• Journal of Pharmaceutical Investigation
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• v.17 no.2
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• pp.47-53
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• 1987

Furosemide retard tablets were prepared using hydroxyethylcellulose(HEC) as a matrix material. Dissolution of furosemide from this tablet was retarded significantly comparing with conventional tablets and greatly dependent on HEC concentration and pH of the dissolution medium. The mechanism of retarded release was supposed to be due to HEC gel formation and drug diffusion through the gel matrix.

• Journal of Biomedical Engineering Research
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• v.8 no.2
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• pp.135-144
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• 1987

Polyamide microcapsules were designed for a sustained drug release. As a model, riboflavin was e no apsulated in polyamide microcapsules. Polyamide microcapsules were prepared from thiamines and acid bichlorides by the interfacial polycondensation reaction. The diamines used in ttlis works were ethylenediamine and 1, 6-hexamethylenediamine. Sebacoylchloride and teruphthaloylchloride were employed as acid bichlorides. The following parameters were studied; the release of several kinds of polyamide microcapsules , the various concentrations of diamines and acid dichlorides ; the various concentrations of surfactants : the various pH range of sink solution during the dissolution test. The release amount of riboflavin from aromatic polyamide micrcapsule was higher than that of aliphatic polyamide microcapsule The release rate of riboflavin from the polyamide microcapsule was decreased with increase of concentration of thiamines, arid dichlorides and surfactants which is used for preparing polyamide microcapsule. Release riboflavin from polyamide microcapsule was lower at pH 7 than pH 2 in sink-solution for dissolution test.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.104-104
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• 1993

시방성 제제에 대한 연구는 주로 제제학적 수단에 의한 약효의 지속화로서 제제설계상 제형개발 및 투여제형에서의 약물방출 조절로 체내의 유효 혈중농도를 유지한다. 이에 약물 방출 조절용 물질의 하나로서 체내 분해가 가능하고 독성이 없는 생체 고분자인 Chitosan이 약물방출 담체로서 양호함에 착안하여 약물의 서방화를 기하고자 본 실험에 착수 하였다. 모델 약물로서는 sulfamethoxazole, acetaminophen, sylimarin을 사용하여 chitosan gel 과 혼합비를 달리하여 고형 문산체를 조제하고 이것을 formaldehyde, glutaraldehyde, 1acetaldehyde, butylaldehyde 4종의 aldehyde를 사용하여 농도에 따른 가교화가 in vitro에서의 약물용출에 미치는 영향을 검토하였으며, 또한 위장을 거쳐 소화효소 또는 장내미생물 효소에 의한 chitosan 분해로 약물 방출의 촉진을 실험한바 지견을 얻었기에 보고한다.

• Defense and Technology
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• no.10 s.128
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• pp.24-32
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• 1989

중국 해군에 대한 이 간략한 조사 보고는 최근 10년동안 상당한 전력증강을 달성하였음을 나타내주고 있다. 최근의 북경사태에 뒤따른 서방국가들과의 마찰과 소련에 대한 분쟁의 외형적 타결뒤의 의혹등이 예상되기도 하나, 중국의 지도자들은 신기술과 향상된 산업적 생산의 필요성을 인식하고 있다. 만약에 자원만 가용한다면, 소련 해군이 최근 이룩한 업적만큼 중국 해군이 못할 이유도 없을 것이다

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.201-201
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• 1994

항암 및 면역조절작용을 가지고 있으며 그자체가 서방성 prodrug으로서 약효를 나타낼것으로 기대되는 ara-C와 etherphospholipid의 conjugate인 ara-CDP-DL-PCA.2Na의 실험동물(rat)에서의 체내동태를 HPLC 정량법으로 시행 하였다. Ara-CDP-DL-PCA.2Na의 정맥내 투여(20mg/300g)의 경우 혈장중 반감기는 분포상에 있어서는 평균 20min, 소실상 에서는 4.42hr이었다. 분포 용적은 0.1635Lㆍkg$^{-1}$이었고, 전신 clearance 는 25.63ml.$hr^{-1}$.kg$^{-1}$이었다. 한편 AUC는 2601$\mu\textrm{g}$.hr.ml$^{-1}$이었다. 복강내 주사(1g/kg)의 경우 소실상의 반감기는 3.28hr, AUC는 439.3$\mu\textrm{g}$.hr.ml$^{-1}$이었다. 최고 혈중농도 도달시간은 4.4hr이었으며 그때의 농도는 33.19$\mu\textrm{g}$.ml$^{-1}$이었다. 한편 흡수속도 정수는 0.2493$hr^{-1}$이었다. 정맥내 투여에 대한 복강내 투여의 생체 이용율은 1.1252%로 복강내 투여시 흡수율이 좋지 않음을 시사하고 있다. 이는 투여 시료인 micellar solution이 일종의 약물저장 형태로 작용하여 활성물질을 서서히 방출 하기 때문인 것으로 사료된다. 한편 예비적 대사연구결과 TLC에서 뇨나 담즙으로 배설되는 유의한 농도수준의 ara-CDP-DL-PCA.2Na가 없는 것으로 평가되었다. 이는 생체내에서 enzyme등에 의한 대사과정을 거치는 것으로 사료되는바 방사성 동위원소 표지화합물을 이용한 충분한 대사연구가 필요한 것으로 사료된다.

