• Korean Journal of Microbiology
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• v.49 no.3
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• pp.275-281
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• 2013

Probiotics have been reported to benefit human health by modulating immunity, lowering cholesterol, improving lactose tolerance, and preventing some cancer. Once ingested, probiotic microorganisms have to survive harsh conditions such as low pH, protease-rich condition, and bile salts during their passage through the gastro-intestinal (GI) tract colonize and proliferate to exert their probiotic effects. The dual coating technology, by which the bacteria are doubly coated with peptides and polysaccharides in consecutive order, was developed to protect the ingested bacteria from the harsh conditions. The aim of the study was to evaluate the viable stability of a doubly coated blend of four species of Bifidobacterium by comparing its bile/acid resistance and heat viability in vitro with that of the non-coated blend. After challenges with acid, bile salts, heat, and viable cell counts (VVCs) of the dual coated and non-coated blend were determined by cultivation on agar plates or flow cytometric measurement after being stain with the BacLigtht kit$^{TM}$. The results showed that the dual coated blend was much higher resistant to the acidic or bile salt condition than the non-coated blend and heat viability was also higher, indicating that the dual coating can improve the survival of probiotic bacteria during their transit through the GI tract after consumption.

• The Korean Journal of Applied Statistics
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• v.22 no.3
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• pp.595-606
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• 2009

Two tests were introduced for comparing several survival functions with doubly interval-censored data and illustrated with data surveyed by Korean Cancer Prevention Study (Jee et al., 2005). The test which extended Kim et al. (2006)'s test to the doubly interval-censored data has an advantage over Sun (2006)'s test in terms of saving computation time because the proposed test only depends on the size of risk set, and also the proposed test is applicable to continuous failure time data as well as discrete failure time data unlike Sun's test. Comparing male with female groups on the incubation time of diabetes was highly different and the survival of female group was longer than that of male one. Regardless of gender, the difference in survival functions of four age groups was highly significant with p-value of less than 0.001. This trend was more remarkable for female group than for male one. Simulation results showed that the significance level of both tests was well controlled and the proposed test was better than Sun's test in terms of power.

• Journal of the Korean Data and Information Science Society
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• v.25 no.5
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• pp.1095-1106
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• 2014

Symbolic data analysis extends the data mining and exploratory data analysis to the knowledge mining, we can suggest the SDA tree model on clinical and genomic data with new knowledge mining SDA approach. Using SDA application for huge genomic SNP data, we can get the correlation the availability of understanding of hidden structure of HCC data could be proved. We can confirm validity of application of SDA to the tree structured progression model and to quantify the clinical lab data and SNP data for early diagnosis of HCC. Our proposed model constructs the representative model for HCC survival time and causal association with their SNP gene data. To fit the simple and easy interpretation tree structured survival model which could reduced from huge clinical and genomic data under the new statistical theory of knowledge mining with SDA.

• Journal of Digital Convergence
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• v.10 no.5
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• pp.177-183
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• 2012

The technological innovation of IT industry is the competitive tool for them to survive in the environment of an intensive competition. This technological innovation is critical in the survival of firms, but various factors should be considered to embody technological innovation success. This paper aims to identify the determinant factors of the outcome which influence the technological innovation based on the IT industry, and set up a model for measuring technological innovation success with its relevant understanding through the preceding studies. In addition, research with other related research model is to parallel.

• The Korean Journal of Applied Statistics
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• v.7 no.2
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• pp.79-88
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• 1994

Weighted log rank test is a widely applicable test when one is interested in detecting the differences between two groups. In man clinical trials it is common to see no differences in early experiments and does show significant differences later. We propose new weighted log rank test and illustrate it through an example. We also examine the empirical powers and show that the proposed test is more sensitive to detect late differences.

• Journal of the Korea Convergence Society
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• v.12 no.4
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• pp.285-291
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• 2021

This study is a retrospective study attempted to determine the factors that influence the survival of patients with traumatic acute subdural hematoma. The study subjects were 207 patients with traumatic subdural hematoma who visited the emergency room from January 2017 to February 2019 at C University Hospital in G Metropolitan City. Data analysis was using the SPSS 23.0 program, and χ2-test, t-test, and logistic regression analysis. As a result of the study, the factors affecting the survival of the subjects were under disease, complications, and initial GCS. Therefore, it is necessary to establish a medical system to check the subject's history and to train medical staff to prevent complications. In addition, it is necessary to improve the transfer system so that the GCS of the subject can be measured from the stage before transfer to a medical institution and transferred to a hospital that can be treated quickly.

