• Korean Journal of Food Science and Technology
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• v.53 no.2
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• pp.223-229
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• 2021

To evaluate the protective effect of Codium fragile on fine dust (PM2.5)-induced cytotoxicity, we investigated its antioxidant activity and cell protective effect on PM2.5-exposed cells. The 40% ethanolic extract of C. fragile showed the highest total phenolic content, whereas the water extract of C. fragile showed the highest total polysaccharide content. The protective effect of the extracts on PM2.5-induced oxidative damage in nasal cavity (RPMI2650), lung (A549), brain (MC-IXC), hippocampus (HT-22), and microglia (BV-2) cells was evaluated by measuring the intracellular reactive oxygen species (ROS) content and cell viability. The results showed that the 40% ethanolic extract more efficiently inhibited ROS production than the water extract. In contrast, PM2.5-exposed cells treated with the water extract showed higher viability than those treated with the 40% ethanolic extract.

• Korean Journal of Food Science and Technology
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• v.53 no.3
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• pp.267-277
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• 2021

To evaluate hepatoprotective effects, the antioxidant capacities of matcha green tea extract (Camellia sinenesis) were compared to those of green leaf tea and the anti-inflammatory activities in HepG2 cells were investigated. Evaluation of the total phenolic and total flavonoid content, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and inhibitory effect on lipid peroxidation indicated that the aqueous extract of matcha green tea presented significant catechin content and antioxidant capacity compared to those of green leaf tea. In addition, the extract had considerable inhibitory effects on α-glucosidase, α-amylase, and advanced glycation end-products. The matcha green tea extract significantly increased cell viability and reduced reactive oxygen species in H₂O₂- and high-glucose-treated HepG2 cells. Furthermore, in response to oleic acid-induced HepG2 cell injury, treatment with matcha green tea aqueous extract inhibited lipid accumulation and regulated the expression of inflammatory proteins such as p-JNK, p-Akt, p-GSK-3β, caspase-3, COX-2, iNOS, and TNF-α. Matcha green tea could be used as a functional material to ameliorate hepatic lipid accumulation and inflammation.

• Journal of Life Science
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• v.15 no.1 s.68
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• pp.152-159
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• 2005

This research was conducted to make suggestions for the promotion of research activities in the Life Sciences field, and we evaluated the research funding trend and the present status of research funding offered by KOSEF in this field. Researchers in this field have received more research funding from the group-based programme than from the individual-based programme. Also, they have received less money (per project) than did researchers in other Science and Technology fields. The portion of research funds given to the Medical Sciences fields has markedly increased year by year, whereas the portion of funding given to the Agricultural Sciences and Biological Sciences fields has decreased annually. To encourage research activities in the Life Sciences field in Korea, the following actions and systems are required: 1) formulation of a mid-and a long-term research master plan, 2) development of a database on man power in related fields, 3) activation of top-down research topics, and associated increase of individual research grants, 4) development of special national programs for basic researches in Life Sciences, 5) organization of a committee for policy and planning within related societies, and 6) system development for fair evaluation of the results of research activities.

• Korea journal of population studies
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• v.29 no.3
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• pp.51-72
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• 2006

In Korea, most studies have used the conventional Wolfbein and Wool method, which cannot be applied to women's work-life table because of bimodality and/or M curve of female labor force participation. The increment/decrement work-life table method, however, is equally applicable to both men and women, but requires individual data on employment transition. This paper demonstrates that the Garfinkle-Pollard method is the same as the increment/decrement work-life table method developed by Hoem, Schoen and Woodrow and adopted by BLS. The merit of Garfinkle-Pollard method is to produce work-life table using labor force participation rate without individual employment transition. This paper applies the Garfinkle-Pollard methods to the estimation and projection of work-life of Korean labor force for the period of 2000-2050, using the abridged life tables provided by Korean National Statistical Office and a projection of labor force participation rates. The work-life expectancy at 65 is 5.8 years for men and 4.1 years for women in 2000, and it increased to 7.7 years for men and 5.1 years in 2050. However, differences in work-life expectancy are found depending on the data processing of elderly labor force participation and mortality assumption. Detailed data on elderly labor force participation and further study on future mortality are required to estimate and project more accurate work-life expectancy.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.3
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• pp.265-271
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• 2021

Nanoparticles are substances that are smaller in size and smaller than cells that make up the skin. Therefore, they are very suitable as mediators for transmitting drugs or genes across cell membranes, and also deliver specific ingredients into the skin.In this study, nanoparticles were extracted from mugwort and particles of around 100 nm were obtained through dynamic light scattering (DLS), and the results of concentration-dependent enhancement of cell viability in fibroblasts were obtained through MTT assay. In addition, it was confirmed that the COL1A1 mRNA expression level was increased and the IL-6 mRNA expression level was decreased through the quantitative real-time PCR analysis method. Moreover, as these nanoparticles were confirmed to be stable, they can be applied not only to cell experiments but also to cosmetic formulations. While the demand for plant-derived ingredients continues to increase, excluding chemical ingredients from the recent cosmetics industry trend, there is a limitation in that there are few research results suggesting the application field of plant-derived nanoparticles. Therefore, in order to overcome the limitations of the cosmetic industry at the present time, the results obtained in this study present nanoparticles derived from Artemisia princeps (NDAP) as a highly functional cosmetic material.