• Polymer(Korea)
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• v.25 no.3
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• pp.334-342
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• 2001

Gentamicin sulfate (GS)-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) devices were prepared for controlled-release of antibiotics. In this study, the effects of thickness, hydroxyvalerate (HV) content, initial drug-loading ratio, and additive content on the release profile have been investigated. The morphology of devices was examined with scanning electron microscope (SEM) before and after in vitro release; their highly porous surface and cross-sectional were observed. It could be suggested that device would be affected by the packing of the HV and additive content, which would depend on their structure. A high performance liquid chromatography (HPLC) was used to detect and quantify the release of GS from the device. The drug release from all the devices showed biphasic release patterns, and some matrices released the incorporated antibiotic throughout 30 days with a near zero-order release rate. The release patterns were shown to be changed by altering the thickness, copolymer ratio, and additive content.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2000.10a
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• pp.290-291
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• 2000

우리나라 주변해역에 출현하는 아귀류는 아귀과(Lophiidae)에 속하는 저서성 어류로서 황아귀, Lophius litulon(Jordan)와 아귀 Lophiomus setigerus(Vahl) 두 종이 알려져 있다. 황아귀는 주로 중국의 하북성, 산동성 연안, 한국 서해 및 제주도 서방 등 동중국해 북부 및 황해에 분포하고 아귀는 주로 동중국해 남부 및 필리핀근해 등에 분포한다(Seikai Regional Fisheries Research Laboratory, 1986). (중략)

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2000.05a
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• pp.330-331
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• 2000

우리나라 주변해역에 출현하는 아귀류는 아귀과 (Lophiidae)에 속하는 저서성 어류로서 황아귀, Lophius litulon (Jordan)와 아귀, Lophiomus setigerus (Vahl) 두 종이 알려져 있다. 황아귀는 주로 중국의 하북성, 산동성 연안, 한국 서해 및 제주도 서방 등 동중국해 북부 및 황해에 분포하고, 아귀는 주로 동중국해 남부 및 필리핀 근해 등에 분포한다(Seikai Regional Fisheries Research Laboratory, 1986). (중략)

• Polymer(Korea)
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• v.36 no.2
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• pp.182-189
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• 2012

In this study, poloxamer hydrogels were prepared by electron beam irradiation and evaluated for potential application as a buccal mucoadhesive drug delivery system. Poloxamer, one of typical thermoresponsive polymers, was modified to have vinyl end groups for crosslinking reaction, and its hydrogels were fabricated by irradiation crosslinking reaction. Carbopol as a mucoadhesive polymeric additive was introduced to improve the mucoadhesive property of the hydrogels and its effect on the mucoadhesion and drug release properties was investigated. The results showed that the end group modification of poloxamer and the addition of carbopol improved mucoadhesive force and mechanical properties and led to a sustained drug release behavior.

• Polymer(Korea)
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• v.25 no.3
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• pp.318-326
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• 2001

PLLA scaffold loaded with gentamicin sulfate (GS) was prepared by emulsion freeze-drying method for the prevention of infection and the improvement of wettability. i.e., the cell- and tissue-compatibility. GS-loaded PLLA scaffolds were characterized by scanning electron microscopy (SEM), mercury porosimetry and blue dye intrusion, and the GS release pattern was analyzed by high performance liquid chromatography (HPLC). GS-loaded PLLA scaffolds with porosity above 50%, medium pore size ranging from 30 to 57 ${\mu}{\textrm}{m}$ (with larger pore diameters greater than 150 ${\mu}{\textrm}{m}$), and specific pore area in the range of 35 to 75($m^2$ /g )were manufactured by varying processing parameter as GS concentration. It was observed that GS-loaded PLLA scaffolds were highly porous with good interconnections between pores for allowing cell adhesion and growth. These scaffolds may be applicable for scaffold as structures that facilitate either tissue regeneration or repair during reconstructive operations.