that can automatically manage the large amount of HACCP records or information derived from the HACCP operation results. In this paper, we construct a food information ontology which represents the relationships between ingredients, recipe, and features of food categories. Moreover, we develop HACCP automation application adopt the ontology to verify the semantic quality of the designed ontology model by performing HACCP processes such as HACCP diet classification. We expect to contribute to develop a food hygiene information and improve the accuracy of the HACCP data through the semantic system.

• Ecology and Resilient Infrastructure
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• v.3 no.1
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• pp.1-7
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• 2016

River restoration has recently progressed in consideration of ecological functions along with flood controls and conservation. For river restorations that consider ecological health and diversity, it is important to contemplate the recovery of hydraulic and hydrologic connectivity in isolated spaces by longitudinal structures. In this study, as a first step for the provision of hydraulic and hydrologic data, which is necessary for the ecological connection analysis in isolated spaces, we developed a one-dimensional numerical model for rainfall runoff and channel routing and applied it to the Cheongmi watershed. The developed numerical model can simulate hydraulic and hydrologic analysis at the same time using the rainfall data. Numerical results were compared with observed data and other numerical results. As a result, a very reasonable agreement is observed. The results of this study will be improved so that the long-term hydrologic and hydraulic analysis is possible to predict ecological change.

• Herbal Formula Science
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• v.12 no.2
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• pp.139-154
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• 2004

Acetaminophen은 세계적으로 널리 사용되는 해열 진통제이지만, 또한 과용 및 남용, 알코올 중독과 같은 여러 원인에 의해 간독성을 유발할 수 있는 약물이다. 이러한 acetaminophen의 간독성은 CYP에 의해 생성되는 대사산물인 NAPQI와 활성산소에 의해 유발되는 것으로 알려져 있다. 본 연구에서 5주된 수컷 백서에 acetaminophen (500 mg/kg)을 투여하기 전에 대시호탕 (500 mg/kg)를 일주일간 투여하였다. 이후 GOT, GPT, GST 그리고, 조직사진으로 대시호탕의 간보호작용을 측정하였다. 또한 대시호탕의 간보호작용 기전을 항산화작용과 CYP 2E1 발현조절을 통한 NAPQI 생성억제의 두 가지 면에서 측정하였다. GOT, GPT 그리고 조직사진에서 나타난 결과들은 대시호탕이 고용량의 acetaminophen에 대한 간보호작용이 있음을 증명할 수 있었다. 또한 LPO와 catalase, 그리고 GSH 실험에서 나타난 결과들을 통해 대시호탕이 항산화작용이 있음을 알 수 있었다. 그리고 GSH, GST, RT-PCR, western blot 실험에서 대시호탕이 CYP 2E1의 발현을 조절하여 NAPQI 생성을 억제한다는 것도 알 수 있었다. 이상의 결과들을 바탕으로 대시호탕은 항산화작용에 의한 활성산소 제거력과 CYP 2E1의 발현조절을 통한 NAPQI 생성억제로 고용량 acetaminophen에 의해 유도된 간손상에 대해 유의성 있는 보호작용을 한다는 것을 알 수 있었다.

• The Journal of the Convergence on Culture Technology
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• v.5 no.3
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• pp.139-145
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• 2019

This study investigates the factors of job stress from working environment of employees' in the IT relative industry and explore its effects on both job involvement and affective commitment. 15 companies and individuals(IT freelancers) working in Seoul and Gyeonggi Provence were chosen for this study. Data were collected for 4 weeks from May 27 to June 28, 2019. A total of 400 employees' were attended in this research and finally 352 samples were used for the empirical analysis. The result of this study showed that 'role ambiguity' factor and 'role conflict' factor among the job stress factors influence on job involvement. Moreover, all factors(overload, role ambiguity, role conflict) among job stress influence on affective commitment.

• The Journal of the Convergence on Culture Technology
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• v.7 no.3
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• pp.269-276
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• 2021

The purpose of this study is to investigate the relationship between always being on call and the conflict factors between work and life balance among employees' in the IT relative industry. The results are as follows: always being on call factor perceived by employees' in the IT relative industry influences to conflict factor between work and life balance. Moreover, always being on call factor negatively effects on all factors of job insecurity which are impotent feeling and possibility of job loss. From the analysis of relation between job insecurity and conflict between life and work balance showed that the factor of impotent feeling influence on conflict between life and work balance while the factor of job loss does not. In addition, job insecurity(impotent feeling and possibility of job loss) partially mediated between always being on call and the conflict factors between work and life balance among employees' in the IT relative industry.