• Journal of Hospice and Palliative Care
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• v.8 no.2
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• pp.200-208
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• 2005

Purpose: Palliative procedures or surgical interventions not only manage various symptoms of malignant gastrointestinal obstruction, but also improve the quality of life. We investigated the clinical characteristics and prognostic factors of terminal cancer patients with palliative procedures for malignant gastrointestinal obstruction. Methods: We retrospectively reviewed the medical records of 48 terminal cancer patients with palliative procedures for malignant gastrointestinal obstruction at Sam Anyang hospital from May in 2002 to May in 2005. We excluded patients with palliative tumor resection. We analyzed prognostic factors in symtom-free survival and overall survival using Kaplan-Meier method, univariate and multivariate analysis. Results: There were 25 males (52%) and 23 females (48%), and median age of 48 patients was 65 years. The most common cause of malignant gastrointestinal obstruction was colorectal (26 patients, 55%), followed by stomach (10, 21%). Twenty patients (42%) received previous treatment (chemotherapy, surgery, and radiotherapy) and 28 (58%) never received any. Eighteen of 20 had received chemotherapy. The most common symptom was pain (15 patients, 31%). Twenty three patients (48%) had Eastern Cooperative Oncology Group(ECOG) performance status of 1 or 2 score and 25 patients (52%) 3 or 4 score. The most common palliative procedure was colostomy and there was no mortality concerning the palliative procedures. By univariate and multivariate analysis, performance status was the only independent prognostic factor in overall survival and symptom-free survival. Overall survival was 150 days and symptom-free survival was 90 days. Conclusion:. We confirmed that perftatdormance status is significant independent prognostic factor in terminal cancer patients with palliative procedures for malignant gastrointestinal obstruction.

• Journal of Korea Port Economic Association
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• v.30 no.4
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• pp.219-254
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• 2014

Due to the recent development of globalization and supply chain management, growth of international trade has led to increasing cargo volume around the world. Since maritime logistics environments have changed, increased container ship size, improvement of harbor equipment, global port operation and rapid technological development have had an significant effects on shipping and port industry, which is contributing to competitiveness of port. Since a larger volume of port throughputs are generally regarded as an indicator of the more competitive port, inefficient port operation could reduce its competitiveness. On the other hand, high efficient ports could increase their competitive power while increasing cargo volume. This study aims at comparing competitiveness of the ports in the Northeast Asia by investigating changes of container throughputs and evaluating efficiency performance of ports. Shift-Share analysis and Data Envelopment Analysis(DEA) have been conducted with 21 Northeast Asian ports and then separated them into 4 groups for comparative analysis to identify competitive position of each port. The results of this study show that Incheon and Gwangyang port have been decreased container cargo volume, while volume of Busan port would increase by means of active marketing, various route development and incentive policy for the port.

• Journal of Navigation and Port Research
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• v.34 no.3
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• pp.243-249
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• 2010

The competition between ship management companies is fierce as a result of global trend towards increased specialization. In order for ship management companies to remain competitive, it is necessary to understand the local and global factors and the changing circumstances that impact shipping markets and trade patterns. To better understand these factors, a study and analysis of drawing priority of the competitiveness-evaluation factors of ship management companies was conducted using Analytical Hierarchy Process(AHP) as a method dealing with dicision-making problem. As a consequence of this analysis, it was determined that human resources, both shipboard and land management, were a primary factor in ship management company's competitiveness. Thus, the acquisition and retention of capable staff was a key aspect of assuring a ship management company's competitiveness.

• Journal of Digital Convergence
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• v.10 no.6
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• pp.17-22
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• 2012

The technological innovation of IT industry is the competitive tool for them to survive in the environment of an intensive competition. This technological innovation is critical in the survival of firms, but various factors should be considered to embody technological innovation success. This paper aims to identify the determinant factors of the outcome which influence the technological innovation based on the IT industry, and set up a model for measuring technological innovation success. A hypothesis was established for the impact relation between technological innovation success and government support level, which was verified through the logistic regression analysis. In conclusion, in terms of government support, IT manufacturing companies to the success of product innovation, technology development(R&D) and commercialization of direct support is needed for the financial support. And, the success of process innovation is accomplished through manpower training of technical personnel.