• Korean Journal of Microbiology
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• v.54 no.4
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• pp.456-459
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• 2018

The genus of Olsenella has been isolated from vertebrate animal mouth, rumen, and feces. Olsenella sp. KGMB 04489 was isolated from fecal samples obtained from a healthy Korean. The whole-genome sequence of Olsenella sp. KGMB 04489 was analyzed using the PacBio Sequel platform. The genome comprises a 2,108,034 bp chromosome with a G + C content of 65.50%, 1,838 total genes, 13 rRNA genes, and 52 tRNA genes. Also, we found that strain KGMB 04489 had some genes for hydrolysis enzymes, and antibiotic biosynthesis and resistance in its genome based on the result of genome analysis.

• Journal of the Daesoon Academy of Sciences
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• v.45
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• pp.1-35
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• 2023

This study aims at determining the meaning of Life in The Canonical Scripture of the Daesoon Thought upon the ontological bases of occidental philosophies; especially upon those of Plato and Bergson. In western philosophy, the word ontology designates investigating the meanings of being, which is derived from the Greek 'onto (being)' and 'logia (logical discourse).' The various meanings of life have been sought from ancient times all over the world, for these are the critical and vital questions that pertain to the nature of human existence. Plato had asserted that life, in his word, soul, had three different kinds of aspects of meaning. Immortal, reciprocal, and divine. Plato scheme was such that the soul could die, but after death it could became reborn into another various forms of living creatures. The real inner life of humans, the soul, would live eternally. Henri-Louis Bergson, a famous French philosopher from the 20^th century, claimed that life had three different kinds of aspects. Self-identity, Élan vital (vital impetus) and liberty. Bergson insisted especially the real meaning of life had been characterized by "unité multiple et multiplicitéune," "unity as something multiple and multiplicity something singular." The meaning of life in Daesoon Thought could be said to have three different characteristics, solidarity, earthly immortality and grievance-resolution. Some similarities can be found between certain western ontological meanings of life and those of Daesoon Thought. Namely, the qualities of eternity, reciprocity, and divinity.

• The Korean Society of Law and Medicine
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• v.11 no.1
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• pp.297-329
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• 2010

The bioethics as a comprehensive and normative control method of life sciences including the technology of advanced medical care, on the one hand, it has modified the conditions for allowing the progress of life sciences. On the other hand, it has put the brakes on attempts of life sciences violating the dignity and value of human beings, natural order. Positively, bioethics presents ethical bases, suggests organization of the legal and institutional conditions, and enables elimination of the legal and institutional obstacles, for the progress of life sciences. Negatively, it has presented justifiable prospects and road maps of life sciences, not to take indiscreet and intemperate turn of violating the dignity and value of human beings, natural order, and its such roles must be carried on.

• Proceedings of the Korea Information Processing Society Conference
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• 2005.05a
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• pp.585-588
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• 2005

연구자들이 국외 생명과학관련 문헌정보를 찾으려면 PubMed와 같은 세계적인 문헌정보서비스를 많이 이용하며, 국내 생명과학관련 문헌정보를 찾으려면 KISTI 학회마을, KoreaMed 등 여러 사이트를 방문해야 한다. 이에 생명과학관련 연구를 원활히 수행할 수 있도록 생명정보 데이터베이스와 분석도구를 서비스하고 있는 KISTI 바이오인포매틱스센터(CCBB) 홈페이지에서 인터넷상의 Open Access 문헌정보와 국내 학회정보를 수집하여 메타 데이터베이스를 구축하여 서비스하고자 한다. 또한 생명과학 관련 주제별 Open Archiving 커뮤니티의 구성과 운영을 통한 연구자간의 정보교환을 유도하고, 더불어 논문뿐만 아니라 세미나, 연구노트 등의 최신의 연구정보를 공유할 수 있도록 본 프로토타입 시스템을 설계하였다.

• Proceedings of the Korean Society of Crop Science Conference
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• 2019.09a
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• pp.90-90
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• 2019