Journal of Pharmaceutical Investigation
- Volume 17 Issue 2
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- Pages.47-53
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- 1987
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Preparation of Furosemide Retard Tablets Using Hydroxyethylcellulose as Matrix Forming Material
히드록시에칠셀룰로오스를 겔상 메트릭스로 사용한 서방성 푸로세미드정제의 제조
- Kim, Choong-Ho (College of Pharmacy, Seoul National University) ;
- Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
- Lee, Min-Hwa (College of Pharmacy, Seoul National University) ;
- Kim, Shin-Keun (College of Pharmacy, Seoul National University)
- Published : 1987.06.20
Abstract
Furosemide retard tablets were prepared using hydroxyethylcellulose(HEC) as a matrix material. Dissolution of furosemide from this tablet was retarded significantly comparing with conventional tablets and greatly dependent on HEC concentration and pH of the dissolution medium. The mechanism of retarded release was supposed to be due to HEC gel formation and drug diffusion through the gel matrix.
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